Article
Cell Biology
Abhishek Chandra, Anthony B. Lagnado, Joshua N. Farr, Madison Doolittle, Tamara Tchkonia, James L. Kirkland, Nathan K. LeBrasseur, Paul D. Robbins, Laura J. Niedernhofer, Yuji Ikeno, Joao F. Passos, David G. Monroe, Robert J. Pignolo, Sundeep Khosla
Summary: This study demonstrates that cellular senescence-driven radiation-induced osteoporosis is primarily mediated by p21(Cip1) rather than p16(Ink4a), based on the clearance of senescent cells using genetic models. This approach may be used to investigate the contributions of these pathways in other senescence-associated conditions, including aging across tissues.
Article
Chemistry, Medicinal
Xin Liu, Yanping Ding, Chenxin Jiang, Xin Ma, Yuanyuan Xin, Yingdong Li, Shengxiang Zhang, Baoping Shao
Summary: Radiation can cause nerve cell damage, and AS-IV can alleviate radiation-induced synapse damage through the activation of the BDNF/TrkB pathway.
PHYTOTHERAPY RESEARCH
(2023)
Article
Biology
Yu-Ting Tian, Li-Ping Ma, Chun-Yan Ding, Meng-Meng Liu, Si-Nian Wang, Mei Tian, Ling Gao, Qing-Jie Liu
Summary: This study found that ionizing radiation can induce premature senescence and autophagy in lung adenocarcinoma cells. Autophagy regulates X-ray radiation-induced premature senescence through the STAT3-Beclin1-p62 pathway in lung adenocarcinoma cells.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2022)
Article
Plant Sciences
Jingfeng Liu, Xiaofei Huang, Dandan Liu, Kaiyuan Ji, Cheng Tao, Ren Zhang, Jian Chen
Summary: In this study, we demonstrated that DMB inhibits NSCLC progression by inducing cell cycle arrest and triggering cellular senescence through downregulating the c-Myc/HIF-1 alpha pathway. We also found that DMB suppresses cell migration by inhibiting epithelial-mesenchymal transition (EMT) and accelerates senescence by suppressing HIF-1 alpha expression in NSCLC cells. Additionally, DMB decreases c-Myc expression, an upstream regulator of HIF-1 alpha.
Article
Agriculture, Dairy & Animal Science
Nannan Li, Yanju Xiao, Han Wang, Yuhao Zhong, Hongxuan Yang, Kexin Huang
Summary: The effect of heat stress on insulin-induced intracellular signaling in testicular cells was studied. Heat stress caused significant alterations in insulin-induced intracellular signaling, particularly in the downregulation of the insulin receptor-mediated pathway. Moreover, heat stress induced testicular cell senescence and oxidative stress, suggesting that oxidative stress may be the underlying molecular mechanism by which heat stress disrupts insulin signaling.
ANIMAL BIOTECHNOLOGY
(2023)
Article
Immunology
Haochun Guo, Jiajia Chen, Hanxu Yu, Lei Dong, Ran Yu, Qingju Li, Jian Song, Haoyu Chen, Haijun Zhang, Juan Pu, Wanpeng Wang
Summary: This study demonstrates the protective effect of 654-2 on radiation-induced lung injury (RILI). It mitigates pulmonary pathological damage, inflammation, DNA damage, cellular senescence, and apoptosis, while restoring epithelial cell proliferation ability and enhancing antioxidant capacity. The mechanism involves the activation of the Nrf2/ARE pathway and upregulation of antioxidant gene expression.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Cell Biology
Stefano Fumagalli, Mario Pende
Summary: This article reviews the potential mechanisms of S6K1's action on cell size by considering its main functional targets: substrates involved in nucleic acid and protein synthesis, fat mass accumulation, retrograde control of insulin action, senescence program, and cytoskeleton organization. The interconnection between cell size, regenerative and aging responses, in which S6K1 may be involved, is also discussed.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jianchun Wu, Kaitrin Kramer, David l L. Crowe
Summary: Obesity is the primary preventable cause of breast cancer, and the expression of the nuclear receptor PPAR & gamma; is altered in obese mice, leading to an increased risk of breast cancer. The increased expression of PPAR & gamma; in mammary epithelium of obese mice is associated with higher expression of solute carrier proteins, which contributes to the development of breast cancer.
Article
Ophthalmology
Yurun Liu, Simin Gu, Yaru Su, Shoubi Wang, Yaqi Cheng, Xuan Sang, Lin Jin, Ying Liu, Chaoyang Li, Weiqin Liu, Minghao Chen, Xiaoran Wang, Zhichong Wang
Summary: Embryonic stem cell-derived extracellular vesicles (EVs) can reverse the cellular senescence of retinal pigment epithelial (RPE) cells and exert their effect by inhibiting the p38MAPK pathway.
