Selective antagonism of TRPA1 produces limited efficacy in models of inflammatory- and neuropathic-induced mechanical hypersensitivity in rats

Elevated H2O2levels in trinitrobenzene sulfate-induced colitis rats contributes to visceral hyperalgesia through interaction with the transient receptor potential ankyrin 1 cation channel

(2016) Yoko Kogure et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Optimization of a Novel Quinazolinone-Based Series of Transient Receptor Potential A1 (TRPA1) Antagonists Demonstrating Potent in Vivo Activity

(2016) Laurie B. Schenkel et al.   JOURNAL OF MEDICINAL CHEMISTRY

Lipoic-Based TRPA1/TRPV1 Antagonist to Treat Orofacial Pain

(2015) Roberta Gualdani et al.   ACS Chemical Neuroscience

The involvement of the TRPA1 receptor in a mouse model of sympathetically maintained neuropathic pain

(2015) Francielle de Vargas Pinheiro et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Erratum: Structure of the TRPA1 ion channel suggests regulatory mechanisms

(2015) Candice E. Paulsen et al.   NATURE

Urate Crystal Induced Inflammation and Joint Pain Are Reduced in Transient Receptor Potential Ankyrin 1 Deficient Mice – Potential Role for Transient Receptor Potential Ankyrin 1 in Gout

(2015) Lauri J. Moilanen et al.   PLoS One

Transient Receptor Potential Ankyrin 1 in Spinal Cord Dorsal Horn is Involved in Neuropathic Pain in Nerve Root Constriction Rats

(2014) Tsuyoshi Miyakawa et al.   Molecular Pain

TRPA1 mediates bladder hyperalgesia in a mouse model of cystitis

(2014) Jennifer J. DeBerry et al.   PAIN

Transient Receptor Potential Ankyrin 1 Receptor Activation In Vitro and In Vivo by Pro-tussive Agents: GRC 17536 as a Promising Anti-Tussive Therapeutic

(2014) Indranil Mukhopadhyay et al.   PLoS One

Global Nav1.7 Knockout Mice Recapitulate the Phenotype of Human Congenital Indifference to Pain

(2014) Jacinthe Gingras et al.   PLoS One

Transient Receptor Potential Ankyrin 1 Receptor Stimulation by Hydrogen Peroxide Is Critical to Trigger Pain During Monosodium Urate-Induced Inflammation in Rodents

(2013) Gabriela Trevisan et al.   ARTHRITIS AND RHEUMATISM

Antagonism of the transient receptor potential ankyrin 1 (TRPA1) attenuates hyperalgesia and urinary bladder overactivity in cyclophosphamide-induced haemorrhagic cystitis

(2013) Flavia C. Meotti et al.   CHEMICO-BIOLOGICAL INTERACTIONS

A TRPA1 antagonist reverts oxaliplatin-induced neuropathic pain

(2013) Cristina Nativi et al.   Scientific Reports

Transient Receptor Potential Ankyrin 1 Ion Channel Contributes to Guarding Pain and Mechanical Hypersensitivity in a Rat Model of Postoperative Pain

(2012) Hong Wei et al.   ANESTHESIOLOGY

Afferent drive elicits ongoing pain in a model of advanced osteoarthritis

(2012) Alec Okun et al.   PAIN

TRPA1 Mediates Mechanical Sensitization in Nociceptors during Inflammation

(2012) Richard C. Lennertz et al.   PLoS One

The Dynamic TRPA1 Channel: A Suitable Pharmacological Pain Target?

(2011) Sheldon R. Garrison et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Selective blockade of TRPA1 channel attenuates pathological pain without altering noxious cold sensation or body temperature regulation

(2011) Jun Chen et al.   PAIN

TRPA1 Modulation of Spontaneous and Mechanically Evoked Firing of Spinal Neurons in Uninjured, Osteoarthritic, and Inflamed Rats

(2010) Steve McGaraughty et al.   Molecular Pain

A Gain-of-Function Mutation in TRPA1 Causes Familial Episodic Pain Syndrome

(2010) Barbara Kremeyer et al.   NEURON

TRPA1 Modulates Mechanotransduction in Cutaneous Sensory Neurons

(2009) K. Y. Kwan et al.   JOURNAL OF NEUROSCIENCE

Pharmacological Blockade of TRPA1 Inhibits Mechanical Firing in Nociceptors

(2009) Patrick C Kerstein et al.   Molecular Pain

The involvement of the transient receptor potential A1 (TRPA1) in the maintenance of mechanical and cold hyperalgesia in persistent inflammation

(2009) Diogo Santos M. da Costa et al.   PAIN

HC-030031, a TRPA1 Selective Antagonist, Attenuates Inflammatory- and Neuropathy-Induced Mechanical Hypersensitivity

(2008) Samer R Eid et al.   Molecular Pain

Effects of TRPA1 Agonists Mustard Oil and Cinnamaldehyde on Lumbar Spinal Wide-Dynamic Range Neuronal Responses to Innocuous and Noxious Cutaneous Stimuli in Rats

(2007) Austin W. Merrill et al.   JOURNAL OF NEUROPHYSIOLOGY