Milestones in the journey towards addressing obesity; Past trials and triumphs, recent breakthroughs, and an exciting future in the era of emerging effective medical therapies and integration of effective medical therapies with metabolic surgery
出版年份 2023 全文链接
标题
Milestones in the journey towards addressing obesity; Past trials and triumphs, recent breakthroughs, and an exciting future in the era of emerging effective medical therapies and integration of effective medical therapies with metabolic surgery
作者
关键词
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出版物
METABOLISM-CLINICAL AND EXPERIMENTAL
Volume 148, Issue -, Pages 155689
出版商
Elsevier BV
发表日期
2023-09-08
DOI
10.1016/j.metabol.2023.155689
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- The global burden of metabolic disease: Data from 2000 to 2019
- (2023) Nicholas W.S. Chew et al. Cell Metabolism
- Bariatric–metabolic surgery versus lifestyle intervention plus best medical care in non-alcoholic steatohepatitis (BRAVES): a multicentre, open-label, randomised trial
- (2023) Ornella Verrastro et al. LANCET
- Advances in physiology, design and development of novel medications changing the landscape of obesity pharmacotherapy
- (2023) Chakhtoura Marlene et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- Long-term Clinical Outcomes and Mediating Mechanistic Effects of Bariatric Surgery on Adipokines and Gastrointestinal Hormone Secretion: The First 10-year Long Longitudinal and Case-cohort Study
- (2023) Alexander Kokkinos et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- The global syndemic of metabolic diseases in the young adult population: A consortium of trends and projections from the Global Burden of Disease 2000–2019
- (2023) Bryan Chong et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- Glucagon-like peptide 1 receptor agonists: cardiovascular benefits and mechanisms of action
- (2023) John R. Ussher et al. Nature Reviews Cardiology
- Obesity and the risk of cardiometabolic diseases
- (2023) Pedro L. Valenzuela et al. Nature Reviews Cardiology
- Daily Oral GLP-1 Receptor Agonist Orforglipron for Adults with Obesity
- (2023) Sean Wharton et al. NEW ENGLAND JOURNAL OF MEDICINE
- Effectiveness of semaglutide versus liraglutide for treating post‐metabolic and bariatric surgery weight recurrence
- (2023) Natia Murvelashvili et al. Obesity
- Efficacy of the Glucagon-Like Peptide-1 Receptor Agonists Liraglutide and Semaglutide for the Treatment of Weight Regain After Bariatric surgery: a Retrospective Observational Study
- (2023) Anders Boisen Jensen et al. OBESITY SURGERY
- Pharmacotherapy of obesity: an update on the available medications and drugs under investigation
- (2023) Marlene Chakhtoura et al. EClinicalMedicine
- The first external validation of the Dallas steatosis index in biopsy-proven Non-alcoholic fatty liver Disease: A multicenter study
- (2023) Matina Kouvari et al. DIABETES RESEARCH AND CLINICAL PRACTICE
- Diabetocardiology: a new subspecialty?
- (2023) Eugene Braunwald EUROPEAN HEART JOURNAL
- Tirzepatide once weekly for the treatment of obesity in people with type 2 diabetes (SURMOUNT-2): a double-blind, randomised, multicentre, placebo-controlled, phase 3 trial
- (2023) W Timothy Garvey et al. LANCET
- Sarcopenia, sarcopenic obesity and nonalcoholic fatty liver disease
- (2023) Stergios A. Polyzos et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- From non-alcoholic fatty liver disease (NAFLD) to steatotic liver disease (SLD): an ongoing journey towards refining the terminology for this prevalent metabolic condition and unmet clinical need
- (2023) Michail Kokkorakis et al. METABOLISM-CLINICAL AND EXPERIMENTAL
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- (2023) Matina Kouvari et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- Effect of bariatric surgery on cardio-psycho-metabolic outcomes in severe obesity: A randomized controlled trial
- (2023) Ann-Cathrin Koschker et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- Diet, exercise, and pharmacotherapy for sarcopenia in people with diabetes
