Review
Clinical Neurology
Hailiang Tang, Yao Li, Weijun Tang, Jianhong Zhu, Graham C. Parker, John H. Zhang
Summary: Ischemic stroke is a common cerebrovascular accident that occurs in adults and increases the risk of neural deficits. Stem cell therapy is currently the most promising approach for inducing neurogenesis and repairing neural damage after ischemic stroke.
TRANSLATIONAL STROKE RESEARCH
(2023)
Article
Cell & Tissue Engineering
Filipa F. Ribeiro, Filipa Ferreira, Rui S. Rodrigues, Rita Soares, Diogo M. Pedro, Marta Duarte-Samartinho, Rita I. Aroeira, Elisabete Ferreiro, Jorge Valero, Susana Sola, Helena Mira, Ana M. Sebastiao, Sara Xapelli
Summary: The activation of A(2A) receptors promotes neural stem cell self-renewal, protects committed neuronal cells from cell death, and increases the density of immature and mature neuronal cells. Furthermore, the endogenous activation of A(2A) receptors is essential for BDNF-mediated cell proliferation and neuronal differentiation.
Article
Cell & Tissue Engineering
Takayuki Nakagomi, Akiko Nakano-Doi, Shuji Kubo, Toshinori Sawano, Yoji Kuramoto, Kenichi Yamahara, Tomohiro Matsuyama, Toshinori Takagi, Nobutaka Doe, Shinichi Yoshimura
Summary: A study found that injury or ischemia-induced multipotent stem cells can develop within post-stroke human brains, which can improve neurological function in stroke patients. Transplanting these stem cells into injured mouse brains promoted neural stem cell proliferation and neurogenesis.
STEM CELLS TRANSLATIONAL MEDICINE
(2023)
Article
Cell & Tissue Engineering
Kyung-Joo Seong, Seungho Choi, Hyun-Gwan Lee, Joon Haeng Rhee, Jin Ho Lee, Jeong-Tae Koh, Sun-Hun Kim, Won-Seok Choi, Ji-Yeon Jung, Won-Jae Kim
Summary: Toll-like receptor 5 plays a crucial role in regulating neurogenesis from mouse embryonic stem cells and adult hippocampal neural stem cells, promoting neural differentiation and inhibiting cell proliferation. TLR5 deficiency impairs fear memory performance in mice.
Article
Cell Biology
Mariem Achour, Farhana Ferdousi, Kazunori Sasaki, Hiroko Isoda
Summary: Luteolin upregulated genes related to neurotrophin, dopaminergic, hippo, and Wnt signaling pathways, and downregulated genes involved in p53, TNF, FOXO, and Notch signaling pathways in hNSCs. Luteolin treatment also increased the expression of astrocyte-specific gene GFAP and other genes involved in astrogenesis pathways, while decreasing the expression of genes related to neurogenesis and oligodendrogenesis. Additionally, luteolin showed potential therapeutic benefits in neuroinflammatory and neurodegenerative diseases by modulating different signaling pathways involved in the pathophysiology of depression.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biotechnology & Applied Microbiology
Ghufran Lutfi Ismaeel, Olfet Jabbar Makki AlHassani, Reem S. Alazragi, Ammar Hussein Ahmed, Asma'a H. Mohamed, Nisreen Yasir Jasim, Falah Hassan Shari, Haider Abdulkareem Almashhadani
Summary: Neural stem cells (NSCs) have the potential to self-renew and differentiate into neurons, astrocytes, and oligodendrocytes. They also secrete various mediators and show therapeutic effects in neurodegenerative diseases. However, the limitations of NSCs transplantation, including poor migration, survival, and differentiation, can be overcome through genetic engineering. Genetically modified NSCs offer more promising therapeutic benefits, making them a potential option for neurological disease therapy.
BIOTECHNOLOGY PROGRESS
(2023)
Review
Clinical Neurology
Tong Zhao, Tongming Zhu, Liqian Xie, Yao Li, Rong Xie, Feng Xu, Hailiang Tang, Jianhong Zhu
Summary: Ischemic stroke is a common cerebrovascular accident with severe neurological deficits. Stem cell transplantation shows promising therapeutic role for ischemic stroke, but its mechanisms are still unclear and further clinical studies are needed.
TRANSLATIONAL STROKE RESEARCH
(2022)
Article
Biology
Ruolin Zhang, Weibing Mao, Lumeng Niu, Wendai Bao, Yiqi Wang, Ying Wang, Yasha Zhu, Zhihao Yang, Jincao Chen, Jiawen Dong, Meng Cai, Zilong Yuan, Haikun Song, Guangqiang Li, Min Zhang, Nanxiang Xiong, Jun Wei, Zhiqiang Dong, Keqiang Ye
Summary: Transplantation of neural stem cells (NSCs) can promote functional rehabilitation of brain lesions caused by ischemic stroke. However, the harsh brain environment limits the survival and differentiation rates of NSCs. In this study, NSCs derived from human induced pluripotent stem cells and NSC-derived exosomes were used to treat cerebral ischemia in mice. The results showed that NSC-derived exosomes reduced inflammation, alleviated oxidative stress, and promoted NSC differentiation. The combination of NSCs and exosomes improved brain tissue injury and motor function recovery. The study provides a rationale for using NSC-derived exosomes as a supportive adjuvant for NSC transplantation after stroke.
