标题
C. difficile intoxicates neurons and pericytes to drive neurogenic inflammation
作者
关键词
-
出版物
NATURE
Volume 622, Issue 7983, Pages 611-618
出版商
Springer Science and Business Media LLC
发表日期
2023-09-13
DOI
10.1038/s41586-023-06607-2
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- TFPI is a colonic crypt receptor for TcdB from hypervirulent clade 2 C. difficile
- (2022) Jianhua Luo et al. CELL
- Clostridioides difficile exploits toxin-mediated inflammation to alter the host nutritional landscape and exclude competitors from the gut microbiota
- (2021) Joshua R. Fletcher et al. Nature Communications
- Multi-kingdom ecological drivers of microbiota assembly in preterm infants
- (2021) Chitong Rao et al. NATURE
- Brain capillary pericytes exert a substantial but slow influence on blood flow
- (2021) David A. Hartmann et al. NATURE NEUROSCIENCE
- C. difficile exploits a host metabolite produced during toxin-mediated disease
- (2021) Kali M. Pruss et al. NATURE
- The gut vascular barrier: a new player in the gut–liver–brain axis
- (2021) Paola Brescia et al. TRENDS IN MOLECULAR MEDICINE
- Structural basis for CSPG4 as a receptor for TcdB and a therapeutic target in Clostridioides difficile infection
- (2021) Peng Chen et al. Nature Communications
- Clostridioides difficile toxins: mechanisms of action and antitoxin therapeutics
- (2021) Shannon L. Kordus et al. NATURE REVIEWS MICROBIOLOGY
- Structural basis for selective modification of Rho and Ras GTPases by Clostridioides difficile toxin B
- (2021) Zheng Liu et al. Science Advances
- Lineage-dependent gene expression programs influence the immune landscape of colorectal cancer
- (2020) Hae-Ock Lee et al. NATURE GENETICS
- Trends in U.S. Burden of Clostridioides difficile Infection and Outcomes
- (2020) Alice Y. Guh et al. NEW ENGLAND JOURNAL OF MEDICINE
- Clostridioides difficileinfection damages colonic stem cells via TcdB, impairing epithelial repair and recovery from disease
- (2020) Steven J. Mileto et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Immune Profiling To Predict Outcome of Clostridioides difficile Infection
- (2020) Mayuresh M. Abhyankar et al. mBio
- Single-cell analysis uncovers fibroblast heterogeneity and criteria for fibroblast and mural cell identification and discrimination
- (2020) Lars Muhl et al. Nature Communications
- Subtyping analysis reveals new variants and accelerated evolution of Clostridioides difficile toxin B
- (2020) Enhui Shen et al. Communications Biology
- The Human and Mouse Enteric Nervous System at Single-Cell Resolution
- (2020) Eugene Drokhlyansky et al. CELL
- Low Density Lipoprotein Receptor-Related Protein-1 (LRP1) Is Involved in the Uptake of Clostridioides difficile Toxin A and Serves as an Internalizing Receptor
- (2020) Dennis Schöttelndreier et al. Frontiers in Cellular and Infection Microbiology
- Phylogenomics of 8,839 Clostridioides difficile genomes reveals recombination-driven evolution and diversification of toxin A and B
- (2020) Michael J. Mansfield et al. PLoS Pathogens
- Natural Killer Cells Degenerate Intact Sensory Afferents following Nerve Injury
- (2019) Alexander J. Davies et al. CELL
- Host immune markers distinguish C. difficile infection from asymptomatic carriage and non-C. difficile diarrhea
- (2019) Ciaran P Kelly et al. CLINICAL INFECTIOUS DISEASES
- Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2
- (2019) Evan Bolyen et al. NATURE BIOTECHNOLOGY
- Molecular dissection of box jellyfish venom cytotoxicity highlights an effective venom antidote
- (2019) Man-Tat Lau et al. Nature Communications
- Toxin B Variants from Clostridium difficile Strains VPI 10463 and NAP1/027 Share Similar Substrate Profile and Cellular Intoxication Kinetics but Use Different Host Cell Entry Factors
- (2019) Diana López-Ureña et al. Toxins
- Sulfated glycosaminoglycans and low-density lipoprotein receptor contribute to Clostridium difficile toxin A entry into cells
- (2019) Liang Tao et al. Nature Microbiology
- Gut-Innervating Nociceptor Neurons Regulate Peyer’s Patch Microfold Cells and SFB Levels to Mediate Salmonella Host Defense
- (2019) Nicole Y. Lai et al. CELL
- Single-cell RNAseq reveals seven classes of colonic sensory neuron
- (2018) James R F Hockley et al. GUT
- Structural basis for recognition of frizzled proteins byClostridium difficiletoxin B
- (2018) Peng Chen et al. SCIENCE
- Skin neurogenic inflammation
