Boron in cancer therapeutics: An overview

The Dawn of a New Era: Tumor-Targeting Boron Agents for Neutron Capture Therapy

(2023) Ting Luo et al.   MOLECULAR PHARMACEUTICS

Optimizing Boron Neutron Capture Therapy (BNCT) to Treat Cancer: An Updated Review on the Latest Developments on Boron Compounds and Strategies

(2023) Andrea Monti Hughes et al.   Cancers

Arginase: An emerging and promising therapeutic target for cancer treatment

(2022) Fanglin Niu et al.   BIOMEDICINE & PHARMACOTHERAPY

Boron-Containing heterocycles as promising pharmacological agents

(2022) Bhaskar C. Das et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Anti-cancer effect of boron derivatives on small-cell lung cancer

(2022) Emre Cebeci et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

Serum PSA-based early detection of prostate cancer in Europe and globally: past, present and future

(2022) Hendrik Van Poppel et al.   Nature Reviews Urology

Exploring the Biological and Physical Basis of Boron Neutron Capture Therapy (BNCT) as a Promising Treatment Frontier in Breast Cancer

(2022) Danushka Seneviratne et al.   Cancers

Effect of probiotics on hemodynamic changes and complications associated with cirrhosis: A pilot randomized controlled trial

(2022) Roman Maslennikov et al.   World Journal of Hepatology

Boron Vehiculating Nanosystems for Neutron Capture Therapy in Cancer Treatment

(2022) Giorgia Ailuno et al.   Cells

Both Hypoxia-Inducible Factor 1 and MAPK Signaling Pathway Attenuate PI3K/AKT via Suppression of Reactive Oxygen Species in Human Pluripotent Stem Cells

(2021) Petr Fojtík et al.   Frontiers in Cell and Developmental Biology

Boron clusters as breast cancer therapeutics

(2021) N. Murphy et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Boron Neutron Capture Therapy: A Review of Clinical Applications

(2021) Timothy D. Malouff et al.   Frontiers in Oncology

Fructose-functionalized polymers to enhance therapeutic potential of p-boronophenylalanine for neutron capture therapy

(2021) Takahiro Nomoto et al.   JOURNAL OF CONTROLLED RELEASE

Steroid Sulphatase and Its Inhibitors: Past, Present, and Future

(2021) Paul A. Foster   MOLECULES

Evaluation of local, regional and abscopal effects of Boron Neutron Capture Therapy (BNCT) combined with immunotherapy in an ectopic colon cancer model

(2021) Verónica A. Trivillin et al.   BRITISH JOURNAL OF RADIOLOGY

Autophagy and tumorigenesis

(2021) Michael Rangel et al.   FEBS Journal

HIF-1α affects sensitivity of murine squamous cell carcinoma to boron neutron capture therapy with BPA

(2021) Yu Sanada et al.   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

The efficacy and mechanism of proteasome inhibitors in solid tumor treatment

(2021) Lei Zhang et al.   Recent Patents on Anti-Cancer Drug Discovery

Progress on the Application of Bortezomib and Bortezomib-Based Nanoformulations

(2021) Jianhao Liu et al.   Biomolecules

Boron Chemistry for Medical Applications

(2020) Fayaz Ali et al.   MOLECULES

Discovery and Optimization of Rationally Designed Bicyclic Inhibitors of Human Arginase to Enhance Cancer Immunotherapy

(2020) Matthew J. Mitcheltree et al.   ACS Medicinal Chemistry Letters

Discovery and Pharmacokinetics of Sulfamides and Guanidines as Potent Human Arginase 1 Inhibitors

(2020) Roman Blaszczyk et al.   ACS Medicinal Chemistry Letters

Boronic acid-based arginase inhibitors in cancer immunotherapy

(2020) Bartlomiej Borek et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Steroid Sulfatase Stimulates Intracrine Androgen Synthesis and is a Therapeutic Target for Advanced Prostate Cancer

(2020) Cameron M. Armstrong et al.   CLINICAL CANCER RESEARCH

Glycoconjugates for glucose transporter-mediated cancer-specific targeting and treatment

(2020) Junjie Fu et al.   CARBOHYDRATE RESEARCH

The transcriptional factors HIF-1 and HIF-2 and their novel inhibitors in cancer therapy

(2019) Najah Albadari et al.   Expert Opinion on Drug Discovery

Anomeric sugar boronic acid analogues as potential agents for boron neutron capture therapy

(2019) Daniela Imperio et al.   Beilstein Journal of Organic Chemistry

Boron-Nanoparticle-Loaded Folic-Acid-Functionalized Liposomes to Achieve Optimum Boron Concentration for Boron Neutron Capture Therapy of Cancer

