Large-scale plasma proteomics comparisons through genetics and disease associations

Genome-wide genotype-serum proteome mapping provides insights into the cross-ancestry differences in cardiometabolic disease susceptibility

(2023) Fengzhe Xu et al.   Nature Communications

Proteogenomic links to human metabolic diseases

(2023) Mine Koprulu et al.   Nature Metabolism

Plasma proteomic associations with genetics and health in the UK Biobank

(2023) Benjamin B. Sun et al.   NATURE

Understanding the assumptions underlying Mendelian randomization

(2022) Christiaan de Leeuw et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Plasma proteome analyses in individuals of European and African ancestry identify cis-pQTLs and models for proteome-wide association studies

(2022) Jingning Zhang et al.   NATURE GENETICS

The sequences of 150,119 genomes in the UK Biobank

(2022) Bjarni V. Halldorsson et al.   NATURE

Exocrine-Endocrine Crosstalk: The Influence of Pancreatic Cellular Communications on Organ Growth, Function and Disease

(2022) Danielle L. Overton et al.   Frontiers in Endocrinology

Differences and commonalities in the genetic architecture of protein quantitative trait loci in European and Arab populations

(2022) Gaurav Thareja et al.   HUMAN MOLECULAR GENETICS

Proteomic profiling platforms head to head: Leveraging genetics and clinical traits to compare aptamer- and antibody-based methods

(2022) Daniel H. Katz et al.   Science Advances

The genetic regulation of protein expression in cerebrospinal fluid

(2022) Oskar Hansson et al.   EMBO Molecular Medicine

The STRING database in 2023: protein–protein association networks and functional enrichment analyses for any sequenced genome of interest

(2022) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

Genetic link between rheumatoid arthritis and autoimmune liver diseases: A two-sample Mendelian randomization study

(2022) Junyu Fan et al.   SEMINARS IN ARTHRITIS AND RHEUMATISM

A Systematic Review of Monogenic Inflammatory Bowel Disease

(2021) Ryusuke Nambu et al.   Clinical Gastroenterology and Hepatology

Large‐scale plasma proteomic profiling identifies a high‐performance biomarker panel for Alzheimer's disease screening and staging

(2021) Yuanbing Jiang et al.   Alzheimers & Dementia

Genomic atlas of the proteome from brain, CSF and plasma prioritizes proteins implicated in neurological disorders

(2021) Chengran Yang et al.   NATURE NEUROSCIENCE

Blood-based biomarkers for Alzheimer's disease: towards clinical implementation

(2021) Charlotte E Teunissen et al.   LANCET NEUROLOGY

Large-scale integration of the plasma proteome with genetics and disease

(2021) Egil Ferkingstad et al.   NATURE GENETICS

Mapping the proteo-genomic convergence of human diseases

(2021) Maik Pietzner et al.   SCIENCE

Synergistic insights into human health from aptamer- and antibody-based proteomic profiling

(2021) Maik Pietzner et al.   Nature Communications

Comparison of Proteomic Assessment Methods in Multiple Cohort Studies

(2020) Laura M. Raffield et al.   PROTEOMICS

Genome-wide analysis highlights contribution of immune system pathways to the genetic architecture of asthma

(2020) Yi Han et al.   Nature Communications

FLT3 stop mutation increases FLT3 ligand level and risk of autoimmune thyroid disease

(2020) Saedis Saevarsdottir et al.   NATURE

Neurofilament light chain (NfL) as a biomarker of hereditary transthyretin-mediated amyloidosis

(2020) Simina Ticau et al.   NEUROLOGY

UniProt: the universal protein knowledgebase in 2021

(2020) et al.   NUCLEIC ACIDS RESEARCH

Genetic architecture of host proteins involved in SARS-CoV-2 infection

(2020) Maik Pietzner et al.   Nature Communications

The Missing Diversity in Human Genetic Studies

(2019) Giorgio Sirugo et al.   CELL

Reduced IL-2 response from peripheral blood mononuclear cells exposed to bacteria at 6 months of age is associated with elevated total-IgE and allergic rhinitis during the first 7 years of life

(2019) Ni Wang et al.   EBioMedicine

ErbB4 deletion predisposes to development of metabolic syndrome in mice

(2018) Fenghua Zeng et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Meta-analysis of genome-wide association studies for body fat distribution in 694,649 individuals of European ancestry