- (2023) Yoshitaka Hashimoto et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- The key role of inflammation in the pathogenesis and management of obesity and CVD
- (2023) Chrysoula Boutari et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- Triple–Hormone-Receptor Agonist Retatrutide for Obesity — A Phase 2 Trial
- (2023) Ania M. Jastreboff et al. NEW ENGLAND JOURNAL OF MEDICINE
- Safety and Efficacy of Liraglutide, 3.0 mg, Once Daily vs Placebo in Patients With Poor Weight Loss Following Metabolic Surgery
- (2023) Jessica Mok et al. JAMA Surgery
- Effect of Weekly Subcutaneous Semaglutide vs Daily Liraglutide on Body Weight in Adults With Overweight or Obesity Without Diabetes
- (2022) Domenica M. Rubino et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- A 2022 update on the epidemiology of obesity and a call to action: as its twin COVID-19 pandemic appears to be receding, the obesity and dysmetabolism pandemic continues to rage on
- (2022) Chrysoula Boutari et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- Editorial: Obesity, metabolic phenotypes and COVID-19
- (2022) Despina Sanoudou et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- Changes in Gastric Inhibitory Polypeptide (GIP) After Roux-en-Y Gastric Bypass in Obese Patients: a Meta-analysis
- (2022) Zhiguang Gao et al. OBESITY SURGERY
- Surgical Treatment of Obesity. Special Mention to Roux-en-Y Gastric Bypass and Vertical Gastrectomy
- (2022) María José Luesma et al. Frontiers in Endocrinology
- Real-world use of once-weekly semaglutide in patients with type 2 diabetes: pooled analysis of data from four SURE studies by baseline characteristic subgroups
- (2022) Jean-François Yale et al. BMJ Open Diabetes Research & Care
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- (2022) Hexiang Peng et al. METABOLISM-CLINICAL AND EXPERIMENTAL
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- (2022) Paulina Salminen et al. JAMA Surgery
- Circulating levels of five proglucagon-derived peptides in response to intravenous or oral glucose or lipids and to a mixed-meal in subjects with normal weight, overweight, and obesity
- (2022) Nikolaos Perakakis et al. CLINICAL NUTRITION
- AGA Clinical Practice Guideline on Pharmacological Interventions for Adults With Obesity
- (2022) Eduardo Grunvald et al. GASTROENTEROLOGY
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- (2022) Jinbo Hu et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- 2022 American Society for Metabolic and Bariatric Surgery (ASMBS) and International Federation for the Surgery of Obesity and Metabolic Disorders (IFSO): Indications for Metabolic and Bariatric Surgery
- (2022) Dan Eisenberg et al. Surgery for Obesity and Related Diseases
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- (2022) Ishnoor Singh et al. Cell and Bioscience
- Once-Weekly Semaglutide Use in Type 2 Diabetes: Real-World Data from the SURE Netherlands Observational Study
- (2022) Bruce H. R. Wolffenbuttel et al. ADVANCES IN THERAPY
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- (2022) Susanna C. Larsson et al. METABOLISM-CLINICAL AND EXPERIMENTAL
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- (2021) Joanna Michałowska et al. Nutrients
- Leptin in Leanness and Obesity
- (2021) Nikolaos Perakakis et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Semaglutide 2·4 mg once a week in adults with overweight or obesity, and type 2 diabetes (STEP 2): a randomised, double-blind, double-dummy, placebo-controlled, phase 3 trial
- (2021) Melanie Davies et al. LANCET
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- (2021) John P.H. Wilding et al. NEW ENGLAND JOURNAL OF MEDICINE
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- (2021) Tiffany M. Powell-Wiley et al. CIRCULATION
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- (2021) Nicholas L Syn et al. LANCET
- Cagrilintide plus semaglutide for obesity management
- (2021) Sara Becerril et al. LANCET
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- (2021) John A. Bostrom et al. Current Atherosclerosis Reports
- Arcuate nucleus-dependent regulation of metabolism - pathways to obesity and diabetes mellitus
- (2021) Alexander Jais et al. ENDOCRINE REVIEWS