(2019) Ajay Singh et al.   Journal of Biomedical Nanotechnology

Assessment of long-term risks of secondary cancer in pediatric patients with brain tumor after boron neutron capture therapy

(2019) Xinxin Zhang et al.   JOURNAL OF RADIOLOGICAL PROTECTION

Discovery of N-Substituted 3-Amino-4-(3-boronopropyl)pyrrolidine-3-carboxylic Acids as Highly Potent Third-Generation Inhibitors of Human Arginase I and II

(2019) Michael C. Van Zandt et al.   JOURNAL OF MEDICINAL CHEMISTRY

Development of theranostic active-targeting boron-containing gold nanoparticles for boron neutron capture therapy (BNCT)

(2019) Chun-Yi Wu et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Calculation by GAMOS/Geant4 simulation of cellular energy distributions from alpha and lithium-7 particles created by BNCT

(2018) Ayse Karaoglu et al.   APPLIED RADIATION AND ISOTOPES

The Physiological Role of Boron on Health

(2018) Haseeb Khaliq et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Synthesis and biological evaluation of curcumin derivatives modified with α-amino boronic acid as proteasome inhibitors

(2018) Wenjie Zhang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Research of novel anticancer agents targeting arginase inhibition

(2018) Thanh-Nhat Pham et al.   DRUG DISCOVERY TODAY

Nanostructured boron compounds for cancer therapy

(2018) Yinghuai Zhu et al.   PURE AND APPLIED CHEMISTRY

Design and synthesis of boron containing monosaccharides by the hydroboration of d-glucal for use in boron neutron capture therapy (BNCT)

(2018) Taiki Itoh et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Boron-based small molecules in disease detection and treatment (2013–2016)

(2017) Suresh Thareja et al.   HETEROCYCLIC COMMUNICATIONS

Proteasome inhibitors in cancer therapy

(2017) Elisabet E. Manasanch et al.   Nature Reviews Clinical Oncology

An Assessment of the Potential Use of BNNTs for Boron Neutron Capture Therapy

(2017) Tiago Ferreira et al.   Nanomaterials

Inhibition of arginase by CB-1158 blocks myeloid cell-mediated immune suppression in the tumor microenvironment

(2017) Susanne M. Steggerda et al.   Journal for ImmunoTherapy of Cancer

Amphiphilic Polycarbonates from Carborane-Installed Cyclic Carbonates as Potential Agents for Boron Neutron Capture Therapy

(2016) Hejian Xiong et al.   BIOCONJUGATE CHEMISTRY

Abstract 552: Immuno-oncology agent CB-1158 is a potent and selective arginase inhibitor and causes an immune-mediated anti-tumor response

(2016) Melissa Works et al.   CANCER RESEARCH

Arginase inhibitor CB-1158 elicits immune-mediated anti-tumor responses as a single agent and enhances the efficacy of other immunotherapies

(2016) S. Steggerda et al.   EUROPEAN JOURNAL OF CANCER

Design, Synthesis, and Bioactivation of O-Glycosylated Prodrugs of the Natural Nitric Oxide Precursor Nω-Hydroxy-l-arginine

(2016) Felix-A. Litty et al.   JOURNAL OF MEDICINAL CHEMISTRY

Challenges and Opportunities for the Application of Boron Clusters in Drug Design

(2016) Zbigniew J. Leśnikowski   JOURNAL OF MEDICINAL CHEMISTRY

An amphiphilic block copolymer conjugated with carborane and a NIR fluorescent probe for potential imaging-guided BNCT therapy

(2016) Zheng Ruan et al.   Polymer Chemistry

Abstract B045: Arginase inhibitor CB-1158 elicits immune-mediated antitumor responses as a single agent and in combination with other immunotherapies

(2016) Susanne M. Steggerda et al.   Cancer Immunology Research

An economic model to assess the cost-benefit of BNCT

(2015) Martti Kulvik et al.   APPLIED RADIATION AND ISOTOPES

Proteasome inhibitors

(2015) Beverly A. Teicher et al.   BIOCHEMICAL PHARMACOLOGY

Doxorubicin-Loaded Carborane-Conjugated Polymeric Nanoparticles as Delivery System for Combination Cancer Therapy

(2015) Hejian Xiong et al.   BIOMACROMOLECULES

Antitumor effect of boron nitride nanotubes in combination with thermal neutron irradiation on BNCT

(2015) Hiroyuki Nakamura et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

ortho-Carboranylphenoxyacetanilides as inhibitors of hypoxia-inducible factor (HIF)-1 transcriptional activity and heat shock protein (HSP) 60 chaperon activity

(2015) Guangzhe Li et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Efficient Chemical Modification of Carbon Nanotubes with Metallacarboranes

