Metabolism of 20(S)-Ginsenoside Rg2 by Rat Liver Microsomes: Bioactivation to SIRT1-Activating Metabolites

Specific Turn-On Fluorescent Probe with Aggregation-Induced Emission Characteristics for SIRT1 Modulator Screening and Living-Cell Imaging

(2015) Yi Wang et al.   ANALYTICAL CHEMISTRY

Four new ginsenosides from red ginseng with inhibitory activity on melanogenesis in melanoma cells

(2015) Qi-Le Zhou et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

New SIRT1 activator from alkaline hydrolysate of total saponins in the stems-leaves of Panax ginseng

(2015) Li-Yuan Ma et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Anti-inflammatory Mechanism of Ginseng Saponin Metabolite Rh3 in Lipopolysaccharide-Stimulated Microglia: Critical Role of 5′-Adenosine Monophosphate-Activated Protein Kinase Signaling Pathway

(2015) Yu Young Lee et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Pharmacokinetic profile and metabolite identification of yuanhuapine, a bioactive component in Daphne genkwa by ultra-high performance liquid chromatography coupled with tandem mass spectrometry

(2015) Yanyan Chen et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Simultaneous Determination of Eight Ginsenosides in Rat Plasma by Liquid Chromatography–Electrospray Ionization Tandem Mass Spectrometry: Application to Their Pharmacokinetics

(2015) Li-Yuan Ma et al.   MOLECULES

Metabolic profile of Yi-Xin-Shu capsule in rat by ultra-performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry analysis

(2015) Hongping Wang et al.   RSC Advances

Korean Red Ginseng attenuates ethanol-induced steatosis and oxidative stress via AMPK/Sirt1 activation

(2015) Jae Yun Han et al.   Journal of Ginseng Research

SIRT1 prevents genotoxic stress-induced p53 activation in acute myeloid leukemia

(2014) D. Sasca et al.   BLOOD

SIRT1 Mediates the Effect of GLP-1 Receptor Agonist Exenatide on Ameliorating Hepatic Steatosis

(2014) Fen Xu et al.   DIABETES

Dammarane Triterpenes as Potential SIRT1 Activators from the Leaves of Panax ginseng

(2014) Jun-Li Yang et al.   JOURNAL OF NATURAL PRODUCTS

Ginsenoside Rb1 Prevents H2O2-Induced HUVEC Senescence by Stimulating Sirtuin-1 Pathway

(2014) Zhiming Song et al.   PLoS One

Small molecule SIRT1 activators for the treatment of aging and age-related diseases

(2014) Basil P. Hubbard et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Ginsenoside Rc modulates Akt/FoxO1 pathways and suppresses oxidative stress

(2013) Dae Hyun Kim et al.   ARCHIVES OF PHARMACAL RESEARCH

Evidence for a Common Mechanism of SIRT1 Regulation by Allosteric Activators

(2013) B. P. Hubbard et al.   SCIENCE

Determination of 22 Ginsenosides in Ginseng Products using Ultra-High-Performance Liquid Chromatography

(2012) J. Ha et al.   JOURNAL OF CHROMATOGRAPHIC SCIENCE

The sirtuin pathway in ageing and Alzheimer disease: mechanistic and therapeutic considerations

(2011) David J Bonda et al.   LANCET NEUROLOGY

A new ocotillol-type triterpenoid saponin from red American ginseng

(2011) Jin-Ping Liu et al.   NATURAL PRODUCT RESEARCH

Four New Dammarane-Type Triterpene Saponins from the Stems and Leaves ofPanax ginsengand Their Cytotoxicity on HL-60 Cells

(2011) Ke-Ke Li et al.   PLANTA MEDICA

Sirt1 inhibition promotes in vivo arterial thrombosis and tissue factor expression in stimulated cells

(2010) Alexander Breitenstein et al.   CARDIOVASCULAR RESEARCH

Interplay between SIRT proteins and tumour suppressor transcription factors in chemotherapeutic resistance of cancer

(2010) Yolanda Olmos et al.   DRUG RESISTANCE UPDATES