Article
Biochemistry & Molecular Biology
Dan Shu, Ying Zhu, Meng Lu, Ao-Di He, Jiang-Bin Chen, Ding-Song Ye, Yue Liu, Xiang-Bin Zeng, Rong Ma, Zhang-Yin Ming
Summary: Sanguinarine demonstrates antiplatelet activity by inhibiting thrombus formation and platelet activation through multiple molecular mechanisms. This indicates its potential clinical value in treating cardiovascular diseases involving excessive platelet activation.
Article
Pharmacology & Pharmacy
Shukun Sun, Bao Qiao, Yu Han, Bailu Wang, Shujian Wei, Yuguo Chen
Summary: Platelets play a crucial role in normal hemostasis, but pathological platelet adhesion can lead to cardiovascular events. Traditional antithrombotic drugs have limited effects on platelet adhesion receptors, while posttranslational modifications (PTMs) can increase the functional diversity of these receptors and affect platelet processes. Targeting PTMs of platelet adhesion receptors with antithrombotic drugs may offer a new therapeutic approach.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Hematology
Natalie J. J. Jooss, Yvonne M. C. Henskens, Steve P. P. Watson, Richard W. W. Farndale, Meinrad P. P. Gawaz, Martine Jandrot-Perrus, Natalie S. S. Poulter, Johan W. M. Heemskerk
Summary: In this study, four inhibitors of platelet-collagen interactions were compared for their antithrombotic potential. The results showed that Revacept and 9O12-Fab had strong inhibitory effects on highly GPVI-activating surfaces, while 9O12-Fab had varying inhibitory effects on all surfaces. The effects of GPVI-directed interventions were surpassed by Syk inhibition, and 6F1 mAb had the strongest intervention effect on collagen substrates compared to Revacept and 9O12-Fab. These findings reveal the unique pharmacological profiles of these drugs and provide insights into additive antithrombotic mechanisms.
THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Hematology
Jianmin Liu, Fan Lu, Sujay Subbayya Ithychanda, Marcin Apostol, Mitali Das, Gauravi Deshpande, Edward F. Plow, Jun Qin
Summary: This study reveals that filamin associates with both inactive and active forms of alpha IIb ss 3, promoting platelet spreading. Furthermore, the study demonstrates that filamin undergoes spatiotemporal rearrangement upon alpha IIb ss 3 activation, binding to the alpha IIb cytoplasmic tail alone. This novel alpha IIb CT-filamin-actin linkage plays a crucial role in integrin outside-in signaling.
Article
Multidisciplinary Sciences
Brian D. D. Adair, Jian-Ping Xiong, Mark Yeager, M. Amin Arnaout
Summary: This study determines the cryoEM structure of full-length platelet integrin αIIbβ3 in both its apo and eptifibatide-bound states, providing insights into its conformational changes in response to intracellular signals and drug binding, and suggesting potential adverse effects on platelet hemostasis.
NATURE COMMUNICATIONS
(2023)
Article
Hematology
Rainer Kaiser, Raphael Escaig, Jan Kranich, Marie-Louise Hoffknecht, Afra Anjum, Vivien Polewka, Magdalena Mader, Wenbo Hu, Larissa Belz, Christoph Gold, Anna Titova, Michael Lorenz, Kami Pekayvaz, Stefan Kaab, Florian Gaertner, Konstantin Stark, Thomas Brocker, Steffen Massberg, Leo Nicolai
Summary: Impairment of vascular integrity is a characteristic of inflammatory diseases. This study demonstrates the essential role of procoagulant platelets in preventing inflammatory bleeding by promoting coagulation cascade activation. The presence of exposed collagen triggers platelet arrest and subsequent procoagulant activation. The findings highlight the importance of procoagulant platelets in maintaining vascular integrity during inflammation.
Article
Biochemistry & Molecular Biology
Daniel Gao, Caroline W. Sun, Angela B. Woodley, Jing-fei Dong
Summary: Clot retraction, which requires the functional platelet alpha(IIb)beta(3) integrin, is an important measure of platelet function and can be used to detect functional changes in platelets. Platelet counts and the surface density of the integrin alpha(IIb)beta(3) affect clot retraction.
Article
Multidisciplinary Sciences
Yaping Zhang, Xiaojuan Zhao, Bo Shen, Yanyan Bai, Claire Chang, Aleksandra Stojanovic, Can Wang, Andrew Mack, Gary Deng, Randal A. Skidgel, Ni Cheng, Xiaoping Du
Summary: Zhang et al. demonstrate that integrin β3 receptor inhibits G protein-mediated RhoA activation and granule secretion. A peptide mimicking this effect selectively inhibits platelet secretion without affecting integrin-mediated adhesion. The cross-talk between integrins and G protein-coupled receptors is crucial and has implications for therapeutic approaches in platelet and cell adhesion-related diseases.