Article
Cell & Tissue Engineering
Bo Yang, Li'e Zang, Jingwen Cui, Linlin Wei
Summary: The study revealed that circTTC3 plays a role in regulating CIR injury and NSCs, with its depletion shown to reduce cerebral infarction and promote NSC proliferation. CircTTC3 was found to sponge miR-372-3p and regulate TLR4 expression, suggesting potential targets for stroke treatment.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Pharmacology & Pharmacy
Tianlong Liu, Yao Zhang, Jing Liu, Junwen Peng, Xin Jia, Yunfeng Xiao, Lanbing Zheng, Yu Dong
Summary: The study found that Jaranol was relatively safe in mice when administered orally in both acute and sub-acute toxicity tests, but caused changes in body weight and biochemical parameters. More chronic toxicity studies are recommended to ensure its safety for human use.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xue Li, Xinfeng Tan, Qingshuang Chen, Xiaoling Zhu, Jing Zhang, Jie Zhang, Baolei Jia
Summary: Oral administration of prodigiosin can improve the intestinal microbiota of mice, demonstrating potential probiotic effects.
Article
Biochemistry & Molecular Biology
Fang Li, Hui Huang, Yangkun Wu, Zhe Lu, Xianrong Zhou, Fang Tan, Xin Zhao
Summary: Research has shown that Lactobacillus fermentum HFY06 can effectively alleviate age-related symptoms in elderly mice by activating the Nrf2 signaling pathway and increasing levels of antioxidant enzymes. This suggests that consumption of HFY06 may help prevent aging and reduce oxidative stress.
Article
Neurosciences
Adrien Cogo, Gabrielle Mangin, Sarah Mouazan, Tatiana Merkulova-Rainon, Jean-Pierre Riveline, Jean-Francois Gautier, Mathilde Varret, Nathalie Kubis
Summary: Transplantation of peripheral blood mononuclear cells was found to alleviate neurological deficits, reduce infarct volume, and apoptosis in post-stroke diabetic mice. However, the prevention effect on long-term memory loss was limited, and the impact of diabetes on cell therapy efficacy needs further investigation in future studies.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Nutrition & Dietetics
Xu Zhou, Yafang Chen, Xin Ma, Yang Yu, Xueping Yu, Xiaoyong Chen, Huayi Suo
Summary: In this study, the laxative effect of Bacillus coagulans BC01 was investigated in a functional constipation mouse model. The results showed that BC01 significantly increased intestinal propulsion rate and fecal water content in mice, and it alleviated constipation by regulating gastrointestinal motility, gene expression, intestinal inflammation, and the intestinal microbiota composition. The high-dose BC01 treatment had the best preventive effect on constipation.
FRONTIERS IN NUTRITION
(2022)
Article
Materials Science, Multidisciplinary
Hongfei Ge, Quan Hu, Tunan Chen, Yang Yang, Chao Zhang, Jun Zhong, Yi Yin, Xuheng Jiang, Xin Zhou, Shuhong Wang, Rong Hu, Wenyan Li, Hua Feng
Summary: A feasible method for modifying grafted neural stem cells (NSCs) using layer-by-layer (LbL) assembly has been developed, which enhances their regenerative ability and survival rate, showing potential application in the treatment of ischemic stroke.
APPLIED MATERIALS TODAY
(2022)
Article
Neurosciences
Furong Ju, Yanli Ran, Lirui Zhu, Xiaofeng Cheng, Hao Gao, Xiaoxia Xi, Zhanli Yang, Shengxiang Zhang
FRONTIERS IN CELLULAR NEUROSCIENCE
(2018)
Review
Clinical Neurology
Shengxiang Zhang
STROKE AND VASCULAR NEUROLOGY
(2019)
Article
Pharmacology & Pharmacy
Xin Liu, Shuying Shang, Weiwei Chu, Liang Ma, Chenxin Jiang, Yanping Ding, Jianlin Wang, Shengxiang Zhang, Baoping Shao
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2020)
Article
Chemistry, Analytical
Ying Long, Junru Liu, Dihua Tian, Fang Dai, Shengxiang Zhang, Bo Zhou
ANALYTICAL CHEMISTRY
(2020)
Article
Chemistry, Analytical
Yong-Peng Yang, Fu-Jian Qi, Yi-Ping Qian, Xia-Zhen Bao, Han-Chen Zhang, Bin Ma, Fang Dai, Sheng-Xiang Zhang, Bo Zhou
Summary: The newly developed two-photon probe QBMP showed good binding with NQO1 and exhibited superior properties such as rapid response, large Stokes shift, ultra-low detection limit, favorable two-photon cross section, and deep tissue penetration.
