标题
Statistical power and significance testing in large-scale genetic studies
作者
关键词
-
出版物
NATURE REVIEWS GENETICS
Volume 15, Issue 5, Pages 335-346
出版商
Springer Nature
发表日期
2014-04-17
DOI
10.1038/nrg3706
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Searching for missing heritability: Designing rare variant association studies
- (2014) O. Zuk et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Meta-analysis of Gene-Level Associations for Rare Variants Based on Single-Variant Statistics
- (2013) Yi-Juan Hu et al. AMERICAN JOURNAL OF HUMAN GENETICS
- General Framework for Meta-analysis of Rare Variants in Sequencing Association Studies
- (2013) Seunggeun Lee et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Analysis of copy number variations at 15 schizophrenia-associated loci
- (2013) Elliott Rees et al. BRITISH JOURNAL OF PSYCHIATRY
- Empirical power of very rare variants for common traits and disease: results from sanger sequencing 1998 individuals
- (2013) Martin Ladouceur et al. EUROPEAN JOURNAL OF HUMAN GENETICS
- Family-based association tests for sequence data, and comparisons with population-based association tests
- (2013) Iuliana Ionita-Laza et al. EUROPEAN JOURNAL OF HUMAN GENETICS
- Rare Complete Knockouts in Humans: Population Distribution and Significant Role in Autism Spectrum Disorders
- (2013) Elaine T. Lim et al. NEURON
- Analysis of Rare, Exonic Variation amongst Subjects with Autism Spectrum Disorders and Population Controls
- (2013) Li Liu et al. PLoS Genetics
- Integrated Model of De Novo and Inherited Genetic Variants Yields Greater Power to Identify Risk Genes
- (2013) Xin He et al. PLoS Genetics
- Five Years of GWAS Discovery
- (2012) Peter M. Visscher et al. AMERICAN JOURNAL OF HUMAN GENETICS
- SimRare: a program to generate and analyze sequence-based data for association studies of quantitative and qualitative traits
- (2012) B. Li et al. BIOINFORMATICS
- Optimal tests for rare variant effects in sequencing association studies
- (2012) S. Lee et al. BIOSTATISTICS
- Immunochip analyses identify a novel risk locus for primary biliary cirrhosis at 13q14, multiple independent associations at four established risk loci and epistasis between 1p31 and 7q32 risk variants
- (2012) Brian D. Juran et al. HUMAN MOLECULAR GENETICS
- Analysis of 6,515 exomes reveals the recent origin of most human protein-coding variants
- (2012) Wenqing Fu et al. NATURE
- Including known covariates can reduce power to detect genetic effects in case-control studies
- (2012) Matti Pirinen et al. NATURE GENETICS
- Exome sequencing and the genetic basis of complex traits
- (2012) Adam Kiezun et al. NATURE GENETICS
- Differential confounding of rare and common variants in spatially structured populations
- (2012) Iain Mathieson et al. NATURE GENETICS
- De Novo Gene Disruptions in Children on the Autistic Spectrum
- (2012) Ivan Iossifov et al. NEURON
- A comprehensive framework for prioritizing variants in exome sequencing studies of Mendelian diseases
- (2012) Miao-Xin Li et al. NUCLEIC ACIDS RESEARCH
- Statistical Guidance for Experimental Design and Data Analysis of Mutation Detection in Rare Monogenic Mendelian Diseases by Exome Sequencing
- (2012) Degui Zhi et al. PLoS One
- An Abundance of Rare Functional Variants in 202 Drug Target Genes Sequenced in 14,002 People
- (2012) M. R. Nelson et al. SCIENCE
- The Empirical Power of Rare Variant Association Methods: Results from Sanger Sequencing in 1,998 Individuals
- (2012) Martin Ladouceur et al. PLoS Genetics
- The Metabochip, a Custom Genotyping Array for Genetic Studies of Metabolic, Cardiovascular, and Anthropometric Traits
- (2012) Benjamin F. Voight et al. PLoS Genetics
- A General Framework for Detecting Disease Associations with Rare Variants in Sequencing Studies
- (2011) Dan-Yu Lin et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Rare-Variant Association Testing for Sequencing Data with the Sequence Kernel Association Test
- (2011) Michael C. Wu et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Robust Association Tests Under Different Genetic Models, Allowing for Binary or Quantitative Traits and Covariates
- (2011) Hon-Cheong So et al. BEHAVIOR GENETICS
- Detecting multiple causal rare variants in exome sequence data
- (2011) Kenny Q. Ye et al. GENETIC EPIDEMIOLOGY
- Using extreme phenotype sampling to identify the rare causal variants of quantitative traits in association studies
- (2011) Dalin Li et al. GENETIC EPIDEMIOLOGY
- Comparison of statistical tests for disease association with rare variants
- (2011) Saonli Basu et al. GENETIC EPIDEMIOLOGY
- Evaluating the effective numbers of independent tests and significant p-value thresholds in commercial genotyping arrays and public imputation reference datasets