(2018) Sara L Pulit et al.   HUMAN MOLECULAR GENETICS

Genomic atlas of the human plasma proteome

(2018) Benjamin B. Sun et al.   NATURE

Leveraging Polygenic Functional Enrichment to Improve GWAS Power

(2018) Gleb Kichaev et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The UK Biobank resource with deep phenotyping and genomic data

(2018) Clare Bycroft et al.   NATURE

Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

(2018) Anubha Mahajan et al.   NATURE GENETICS

The NHGRI-EBI GWAS Catalog of published genome-wide association studies, targeted arrays and summary statistics 2019

(2018) Annalisa Buniello et al.   NUCLEIC ACIDS RESEARCH

Graphtyper enables population-scale genotyping using pangenome graphs

(2017) Hannes P Eggertsson et al.   NATURE GENETICS

Mapping of 79 loci for 83 plasma protein biomarkers in cardiovascular disease

(2017) Lasse Folkersen et al.   PLoS Genetics

Assessment of Variability in the SOMAscan Assay

(2017) Julián Candia et al.   Scientific Reports

Effects of Long-Term Storage Time and Original Sampling Month on Biobank Plasma Protein Concentrations

(2016) Stefan Enroth et al.   EBioMedicine

Comprehensively Evaluating cis -Regulatory Variation in the Human Prostate Transcriptome by Using Gene-Level Allele-Specific Expression

(2015) Nicholas B. Larson et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Activation of the prostaglandin D2 metabolic pathway in Crohn’s disease: involvement of the enteric nervous system

(2015) Anne-Gaelle Le Loupp et al.   BMC GASTROENTEROLOGY

Genetics of human metabolism: an update

(2015) Gabi Kastenmüller et al.   HUMAN MOLECULAR GENETICS

A global reference for human genetic variation

(2015) Richard A. Gibbs et al.   NATURE

Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations

(2015) Jimmy Z Liu et al.   NATURE GENETICS

Large-scale whole-genome sequencing of the Icelandic population

(2015) Daniel F Gudbjartsson et al.   NATURE GENETICS

LD Score regression distinguishes confounding from polygenicity in genome-wide association studies

(2015) Brendan K Bulik-Sullivan et al.   NATURE GENETICS

Efficient Bayesian mixed-model analysis increases association power in large cohorts

(2015) Po-Ru Loh et al.   NATURE GENETICS

Tissue-based map of the human proteome

(2015) M. Uhlen et al.   SCIENCE

Novel insights into the genetics of smoking behaviour, lung function, and chronic obstructive pulmonary disease (UK BiLEVE): a genetic association study in UK Biobank

(2015) Louise V Wain et al.   Lancet Respiratory Medicine

Statistical power and significance testing in large-scale genetic studies

(2014) Pak C. Sham et al.   NATURE REVIEWS GENETICS

Homogenous 96-Plex PEA Immunoassay Exhibiting High Sensitivity, Specificity, and Excellent Scalability

(2014) Erika Assarsson et al.   PLoS One

Protein-based matrix interferences in ligand-binding assays

(2014) Boris Gorovits et al.   Bioanalysis

Bayesian Test for Colocalisation between Pairs of Genetic Association Studies Using Summary Statistics

(2014) Claudia Giambartolomei et al.   PLoS Genetics

Nucleic Acid Ligands With Protein-like Side Chains: Modified Aptamers and Their Use as Diagnostic and Therapeutic Agents

(2014) John C Rohloff et al.   Molecular Therapy-Nucleic Acids

Proteoform: a single term describing protein complexity

(2013) Lloyd M Smith et al.   NATURE METHODS

Neurofilaments at a glance

(2012) A. Yuan et al.   JOURNAL OF CELL SCIENCE

Bayesian refinement of association signals for 14 loci in 3 common diseases

(2012) Julian B Maller et al.   NATURE GENETICS

Homogeneous antibody-based proximity extension assays provide sensitive and specific detection of low-abundant proteins in human blood

(2011) Martin Lundberg et al.   NUCLEIC ACIDS RESEARCH

Aptamer-Based Multiplexed Proteomic Technology for Biomarker Discovery

(2011) Larry Gold et al.   PLoS One

The Role of IL-15 Deficiency in the Pathogenesis of Virus-Induced Asthma Exacerbations

(2011) Vasile Laza-Stanca et al.   PLoS Pathogens

Detection of sharing by descent, long-range phasing and haplotype imputation

(2008) Augustine Kong et al.   NATURE GENETICS