SIRT1 prevents genotoxic stress-induced p53 activation in acute myeloid leukemia

Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia

(2013)   NEW ENGLAND JOURNAL OF MEDICINE

Activation of p53 by SIRT1 Inhibition Enhances Elimination of CML Leukemia Stem Cells in Combination with Imatinib

(2012) Ling Li et al.   CANCER CELL

STAT5 Is Crucial to Maintain Leukemic Stem Cells in Acute Myelogenous Leukemias Induced by MOZ-TIF2

(2012) W. F. Tam et al.   CANCER RESEARCH

Regulation of SIRT1 activity by genotoxic stress

(2012) J. Yuan et al.   GENES & DEVELOPMENT

High expression of the longevity gene product SIRT1 and apoptosis induction by sirtinol in adult T-cell leukemia cells

(2012) Tomohiro Kozako et al.   INTERNATIONAL JOURNAL OF CANCER

Histone Deacetylase in Chronic Lymphocytic Leukemia

(2012) J.C. Wang et al.   ONCOLOGY

DBC1 phosphorylation by ATM/ATR inhibits SIRT1 deacetylase in response to DNA damage

(2012) Laura Zannini et al.   Journal of Molecular Cell Biology

Regulation of Sirtuin Function by Posttranslational Modifications

(2012) Franziska Flick et al.   Frontiers in Pharmacology

The cell cycle regulator CDC25A is a target for JAK2V617F oncogene

(2011) E.-F. Gautier et al.   BLOOD

Activation of stress response gene SIRT1 by BCR-ABL promotes leukemogenesis

(2011) H. Yuan et al.   BLOOD

TP53 alterations in acute myeloid leukemia with complex karyotype correlate with specific copy number alterations, monosomal karyotype, and dismal outcome

(2011) F. G. Rucker et al.   BLOOD

The role of sirtuin 2 activation by nicotinamide phosphoribosyltransferase in the aberrant proliferation and survival of myeloid leukemia cells

(2011) L. Dan et al.   HAEMATOLOGICA

Mammalian Sirtuins: Biological Insights and Disease Relevance

(2010) Marcia C. Haigis et al.   Annual Review of Pathology-Mechanisms of Disease

FLT3 as a therapeutic target in AML: still challenging after all these years

(2010) T. Kindler et al.   BLOOD

FLT3-ITD up-regulates MCL-1 to promote survival of stem cells in acute myeloid leukemia via FLT3-ITD-specific STAT5 activation

(2009) G. Yoshimoto et al.   BLOOD

Enhanced activation of STAT pathways and overexpression of survivin confer resistance to FLT3 inhibitors and could be therapeutic targets in AML

(2009) J. Zhou et al.   BLOOD

The prognostic impact of 17p (p53) deletion in 2272 adults with acute myeloid leukemia

(2009) H Seifert et al.   LEUKEMIA

SIRT1 Expression is Associated With Poor Prognosis of Diffuse Large B-Cell Lymphoma

(2008) Kyu Yun Jang et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

Impaired DNA Damage Response, Genome Instability, and Tumorigenesis in SIRT1 Mutant Mice

(2008) Rui-Hong Wang et al.   CANCER CELL

Epigenetic Control of rDNA Loci in Response to Intracellular Energy Status

(2008) Akiko Murayama et al.   CELL

SIRT1 Redistribution on Chromatin Promotes Genomic Stability but Alters Gene Expression during Aging

(2008) Philipp Oberdoerffer et al.   CELL

Negative regulation of the deacetylase SIRT1 by DBC1

(2008) Wenhui Zhao et al.   NATURE

DBC1 is a negative regulator of SIRT1

(2008) Ja-Eun Kim et al.   NATURE

In vivo identification of novel STAT5 target genes

(2008) B. Basham et al.   NUCLEIC ACIDS RESEARCH

The SIRT1 Deacetylase Suppresses Intestinal Tumorigenesis and Colon Cancer Growth

(2008) Ron Firestein et al.   PLoS One

Phosphorylation Regulates SIRT1 Function

(2008) Tsutomu Sasaki et al.   PLoS One

miR-34a repression of SIRT1 regulates apoptosis

(2008) M. Yamakuchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Oncogene-Induced DNA Damage Model for Cancer Development

(2008) T. D. Halazonetis et al.   SCIENCE