- (2011) Miao-Xin Li et al. HUMAN GENETICS
- Linkage Analysis in the Next-Generation Sequencing Era
- (2011) Joan E. Bailey-Wilson et al. HUMAN HEREDITY
- What should the genome-wide significance threshold be? Empirical replication of borderline genetic associations
- (2011) Orestis A Panagiotou et al. INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
- Exome sequencing as a tool for Mendelian disease gene discovery
- (2011) Michael J. Bamshad et al. NATURE REVIEWS GENETICS
- Design Considerations for Massively Parallel Sequencing Studies of Complex Human Disease
- (2011) Bing-Jian Feng et al. PLoS One
- Testing for an Unusual Distribution of Rare Variants
- (2011) Benjamin M. Neale et al. PLoS Genetics
- Computational and statistical approaches to analyzing variants identified by exome sequencing
- (2011) Nathan O Stitziel et al. GENOME BIOLOGY
- Pooled Association Tests for Rare Variants in Exon-Resequencing Studies
- (2010) Alkes L. Price et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Replication Strategies for Rare Variant Complex Trait Association Studies via Next-Generation Sequencing
- (2010) Dajiang J. Liu et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Functional impact of global rare copy number variation in autism spectrum disorders
- (2010) Dalila Pinto et al. NATURE
- Exome sequencing identifies MLL2 mutations as a cause of Kabuki syndrome
- (2010) Sarah B Ng et al. NATURE GENETICS
- A method and server for predicting damaging missense mutations
- (2010) Ivan A Adzhubei et al. NATURE METHODS
- Statistical analysis strategies for association studies involving rare variants
- (2010) Vikas Bansal et al. NATURE REVIEWS GENETICS
- Three Ways of Combining Genotyping and Resequencing in Case-Control Association Studies
- (2010) Jeffrey A. Longmate et al. PLoS One
- Novel Sib Pair Selection Strategy Increases Power in Quantitative Association Analysis
- (2009) Johnny S. H. Kwan et al. BEHAVIOR GENETICS
- Establishing an adjusted p-value threshold to control the family-wide type 1 error in genome wide association studies
- (2009) Priya Duggal et al. BMC GENOMICS
- A new measure of the effective number of tests, a practical tool for comparing families of non-independent significance tests
- (2009) Nicholas W. Galwey GENETIC EPIDEMIOLOGY
- Bayesian statistical methods for genetic association studies
- (2009) Matthew Stephens et al. NATURE REVIEWS GENETICS
- How Many Genetic Variants Remain to Be Discovered?
- (2009) Yudi Pawitan et al. PLoS One
- Rare Variants of IFIH1, a Gene Implicated in Antiviral Responses, Protect Against Type 1 Diabetes
- (2009) S. Nejentsev et al. SCIENCE
- Discovery of Rare Variants via Sequencing: Implications for the Design of Complex Trait Association Studies
- (2009) Bingshan Li et al. PLoS Genetics
- A Groupwise Association Test for Rare Mutations Using a Weighted Sum Statistic
- (2009) Bo Eskerod Madsen et al. PLoS Genetics
- Estimating Odds Ratios in Genome Scans: An Approximate Conditional Likelihood Approach
- (2008) Arpita Ghosh et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Methods for Detecting Associations with Rare Variants for Common Diseases: Application to Analysis of Sequence Data
- (2008) Bingshan Li et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Efficient Approximation of P-value of the Maximum of Correlated Tests, with Applications to Genome-Wide Association Studies
- (2008) Qizhai Li et al. ANNALS OF HUMAN GENETICS
- Bias-reduced estimators and confidence intervals for odds ratios in genome-wide association studies
- (2008) H. Zhong et al. BIOSTATISTICS
- Why Most Discovered True Associations Are Inflated
- (2008) John P. A. Ioannidis EPIDEMIOLOGY
- Maximizing association statistics over genetic models
- (2008) Juan R. González et al. GENETIC EPIDEMIOLOGY
- Estimation of significance thresholds for genomewide association scans
- (2008) Frank Dudbridge et al. GENETIC EPIDEMIOLOGY
- Genome-wide significance for dense SNP and resequencing data
- (2008) Clive J. Hoggart et al. GENETIC EPIDEMIOLOGY
- On multiple-testing correction in genome-wide association studies
- (2008) Valentina Moskvina et al. GENETIC EPIDEMIOLOGY
- Estimation of the multiple testing burden for genomewide association studies of nearly all common variants
- (2008) Itsik Pe'er et al. GENETIC EPIDEMIOLOGY
- Bayes factors for genome-wide association studies: comparison withP-values
- (2008) Jon Wakefield GENETIC EPIDEMIOLOGY
- Genome-wide association studies for complex traits: consensus, uncertainty and challenges
- (2008) Mark I. McCarthy et al. NATURE REVIEWS GENETICS
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