Discovery of potential novel microsomal triglyceride transfer protein inhibitors via virtual screening of pharmacophore modelling and molecular docking

Unknown

(2016)   INTERNATIONAL JOURNAL OF CLINICAL PRACTICE

Novel missense MTTP gene mutations causing abetalipoproteinemia

(2014) Sharon A. Miller et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

The Role of Microsomal Triglyceride Transfer Protein Inhibitors in the Treatment of Patients with Familial Hypercholesterolemia: Risks, Benefits, and Management

(2014) Zahid Ahmad et al.   Current Atherosclerosis Reports

Mosquito Larvicidal Constituents from the Ethanol Extract ofInula racemosaHook. f. Roots againstAedes albopictus

(2014) Qing He et al.   Journal of Chemistry

Mitochondrial Triglyceride Transfer Protein Inhibition: New Achievements in the Treatment of Dyslipidemias

(2013) Michael S. Kostapanos et al.   CURRENT PHARMACEUTICAL DESIGN

Toll-Like Receptor 7 Agonists: Chemical Feature Based Pharmacophore Identification and Molecular Docking Studies

(2013) Hui Yu et al.   PLoS One

Efficacy and safety of a microsomal triglyceride transfer protein inhibitor in patients with homozygous familial hypercholesterolaemia: a single-arm, open-label, phase 3 study

(2012) Marina Cuchel et al.   LANCET

Discovery of microsomal triglyceride transfer protein (MTP) inhibitors with potential for decreased active metabolite load compared to dirlotapide

(2011) Ralph P. Robinson et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

JTT-130, a novel intestine-specific inhibitor of microsomal triglyceride transfer protein, ameliorates impaired glucose and lipid metabolism in Zucker diabetic fatty rats

(2011) T. Hata et al.   DIABETES OBESITY & METABOLISM

A Small-Molecule Inhibitor of Enterocytic Microsomal Triglyceride Transfer Protein, SLx-4090: Biochemical, Pharmacodynamic, Pharmacokinetic, and Safety Profile

(2011) E. Kim et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Ligand binding to protein-binding pockets with wet and dry regions

(2011) L. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conserved residue clusters at protein-protein interfaces and their use in binding site identification

(2010) Mainak Guharoy et al.   BMC BIOINFORMATICS

Nicotinic acid– and monomethyl fumarate–induced flushing involves GPR109A expressed by keratinocytes and COX-2–dependent prostanoid formation in mice

(2010) Julien Hanson et al.   JOURNAL OF CLINICAL INVESTIGATION

Identification and structure–activity relationships of ortho-biphenyl carboxamides as potent Smoothened antagonists inhibiting the Hedgehog signaling pathway

(2008) Stefan Peukert et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Fibrate-Associated Adverse Effects Beyond Muscle and Liver Toxicity

(2008) M. Elisaf et al.   CURRENT PHARMACEUTICAL DESIGN

HOMCOS: a server to predict interacting protein pairs and interacting sites by homology modeling of complex structures

(2008) N. Fukuhara et al.   NUCLEIC ACIDS RESEARCH