EXPERIMENTAL EYE RESEARCH
(2023)
Article
Oncology
Charlotte Linke, Thomas Freitag, Christin Riess, Jana Vanessa Scheffler, Katharina del Moral, Nina Schoenwaelder, Tomas Fiedler, Adina Fiebig, Philipp Kaps, Daniel Dubinski, Bjoern Schneider, Wendy Bergmann, Carl Friedrich Classen, Claudia Maletzki
Summary: In this study, the combination therapy of Mithramycin A (MitA) and arginine deiminase (SpyADI) demonstrated significant therapeutic effects on glioblastoma multiforme (GBM), inhibiting cell proliferation and invasion, and inducing senescence and apoptosis. This novel combination approach may provide a new treatment strategy for GBM.
CANCER CELL INTERNATIONAL
(2023)
Article
Medicine, Research & Experimental
Andres Fuentes-Flores, Cristian Geronimo-Olvera, Karina Girardi, David Necunir-Ibarra, Sandip Kumar Patel, Joanna Bons, Megan C. Wright, Daniel Geschwind, Ahmet Hoke, Jose A. Gomez-Sanchez, Birgit Schilling, Daniela L. Rebolledo, Judith Campisi, Felipe A. Court
Summary: Reparative Schwann cells transition into a senescent phenotype in aging and chronic denervation, leading to inhibition of axonal regeneration. Elimination of senescent cells improves nerve regeneration and functional recovery.
EMBO MOLECULAR MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Yang Li, Wenzhen Deng, Jinlin Wu, Qirui He, Gangyi Yang, Xie Luo, Yanjun Jia, Yaqian Duan, Liping Zhou, Dongfang Liu
Summary: This study investigated the effects and mechanisms of TXNIP on the senescence and aging- and diet-related dysfunction of beta cells. The results showed that TXNIP expression was age-related in human beta cells and serum samples. TXNIP induced cell cycle arrest through the p38-p16/p21-CDK-Rb pathway, accelerating beta cell senescence and age-related dysfunction.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Article
Medicine, Research & Experimental
Tongshuai Chen, Chang Ma, Guanqi Fan, Hui Liu, Xie Lin, Jingyuan Li, Na Li, Shujian Wang, Mei Zeng, Yun Zhang, Peili Bu
Summary: Hyperglycemia accelerates endothelial cell dysfunction and vascular complications by inducing ECs senescence, with molecular mechanisms involving SIRT3-p53 pathway.
Article
Biochemistry & Molecular Biology
Maria Russo, Stefania Moccia, Carmela Spagnuolo, Idolo Tedesco, Gian Luigi Russo
Summary: This study demonstrated that carotenoid-enriched nanoemulsions (CEN) can activate a cytostatic form of autophagy and decrease the expression of the senescence marker p16(INK4) in SAOS400 cells. When combined with gamma-irradiation, CEN can induce cytotoxic autophagy and enhance cell death. Beta-carotene, a component of CEN, did not show radiosensitizing effect, suggesting that other bioactive molecules present in CEN may contribute to its biological effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Quinn T. Storozynsky, Xuefei Han, Shae Komant, Kate C. Agopsowicz, Kyle G. Potts, Armin M. Gamper, Roseline Godbout, David H. Evans, Mary M. Hitt
Summary: Researchers found that cellular senescence induced by radiotherapy may impact the therapeutic potential of vaccinia virus (VACV)-based oncolytic viruses (OV) in treating glioblastoma (GBM). Both a VACV mutant, increment F4L & UDelta;J2R, and the wild-type VACV exhibited attenuated oncolytic properties towards GBM cells under irradiated senescence-enriched conditions, suggesting the presence of senescence-associated antiviral activity.
Article
Chemistry, Analytical
Ying Long, Junru Liu, Dihua Tian, Fang Dai, Shengxiang Zhang, Bo Zhou
ANALYTICAL CHEMISTRY
(2020)
Article
Chemistry, Analytical
Yong-Peng Yang, Fu-Jian Qi, Yi-Ping Qian, Xia-Zhen Bao, Han-Chen Zhang, Bin Ma, Fang Dai, Sheng-Xiang Zhang, Bo Zhou
Summary: The newly developed two-photon probe QBMP showed good binding with NQO1 and exhibited superior properties such as rapid response, large Stokes shift, ultra-low detection limit, favorable two-photon cross section, and deep tissue penetration.