- Preoperative Weight Loss as a Predictor of Bariatric Surgery Postoperative Weight Loss and Complications
- (2021) Jamil S. Samaan et al. JOURNAL OF GASTROINTESTINAL SURGERY
- Efficacy and safety of a novel dual GIP and GLP-1 receptor agonist tirzepatide in patients with type 2 diabetes (SURPASS-1): a double-blind, randomised, phase 3 trial
- (2021) Julio Rosenstock et al. LANCET
- Early benefits of bariatric surgery on subclinical cardiac function: Contribution of visceral fat mobilization
- (2021) Marie-Eve Piché et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- Tirzepatide versus Semaglutide Once Weekly in Patients with Type 2 Diabetes
- (2021) Juan P. Frías et al. NEW ENGLAND JOURNAL OF MEDICINE
- Efficacy and safety of once-weekly semaglutide 2·0 mg versus 1·0 mg in patients with type 2 diabetes (SUSTAIN FORTE): a double-blind, randomised, phase 3B trial
- (2021) Juan P Frías et al. Lancet Diabetes & Endocrinology
- GLP-1 Receptor Agonists: Beyond Their Pancreatic Effects
- (2021) Xin Zhao et al. Frontiers in Endocrinology
- Weight loss is the deciding factor to predict the outcome of RYGB in obese Chinese with a BMI < 35 kg/m2
- (2021) Dexiao Du et al. Asian Journal of Surgery
- Novel Noninvasive Approaches to the Treatment of Obesity: From Pharmacotherapy to Gene Therapy
- (2021) Angeliki M Angelidi et al. ENDOCRINE REVIEWS
- GLP-1 physiology informs the pharmacotherapy of obesity
- (2021) Daniel J. Drucker Molecular Metabolism
- The Mitigating Effect of Phentermine and Topiramate on Weight Regain After Roux‐en‐Y Gastric Bypass Surgery
- (2020) Nawfal W. Istfan et al. Obesity
- Altered metabolic and hormonal responses to moderate exercise in overweight/obesity
- (2020) Christina Gar et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- GLP-1 Analogues as a Complementary Therapy in Patients after Metabolic Surgery: a Systematic Review and Qualitative Synthesis
- (2020) Romano Schneider et al. OBESITY SURGERY
- Liraglutide Augments Weight Loss After Laparoscopic Sleeve Gastrectomy: a Randomised, Double-Blind, Placebo-Control Study
- (2020) Uttam Thakur et al. OBESITY SURGERY
- Association of Preoperative Body Weight and Weight Loss With Risk of Death After Bariatric Surgery
- (2020) Yangbo Sun et al. JAMA Network Open
- Efficacy and safety of once‐weekly semaglutide vs once‐daily sitagliptin as add‐on to metformin in patients with type 2 diabetes ( SUSTAIN China): a 30‐week double‐blind, phase 3a, randomised trial
- (2020) Linong Ji et al. DIABETES OBESITY & METABOLISM
- Leptin alters energy intake and fat mass but not energy expenditure in lean subjects
- (2020) Pavlina Chrysafi et al. Nature Communications
- GLP-1 receptor agonists in the treatment of type 2 diabetes – state-of-the-art
- (2020) Michael A. Nauck et al. Molecular Metabolism
- Preoperative considerations of new long-acting glucagon-like peptide-1 receptor agonists in diabetes mellitus
- (2020) Abraham H. Hulst et al. BRITISH JOURNAL OF ANAESTHESIA
- Circulating profile of Activin-Follistatin-Inhibin Axis in women with hypothalamic amenorrhea in response to leptin treatment
- (2020) Eirini Bouzoni et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- Effect of Laparoscopic Sleeve Gastrectomy vs Roux-en-Y Gastric Bypass on Weight Loss and Quality of Life at 7 Years in Patients With Morbid Obesity
- (2020) Sofia Grönroos et al. JAMA Surgery
- Efficacy and safety of setmelanotide, an MC4R agonist, in individuals with severe obesity due to LEPR or POMC deficiency: single-arm, open-label, multicentre, phase 3 trials
- (2020) Karine Clément et al. Lancet Diabetes & Endocrinology
- Physiology and Pharmacology of DPP-4 in Glucose Homeostasis and the Treatment of Type 2 Diabetes
- (2019) Carolyn F. Deacon Frontiers in Endocrinology
- Semaglutide once weekly as add-on to SGLT-2 inhibitor therapy in type 2 diabetes (SUSTAIN 9): a randomised, placebo-controlled trial
- (2019) Bernard Zinman et al. Lancet Diabetes & Endocrinology
- Systematic Review and Meta-analysis of the Change in Ghrelin Levels After Roux-en-Y Gastric Bypass
- (2019) Hang-Cheng Xu et al. OBESITY SURGERY
