The challenge of identifying senescent cells

Single-cell transcriptomics identifies Mcl-1 as a target for senolytic therapy in cancer

(2022) Martina Troiani et al.   Nature Communications

A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues

(2022) Dominik Saul et al.   Nature Communications

Pathological angiogenesis in retinopathy engages cellular senescence and is amenable to therapeutic elimination via BCL-xL inhibition

(2021) Sergio Crespo-Garcia et al.   Cell Metabolism

Oxylipin biosynthesis reinforces cellular senescence and allows detection of senolysis

(2021) Christopher D. Wiley et al.   Cell Metabolism

The Cancer SENESCopedia: A delineation of cancer cell senescence

(2021) Fleur Jochems et al.   Cell Reports

Defined p16High Senescent Cell Types Are Indispensable for Mouse Healthspan

(2020) Laurent Grosse et al.   Cell Metabolism

Senolytic CAR T cells reverse senescence-associated pathologies

(2020) Corina Amor et al.   NATURE

The senescence-associated secretome as an indicator of age and medical risk

(2020) Marissa J. Schafer et al.   JCI Insight

Senolytics prevent mt-DNA-induced inflammation and promote the survival of aged organs following transplantation

(2020) Jasper Iske et al.   Nature Communications

Cellular Senescence: Defining a Path Forward

(2019) Vassilis Gorgoulis et al.   CELL

A versatile drug delivery system targeting senescent cells

(2018) Daniel Muñoz‐Espín et al.   EMBO Molecular Medicine

Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

(2016) Darren J. Baker et al.   NATURE