Investigation of the Metabolism of Astragaloside IV in a Puromycin-Damaged Rat Model by UPLC-Q-TOF-MS/MS Analysis

Effects of Astragaloside IV on the Pharmacokinetics of Metoprolol in Rats and Its Mechanism

(2022) Zhongbo Shi et al.   CURRENT DRUG METABOLISM

Kidney and plasma metabolomics provide insights into the molecular mechanisms of urate nephropathy in a mouse model of hyperuricemia

(2022) Hailong Li et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Metabolomics analysis of human plasma reveals decreased production of trimethylamine N‐oxide retards the progression of chronic kidney disease

(2022) Da‐Yong Hu et al.   BRITISH JOURNAL OF PHARMACOLOGY

Surface-Enhanced Raman Spectroscopy Analysis of Astragalus Saponins and Identification of Metabolites After Oral Administration in Rats by Ultrahigh-Performance Liquid Chromatography/Quadrupole Time-of-Flight Mass Spectrometry Analysis

(2022) Shengnan Kong et al.   Frontiers in Pharmacology

Epidemiology of chronic kidney disease: an update 2022

(2022) Csaba P. Kovesdy   Kidney International Supplements

Integrative phosphatidylcholine metabolism through phospholipase A2 in rats with chronic kidney disease

(2022) Yan-ni Wang et al.   ACTA PHARMACOLOGICA SINICA

Healthcare resource utilisation and related costs of patients with CKD from the UK: a report from the DISCOVER CKD retrospective cohort

(2022) Carol Pollock et al.   Clinical Kidney Journal

Microbiome-Metabolomics Analysis Reveals the Protection Mechanism of α-Ketoacid on Adenine-Induced Chronic Kidney Disease in Rats

(2021) Yenan Mo et al.   Frontiers in Pharmacology

Astragaloside IV ameliorates diabetic nephropathy in db/db mice by inhibiting NLRP3 inflammasome‑mediated inflammation

(2021) Hui Feng et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Targeted Inhibition of Gut Microbial Trimethylamine N-Oxide Production Reduces Renal Tubulointerstitial Fibrosis and Functional Impairment in a Murine Model of Chronic Kidney Disease

(2020) Nilaksh Gupta et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Astragaloside IV alleviates mouse slow transit constipation by modulating gut microbiota profile and promoting butyric acid generation

(2020) Qiulan He et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Protective role of Astragaloside IV in chronic glomerulonephritis by activating autophagy through PI3K/AKT/AS160 pathway

(2020) Ruirui Lu et al.   PHYTOTHERAPY RESEARCH

Analysis of Patient Preferences in Lung Cancer – Estimating Acceptable Tradeoffs Between Treatment Benefit and Side Effects

(2020) Ellen M Janssen et al.   Patient Preference and Adherence

Mechanisms of Renal Fibrosis

(2018) Benjamin D. Humphreys   Annual Review of Physiology

The global burden of kidney disease and the sustainable development goals

(2018) Valerie A Luyckx et al.   BULLETIN OF THE WORLD HEALTH ORGANIZATION

Astragaloside IV Alleviates Lipopolysaccharide-Induced Acute Kidney Injury Through Down-Regulating Cytokines, CCR5 and p-ERK, and Elevating Anti-Oxidative Ability

(2017) Wei Zhou et al.   MEDICAL SCIENCE MONITOR

Pharmacokinetics, metabolism, and excretion of cycloastragenol, a potent telomerase activator in rats

(2016) Peng-Kai Ma et al.   XENOBIOTICA

Global Prevalence of Chronic Kidney Disease – A Systematic Review and Meta-Analysis

(2016) Nathan R. Hill et al.   PLoS One

Disposition of Astragaloside IV via Enterohepatic Circulation Is Affected by the Activity of the Intestinal Microbiome

(2015) Yi Jin et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Astragaloside IV and cycloastragenol are equally effective in inhibition of endoplasmic reticulum stress-associated TXNIP/NLRP3 inflammasome activation in the endothelium

(2015) Yan Zhao et al.   JOURNAL OF ETHNOPHARMACOLOGY

Profiling the Metabolism of Astragaloside IV by Ultra Performance Liquid Chromatography Coupled with Quadrupole/Time-of-Flight Mass Spectrometry

(2014) Xu-Dong Cheng et al.   MOLECULES

Intestinal Microbial Metabolism of Phosphatidylcholine and Cardiovascular Risk

(2013) W.H. Wilson Tang et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pharmacokinetic Evidence on the Contribution of Intestinal Bacterial Conversion to Beneficial Effects of Astragaloside IV, a Marker Compound of Astragali Radix, in Traditional Oral Use of the Herb

(2012) Rui-Na Zhou et al.   Drug Metabolism and Pharmacokinetics

Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease

(2011) Zeneng Wang et al.   NATURE