Perturbation of neddylation-dependent NF-κB responses in the intestinal epithelium drives apoptosis and inhibits resolution of mucosal inflammation

Stabilization of HIF through inhibition of Cullin-2 neddylation is protective in mucosal inflammatory responses

(2015) Valerie F. Curtis et al.   FASEB JOURNAL

Targeting neddylation effectively antagonizes nuclear factor-κB in chronic lymphocytic leukemia B-cells

(2015) J. Claire Godbersen et al.   LEUKEMIA & LYMPHOMA

Lactobacilli Modulate Epithelial Cytoprotection through the Nrf2 Pathway

(2015) Rheinallt M. Jones et al.   Cell Reports

Control of IFN- A by CD73: Implications for Mucosal Inflammation

(2014) N. A. Louis et al.   JOURNAL OF IMMUNOLOGY

The Discovery of a Reciprocal Relationship between Tyrosine-Kinase Signaling and Cullin Neddylation

(2013) Samantha F. Friend et al.   PLoS One

Regulation of NF-κB by ubiquitination and degradation of the IκBs

(2012) Naama Kanarek et al.   IMMUNOLOGICAL REVIEWS

Implications of Protein Post-Translational Modifications in IBD

(2012) Stefan F. Ehrentraut et al.   INFLAMMATORY BOWEL DISEASES

Central Role for Endothelial Human Deneddylase-1/SENP8 in Fine-Tuning the Vascular Inflammatory Response

(2012) S. F. Ehrentraut et al.   JOURNAL OF IMMUNOLOGY

Glutamine Treatment Attenuates Endoplasmic Reticulum Stress and Apoptosis in TNBS-Induced Colitis

(2012) Irene Crespo et al.   PLoS One

Neddylation pathway regulates T-cell function by targeting an adaptor protein Shc and a protein kinase Erk signaling

(2012) H.-s. Jin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cord blood interleukin-6 as a predictor of early-onset neonatal sepsis

(2011) María Cernada et al.   ACTA PAEDIATRICA

The Life and Death of Epithelia During Inflammation: Lessons Learned from the Gut

(2011) Stefan Koch et al.   Annual Review of Pathology-Mechanisms of Disease

Changes in the ratio of free NEDD8 to ubiquitin triggers NEDDylation by ubiquitin enzymes

(2011) Roland Hjerpe et al.   BIOCHEMICAL JOURNAL

NFκB and HIF display synergistic behaviour during hypoxic inflammation

(2011) Ulrike Bruning et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The Search for Effective Therapy for Sepsis

(2011) Derek C. Angus   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

MLN4924, a NEDD8-activating enzyme inhibitor, is active in diffuse large B-cell lymphoma models: rationale for treatment of NF- B-dependent lymphoma

(2010) M. A. Milhollen et al.   BLOOD

Interferon-γ Regulates Intestinal Epithelial Homeostasis through Converging β-Catenin Signaling Pathways

(2010) Porfirio Nava et al.   IMMUNITY

Regulation of cullin-RING E3 ubiquitin-ligases by neddylation and dimerization

(2009) J. Merlet et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

(2009) Teresa A. Soucy et al.   NATURE

Activation of hypoxia-inducible factor attenuates renal injury in rat remnant kidney

(2009) Y. R. Song et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Mucosal Protection by Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibition

(2007) Andreas Robinson et al.   GASTROENTEROLOGY

NF-κB and the intestine: Friend or foe?

(2007) Thomas Karrasch et al.   INFLAMMATORY BOWEL DISEASES