Investigating the Potential Anti-Alzheimer’s Disease Mechanism of Marine Polyphenols: Insights from Network Pharmacology and Molecular Docking

Naringin Protects against Tau Hyperphosphorylation in Aβ25–35-Injured PC12 Cells through Modulation of ER, PI3K/AKT, and GSK-3β Signaling Pathways

(2023) Qi Qiu et al.   BEHAVIOURAL NEUROLOGY

An Overview on Antimicrobial Potential of Edible Terrestrial Plants and Marine Macroalgae Rhodophyta and Chlorophyta Extracts

(2023) Silvia Lomartire et al.   Marine Drugs

Network pharmacology reveals that Berberine may function against Alzheimer’s disease via the AKT signaling pathway

(2023) Wei Wei et al.   Frontiers in Neuroscience

Phlorotannins–bioactivity and extraction perspectives

(2022) Lekshmi R. G. Kumar et al.   JOURNAL OF APPLIED PHYCOLOGY

Computational approach to decode the mechanism of curcuminoids against neuropathic pain

(2022) Chunxiao Xiang et al.   COMPUTERS IN BIOLOGY AND MEDICINE

Microalgae as sustainable food and feed sources for animals and humans – Biotechnological and environmental aspects

(2021) Adi Kusmayadi et al.   CHEMOSPHERE

Dieckol Ameliorates Aβ Production via PI3K/Akt/GSK-3β Regulated APP Processing in SweAPP N2a Cell

(2021) Jeong-Hyun Yoon et al.   Marine Drugs

The PI3K/Akt signaling axis in Alzheimer’s disease: a valuable target to stimulate or suppress?

(2021) Elham Razani et al.   CELL STRESS & CHAPERONES

MEK1/2-ERK Pathway Alterations as a Therapeutic Target in Sporadic Alzheimer’s Disease: A Study in Senescence-Accelerated OXYS Rats

(2021) Natalia A. Muraleva et al.   Antioxidants

Triclosan-induced glycolysis drives inflammatory activation in microglia via the Akt/mTOR/HIF 1α signaling pathway

(2021) Jieyu Liu et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Edible Seaweeds: A Potential Novel Source of Bioactive Metabolites and Nutraceuticals With Human Health Benefits

(2021) Babita Choudhary et al.   Frontiers in Marine Science

LigRMSD: a web server for automatic structure matching and RMSD calculations among identical and similar compounds in protein-ligand docking

(2020) José Luis Velázquez-Libera et al.   BIOINFORMATICS

Dementia prevention, intervention, and care: 2020 report of the Lancet Commission

(2020) Gill Livingston et al.   LANCET

Role of EGFR in the Nervous System

(2020) Roberta Romano et al.   Cells

Mitochondrial Dysfunction, Oxidative Stress, and Neuroinflammation: Intertwined Roads to Neurodegeneration

(2020) Anna Picca et al.   Antioxidants

Inhibition of the NLRP3 inflammasome by HSP90 inhibitors

(2020) Sohaib Nizami et al.   IMMUNOLOGY

Dual BACE1 and Cholinesterase Inhibitory Effects of Phlorotannins from Ecklonia cava—An In Vitro and in Silico Study

(2019) Jinhyuk Lee et al.   Marine Drugs

The new genetic landscape of Alzheimer’s disease: from amyloid cascade to genetically driven synaptic failure hypothesis?

(2019) Pierre Dourlen et al.   ACTA NEUROPATHOLOGICA

Identifying Phlorofucofuroeckol-A as a Dual Inhibitor of Amyloid-β25-35 Self-Aggregation and Insulin Glycation: Elucidation of the Molecular Mechanism of Action

(2019) Seong et al.   Marine Drugs

Role of p38/MAPKs in Alzheimer’s disease: implications for amyloid beta toxicity targeted therapy

(2018) Ghazaleh Kheiri et al.   REVIEWS IN THE NEUROSCIENCES

Orally Administered Phlorotannins from Eisenia arborea Suppress Chemical Mediator Release and Cyclooxygenase-2 Signaling to Alleviate Mouse Ear Swelling

(2018) Yoshimasa Sugiura et al.   Marine Drugs

Anti-Neuroinflammatory Property of Phlorotannins from Ecklonia cava on Aβ25-35-Induced Damage in PC12 Cells

(2018) Seungeun Lee et al.   Marine Drugs

Alzheimer's disease

(2017) C. A. Lane et al.   EUROPEAN JOURNAL OF NEUROLOGY

High salt diet impairs memory-related synaptic plasticity via increased oxidative stress and suppressed synaptic protein expression

(2017) Qian Ge et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Aberrant protein phosphorylation in Alzheimer disease brain disturbs pro-survival and cell death pathways

(2016) M. Perluigi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Blood-brain barrier-permeable fluorone-labeled dieckols acting as neuronal ER stress signaling inhibitors

(2015) Jong Hwan Kwak et al.   BIOMATERIALS

Network pharmacology applications to map the unexplored target space and therapeutic potential of natural products

(2015) Milla Kibble et al.   NATURAL PRODUCT REPORTS

Src protein-tyrosine kinase structure, mechanism, and small molecule inhibitors

(2015) Robert Roskoski   PHARMACOLOGICAL RESEARCH

The Role of Vascular Endothelial Growth Factor in Neurodegeneration and Cognitive Decline

(2015) Timothy J. Hohman et al.   JAMA Neurology

Downregulation of PI3K/Akt/mTOR signaling pathway in curcumin-induced autophagy in APP/PS1 double transgenic mice

(2014) Chen Wang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

8,8′-Bieckol, isolated from edible brown algae, exerts its anti-inflammatory effects through inhibition of NF-κB signaling and ROS production in LPS-stimulated macrophages

(2014) Yeong-In Yang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

In vitro antioxidant properties of crude extracts and compounds from brown algae

(2012) Elena M. Balboa et al.   FOOD CHEMISTRY

Interactome Networks and Human Disease

(2011) Marc Vidal et al.   CELL

Activity Patterns Govern Synapse-Specific AMPA Receptor Trafficking between Deliverable and Synaptic Pools

(2009) Anders Kielland et al.   NEURON

Ecklonia cava ethanolic extracts inhibit lipopolysaccharide-induced cyclooxygenase-2 and inducible nitric oxide synthase expression in BV2 microglia via the MAP kinase and NF-κB pathways

(2008) Won-Kyo Jung et al.   FOOD AND CHEMICAL TOXICOLOGY