Article
Biochemistry & Molecular Biology
Jie Chen, Jiao Zhang, Jie Li, Ran Qin, Na Lu, David Goltzman, Dengshun Miao, Renlei Yang
Summary: Emerging observational data suggest that vitamin D deficiency is associated with knee osteoarthritis. However, the relationship between vitamin D level and osteoarthritis, as well as the role of vitamin D supplementation in prevention, are still controversial. This study found that 1,25(OH)2D3 deficiency accelerated the development of knee osteoarthritis in mice, while supplementation with 1,25(OH)2D3 rescued the phenotypes of osteoarthritis.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Endocrinology & Metabolism
Johanna Oberg, Rolf Jorde, Bjorg Almas, Christopher Sivert Nielsen, Thomas Alexander Gerds, Kevin D. Cashman, Guri Grimnes
Summary: This study presents population-based data from an Arctic adolescent population, investigating the changes in vitamin D status during adolescence and the potential impact of lifestyle changes on vitamin D levels.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Nutrition & Dietetics
Wen Liu, Cui Zhou, Yushan Wang, Huiyan Yu, Xiaona Zhang, Tao Wang, Lijing Wang, Ling Hao, Zhongsheng Qin, Rong Xiao
Summary: This study found that individuals with vitamin D deficiency are more likely to develop cognitive impairment, and serum vitamin D concentrations are negatively correlated with lipid and oxysterol concentrations. There is a positive correlation between serum vitamin D concentrations and cognitive function.
JOURNAL OF NUTRITION
(2021)
Article
Environmental Sciences
Johan Lundqvist, Geeta Mandava, Agneta Oskarsson
Summary: Compounds with VDR antagonistic properties were found in environmental samples, which could potentially pose a hazard to human health and aquatic life.
ENVIRONMENTAL SCIENCES EUROPE
(2023)
Article
Biochemistry & Molecular Biology
Mark B. Mayer, Carlos Bernal-Mizrachi, Daniel D. Bikle, Madhu Biyani, Moray J. Campbell, Snehal N. Chaudhari, Sylvia Christakos, Sue A. Ingles, Megan M. Knuth, Seong Min Lee, Thomas S. Lisse, Eva S. Liu, Isabelle Piec, Lori A. Plum, Sudhaker D. Rao, Carmen J. Reynolds, Tom D. Thacher, John H. White, Margherita T. Cantorna
Summary: This article summarizes the 24th Workshop on Vitamin D that took place on September 7-9, 2022 in Austin, Texas. The workshop featured a diverse range of research on vitamin D from around the world. The summary provides an overview of the meeting, individual sessions, awards, and presentations.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2023)
Article
Nutrition & Dietetics
Wei Lu, Zhengyuan Wang, Zhuo Sun, Zehuan Shi, Qi Song, Xueying Cui, Liping Shen, Mengying Qu, Shupeng Mai, Jiajie Zang
Summary: The study found that pregnant women with severe vitamin D deficiency combined with excess iodine have a significantly higher risk of thyroid disorder.
Article
Cell Biology
Jennifer M. Hahn, Kelly A. Combs, Heather M. Powell, Dorothy M. Supp
Summary: Keloids are challenging to treat and have high recurrence rates. The genetic causes and molecular mechanisms of keloid formation are not fully understood. Dark-skinned individuals, who are at higher risk of keloids, may also have lower vitamin D levels, suggesting a potential role for vitamin D in keloid pathology. Studies have found reduced vitamin D receptor expression in keloid lesions, indicating a possible therapeutic role for vitamin D in suppressing keloid fibrosis.
WOUND REPAIR AND REGENERATION
(2023)
Article
Biochemistry & Molecular Biology
Miguel A. Olivencia, Marta Villegas-Esguevillas, Maria Sancho, Bianca Barreira, Elena Paternoster, Rui Adao, Maria Jesus Larriba, Angel Cogolludo, Francisco Perez-Vizcaino
Summary: Recent evidence suggests that vitamin D is involved in the development of pulmonary arterial hypertension (PAH). This study analyzed the electrophysiological and contractile properties of pulmonary arteries (PAs) in vitamin D receptor knockout mice (Vdr(-)(/-)). The results show that while Vdr(-)(/-) mice did not develop pulmonary hypertension, there was increased response to a Kv7 activator in their resistance PAs. This suggests that although Vdr deficiency alone may not induce PAH, the contribution of Kv7 channel currents to PA tone is increased in Vdr(-/-) mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Pan Cui, Wanting Lu, Junjie Wang, Fei Wang, Xiyue Zhang, Xiaodan Hou, Fang Xu, Yan Liang, Guoliang Chai, Junwei Hao
Summary: In this study, the researchers investigated the molecular mechanisms of vitamin D signaling in regulating stroke progression. They found that the vitamin D receptor (VDR) was upregulated in microglia/macrophages following cerebral ischemia. Inactivation of VDR in these cells led to increased infarct volumes and neurological deficits. VDR-deficient microglia/macrophages exhibited a proinflammatory phenotype and released cytokines that promoted blood-brain barrier disruption and infiltration of peripheral T lymphocytes. Blocking these cytokines improved stroke outcomes in mice. These findings highlight the importance of maintaining functional vitamin D signaling in the management of acute ischemic stroke.
