CD137L Inhibition Ameliorates Hippocampal Neuroinflammation and Behavioral Deficits in a Mouse Model of Sepsis-Associated Encephalopathy

CD137L-macrophage induce lymphatic endothelial cells autophagy to promote lymphangiogenesis in renal fibrosis

(2022) Haotian Wei et al.   International Journal of Biological Sciences

Current Understanding of Long-Term Cognitive Impairment After Sepsis

(2022) Ying Li et al.   Frontiers in Immunology

A preoptic neuronal population controls fever and appetite during sickness

(2022) Jessica A. Osterhout et al.   NATURE

The Key Drivers of Brain Injury by Systemic Inflammatory Responses after Sepsis: Microglia and Neuroinflammation

(2022) Yuewen Xin et al.   MOLECULAR NEUROBIOLOGY

Activation of CD137 signaling promotes macrophage apoptosis dependent on p38 MAPK pathway-mediated mitochondrial fission

(2021) Yu Xu et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

CD137 (4-1BB) stimulation leads to metabolic and functional reprogramming of human monocytes/macrophages enhancing their tumoricidal activity

(2021) A. Stoll et al.   LEUKEMIA

Early-life inflammation promotes depressive symptoms in adolescence via microglial engulfment of dendritic spines

(2021) Peng Cao et al.   NEURON

Sepsis-associated encephalopathy: a vicious cycle of immunosuppression

(2020) Chao Ren et al.   Journal of Neuroinflammation

Incidence and mortality of hospital- and ICU-treated sepsis: results from an updated and expanded systematic review and meta-analysis

(2020) C. Fleischmann-Struzek et al.   INTENSIVE CARE MEDICINE

CD137 / CD137 ligand signalling regulates the immune balance: A potential target for novel immunotherapy of autoimmune diseases

(2020) Hiu Yi Wong et al.   JOURNAL OF AUTOIMMUNITY

Mitochondrial Transplantation Attenuates Brain Dysfunction in Sepsis by Driving Microglial M2 Polarization

(2020) Chaoying Yan et al.   MOLECULAR NEUROBIOLOGY

New emerging targets in cancer immunotherapy: CD137/4-1BB costimulatory axis

(2020) Iñaki Etxeberria et al.   ESMO Open

Microglia: A Potential Therapeutic Target for Sepsis-Associated Encephalopathy and Sepsis-Associated Chronic Pain

(2020) Yi Li et al.   Frontiers in Pharmacology

Ciprofloxacin and levofloxacin attenuate microglia inflammatory response via TLR4/NF-kB pathway

(2019) Morena Zusso et al.   Journal of Neuroinflammation

Deletion of CD137 Ligand Exacerbates Renal and Cutaneous but Alleviates Cerebral Manifestations in Lupus

(2019) Anselm Mak et al.   Frontiers in Immunology

CD137L-DCs, Potent Immune-Stimulators—History, Characteristics, and Perspectives

(2019) Qun Zeng et al.   Frontiers in Immunology

Evaluation of Brain Nuclear Medicine Imaging Tracers in a Murine Model of Sepsis-Associated Encephalopathy

(2018) Dávid Szöllősi et al.   MOLECULAR IMAGING AND BIOLOGY

Factors Associated With Short and Long Term Cognitive Changes in Patients With Sepsis

(2018) Allan J. C. Calsavara et al.   Scientific Reports

TOPK Promotes Microglia/Macrophage Polarization towards M2 Phenotype via Inhibition of HDAC1 and HDAC2 Activity after Transient Cerebral Ischemia

(2018) Ziping Han et al.   Aging and Disease

Sepsis-associated encephalopathy

(2018) Dario-Lucas Helbing et al.   CANADIAN MEDICAL ASSOCIATION JOURNAL

Constitutive interaction between 4-1BB and 4-1BBL on murine LPS-activated bone marrow dendritic cells masks detection of 4-1BBL by TKS-1 but not 19H3 antibody

(2017) Achire N. Mbanwi et al.   JOURNAL OF IMMUNOLOGICAL METHODS

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

(2016) Mervyn Singer et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Microglia in central nervous system repair after injury

(2016) Xuemei Jin et al.   JOURNAL OF BIOCHEMISTRY

Lipopolysaccharide-induced sepsis induces long-lasting affective changes in the mouse

(2015) Seán T. Anderson et al.   BRAIN BEHAVIOR AND IMMUNITY

Protective Effect of Arabinoxylan against Scopolamine-Induced Learning and Memory Impairment

(2014) Chang-Yul Kim et al.   Biomolecules & Therapeutics

Neuroinflammation and M2 microglia: the good, the bad, and the inflamed

(2014) Jonathan D Cherry et al.   Journal of Neuroinflammation

Acute Brain Inflammation and Oxidative Damage Are Related to Long-Term Cognitive Deficits and Markers of Neurodegeneration in Sepsis-Survivor Rats

(2013) Mágada T. Schwalm et al.   MOLECULAR NEUROBIOLOGY

Involvement of CD137 ligand signaling in neural stem cell death

(2013) Chang Ho Yun et al.   MOLECULES AND CELLS

The TNF Family Member 4-1BBL Sustains Inflammation by Interacting with TLR Signaling Components During Late-Phase Activation

(2013) J. Ma et al.   Science Signaling

CD137 ligand activated microglia induces oligodendrocyte apoptosis via reactive oxygen species

(2012) Yee Andy Yeo et al.   Journal of Neuroinflammation

Persistent cognitive impairment, hippocampal atrophy and EEG changes in sepsis survivors

(2012) Alexander Semmler et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

4-1BB/4-1BBL Interaction Promotes Obesity-Induced Adipose Inflammation by Triggering Bidirectional Inflammatory Signaling in Adipocytes/Macrophages

(2012) Thai Hien Tu et al.   MEDIATORS OF INFLAMMATION

Sepsis-associated encephalopathy

(2012) Teneille E. Gofton et al.   Nature Reviews Neurology

Recombinant TAT-CD137 Ligand Cytoplasmic Domain Fusion Protein Induces the Production of IL-6 and TNF-α in Peritoneal Macrophages

(2011) Jung Dae Kim et al.   Immune Network

Blockade of CD137 Signaling Counteracts Polymicrobial Sepsis Induced by Cecal Ligation and Puncture

(2009) Q.-T. Nguyen et al.   INFECTION AND IMMUNITY

Heterogeneity of Microglial Activation in the Innate Immune Response in the Brain

(2009) Carol A. Colton   Journal of Neuroimmune Pharmacology