Protective role of metformin in preeclampsia via the regulation of NF-κB/sFlt-1 and Nrf2/HO-1 signaling pathways by activating AMPK

NCOA2-induced secretion of leptin leads to fetal growth restriction via the NF-κB signaling pathway

(2023) Lin Qu et al.   Annals of Translational Medicine

Clinical utility of sFlt‐1 and PlGF in screening, prediction, diagnosis and monitoring of pre‐eclampsia and fetal growth restriction

(2022) H. Stepan et al.   ULTRASOUND IN OBSTETRICS & GYNECOLOGY

Pre-eclampsia

(2021) Lucy C Chappell et al.   LANCET

Atractylenolide inhibits apoptosis and oxidative stress of HTR-8/SVneo cells by activating MAPK/ERK signalling in preeclampsia

(2021) Mei Liu et al.   PHYTOMEDICINE

Metformin attenuates osteoclast-mediated abnormal subchondral bone remodeling and alleviates osteoarthritis via AMPK/NF-κB/ERK signaling pathway

(2021) Haohui Guo et al.   PLoS One

Novel Interventions for the Prevention of Preeclampsia

(2020) Marwan Ma’ayeh et al.   CURRENT HYPERTENSION REPORTS

Metformin activates AMPK/SIRT1/NF-κB pathway and induces mitochondrial dysfunction to drive caspase3/GSDME-mediated cancer cell pyroptosis

(2020) Zhaodi Zheng et al.   CELL CYCLE

Benefits of Metformin in Attenuating the Hallmarks of Aging

(2020) Ameya S. Kulkarni et al.   Cell Metabolism

SGL 121 Attenuates Nonalcoholic Fatty Liver Disease through Adjusting Lipid Metabolism Through AMPK Signaling Pathway

(2020) Da Eun Kim et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Implication of nuclear factor‐erythroid 2‐like 2/heme oxygenase 1 pathway in the protective effects of coenzyme Q10 against preeclampsia‐like in a rat model

(2020) Lei Li et al.   MICROCIRCULATION

Pravastatin, proton-pump inhibitors, metformin, micronutrients, and biologics: new horizons for the prevention or treatment of preeclampsia

(2020) Stephen Tong et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

PAPP‐A2 and Inhibin A as Novel Predictors for Pregnancy Complications in Women With Suspected or Confirmed Preeclampsia

(2020) Rugina I. Neuman et al.   Journal of the American Heart Association

Apocynin inhibits placental TLR4/NF-κB signaling pathway and ameliorates preeclampsia-like symptoms in rats

(2020) Han Sha et al.   Pregnancy Hypertension-An International Journal of Womens Cardiovascular Health

A novel peptide relieves endothelial cell dysfunction in preeclampsia by regulating the PI3K/mTOR/HIF1α pathway

(2020) Lu Xue et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

NF-κB as the mediator of metformin's effect on ageing and ageing-related diseases

(2019) Gönül Kanigur Sultuybek et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Preeclampsia

(2019) Sarosh Rana et al.   CIRCULATION RESEARCH

Cross-Talk between Oxidative Stress and Inflammation in Preeclampsia

(2019) Marilene Brandão Tenório et al.   Oxidative Medicine and Cellular Longevity

Metformin Activates the Protective Effects of the AMPK Pathway in Acute Lung Injury Caused by Paraquat Poisoning

(2019) Liaozhang Wu et al.   Oxidative Medicine and Cellular Longevity

Metformin Improves Mitochondrial Respiratory Activity through Activation of AMPK

(2019) Yu Wang et al.   Cell Reports

Metformin alleviates oxidative stress and enhances autophagy in diabetic kidney disease via AMPK/SIRT1-FoxO1 pathway

(2019) Huiwen Ren et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Effect of Metformin on a Preeclampsia-Like Mouse Model Induced by High-Fat Diet

(2019) Fuchuan Wang et al.   Biomed Research International

Maternal serum AMP-activated protein kinase levels in mild and severe preeclampsia

(2018) Nadiye Koroglu et al.   Journal of Maternal-Fetal & Neonatal Medicine

Activation of AMPK inhibits inflammatory response during hypoxia and reoxygenation through modulating JNK-mediated NF-κB pathway

(2018) Xu Chen et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Curcumin augments the cardioprotective effect of metformin in an experimental model of type I diabetes mellitus; Impact of Nrf2/HO-1 and JAK/STAT pathways

(2018) Eman M. Abdelsamia et al.   BIOMEDICINE & PHARMACOTHERAPY

Metformin-treated cancer cells modulate macrophage polarization through AMPK-NF-κB signaling

(2017) Chi-Fu Chiang et al.   Oncotarget

Preeclampsia; short and long-term consequences for mother and neonate

(2016) Anouk Bokslag et al.   EARLY HUMAN DEVELOPMENT

Predictive Value of the sFlt-1:PlGF Ratio in Women with Suspected Preeclampsia

(2016) Harald Zeisler et al.   NEW ENGLAND JOURNAL OF MEDICINE

Angiogenesis-Related Biomarkers (sFlt-1/PLGF) in the Prediction and Diagnosis of Placental Dysfunction: An Approach for Clinical Integration

(2015) Ignacio Herraiz et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Synthesis of sFlt-1 by platelet-monocyte aggregates contributes to the pathogenesis of preeclampsia

(2014) Heather D. Major et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Nrf2, a Regulator of the Proteasome, Controls Self-Renewal and Pluripotency in Human Embryonic Stem Cells

(2014) Jiwon Jang et al.   STEM CELLS

Metformin inhibits the senescence-associated secretory phenotype by interfering with IKK/NF-κB activation

(2013) Olga Moiseeva et al.   AGING CELL

New Insights into the Pathogenesis of Preeclampsia – The Role of Nrf2 Activators and their Potential Therapeutic Impact

(2013) N. Kweider et al.   GEBURTSHILFE UND FRAUENHEILKUNDE