JOURNAL OF NEUROINFLAMMATION
(2023)
Review
Pharmacology & Pharmacy
Sofie-Louise Feentved Odum, Martin Kongsbak-Wismann
Summary: The impact of the SARS-CoV-2 virus causing the COVID-19 pandemic has been severe worldwide. There is no clear consensus on whether vitamin D supplementation affects the burden of COVID-19. Various studies have shown different results, with some suggesting a beneficial effect of vitamin D on disease severity and mortality, while others found no such effects. Investigating the role of the vitamin D receptor (VDR) in immune responses to SARS-CoV-2 can provide insights into the lack of consensus.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Charlotte Delrue, Reinhart Speeckaert, Joris R. R. Delanghe, Marijn M. M. Speeckaert
Summary: Vitamin D is an immune modulator that affects infection susceptibility. The relationship between vitamin D deficiency and mortality in sepsis patients remains unclear. Adequate vitamin D concentration may reduce mortality in sepsis patients with severe deficiency.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Anna Gabryanczyk, Sylwia Klimczak, Izabela Szymczak-Pajor, Agnieszka Sliwinska
Summary: Vitamin D deficiency may contribute to increased cancer risk in T2DM patients by impacting factors such as insulin resistance and hyperglycemia. Vitamin D can reduce diabetes-driven cancer risk factors through mechanisms such as regulating DNA repair, cancer cell apoptosis, and signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Health Care Sciences & Services
Jiyoun Kim, Jinho Park, Wi-Young So
Summary: This study aimed to investigate the relationship between vitamin D levels and physical activity in adolescents. The study found that reduced participation in physical activity was correlated with vitamin D deficiency, and the risk of vitamin D deficiency was higher among high school students and girls.
Review
Nutrition & Dietetics
Zaleha Md Isa, Norizzati Amsah, Norfazilah Ahmad
Summary: Vitamin D deficiency and insufficiency have negative effects on the outcome of Type 2 Diabetes Mellitus patients, including glycaemic control and the development of complications. Thus, screening for vitamin D levels in T2DM patients may be beneficial.
Review
Nutrition & Dietetics
Mohammed M. Hassanein, Hasniza Zaman Huri, Abduelmula R. Abduelkarem, Kauser Baig
Summary: In recent years, there has been increasing evidence suggesting the potential role of vitamin D in women's health, particularly in postmenopausal women. This evidence includes the connection between vitamin D and various genitourinary disorders and symptoms. Clinical studies have found that vitamin D supplementation can improve vulvovaginal symptoms associated with the genitourinary syndrome of menopause (GSM), such as vaginal pH, dryness, sexual functioning, libido, and urinary tract infections. The effects of vitamin D are mediated through vitamin D receptors (VDRs) and its role in supporting immune function and modulating defense mechanisms. Further research is needed to fully understand these effects. This article aims to review the existing evidence on vitamin D's impact on the vaginal, sexual, and urological health of postmenopausal women. As research in this area continues, vitamin D has the potential to support urogenital and sexual health during the menopausal transition and postmenopausal periods.