(2015) Laura Cabana et al.   CHEMISTRY-A EUROPEAN JOURNAL

Synthesis and biological evaluation of meta -carborane-containing phenoxyacetanilides as inhibitors of hypoxia-inducible factor (HIF)-1 transcriptional activity

(2015) Guangzhe Li et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY

Diaryl-substituted carboranes as inhibitors of hypoxia inducible factor-1 transcriptional activity

(2015) Hiroyuki Nakamura et al.   PURE AND APPLIED CHEMISTRY

Mechanism of Action of Bortezomib and the New Proteasome Inhibitors on Myeloma Cells and the Bone Microenvironment: Impact on Myeloma-Induced Alterations of Bone Remodeling

(2015) Fabrizio Accardi et al.   Biomed Research International

Preparation and evaluation of carborane-derived inhibitors of prostate specific membrane antigen (PSMA)

(2014) Mohamed E. El-Zaria et al.   DALTON TRANSACTIONS

Proteasome inhibitor patents (2010 – present)

(2014) Rainer Metcalf et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

One Stone Kills Three Birds: Novel Boron-Containing Vesicles for Potential BNCT, Controlled Drug Release, and Diagnostic Imaging

(2014) Gaojian Chen et al.   MOLECULAR PHARMACEUTICS

Critical review, with an optimistic outlook, on Boron Neutron Capture Therapy (BNCT)

(2013) Raymond L. Moss   APPLIED RADIATION AND ISOTOPES

The combined effects of size and surface chemistry on the accumulation of boronic acid-rich protein nanoparticles in tumors

(2013) Jing Wang et al.   BIOMATERIALS

Synthesis of quaternary α-amino acid-based arginase inhibitors via the Ugi reaction

(2013) Adam Golebiowski et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The significance and impact of Wade's rules

(2013) Alan J. Welch   CHEMICAL COMMUNICATIONS

Diaryl-substituted ortho-carboranes as a new class of hypoxia inducible factor-1α inhibitors

(2013) Hiroyuki Nakamura et al.   DALTON TRANSACTIONS

Boron chemicals in diagnosis and therapeutics

(2013) Bhaskar C Das et al.   Future Medicinal Chemistry

Discovery of (R)-2-Amino-6-borono-2-(2-(piperidin-1-yl)ethyl)hexanoic Acid and Congeners As Highly Potent Inhibitors of Human Arginases I and II for Treatment of Myocardial Reperfusion Injury

(2013) Michael C. Van Zandt et al.   JOURNAL OF MEDICINAL CHEMISTRY

Current status on development of steroids as anticancer agents

(2013) Atul Gupta et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Arginase: The Emerging Therapeutic Target for Vascular Oxidative Stress and Inflammation

(2013) Zhihong Yang et al.   Frontiers in Immunology

Development of hypoxia-inducible factor (HIF)-1α inhibitors: Effect of ortho-carborane substituents on HIF transcriptional activity under hypoxia

(2012) Hiroyuki Nakamura et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and Biological Evaluation of Diaryl-Substituted Carboranes as Inhibitors of Hypoxia Inducible Factor (HIF)-1 Transcriptional Activity

(2012) Hidemitsu Minegishi et al.   ChemMedChem

Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy

(2012) Gregg L. Semenza   TRENDS IN PHARMACOLOGICAL SCIENCES

A clinical trial protocol for second line treatment of malignant brain tumors with BNCT at University of Tsukuba

(2011) H. Aiyama et al.   APPLIED RADIATION AND ISOTOPES

Sodium mercaptoundecahydro-closo-dodecaborate (BSH), a boron carrier that merits more attention

(2011) Andrea Wittig et al.   APPLIED RADIATION AND ISOTOPES

Boron nitride nanotubes for boron neutron capture therapy as contrast agents in magnetic resonance imaging at 3T

(2011) L. Menichetti et al.   APPLIED RADIATION AND ISOTOPES

Design of multivalent galactosyl carborane as a targeting specific agent for potential application to boron neutron capture therapy

(2011) Chian-Hui Lai et al.   CHEMICAL COMMUNICATIONS

Carbaboranes as Pharmacophores: Properties, Synthesis, and Application Strategies

(2011) Matthias Scholz et al.   CHEMICAL REVIEWS

Boron-containing inhibitors of synthetases

(2011) Stephen J. Baker et al.   CHEMICAL SOCIETY REVIEWS

In Vitro and In Vivo Selective Antitumor Activity of a Novel Orally Bioavailable Proteasome Inhibitor MLN9708 against Multiple Myeloma Cells

(2011) Dharminder Chauhan et al.   CLINICAL CANCER RESEARCH

Bortezomib represses HIF-1α protein expression and nuclear accumulation by inhibiting both PI3K/Akt/TOR and MAPK pathways in prostate cancer cells