ANALYTICAL CHEMISTRY
(2021)
Article
Immunology
Ting Li, Jin Zhao, Wenguang Xie, Wanru Yuan, Jing Guo, Shengru Pang, Wen-Biao Gan, Diego Gomez-Nicola, Shengxiang Zhang
Summary: The specific depletion of microglia in the early stage of ischemic stroke can significantly reduce the infarct volume and improve motor ability. Depleting microglia also leads to a decrease in degenerating neurons and inducible nitric oxide synthase positive (iNOS(+)) cells. Moreover, the depletion of microglia results in an increase in anti-inflammatory factors and a decrease in pro-inflammatory factors 3 days after stroke. These findings suggest that modulation of the inflammatory response through the elimination of microglia may be a promising therapeutic approach for the treatment of cerebral ischemia.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Chemistry, Multidisciplinary
Guodong Hu, Miao Zhong, Jintao Zhao, Hao Gao, Lu Gan, Hong Zhang, Shengxiang Zhang, Jianguo Fang
Summary: Cellular redox homeostasis is primarily regulated by the ratio of thiols and disulfides, with reversible thioldisulfide exchange reactions being crucial. Detecting protein disulfides (PDS) poses challenges due to dynamic exchanges of thiols and disulfides. Researchers have designed a probe that selectively recognizes PDS in live organisms, revealing an increase of PDS in mouse brains of a stroke model.
Article
Chemistry, Analytical
Yong-Peng Yang, Fu-Jian Qi, Ya-Long Zheng, De-Chen Duan, Xia-Zhen Bao, Fang Dai, Shengxiang Zhang, Bo Zhou
Summary: This study developed a fast imaging probe for mitochondrial TrxR2 and visualized the increased activity of TrxR2 in cancer cells, as well as the decreased activity in Parkinson's disease and ischemic stroke.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Medicinal
Lanning Zhao, Yuan Qu, Fang Zhang, Di Ma, Hao Gao, Lu Gan, Hong Zhang, Shengxiang Zhang, Jianguo Fang
Summary: We report a versatile thiol-triggered fluorogenic release system that can rapidly release a molecule of interest and has been validated for its therapeutic potential in live cells and animal models.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Fang Dai, Shengxiang Zhang, Bo Zhou, De-Chen Duan, Junru Liu, Ya-Long Zheng, Hao Chen, Xinying Zhang, Yu Zhang
Summary: We designed a fluorescent probe NADH-R for imaging NAD(P)H in living cells, which showed a turn-on red-emitting fluorescence response with an ultralow detection limit. This probe allowed us to monitor the generation and dynamic changes of NAD(P)H in living cells and visualize the declined NAD(P)H levels in a stroke model. Moreover, we discovered that NADH-RH is a novel nucleus-directed dye scaffold, which could facilitate the development of nucleus-targeting fluorescent probes and drugs.
ANALYTICAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Zan Song, Lin Liu, Yanyi Xu, Ruofan Cao, Xianyong Lan, Chuanying Pan, Shengxiang Zhang, Haiyu Zhao
Summary: Chronic caffeine-induced sleep restriction affects the diversity and composition of the gut microbiota in mice and substantially alters the metabolic profiles of the gut microbiome.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Zuo Wang, Yi Bi, Kemin Li, Zan Song, Chuanying Pan, Shengxiang Zhang, Xianyong Lan, Nicholas S. Foulkes, Haiyu Zhao
Summary: This study investigated the neurotoxic effects of nickel oxide nanoparticles (NiO-NPs) on zebrafish larvae and found that exposure to environmental levels of NiO-NPs affected embryonic development, neurobehavior, and neurodevelopment. The observed disorders were attributed to ROS-mediated apoptosis and iron-mediated ferroptosis, and pharmacological interventions further confirmed their role in NiO-NPs induced neurotoxicity.
ENVIRONMENTAL SCIENCE-NANO
(2023)
Article
Chemistry, Medicinal
Xin Liu, Yanping Ding, Chenxin Jiang, Xin Ma, Yuanyuan Xin, Yingdong Li, Shengxiang Zhang, Baoping Shao
Summary: Radiation can cause nerve cell damage, and AS-IV can alleviate radiation-induced synapse damage through the activation of the BDNF/TrkB pathway.
PHYTOTHERAPY RESEARCH
(2023)
Article
Materials Science, Biomaterials
Wenguang Xie, Xiao-Ting Gong, Xiaofeng Cheng, Jingjing Cao, Jin Zhao, Hao-Li Zhang, Shengxiang Zhang
Summary: Visualization of cerebrovascular networks is crucial for understanding neurological diseases. Optical clearing techniques and nanotechnology enable precise imaging of brain vessels with functionalized micro/nanoparticles, providing a novel tool for analyzing vascular dysfunction and diseases. The LIMPID method shows high robustness in vessel labeling without sacrificing fluorescence signals and clearing performance.
BIOMATERIALS SCIENCE
(2021)
Article
Materials Science, Biomaterials
Xiao-Ting Gong, Wenguang Xie, Jing-Jing Cao, Shengxiang Zhang, Kanyi Pu, Hao-Li Zhang
BIOMATERIALS SCIENCE
(2020)