NATURE COMMUNICATIONS
(2023)
Article
Integrative & Complementary Medicine
Bo-Ra Jeon, Muhammad Irfan, Seung Eun Lee, Jeong Hoon Lee, Man Hee Rhee
Summary: The study found that Rumex acetosella extract has inhibitory effects on platelet activity and can exert its effects by modulating signaling pathways. This suggests that Rumex acetosella may have a protective role in the development of cardiovascular diseases.
CHINESE JOURNAL OF INTEGRATIVE MEDICINE
(2022)
Article
Biochemical Research Methods
Lancong Liu, Wenfeng Ding, Lili He, Yi Yang, Fuyi Guan, Xinlin Sun, Yan Peng, Xue Chen, Wenhao Zhao, Yu Xiao, Pei Luo
Summary: We synthesized a novel peptide, WK001, by modifying the RGD structure to combine with scutellarin. Experimental and docking evidence showed that WK001 provides immediate and potent platelet inhibition, surpassing the inhibition of eptifibatide and scutellarin in platelet aggregation. In vivo studies demonstrated that WK001 administered intravenously prevents thrombus formation and attenuates myocardial fibrosis progression. Therefore, WK001 has the potential to be developed as an antiplatelet drug for thrombosis-associated diseases, such as stroke and myocardial infarction.
BIOCONJUGATE CHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Zeynep Itah, Shanzah Chaudhry, Sithara Raju Ponny, Ozkan Aydemir, Alexandra Lee, Julie Cavanagh-Kyros, Cathy Tournier, William J. Muller, Roger J. Davis
Summary: The HER2(+) subtype of human breast cancer is associated with the malignant transformation of luminal ductal cells of the mammary epithelium. Loss of function mutations and deletions of the MAP2K4 and MAP2K7genes that encode direct activators of the JUN NH2-terminal kinase (JNK) were found in tumor DNA sequence analysis. In vitro and in vivo studies demonstrated that JNK pathway deficiency promotes HER2(+)-driven breast cancer.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Hematology
Gina Perrella, Magdolna Nagy, Steve P. Watson, Johan W. M. Heemskerk
Summary: GPVI is a receptor expressed on megakaryocytes and platelets that plays a role in both arterial and venous thrombus formation, as well as in the formation of platelet-leukocyte complexes. It is emerging as a potential therapeutic target for venous thrombosis, pulmonary thromboembolism, and cancer metastasis due to its involvement in venous thrombus formation and thromboinflammation. Circulating soluble GPVI is also being explored as a biomarker for thrombosis-related complications.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Lijun Zhong, Lin Tang, Xiaoxia He
Summary: It has been discovered that ANGPTL3 plays an oncogenic role in several types of human malignancies. This study found that ANGPTL3 is highly expressed in cervical cancer cells and silencing ANGPTL3 can inhibit cell proliferation, migration, invasion, and angiogenesis. The inhibitory effect of ANGPTL3 can be offset by upregulating the expression of alpha v beta 3, which also promotes blood vessel formation and the secretion of VEGF and VEGFR2 in cervical cancer cells.
Article
Oncology
Mark Sutherland, Andrew Gordon, Fatemah O. F. O. Al-Shammari, Adam Throup, Amy Cilia La Corte, Helen Philippou, Steven D. Shnyder, Laurence H. Patterson, Helen M. Sheldrake
Summary: This study presents a new ligand-mimetic beta 3 integrin antagonist that exhibits high activity against alpha v beta 3 and moderate affinity for alpha IIb beta 3, suggesting a new approach to integrin targeting in cancer.
Article
Multidisciplinary Sciences
Dan-yang Guo, Zhong-hua Chen, Yi-fei Fu, Yue-yue Li, Meng-nan Chen, Jun-jie Wu, Zheng-dong Yuan, Jun-Xing Ye, Xia Li, Feng-lai Yuan
Summary: By blocking the signaling pathway of integrin alpha(v)beta(3), cilengitide effectively inhibits the functionality and formation of osteoclasts, resulting in diminished adhesion and bone resorption. The expression of key signaling molecules associated with the osteoclast cytoskeleton are downregulated by cilengitide.