- Lorcaserin treatment decreases body weight and reduces cardiometabolic risk factors in obese adults: A six‐month, randomized, placebo‐controlled, double‐blind clinical trial
- (2019) Dario Tuccinardi et al. DIABETES OBESITY & METABOLISM
- Use of phentermine-topiramate extended release in combination with sleeve gastrectomy in patients with BMI 50 kg/m2 or more
- (2019) Jamy D. Ard et al. Surgery for Obesity and Related Diseases
- Adjunctive liraglutide treatment in patients with persistent or recurrent type 2 diabetes after metabolic surgery (GRAVITAS): a randomised, double-blind, placebo-controlled trial
- (2019) Alexander Dimitri Miras et al. Lancet Diabetes & Endocrinology
- Efficacy and safety of once-weekly semaglutide 1.0 mg vs once-daily liraglutide 1.2 mg as add-on to 1–3 oral antidiabetic drugs in subjects with type 2 diabetes (SUSTAIN 10)
- (2019) M.S. Capehorn et al. DIABETES & METABOLISM
- Efficacy and safety of once-weekly semaglutide versus daily canagliflozin as add-on to metformin in patients with type 2 diabetes (SUSTAIN 8): a double-blind, phase 3b, randomised controlled trial
- (2019) Ildiko Lingvay et al. Lancet Diabetes & Endocrinology
- Liraglutide for perioperative management of hyperglycaemia in cardiac surgery patients: a multicentre randomized superiority trial
- (2019) Abraham H. Hulst et al. DIABETES OBESITY & METABOLISM
- Circulating levels of gastrointestinal hormones in response to the most common types of bariatric surgery and predictive value for weight loss over one year: Evidence from two independent trials
- (2019) Nikolaos Perakakis et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- Leptin, cardiovascular diseases and type 2 diabetes mellitus
- (2018) Niki Katsiki et al. ACTA PHARMACOLOGICA SINICA
- Safety and efficacy of once-weekly semaglutide vs additional oral antidiabetic drugs in Japanese people with inadequately controlled type 2 diabetes: A randomized trial
- (2018) Kohei Kaku et al. DIABETES OBESITY & METABOLISM
- Effect of Laparoscopic Sleeve Gastrectomy vs Laparoscopic Roux-en-Y Gastric Bypass on Weight Loss in Patients With Morbid Obesity
- (2018) Ralph Peterli et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Effect of Laparoscopic Sleeve Gastrectomy vs Laparoscopic Roux-en-Y Gastric Bypass on Weight Loss at 5 Years Among Patients With Morbid Obesity
- (2018) Paulina Salminen et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Semaglutide Added to Basal Insulin in Type 2 Diabetes (SUSTAIN 5): A Randomized, Controlled Trial
- (2018) Helena W Rodbard et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Efficacy of High-Dose Liraglutide as an Adjunct for Weight Loss in Patients with Prior Bariatric Surgery
- (2018) Peter Rye et al. OBESITY SURGERY
- Mechanisms in bariatric surgery: Gut hormones, diabetes resolution, and weight loss
- (2018) Jens Juul Holst et al. Surgery for Obesity and Related Diseases
- Semaglutide versus dulaglutide once weekly in patients with type 2 diabetes (SUSTAIN 7): a randomised, open-label, phase 3b trial
- (2018) Richard E Pratley et al. Lancet Diabetes & Endocrinology
- Obesity and nonalcoholic fatty liver disease: From pathophysiology to therapeutics
- (2018) Stergios A. Polyzos et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- Pharmacotherapy of obesity: Available medications and drugs under investigation
- (2018) Eleni Pilitsi et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- Obesity and cancer risk: Emerging biological mechanisms and perspectives
- (2018) Konstantinos I. Avgerinos et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- Leptin in depression: a potential therapeutic target
- (2018) Tongtong Ge et al. Cell Death & Disease
- Leptin trajectories from birth to mid-childhood and cardio-metabolic health in early adolescence
- (2018) Ling-Jun Li et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- GEOFFREY HARRIS PRIZE LECTURE 2018: Novel pathways regulating neuroendocrine function, energy homeostasis and metabolism in humans
- (2018) Aimilia Eirini Papathanasiou et al. EUROPEAN JOURNAL OF ENDOCRINOLOGY
- Treating prediabetes in the obese: are GLP-1 analogues the answer?