- (2018) Jae Eun Choi et al. Seminars in Immunopathology
- The Conserved Cys-2232 in Clostridioides difficile Toxin B Modulates Receptor Binding
- (2018) Soo-Young Chung et al. Frontiers in Microbiology
- Clostridium difficile toxins induce VEGF-A and vascular permeability to promote disease pathogenesis
- (2018) Jun Huang et al. Nature Microbiology
- Engineered AAVs for efficient noninvasive gene delivery to the central and peripheral nervous systems
- (2017) Ken Y Chan et al. NATURE NEUROSCIENCE
- Generation of aNK1R-CreERknockin mouse strain to study cells involved in Neurokinin 1 Receptor signaling
- (2016) Huizhen Huang et al. GENESIS
- Frizzled proteins are colonic epithelial receptors for C. difficile toxin B
- (2016) Liang Tao et al. NATURE
- Pericytes of the neurovascular unit: key functions and signaling pathways
- (2016) Melanie D Sweeney et al. NATURE NEUROSCIENCE
- Clostridium difficile infection
- (2016) Wiep Klaas Smits et al. Nature Reviews Disease Primers
- Enteric glia express proteolipid protein 1 and are a transcriptionally unique population of glia in the mammalian nervous system
- (2015) Meenakshi Rao et al. GLIA
- A gut-vascular barrier controls the systemic dissemination of bacteria
- (2015) Ilaria Spadoni et al. SCIENCE
- Defining the Roles of TcdA and TcdB in Localized Gastrointestinal Disease, Systemic Organ Damage, and the Host Response during Clostridium difficile Infections
- (2015) Glen P. Carter et al. mBio
- Chondroitin sulfate proteoglycan 4 functions as the cellular receptor for Clostridium difficile toxin B
- (2014) Pengfei Yuan et al. CELL RESEARCH
- Wnt-Fzd Signaling Sensitizes Peripheral Sensory Neurons via Distinct Noncanonical Pathways
- (2014) Manuela Simonetti et al. NEURON
- Calcitonin Gene-Related Peptide: Physiology and Pathophysiology
- (2014) F. A. Russell et al. PHYSIOLOGICAL REVIEWS
- Anatomical characterization of Cre driver mice for neural circuit mapping and manipulation
- (2014) Julie A. Harris et al. Frontiers in Neural Circuits
- PEAR: a fast and accurate Illumina Paired-End reAd mergeR
- (2013) J. Zhang et al. BIOINFORMATICS
- Markers of Intestinal Inflammation, Not Bacterial Burden, Correlate With Clinical Outcomes in Clostridium difficile Infection
- (2013) Rana E. El Feghaly et al. CLINICAL INFECTIOUS DISEASES
- Mortality in patients with Clostridium difficile infection correlates with host pro-inflammatory and humoral immune responses
- (2013) K. Solomon et al. JOURNAL OF MEDICAL MICROBIOLOGY
- Clostridium difficile 027/BI/NAP1 Encodes a Hypertoxic and Antigenically Variable Form of TcdB
- (2013) Jordi M. Lanis et al. PLoS Pathogens
- Multiple roles for the actin cytoskeleton during regulated exocytosis
- (2012) Natalie Porat-Shliom et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Pericytes support neutrophil subendothelial cell crawling and breaching of venular walls in vivo
- (2012) Doris Proebstl et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Emergence and global spread of epidemic healthcare-associated Clostridium difficile
- (2012) Miao He et al. NATURE GENETICS
- Capillary and arteriolar pericytes attract innate leukocytes exiting through venules and 'instruct' them with pattern-recognition and motility programs
- (2012) Konstantin Stark et al. NATURE IMMUNOLOGY
- Neurogenic inflammation and the peripheral nervous system in host defense and immunopathology
- (2012) Isaac M Chiu et al. NATURE NEUROSCIENCE
- The SILVA ribosomal RNA gene database project: improved data processing and web-based tools
- (2012) Christian Quast et al. NUCLEIC ACIDS RESEARCH
- Functional characterization of pulmonary neuroendocrine cells in lung development, injury, and tumorigenesis
- (2012) H. Song et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The role of toxin A and toxin B in Clostridium difficile infection
- (2010) Sarah A. Kuehne et al. NATURE
- Identification of a conserved membrane localization domain within numerous large bacterial protein toxins
- (2010) B. Geissler et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Toxin B is essential for virulence of Clostridium difficile
- (2009) Dena Lyras et al. NATURE
- A robust and high-throughput Cre reporting and characterization system for the whole mouse brain
- (2009) Linda Madisen et al. NATURE NEUROSCIENCE
- A Mouse Model of Clostridium difficile–Associated Disease
- (2008) Xinhua Chen et al. GASTROENTEROLOGY
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now