Opioid ligands may act by blocking the muscarinic anti-inflammatory effect through allostericity in M1 receptors

Recent Advances in the Discovery of Nicotinic Acetylcholine Receptor Allosteric Modulators

(2023) Dina Manetti et al.   MOLECULES

Dynorphin 1-17 biotransformation peptides: properties, challenges and solutions for future therapeutics development

(2023) Rama Ballouze et al.   Future Medicinal Chemistry

Pain-related Behavioral and Electrophysiological Actions of Dynorphin A (1-17)

(2023) Justin E LaVigne et al.   Molecular Pain

Molecular mechanism of biased signaling at the kappa opioid receptor

(2023) Amal El Daibani et al.   Nature Communications

Anti‐inflammatory effects of vagal nerve stimulation with a special attention to intestinal barrier dysfunction

(2022) Bruno Bonaz   NEUROGASTROENTEROLOGY AND MOTILITY

Fine Tuning Muscarinic Acetylcholine Receptor Signaling Through Allostery and Bias

(2021) Emma T. van der Westhuizen et al.   Frontiers in Pharmacology

McN-A-343, a muscarinic agonist, reduces inflammation and oxidative stress in an experimental model of ulcerative colitis

(2021) Diva de Aguiar Magalhães et al.   LIFE SCIENCES

Biased Allosteric Modulators: New Frontiers in GPCR Drug Discovery

(2021) Lauren M. Slosky et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Endogenous Opioid Dynorphin Is a Potential Link between Traumatic Brain Injury, Chronic Pain, and Substance Use Disorder

(2021) Kaitlin M. Best et al.   JOURNAL OF NEUROTRAUMA

Allosteric Modulator Leads Hiding in Plain Site: Developing Peptide and Peptidomimetics as GPCR Allosteric Modulators

(2021) Keith M. Olson et al.   Frontiers in Chemistry

Current Advances in Allosteric Modulation of Muscarinic Receptors

(2020) Jan Jakubik et al.   Biomolecules

Carbachol dimers with primary carbamate groups as homobivalent modulators of muscarinic receptors

(2020) Rosanna Matucci et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Repeated Administration of Norbinaltorphimine Produces Cumulative Kappa Opioid Receptor Inactivation

(2019) Charles Chavkin et al.   Frontiers in Pharmacology

Second M 3 muscarinic receptor binding site contributes to bronchoprotection by tiotropium

(2019) Loes E.M. Kistemaker et al.   BRITISH JOURNAL OF PHARMACOLOGY

Impact of Pharmacological Manipulation of the κ-Opioid Receptor System on Self-grooming and Anhedonic-like Behaviors in Male Mice

(2019) Eduardo R. Butelman et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Muscarinic M1 and M2 receptor subtypes play opposite roles in LPS-induced septic shock

(2019) Zhen Wang et al.   Pharmacological Reports

Allosteric modulators targeting CNS muscarinic receptors

(2018) Andreas Bock et al.   NEUROPHARMACOLOGY

Systemic Administration of Sialorphin Attenuates Experimental Colitis in Mice via Interaction With Mu and Kappa Opioid Receptors

(2017) M Sałaga et al.   Journal of Crohns & Colitis

Expression and Function of the Cholinergic System in Immune Cells

(2017) Takeshi Fujii et al.   Frontiers in Immunology

Opioidergic effects on enteric and sensory nerves in the lower GI tract: basic mechanisms and clinical implications

(2016) Patrick A. Hughes et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

The Involvement of Parasympathetic and Sympathetic Nerve in the Inflammatory Reflex

(2016) Mariana Rodrigues Pereira et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Characterization of kappa opioid receptor mediated, dynorphin-stimulated [35S]GTPγS binding in mouse striatum for the evaluation of selective KOR ligands in an endogenous setting

(2015) Lei Zhou et al.   NEUROPHARMACOLOGY

Molecular Determinants of Allosteric Modulation at the M1Muscarinic Acetylcholine Receptor

(2014) Alaa Abdul-Ridha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Central Muscarinic Cholinergic Activation Alters Interaction between Splenic Dendritic Cell and CD4+CD25- T Cells in Experimental Colitis

(2014) Peris Munyaka et al.   PLoS One

Central cholinergic activation of a vagus nerve-to-spleen circuit alleviates experimental colitis

(2013) H Ji et al.   Mucosal Immunology

Selective κ Opioid Antagonists nor-BNI, GNTI and JDTic Have Low Affinities for Non-Opioid Receptors and Transporters

(2013) Thomas A. Munro et al.   PLoS One