- (2017) Olivia M Farr et al. LANCET
- Adipose tissue and reproductive health
- (2017) Hannah Mathew et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- A Meta-Analysis of GLP-1 After Roux-En-Y Gastric Bypass: Impact of Surgical Technique and Measurement Strategy
- (2017) Pichamol Jirapinyo et al. OBESITY SURGERY
- The utility of weight loss medications after bariatric surgery for weight regain or inadequate weight loss: A multi-center study
- (2017) Fatima Cody Stanford et al. Surgery for Obesity and Related Diseases
- Efficacy and safety of once-weekly semaglutide versus once-daily sitagliptin as an add-on to metformin, thiazolidinediones, or both, in patients with type 2 diabetes (SUSTAIN 2): a 56-week, double-blind, phase 3a, randomised trial
- (2017) Bo Ahrén et al. Lancet Diabetes & Endocrinology
- Efficacy and safety of once-weekly semaglutide monotherapy versus placebo in patients with type 2 diabetes (SUSTAIN 1): a double-blind, randomised, placebo-controlled, parallel-group, multinational, multicentre phase 3a trial
- (2017) Christopher Sorli et al. Lancet Diabetes & Endocrinology
- Efficacy and safety of once-weekly semaglutide versus once-daily insulin glargine as add-on to metformin (with or without sulfonylureas) in insulin-naive patients with type 2 diabetes (SUSTAIN 4): a randomised, open-label, parallel-group, multicentre, multinational, phase 3a trial
- (2017) Vanita R Aroda et al. Lancet Diabetes & Endocrinology
- The Current Role of Liraglutide in the Pharmacotherapy of Obesity
- (2016) Georgios A. Christou et al. Current Vascular Pharmacology
- Lorcaserin Administration Decreases Activation of Brain Centers in Response to Food Cues and These Emotion- and Salience-Related Changes Correlate With Weight Loss Effects: A 4-Week-Long Randomized, Placebo-Controlled, Double-Blind Clinical Trial
- (2016) Olivia M. Farr et al. DIABETES
- Occurrence of nausea, vomiting and diarrhoea reported as adverse events in clinical trials studying glucagon-like peptide-1 receptor agonists: A systematic analysis of published clinical trials
- (2016) Karolin Bettge et al. DIABETES OBESITY & METABOLISM
- GLP-1 receptors exist in the parietal cortex, hypothalamus and medulla of human brains and the GLP-1 analogue liraglutide alters brain activity related to highly desirable food cues in individuals with diabetes: a crossover, randomised, placebo-controlled trial
- (2016) Olivia M. Farr et al. DIABETOLOGIA
- Leptin and Hormones
- (2016) Georgios A. Triantafyllou et al. ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA
- Association of Pharmacological Treatments for Obesity With Weight Loss and Adverse Events
- (2016) Rohan Khera et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes
- (2016) Steven P. Marso et al. NEW ENGLAND JOURNAL OF MEDICINE
- Liraglutide and Cardiovascular Outcomes in Type 2 Diabetes
- (2016) Steven P. Marso et al. NEW ENGLAND JOURNAL OF MEDICINE
- Roux-En-Y Gastric Bypass Vs. Sleeve Gastrectomy: Balancing the Risks of Surgery with the Benefits of Weight Loss
- (2016) Corey J. Lager et al. OBESITY SURGERY
- Discovery of gastric inhibitory polypeptide and its subsequent fate: Personal reflections
- (2016) Raymond A Pederson et al. Journal of Diabetes Investigation
- Management of Failed Laparoscopic Roux-en-Y Gastric Bypass
- (2016) Ahmad Ibrahim Elnahas et al. Bariatric Surgical Practice and Patient Care
- Weight Loss Before Bariatric Surgery and Postoperative Complications
- (2015) Claes Anderin et al. ANNALS OF SURGERY
- Exenatide Regulates Cerebral Glucose Metabolism in Brain Areas Associated With Glucose Homeostasis and Reward System
- (2015) Giuseppe Daniele et al. DIABETES
- Circulating leptin in non-alcoholic fatty liver disease: a systematic review and meta-analysis
- (2015) Stergios A. Polyzos et al. DIABETOLOGIA
- Leptin in Health and Disease: Facts and Expectations at its Twentieth Anniversary
- (2015) Stergios A. Polyzos et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- 20 years of leptin: From the discovery of the leptin gene to leptin in our therapeutic armamentarium
