Inhibiting poly (ADP-ribose) polymerase 1 activation alleviates acetaminophen-induced acute liver injury in mice

Gα12 overexpression in hepatocytes by ER stress exacerbates acute liver injury via ROCK1-mediated miR-15a and ALOX12 dysregulation

(2022) Jihoon Tak et al.   Theranostics

Nicotinamide adenine dinucleotide attenuates acetaminophen-induced acute liver injury via activation of PARP1, Sirt1, and Nrf2 in mice

(2022) Cuiting Liao et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

TSG101 associates with PARP1 and is essential for PARylation and DNA damage‐induced NF‐κB activation

(2022) Ahmet Buğra Tufan et al.   EMBO JOURNAL

Advanced preclinical models for evaluation of drug-induced liver injury – consensus statement by the European Drug-Induced Liver Injury Network [PRO-EURO-DILI-NET]

(2021) Jose C. Fernandez-Checa et al.   JOURNAL OF HEPATOLOGY

JNK Phosphorylates The Neh6 Domain Of Nrf2 And Downregulates Cytoprotective Genes In Acetaminophen‐Induced Liver Injury

(2020) Yiping Chen et al.   HEPATOLOGY

Peroxiredoxin 6 mediates acetaminophen-induced hepatocyte death through JNK activation

(2020) Dong Hun Lee et al.   Redox Biology

Genistein protects against acetaminophen-induced liver toxicity through augmentation of SIRT1 with induction of Nrf2 signalling

(2020) Linpei Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Poly(ADP-ribose) polymerase inhibition: past, present and future

(2020) Nicola J. Curtin et al.   NATURE REVIEWS DRUG DISCOVERY

Acute liver injury with therapeutic doses of acetaminophen: a prospective study

(2020) Alexandre Louvet et al.   HEPATOLOGY

MORC2 regulates DNA damage response through a PARP1-dependent pathway

(2019) Lin Zhang et al.   NUCLEIC ACIDS RESEARCH

Mangiferin ameliorates acetaminophen-induced hepatotoxicity through APAP-Cys and JNK modulation

(2019) Apu Chowdhury et al.   BIOMEDICINE & PHARMACOTHERAPY

Liver-specific deficiency of unc-51 like kinase 1 and 2 protects mice from acetaminophen-induced liver injury

(2018) Yu Sun et al.   HEPATOLOGY

Poly(ADP-ribosyl)ated PXR is a critical regulator of acetaminophen-induced hepatotoxicity

(2018) Cheng Wang et al.   Cell Death & Disease

PARP1 inhibitor (PJ34) improves the function of aging-induced endothelial progenitor cells by preserving intracellular NAD+ levels and increasing SIRT1 activity

(2018) Siyuan Zha et al.   Stem Cell Research & Therapy

PUMA induction mediates acetaminophen‐induced necrosis and liver injury

(2018) Dongshi Chen et al.   HEPATOLOGY

PARP inhibition protects against alcoholic and non-alcoholic steatohepatitis

(2017) Partha Mukhopadhyay et al.   JOURNAL OF HEPATOLOGY

Unpredicted Downregulation of RAD51 Suggests Genome Instability Induced by Tetrachlorobenzoquinone

(2016) Xiufang Song et al.   CHEMICAL RESEARCH IN TOXICOLOGY

JNK Activation Contributes to Oxidative Stress-Induced Parthanatos in Glioma Cells via Increase of Intracellular ROS Production

(2016) Linjie Zheng et al.   MOLECULAR NEUROBIOLOGY

PARP inhibition prevents acetaminophen-induced liver injury andincreases survival rate in rats

(2015) Melahat DÖNMEZ et al.   Turkish Journal Of Medical Sciences

Poly (ADP-ribose) in the pathogenesis of Parkinson's disease

(2014) Yunjong Lee et al.   BMB Reports

NAD+-Dependent Activation of Sirt1 Corrects the Phenotype in a Mouse Model of Mitochondrial Disease

(2014) Raffaele Cerutti et al.   Cell Metabolism

Inhibition of the activity of poly (ADP-ribose) polymerase reduces heart ischaemia/reperfusion injuryviasuppressing JNK-mediated AIF translocation

(2008) Zhao-Feng Song et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE