Boolean analysis shows a high proportion of dopamine D2 receptors interacting with adenosine A2A receptors in striatal medium spiny neurons of mouse and non-human primate models of Parkinson's disease

A method for Boolean analysis of protein interactions at a molecular level

(2022) Doroteya Raykova et al.   Nature Communications

Rho kinase inhibitor fasudil reduces L‐DOPA‐induced dyskinesia in a rat model of Parkinson´s disease

(2020) Andrea Lopez‐Lopez et al.   BRITISH JOURNAL OF PHARMACOLOGY

Adenosine heteroreceptor complexes in the basal ganglia are implicated in Parkinson’s disease and its treatment

(2019) Dasiel O. Borroto-Escuela et al.   JOURNAL OF NEURAL TRANSMISSION

Effects of Long-Term Alcohol Drinking on the Dopamine D2 Receptor: Gene Expression and Heteroreceptor Complexes in the Striatum in Rats

(2018) Kristin Feltmann et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

N-Methyl-D-Aspartate Receptor Link to the MAP Kinase Pathway in Cortical and Hippocampal Neurons and Microglia Is Dependent on Calcium Sensors and Is Blocked by α-Synuclein, Tau, and Phospho-Tau in Non-transgenic and Transgenic APPSw,Ind Mice

(2018) Rafael Franco et al.   Frontiers in Molecular Neuroscience

Antipsychotic-Like Efficacy of Dopamine D2 Receptor-Biased Ligands is Dependent on Adenosine A2A Receptor Expression

(2017) Kristoffer Sahlholm et al.   MOLECULAR NEUROBIOLOGY

Disruption of a dopamine receptor complex amplifies the actions of cocaine

(2016) Melissa L. Perreault et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Functional role of striatal A2A, D2, and mGlu5 receptor interactions in regulating striatopallidal GABA neuronal transmission

(2016) Sarah Beggiato et al.   JOURNAL OF NEUROCHEMISTRY

Astrocytic adenosine receptor A2A and Gs-coupled signaling regulate memory

(2015) Anna G Orr et al.   NATURE NEUROSCIENCE

Dopaminergic modulation of striatal networks in health and Parkinson's disease

(2014) D James Surmeier et al.   CURRENT OPINION IN NEUROBIOLOGY

Angiotensin type 1 receptor blockage reduces l-dopa-induced dyskinesia in the 6-OHDA model of Parkinson's disease. Involvement of vascular endothelial growth factor and interleukin-1β

(2014) Ana Muñoz et al.   EXPERIMENTAL NEUROLOGY

l-DOPA disrupts adenosine A2A–cannabinoid CB1–dopamine D2 receptor heteromer cross-talk in the striatum of hemiparkinsonian rats: Biochemical and behavioral studies

(2014) Annalisa Pinna et al.   EXPERIMENTAL NEUROLOGY

The G Protein-Coupled Receptor Heterodimer Network (GPCR-HetNet) and Its Hub Components

(2014) Dasiel Borroto-Escuela et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Diversity and Bias through Receptor–Receptor Interactions in GPCR Heteroreceptor Complexes. Focus on Examples from Dopamine D2 Receptor Heteromerization

(2014) Kjell Fuxe et al.   Frontiers in Endocrinology

Modulation of A2a receptor antagonist on D2 receptor internalization and ERK phosphorylation

(2013) Li Huang et al.   ACTA PHARMACOLOGICA SINICA

Dose-response meta-analysis on coffee, tea and caffeine consumption with risk of Parkinson's disease

(2013) Hui Qi et al.   Geriatrics & Gerontology International

Adenosine A2Areceptor antagonist istradefylline reduces daily OFF time in Parkinson's disease

(2013) Yoshikuni Mizuno et al.   MOVEMENT DISORDERS

In vitro pharmacological profile of the A2A receptor antagonist istradefylline

(2013) Mayumi Saki et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

l-DOPA-treatment in primates disrupts the expression of A2A adenosine–CB1 cannabinoid–D2 dopamine receptor heteromers in the caudate nucleus

(2013) Jordi Bonaventura et al.   NEUROPHARMACOLOGY

Detection of antigen interactions ex vivo by proximity ligation assay: endogenous dopamine D2-adenosine A2A receptor complexes in the striatum

(2012) Pierre Trifilieff et al.   BIOTECHNIQUES

Molecular determinants of A2AR-D2R allosterism: role of the intracellular loop 3 of the D2R

(2012) Víctor Fernández-Dueñas et al.   JOURNAL OF NEUROCHEMISTRY

The basal ganglia and thalamus of the long-tailed macaque in stereotaxic coordinates. A template atlas based on coronal, sagittal and horizontal brain sections

(2011) José L. Lanciego et al.   Brain Structure & Function

The Distinct Role of Medium Spiny Neurons and Cholinergic Interneurons in the D2/A2A Receptor Interaction in the Striatum: Implications for Parkinson's Disease

(2011) A. Tozzi et al.   JOURNAL OF NEUROSCIENCE

Striatal Pre- and Postsynaptic Profile of Adenosine A2A Receptor Antagonists

(2011) Marco Orru et al.   PLoS One

Risk-factors for Parkinson's disease: case-control study in the province of Cáceres, Spain

(2010) A. Morano et al.   ACTA NEUROLOGICA SCANDINAVICA

Interactions between Intracellular Domains as Key Determinants of the Quaternary Structure and Function of Receptor Heteromers

(2010) Gemma Navarro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dopamine D1-D2 Receptor Heteromer-mediated Calcium Release Is Desensitized by D1 Receptor Occupancy with or without Signal Activation

(2010) Vaneeta Verma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Looking for the role of cannabinoid receptor heteromers in striatal function

(2008) Sergi Ferré et al.   NEUROPHARMACOLOGY

Detection of Heteromers Formed by Cannabinoid CB1, Dopamine D2, and Adenosine A2AG-Protein-Coupled Receptors by Combining Bimolecular Fluorescence Complementation and Bioluminescence Energy Transfer

(2008) Gemma Navarro et al.   TheScientificWorldJOURNAL