- (2015) Jeffrey M. Friedman et al. METABOLISM-CLINICAL AND EXPERIMENTAL
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- (2015) Claudio Procaccini et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- Leptin in nonalcoholic fatty liver disease: A narrative review
- (2015) Stergios A. Polyzos et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- The role of leptin in regulating bone metabolism
- (2015) Jagriti Upadhyay et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- A Randomized, Controlled Trial of 3.0 mg of Liraglutide in Weight Management
- (2015) Xavier Pi-Sunyer et al. NEW ENGLAND JOURNAL OF MEDICINE
- Bariatric Surgery Worldwide 2013
- (2015) L. Angrisani et al. OBESITY SURGERY
- Leptin applications in 2015
- (2015) Olivia M. Farr et al. Current Opinion in Endocrinology Diabetes and Obesity
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- (2015) Ricardo Godinho et al. Journal of Diabetes Research
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- (2014) D. Beiroa et al. DIABETES
- Leptin Therapy Alters Appetite and Neural Responses to Food Stimuli in Brain Areas of Leptin-Sensitive Subjects Without Altering Brain Structure
- (2014) Olivia M. Farr et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
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- (2014) Sharon H Chou et al. JOURNAL OF ENDOCRINOLOGY
- Narrative Review: The Role of Leptin in Human Physiology: Emerging Clinical Applications
- (2013) Theodore Kelesidis ANNALS OF INTERNAL MEDICINE
- Leptin at the Intersection of Neuroendocrinology and Metabolism: Current Evidence and Therapeutic Perspectives
- (2013) Maria Dalamaga et al. Cell Metabolism
- Pharmacology, Physiology, and Mechanisms of Incretin Hormone Action
- (2013) Jonathan E. Campbell et al. Cell Metabolism
- Mechanism of Metabolic Advantages After Bariatric Surgery: It's all gastrointestinal factors versus it's all food restriction
- (2013) F. K. Knop et al. DIABETES CARE
- Leptin's Role in Lipodystrophic and Nonlipodystrophic Insulin-Resistant and Diabetic Individuals
- (2013) Hyun-Seuk Moon et al. ENDOCRINE REVIEWS
- Weight maintenance and additional weight loss with liraglutide after low-calorie-diet-induced weight loss: The SCALE Maintenance randomized study
- (2013) T A Wadden et al. INTERNATIONAL JOURNAL OF OBESITY
- Long-term Drug Treatment for Obesity
- (2013) Susan Z. Yanovski et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Review of the key results from the Swedish Obese Subjects (SOS) trial - a prospective controlled intervention study of bariatric surgery
- (2013) L. Sjöström JOURNAL OF INTERNAL MEDICINE
- Randomized double-blind placebo-controlled study of leptin administration after gastric bypass
- (2013) Judith Korner et al. Obesity
- Bile acids and gut peptide secretion after bariatric surgery: A 1-year prospective randomized pilot trial
- (2013) Robert E. Steinert et al. Obesity
- Leptin in Relation to the Lipodystrophy-Associated Metabolic Syndrome
- (2012) Christos S. Mantzoros Diabetes & Metabolism Journal
- Leptin in human physiology and pathophysiology
- (2011) Christos S. Mantzoros et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Molecular mechanisms underlying bile acid-stimulated glucagon-like peptide-1 secretion
- (2011) HE Parker et al. BRITISH JOURNAL OF PHARMACOLOGY
- Efficacy of Metreleptin in Obese Patients With Type 2 Diabetes: Cellular and Molecular Pathways Underlying Leptin Tolerance
- (2011) H.-S. Moon et al. DIABETES
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- (2011) C. Sloan et al. DIABETES
- Impaired incretin effect and fasting hyperglucagonaemia characterizing type 2 diabetic subjects are early signs of dysmetabolism in obesity
- (2011) F. K. Knop et al. DIABETES OBESITY & METABOLISM
- Clinical Effects of Long-Term Metreleptin Treatment in Patients with Lipodystrophy
- (2011) Jean Chan et al. Endocrine Practice
- Leptin administration to overweight and obese subjects for 6 months increases free leptin concentrations but does not alter circulating hormones of the thyroid and IGF axes during weight loss induced by a mild hypocaloric diet