Article
Nutrition & Dietetics
Jie Li, Simin Liu, Songtao Li, Rennan Feng, Lixin Na, Xia Chu, Xiaoyan Wu, Yucun Niu, Zongxiang Sun, Tianshu Han, Haoyuan Deng, Xing Meng, Huan Xu, Zhe Zhang, Qiannuo Qu, Qiao Zhang, Ying Li, Changhao Sun
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2017)
Article
Gastroenterology & Hepatology
Songtao Li, Xiaobing Dou, Hua Ning, Qing Song, Wei Wei, Ximei Zhang, Chen Shen, Jiaxin Li, Changhao Sun, Zhenyuan Song
Review
Cardiac & Cardiovascular Systems
M. Huang, J. Li, M. -A. Ha, G. Riccardi, S. Liu
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2017)
Article
Nutrition & Dietetics
Xue Yang, Yifan Huang, Changhao Sun, Jie Li
Article
Endocrinology & Metabolism
Jie Li, Bin Feng, Yaohui Nie, Ping Jiao, Xiaochen Lin, Mengna Huang, Ran An, Qin He, Huilin Emily Zhou, Arthur Salomon, Kirsten S. Sigrist, Zhidan Wu, Simin Liu, Haiyan Xu
Article
Biochemistry & Molecular Biology
Liuyi Hao, Qian Sun, Wei Zhong, Wenliang Zhang, Xinguo Su, Zhanxiang Zhou
Article
Gastroenterology & Hepatology
Wei Zhong, Xiaoyuan Wei, Liuyi Hao, Tai-Du Lin, Ruichao Yue, Xinguo Sun, Wei Guo, Haibo Dong, Tianjin Li, Ali R. Ahnzadi, Zhaoli Sun, Qibin Zhang, Jiangchao Zhao, Zhanxiang Zhou
Article
Gastroenterology & Hepatology
Qing Song, Yingli Chen, Jun Wang, Liuyi Hao, Chuyi Huang, Alexandra Griffiths, Zhaoli Sun, Zhangxiang Zhou, Zhenyuan Song
JOURNAL OF HEPATOLOGY
(2020)
Article
Gastroenterology & Hepatology
Liuyi Hao, Wei Zhong, Jongmin Woo, Xiaoyuan Wei, Hao Ma, Haibo Dong, Wei Guo, Xinguo Sun, Ruichao Yue, Jiangchao Zhao, Qibin Zhang, Zhanxiang Zhou
Summary: This study aimed to investigate the role of intestinal dendritic cells (DCs) in the progression of alcoholic liver disease (ALD). The results showed that deficiency of intestinal DCs exacerbated alcohol-induced gut barrier disruption, bacterial endotoxin translocation, and liver injury. Therefore, targeting intestinal DCs may be a promising therapeutic approach for treating ALD.
Article
Gastroenterology & Hepatology
Liuyi Hao, Wei Zhong, Haibo Dong, Wei Guo, Xinguo Sun, Wenliang Zhang, Ruichao Yue, Tianjiao Li, Alexandra Griffiths, Ali Reza Ahmadi, Zhaoli Sun, Zhenyuan Song, Zhanxiang Zhou
Summary: The study reveals that hepatic ATF4 plays a pathological role in alcohol-induced mitochondrial dysfunction and liver injury by disrupting the NRF1-TFAM pathway. In patients with alcoholic liver disease, the activation of ATF4 is associated with mitochondrial dysfunction. Knocking out ATF4 or overexpressing TFAM can alleviate alcohol-induced liver damage. This is achieved through the negative regulation of TFAM expression by ATF4, affecting ethanol-mediated mitochondrial dysfunction and cell death.
Article
Gastroenterology & Hepatology
Haibo Dong, Liuyi Hao, Wenliang Zhang, Wei Zhong, Wei Guo, Ruichao Yue, Xinguo Sun, Zhanxiang Zhou
Summary: The study reveals that AhR activation serves as a protective response against alcohol-induced hepatic NAD(+) depletion by inducing NQO1 expression. Targeting the hepatic AhR-NQO1 pathway may offer a novel therapeutic approach for ALD.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Meeting Abstract
Gastroenterology & Hepatology
Qing Song, Yingli Chen, Jun Wang, Liuyi Hao, Zhanxiang Zhou, Zhenyuan Song
Meeting Abstract
Immunology
Liuyi Hao, Wei Zhong, Xinguo Sun, Zhanxiang Zhou
JOURNAL OF IMMUNOLOGY
(2019)
Meeting Abstract
Gastroenterology & Hepatology
Wei Zhong, Wenliang Zhang, Liuyi Hao, Wei Guo, Xinguo Sun, Zhanxiang Zhou
Article
Biochemistry & Molecular Biology
Songtao Li, Hua Ning, Yaxin Ye, Wei Wei, Rui Guo, Qing Song, Lei Liu, Yunyun Liu, Lixin Na, Yuchun Niu, Xia Chu, Rennan Feng, Naima Moustaid-Moussa, Ying Li, Changhao Sun
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2017)