ANALYTICAL CHEMISTRY
(2021)
Article
Immunology
Ting Li, Jin Zhao, Wenguang Xie, Wanru Yuan, Jing Guo, Shengru Pang, Wen-Biao Gan, Diego Gomez-Nicola, Shengxiang Zhang
Summary: The specific depletion of microglia in the early stage of ischemic stroke can significantly reduce the infarct volume and improve motor ability. Depleting microglia also leads to a decrease in degenerating neurons and inducible nitric oxide synthase positive (iNOS(+)) cells. Moreover, the depletion of microglia results in an increase in anti-inflammatory factors and a decrease in pro-inflammatory factors 3 days after stroke. These findings suggest that modulation of the inflammatory response through the elimination of microglia may be a promising therapeutic approach for the treatment of cerebral ischemia.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Chemistry, Multidisciplinary
Guodong Hu, Miao Zhong, Jintao Zhao, Hao Gao, Lu Gan, Hong Zhang, Shengxiang Zhang, Jianguo Fang
Summary: Cellular redox homeostasis is primarily regulated by the ratio of thiols and disulfides, with reversible thioldisulfide exchange reactions being crucial. Detecting protein disulfides (PDS) poses challenges due to dynamic exchanges of thiols and disulfides. Researchers have designed a probe that selectively recognizes PDS in live organisms, revealing an increase of PDS in mouse brains of a stroke model.
Article
Chemistry, Analytical
Yong-Peng Yang, Fu-Jian Qi, Ya-Long Zheng, De-Chen Duan, Xia-Zhen Bao, Fang Dai, Shengxiang Zhang, Bo Zhou
Summary: This study developed a fast imaging probe for mitochondrial TrxR2 and visualized the increased activity of TrxR2 in cancer cells, as well as the decreased activity in Parkinson's disease and ischemic stroke.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Medicinal
Lanning Zhao, Yuan Qu, Fang Zhang, Di Ma, Hao Gao, Lu Gan, Hong Zhang, Shengxiang Zhang, Jianguo Fang
Summary: We report a versatile thiol-triggered fluorogenic release system that can rapidly release a molecule of interest and has been validated for its therapeutic potential in live cells and animal models.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Fang Dai, Shengxiang Zhang, Bo Zhou, De-Chen Duan, Junru Liu, Ya-Long Zheng, Hao Chen, Xinying Zhang, Yu Zhang
Summary: We designed a fluorescent probe NADH-R for imaging NAD(P)H in living cells, which showed a turn-on red-emitting fluorescence response with an ultralow detection limit. This probe allowed us to monitor the generation and dynamic changes of NAD(P)H in living cells and visualize the declined NAD(P)H levels in a stroke model. Moreover, we discovered that NADH-RH is a novel nucleus-directed dye scaffold, which could facilitate the development of nucleus-targeting fluorescent probes and drugs.
ANALYTICAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Zan Song, Lin Liu, Yanyi Xu, Ruofan Cao, Xianyong Lan, Chuanying Pan, Shengxiang Zhang, Haiyu Zhao
Summary: Chronic caffeine-induced sleep restriction affects the diversity and composition of the gut microbiota in mice and substantially alters the metabolic profiles of the gut microbiome.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Zuo Wang, Yi Bi, Kemin Li, Zan Song, Chuanying Pan, Shengxiang Zhang, Xianyong Lan, Nicholas S. Foulkes, Haiyu Zhao
Summary: This study investigated the neurotoxic effects of nickel oxide nanoparticles (NiO-NPs) on zebrafish larvae and found that exposure to environmental levels of NiO-NPs affected embryonic development, neurobehavior, and neurodevelopment. The observed disorders were attributed to ROS-mediated apoptosis and iron-mediated ferroptosis, and pharmacological interventions further confirmed their role in NiO-NPs induced neurotoxicity.
ENVIRONMENTAL SCIENCE-NANO
(2023)
Article
Chemistry, Medicinal
Xin Liu, Yanping Ding, Chenxin Jiang, Xin Ma, Yuanyuan Xin, Yingdong Li, Shengxiang Zhang, Baoping Shao
Summary: Radiation can cause nerve cell damage, and AS-IV can alleviate radiation-induced synapse damage through the activation of the BDNF/TrkB pathway.
PHYTOTHERAPY RESEARCH
(2023)
Article
Materials Science, Biomaterials
Wenguang Xie, Xiao-Ting Gong, Xiaofeng Cheng, Jingjing Cao, Jin Zhao, Hao-Li Zhang, Shengxiang Zhang
Summary: Visualization of cerebrovascular networks is crucial for understanding neurological diseases. Optical clearing techniques and nanotechnology enable precise imaging of brain vessels with functionalized micro/nanoparticles, providing a novel tool for analyzing vascular dysfunction and diseases. The LIMPID method shows high robustness in vessel labeling without sacrificing fluorescence signals and clearing performance.
BIOMATERIALS SCIENCE
(2021)
Article
Immunology
Xin Liu, Weiwei Chu, Shuying Shang, Liang Ma, Chenxin Jiang, Yanping Ding, Jianlin Wang, Shengxiang Zhang, Baoping Shao
INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY
(2020)