- (2011) Greeshma K Shetty et al. EUROPEAN JOURNAL OF ENDOCRINOLOGY
- Effect of various treatments on leptin, adiponectin, ghrelin and neuropeptide Y in patients with type 2 diabetes mellitus
- (2011) Niki Katsiki et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- Safety, tolerability and sustained weight loss over 2 years with the once-daily human GLP-1 analog, liraglutide
- (2011) A Astrup et al. INTERNATIONAL JOURNAL OF OBESITY
- Impaired Regulation of the Incretin Effect in Patients with Type 2 Diabetes
- (2011) Jonatan I. Bagger et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Long-term metreleptin treatment increases bone mineral density and content at the lumbar spine of lean hypoleptinemic women
- (2011) Elizabeth Sienkiewicz et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- Ethnic-Specific BMI and Waist Circumference Thresholds
- (2011) Peter T. Katzmarzyk et al. Obesity
- Controlled-Release Phentermine/Topiramate in Severely Obese Adults: A Randomized Controlled Trial (EQUIP)
- (2011) David B. Allison et al. Obesity
- Leptin is an effective treatment for hypothalamic amenorrhea
- (2011) S. H. Chou et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Physiology of Weight Loss Surgery
- (2011) Chan W. Park et al. SURGICAL CLINICS OF NORTH AMERICA
- The contribution of malabsorption to the reduction in net energy absorption after long-limb Roux-en-Y gastric bypass
- (2010) Elizabeth A Odstrcil et al. AMERICAN JOURNAL OF CLINICAL NUTRITION
- Leptin in human physiology and therapeutics
- (2010) Tina A. Dardeno et al. FRONTIERS IN NEUROENDOCRINOLOGY
- Changes in Gastrointestinal Hormones and Leptin after Roux-en-Y Gastric Bypass Procedure: A Review
- (2010) Lauren M. Beckman et al. JOURNAL OF THE AMERICAN DIETETIC ASSOCIATION
- Effect of naltrexone plus bupropion on weight loss in overweight and obese adults (COR-I): a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial
- (2010) Frank L Greenway et al. LANCET
- Lipodystrophy: pathophysiology and advances in treatment
- (2010) Christina G. Fiorenza et al. Nature Reviews Endocrinology
- Differential incretin effects of GIP and GLP-1 on gastric emptying, appetite, and insulin-glucose homeostasis
- (2010) T. Edholm et al. NEUROGASTROENTEROLOGY AND MOTILITY
- Leptin in humans: lessons from translational research
- (2009) Susann Blüher et al. AMERICAN JOURNAL OF CLINICAL NUTRITION
- Preoperative Weight Loss Before Bariatric Surgery
- (2009) Peter N. Benotti ARCHIVES OF SURGERY
- TGR5-Mediated Bile Acid Sensing Controls Glucose Homeostasis
- (2009) Charles Thomas et al. Cell Metabolism
- Effects of liraglutide in the treatment of obesity: a randomised, double-blind, placebo-controlled study
- (2009) Arne Astrup et al. LANCET
- Perioperative Safety in the Longitudinal Assessment of Bariatric Surgery
- (2009) NEW ENGLAND JOURNAL OF MEDICINE
- Leptin-mediated changes in hepatic mitochondrial metabolism, structure, and protein levels
- (2009) A. Singh et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Pharmacokinetics of Subcutaneous Recombinant Methionyl Human Leptin Administration in Healthy Subjects in the Fed and Fasting States
- (2008) Jean L Chan et al. CLINICAL PHARMACOKINETICS
- Central Control of Body Weight and Appetite
- (2008) Stephen C. Woods et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Exenatide once weekly versus twice daily for the treatment of type 2 diabetes: a randomised, open-label, non-inferiority study
- (2008) Daniel J Drucker et al. LANCET
- Liraglutide versus glimepiride monotherapy for type 2 diabetes (LEAD-3 Mono): a randomised, 52-week, phase III, double-blind, parallel-treatment trial
- (2008) Alan Garber et al. LANCET
- Long-term Weight Regain after Gastric Bypass: A 5-year Prospective Study
- (2008) Daniéla Oliveira Magro et al. OBESITY SURGERY
- The Role of Incretins in Glucose Homeostasis and Diabetes Treatment
- (2008) W. Kim et al. PHARMACOLOGICAL REVIEWS
- Molecular and neural mediators of leptin action
- (2008) Scott A. Robertson et al. PHYSIOLOGY & BEHAVIOR
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