(2011) Christina D. Befani et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Synthesis and toxicity of cobaltabisdicarbollide-containing porphyrins of high boron content

(2011) N.V.S. Dinesh K. Bhupathiraju et al.   JOURNAL OF PORPHYRINS AND PHTHALOCYANINES

Application of a novel boronated porphyrin (H2OCP) as a dual sensitizer for both PDT and BNCT

(2011) Ryo Hiramatsu et al.   LASERS IN SURGERY AND MEDICINE

Boron-containing phenoxyacetanilide derivatives as hypoxia-inducible factor (HIF)-1α inhibitors

(2010) Kazuki Shimizu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Identification of HSP60 as a Primary Target ofo-Carboranylphenoxyacetanilide, an HIF-1α Inhibitor

(2010) Hyun Seung Ban et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis of cobalt bis(dicarbollide) conjugates with natural chlorins by the Sonogashira reaction

(2010) M. A. Grin et al.   RUSSIAN CHEMICAL BULLETIN

Conjugates of boron clusters with derivatives of natural chlorin and bacteriochlorin

(2009) V.I. Bregadze et al.   APPLIED RADIATION AND ISOTOPES

A novel boronated-porphyrin as a radio-sensitizing agent for boron neutron capture therapy of tumours: In vitro and in vivo studies

(2009) G Jori et al.   APPLIED RADIATION AND ISOTOPES

Biological evaluation of boronated unnatural amino acids as new boron carriers

(2009) G.W. Kabalka et al.   APPLIED RADIATION AND ISOTOPES

L-Amino Acid Transporter-1 and Boronophenylalanine-Based Boron Neutron Capture Therapy of Human Brain Tumors

(2009) A. Detta et al.   CANCER RESEARCH

Therapeutic potential of boron-containing compounds

(2009) Stephen J Baker et al.   Future Medicinal Chemistry

Synthesis and Reactivity ofortho-Carbaborane-Containing Chiral Aminohalophosphines

(2009) Sven Stadlbauer et al.   INORGANIC CHEMISTRY

Access to Carbaboranyl GlycophosphonatesAn Odyssey

(2009) Sven Stadlbauer et al.   INORGANIC CHEMISTRY

Synthesis of chlorin and bacteriochlorin conjugates for photodynamic and boron neutron capture therapy

(2009) Andrey F. Mironov et al.   JOURNAL OF PORPHYRINS AND PHTHALOCYANINES

Tumor-localizing and radiosensitizing properties of meso-tetra(4-nido-carboranylphenyl)porphyrin (H2TCP)

(2009) Marina Soncin et al.   JOURNAL OF PORPHYRINS AND PHTHALOCYANINES

Noninvasive Sialic Acid Detection at Cell Membrane by Using Phenylboronic Acid Modified Self-Assembled Monolayer Gold Electrode

(2009) Akira Matsumoto et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Noxa: at the tip of the balance between life and death

(2009) C Ploner et al.   ONCOGENE

Novel glycosylated carboranylquinazolines for boron neutron capture therapy of tumors: synthesis, characterization, andin vitro toxicity studies

(2008) Afaf R. Genady et al.   APPLIED ORGANOMETALLIC CHEMISTRY

The role of hypoxia-inducible factors in tumorigenesis

(2008) E B Rankin et al.   CELL DEATH AND DIFFERENTIATION

Biology of HIF-1α

(2008) A Weidemann et al.   CELL DEATH AND DIFFERENTIATION

“Chemical Ligation”: A Versatile Method for Nucleoside Modification with Boron Clusters

(2008) Błazej A. Wojtczak et al.   CHEMISTRY-A EUROPEAN JOURNAL

Mechanisms of proteasome inhibitor action and resistance in cancer

(2008) David J. McConkey et al.   DRUG RESISTANCE UPDATES

Novel Types of Carborane-Carrier Hyaluronan Derivatives via “Click Chemistry”

(2008) Chiara Di Meo et al.   MACROMOLECULAR BIOSCIENCE

Synthesis and biological investigations of tetrakis(p-carboranylthio-tetrafluorophenyl)chlorin (TPFC)

(2008) Erhong Hao et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Boron neutron capture therapy (BNCT) for glioblastoma multiforme: A phase II study evaluating a prolonged high-dose of boronophenylalanine (BPA)

(2008) Roger Henriksson et al.   RADIOTHERAPY AND ONCOLOGY

Nuclear translocation of hypoxia-inducible factors (HIFs): Involvement of the classical importin α/β pathway

(2007) Reinhard Depping et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Synthesis and in vitro properties of trimethylamine- and phosphonate-substituted carboranylporphyrins for application in BNCT

(2007) Michael W. Easson et al.   BIOORGANIC & MEDICINAL CHEMISTRY