Article
Environmental Sciences
Zhao Yin, Hai-Jiang Xu, Xia-Li Yao, Gang Liu, Chun-Jie Nie, Han Wei, Cai Li, Ming-Lu Liang, Zhang-Yin Ming, Xiao-Jian Zhang
ENVIRONMENTAL TOXICOLOGY
(2017)
Article
Genetics & Heredity
Wenjing Xu, Cheng Wang, Minglu Liang, Long Chen, Qin Fu, Fengxiao Zhang, Yan Wang, Dan Huang, Kai Huang
JOURNAL OF MOLECULAR MEDICINE-JMM
(2018)
Article
Dermatology
Juntao Xu, Xiaoru Duan, Feng Hu, Devesh Poorun, Xinxin Liu, Xin Wang, Song Zhang, Lu Gan, Mengwen He, Ke Zhu, Zhangyin Ming, Hongxiang Chen
JOURNAL OF DERMATOLOGICAL SCIENCE
(2018)
Article
Multidisciplinary Sciences
Ao-Di He, Wen Xie, Wei Song, Yuan-Yuan Ma, Gang Liu, Ming-Lu Liang, Xing-Wen Da, Guang-Qiang Yao, Bi-xiang Zhang, Cun-Ji Gao, Ji-zhou Xiang, Zhang-Yin Ming
SCIENTIFIC REPORTS
(2017)
Article
Cardiac & Cardiovascular Systems
Shengnan Zhao, Minglu Liang, Yilong Wang, Ji Hu, Yi Zhong, Jia Li, Kai Huang, Yiqing Li
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS
(2019)
Article
Endocrinology & Metabolism
Wenqi Gao, Wei Wang, Gang Liu, Jing Zhang, Jian Yang, Zhifang Deng
METABOLIC BRAIN DISEASE
(2019)
Article
Cell Biology
Xiaoru Duan, Xinxin Liu, Nian Liu, Yuqiong Huang, Zilin Jin, Song Zhang, Zhangyin Ming, Hongxiang Chen
CELL DEATH & DISEASE
(2020)
Article
Cell Biology
Zhi Zhao, Jianliang Wu, Huzi Xu, Cheng Zhou, Bicui Han, Han Zhu, Zhizhi Hu, Zhimei Ma, Zhangyin Ming, Ying Yao, Rui Zeng, Gang Xu
CELL DEATH & DISEASE
(2020)
Article
Medicine, Research & Experimental
Yue Li, Siyuan Fan, Weichang Xia, Baoru Qiao, Kai Huang, Jingqun Zhou, Minglu Liang
Summary: miR-181b inhibits angiogenesis by targeting CCN1 to suppress the AMPK signaling pathway, providing new insights for the development of pro-angiogenic treatment strategies.
LABORATORY INVESTIGATION
(2021)
Article
Pharmacology & Pharmacy
Gang Liu, Zhaowei Yuan, Xiaoyun Tian, Xiuqin Xiong, Fang Guo, Zihan Lin, Zhen Qin
Summary: Pimpinellin effectively inhibits collagen-induced platelet aggregation and reduces granule levels and secretion. It also decreases clot reaction and TxB2 production in platelets. Additionally, it suppresses adhesion and spreading of human platelets on fibrinogen coated surface while not significantly affecting tail bleeding time in mice.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Health Care Sciences & Services
Xiaojuan Wang, Xiali Yao, Xuedong Jia, Xiangfen Shi, Jie Hao, Yantao Yang, Gang Liu, Xiaojian Zhang, Shuzhang Du, Zhao Yin
Summary: This study explored the working experience of 13 clinical pharmacists during COVID-19 and provided guidance for their participation in public health crisis. The results yielded insights on the roles, experiences, feelings, and career expectations of clinical pharmacists in such emergencies.
BMC HEALTH SERVICES RESEARCH
(2022)
Article
Biotechnology & Applied Microbiology
Jianwei Xu, Gang Liu, Xianyao Wang, Ya'nan Hu, Hongyang Luo, Lan Ye, Zhanhui Feng, Chen Li, Menglan Kuang, Lijuan Zhang, Yixia Zhou, Xiaolan Qi
Summary: This study evaluated the acute and long-term toxicity of human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) in mice and rats. The results showed that there was no obvious acute toxicity of hUC-MSCs in mice at the maximum tolerated dose. Long-term toxicity tests in rats also didn't show significant differences between HUC-MSC-treated and control groups.
Article
Chemistry, Medicinal
Yongxi Dong, Shuxia Wu, Mingji Liu, Jiayu Huang, Yuanhu Mao, Jiquan Zhang, Zhanzhan Yang, Lei Li, Gang Liu, Shanggao Liao, Li Dong
Summary: TMP is a commonly used antiplatelet drug, but with limitations of short half-life and low bioavailability. In this study, conjugates of TMP derivatives were designed to address these issues, with 13 out of 20 showing higher antiplatelet aggregation activity than TMP.
MEDICINAL CHEMISTRY RESEARCH
(2022)
Article
Education & Educational Research
Xiali Yao, Xuedong Jia, Xiangfen Shi, Gang Liu, Yuwei Li, Xiaojian Zhang, Shuzhang Du, Jun Li, Zhao Yin
Summary: This study explores the experiences and expectations of pharmacist interns regarding hospital-based pharmacy internships (HBPI). It finds that HBPI improves the professional knowledge and skills of interns, although there are still challenges and room for improvement in the current internship system in China.
BMC MEDICAL EDUCATION
(2022)
Article
Pharmacology & Pharmacy
Xinyu Zhu, Jiangtong Peng, Liuye Yang, Yi Guo, Pengchao Wang, Kaiyuan Liu, Jingbo Zhu, Shan Deng, Minglu Liang
Summary: This study demonstrates the inhibitory effect of 7-Mif on endothelial inflammation by reducing the expression of endothelial adhesion molecules and monocyte adhesion.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)