Nicotinamide adenine dinucleotide attenuates acetaminophen-induced acute liver injury via activation of PARP1, Sirt1, and Nrf2 in mice

Selective inhibition of cullin 3 neddylation through covalent targeting DCN1 protects mice from acetaminophen-induced liver toxicity

(2021) Haibin Zhou et al.   Nature Communications

Oxidant Stress and Acetaminophen Hepatotoxicity: Mechanism-Based Drug Development

(2021) Anup Ramachandran et al.   ANTIOXIDANTS & REDOX SIGNALING

Protective effect and mechanism of nicotinamide adenine dinucleotide against optic neuritis in mice with experimental autoimmune encephalomyelitis

(2021) Jiangyuan Guo et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Nicotinic Acid against Acetaminophen-Induced Hepatotoxicity via Sirt1/Nrf2 Antioxidative Pathway in Mice

(2021) Da HU et al.   JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY

A review study on the modulation of SIRT1 expression by miRNAs in aging and age-associated diseases

(2021) Aliabbas Zia et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Advanced preclinical models for evaluation of drug-induced liver injury – consensus statement by the European Drug-Induced Liver Injury Network [PRO-EURO-DILI-NET]

(2021) Jose C. Fernandez-Checa et al.   JOURNAL OF HEPATOLOGY

JNK Phosphorylates The Neh6 Domain Of Nrf2 And Downregulates Cytoprotective Genes In Acetaminophen‐Induced Liver Injury

(2020) Yiping Chen et al.   HEPATOLOGY

The Protective Effects of Imperatorin on Acetaminophen Overdose-Induced Acute Liver Injury

(2020) Zhao Gao et al.   Oxidative Medicine and Cellular Longevity

Therapeutic potential of nicotinamide adenine dinucleotide (NAD)

(2020) Marta Arenas-Jal et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Acetaminophen Hepatotoxicity

(2019) Anup Ramachandran et al.   SEMINARS IN LIVER DISEASE

Nicotinamide adenine dinucleotide emerges as a therapeutic target in aging and ischemic conditions

(2019) Leila Hosseini et al.   BIOGERONTOLOGY

Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence

(2018) Luis Rajman et al.   Cell Metabolism

Acetaminophen (APAP or N-Acetyl-p-Aminophenol) and Acute Liver Failure

(2018) Chalermrat Bunchorntavakul et al.   Clinics in Liver Disease

Overexpression of Sirt1 in Mesenchymal Stem Cells Protects against Bone Loss in Mice by FOXO3a Deacetylation and Oxidative Stress Inhibition

(2018) Wen Sun et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

IL-17 deficiency attenuates acetaminophen-induced hepatotoxicity in mice

(2018) Hung-Chen Lee et al.   TOXICOLOGY LETTERS

Astaxanthin pretreatment attenuates acetaminophen-induced liver injury in mice

(2017) Jingyao Zhang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Nicotinamide mononucleotide inhibits JNK activation to reverse Alzheimer disease

(2017) Zhiwen Yao et al.   NEUROSCIENCE LETTERS

Outcomes in Adults With Acute Liver Failure Between 1998 and 2013

(2016) Adrian Reuben et al.   ANNALS OF INTERNAL MEDICINE

Unpredicted Downregulation of RAD51 Suggests Genome Instability Induced by Tetrachlorobenzoquinone

(2016) Xiufang Song et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Nicotinamide adenine dinucleotide biosynthesis promotes liver regeneration

(2016) Sarmistha Mukherjee et al.   HEPATOLOGY

Oxidative stress during acetaminophen hepatotoxicity: Sources, pathophysiological role and therapeutic potential

(2016) Kuo Du et al.   Redox Biology

Eliciting the mitochondrial unfolded protein response by nicotinamide adenine dinucleotide repletion reverses fatty liver disease in mice

(2015) Karim Gariani et al.   HEPATOLOGY

Epigallocatechin-3-gallate (EGCG) attenuates concanavalin A-induced hepatic injury in mice

(2014) Dongmei Liu et al.   ACTA HISTOCHEMICA

Acute liver failure in Chinese children: a multicenter investigation

(2014) Pan Zhao et al.   Hepatobiliary & Pancreatic Diseases International

Fibroblast growth factor 21 protects against acetaminophen-induced hepatotoxicity by potentiating peroxisome proliferator-activated receptor coactivator protein-1α-mediated antioxidant capacity in mice

(2014) Dewei Ye et al.   HEPATOLOGY

Acute exposure to 3-methylcholanthrene induces hepatic oxidative stress via activation of the Nrf2/ARE signaling pathway in mice

(2013) Yuanxiang Jin et al.   ENVIRONMENTAL TOXICOLOGY

Mechanistic biomarkers provide early and sensitive detection of acetaminophen-induced acute liver injury at first presentation to hospital

(2013) Daniel J. Antoine et al.   HEPATOLOGY

Treatment of paracetamol overdose: room for improvement?

(2013) Kevin Park et al.   LANCET

Acute Liver Failure

(2013) William Bernal et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Role of PARP-1 and PARP-2 Enzymes in Metabolic Regulation and Disease

(2012) Péter Bai et al.   Cell Metabolism

Protective effects of nicotinamide against acetaminophen-induced acute liver injury

(2012) Youdan Shi et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Nrf2-dependent upregulation of antioxidative enzymes: a novel pathway for proteasome inhibitor-mediated cardioprotection

(2009) H. Dreger et al.   CARDIOVASCULAR RESEARCH

Role of JNK Translocation to Mitochondria Leading to Inhibition of Mitochondria Bioenergetics in Acetaminophen-induced Liver Injury

(2008) Naoko Hanawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY