PI3K/Akt/FoxO3a signaling mediates cardioprotection of FGF-2 against hydrogen peroxide-induced apoptosis in H9c2 cells

bFGF regulates autophagy and ubiquitinated protein accumulation induced by myocardial ischemia/reperfusion via the activation of the PI3K/Akt/mTOR pathway

(2015) Zhou-Guang Wang et al.   Scientific Reports

The Essential Role of p53-up-regulated Modulator of Apoptosis (Puma) and Its Regulation by FoxO3a Transcription Factor in β-Amyloid-induced Neuron Death

(2014) Rumana Akhter et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

bFGF attenuates endoplasmic reticulum stress and mitochondrial injury on myocardial ischaemia/reperfusionvia activation of PI3K/Akt/ERK1/2 pathway

(2014) Zhouguang Wang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

EPO-Dependent Activation of PI3K/Akt/FoxO3a Signalling Mediates Neuroprotection in In Vitro and In Vivo Models of Parkinson’s Disease

(2014) Yu Jia et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Sodium tanshinone IIA sulfonate protects rat myocardium against ischemia-reperfusion injury via activation of PI3K/Akt/FOXO3A/Bim pathway

(2013) Mei-qi Zhang et al.   ACTA PHARMACOLOGICA SINICA

Janus-like role of fibroblast growth factor 2 in arteriosclerotic coronary artery disease: Atherogenesis and angiogenesis

(2013) Mi-Hua Liu et al.   ATHEROSCLEROSIS

FGF-2 prevents cancer cells from ER stress-mediated apoptosis via enhancing proteasome-mediated Nck degradation

(2013) Bin Li et al.   BIOCHEMICAL JOURNAL

Simvastatin promotes cardiac microvascular endothelial cells proliferation, migration and survival by phosphorylation of p70 S6K and FoxO3a

(2013) Qiao Pan et al.   CELL BIOLOGY INTERNATIONAL

High Glucose Induced Oxidative Stress and Apoptosis in Cardiac Microvascular Endothelial Cells Are Regulated by FoxO3a

(2013) Chaoming Peng et al.   PLoS One

FoxO3a Modulates Hypoxia Stress Induced Oxidative Stress and Apoptosis in Cardiac Microvascular Endothelial Cells

(2013) Shenwei Zhang et al.   PLoS One

The role of Akt/FoxO3a in the protective effect of venlafaxine against corticosterone-induced cell death in PC12 cells

(2013) Haitao Wang et al.   PSYCHOPHARMACOLOGY

FoxO3a is activated and executes neuron death via Bim in response to β-amyloid

(2013) P Sanphui et al.   Cell Death & Disease

FGF-2 inhibits TNF-α mediated apoptosis through up-regulation of Bcl2-A1 and Bcl-xL in ATDC5 cells

(2012) Hey-Ryun Kim et al.   BMB Reports

Basic Fibroblast Growth Factor Protects C17.2 Cells from Radiation-Induced Injury through ERK1/2

(2012) Ping Luan et al.   CNS Neuroscience & Therapeutics

Exogenous Basic Fibroblast Growth Factor Inhibits ER Stress-Induced Apoptosis and Improves Recovery from Spinal Cord Injury

(2012) Hong-Yu Zhang et al.   CNS Neuroscience & Therapeutics

Fibroblast growth factor-2-induced cardioprotection against myocardial infarction occurs via the interplay between nitric oxide, protein kinase signaling, and ATP-sensitive potassium channels

(2012) Janet R. Manning et al.   GROWTH FACTORS

bFGF inhibits ER stress induced by ischemic oxidative injury via activation of the PI3K/Akt and ERK1/2 pathways

(2012) Zhouguang Wang et al.   TOXICOLOGY LETTERS

Diabetes, oxidative stress, molecular mechanism, and cardiovascular disease – an overview

(2012) Vaithinathan Selvaraju et al.   TOXICOLOGY MECHANISMS AND METHODS

bFGF-mediated redox activation of the PI3K/Akt pathway in retinal photoreceptor cells

(2011) Stephen M. J. Farrell et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Fibroblast growth factor 2-induced cytoplasmic asparaginyl-tRNA synthetase promotes survival of osteoblasts by regulating anti-apoptotic PI3K/Akt signaling

(2009) Su Jin Park et al.   BONE

High molecular weight FGF-2 promotes postconditioning-like cardioprotection linked to activation of the protein kinase C isoforms Akt and p70 S6 kinaseThis article is one of a selection of papers published in a special issue celebrating the 125th anniversary of the Faculty of Medicine at the University of Manitoba.

(2009) Zhi-Sheng Jiang et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Involvement of the PTEN–AKT–FOXO3a Pathway in Neuronal Apoptosis in Developing Rat Brain after Hypoxia–Ischemia

(2009) Deyuan Li et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

A benzoxazine derivative induces vascular endothelial cell apoptosis in the presence of fibroblast growth factor-2 by elevating NADPH oxidase activity and reactive oxygen species levels

(2009) Jing Zhao et al.   TOXICOLOGY IN VITRO

Bromelain induces cardioprotection against ischemia-reperfusion injury through Akt/FOXO pathway in rat myocardium

(2008) Bela Juhasz et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

FoxO transcription factors in oxidative stress response and ageing – a new fork on the way to longevity?

(2008) Daniel G. Sedding   BIOLOGICAL CHEMISTRY