Discovery, Characterization, and Bioactivity of the Achromonodins: Lasso Peptides Encoded by Achromobacter

High-Throughput Screen Reveals the Structure–Activity Relationship of the Antimicrobial Lasso Peptide Ubonodin

(2023) Alina Thokkadam et al.   ACS Central Science

Role of Efflux in Antibiotic Resistance of Achromobacter xylosoxidans and Achromobacter insuavis Isolates From Patients With Cystic Fibrosis

(2022) Hussein Chalhoub et al.   Frontiers in Microbiology

Phenotype-Guided Comparative Genomics Identifies the Complete Transport Pathway of the Antimicrobial Lasso Peptide Ubonodin in Burkholderia

(2022) Truc Do et al.   ACS Chemical Biology

Cloacaenodin, an Antimicrobial Lasso Peptide with Activity against Enterobacter

(2022) Drew V. Carson et al.   ACS Infectious Diseases

Achromobacter xylosoxidans and Stenotrophomonas maltophilia: Emerging Pathogens Well-Armed for Life in the Cystic Fibrosis Patients’ Lung

(2021) Quentin Menetrey et al.   Genes

Discovery and Bioactivity of the Novel Lasso Peptide Microcin Y

(2021) Yu Li et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Cellulonodin-2 and Lihuanodin: Lasso Peptides with an Aspartimide Post-Translational Modification

(2021) Li Cao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mining and unearthing hidden biosynthetic potential

(2021) Kirstin Scherlach et al.   Nature Communications

An integrated gene catalog and over 10,000 metagenome-assembled genomes from the gastrointestinal microbiome of ruminants

(2021) Fei Xie et al.   Microbiome

Molecular mechanism of SbmA, a promiscuous transporter exploited by antimicrobial peptides

(2021) Dmitry Ghilarov et al.   Science Advances

Heterologous Production of Lasso Peptide Capistruin in a Burkholderia Host

(2020) Sylvia Kunakom et al.   ACS Synthetic Biology

How to harness biosynthetic gene clusters of lasso peptides

(2020) Shinya Kodani et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Achromobacter Infections and Treatment Options

(2020) Burcu Isler et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Synergy Screening Identifies a Compound That Selectively Enhances the Antibacterial Activity of Nitric Oxide

(2020) Wen Kang Chou et al.   Frontiers in Bioengineering and Biotechnology

Structural mechanism of transcription inhibition by lasso peptides microcin J25 and capistruin

(2019) Nathaniel R. Braffman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Discovery and structure of the antimicrobial lasso peptide citrocin

(2019) Wai Ling Cheung-Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Lasso Peptide Siamycin-I Targets Lipid II at the Gram-Positive Cell Surface

(2019) Stephanie Tan et al.   ACS Chemical Biology

Breaching the Barrier: Quantifying Antibiotic Permeability across Gram-negative Bacterial Membranes

(2019) Jehangir Cama et al.   JOURNAL OF MOLECULAR BIOLOGY

Distinct Roles of Outer Membrane Porins in Antibiotic Resistance and Membrane Integrity in Escherichia coli

(2019) Umji Choi et al.   Frontiers in Microbiology

Factors Governing the Thermal Stability of Lasso Peptides

(2019) Julian D. Hegemann   CHEMBIOCHEM

The Evolution and Ecology of Bacterial Warfare

(2019) Elisa T. Granato et al.   CURRENT BIOLOGY

Achromobacter spp. healthcare associated infections in the French West Indies: a longitudinal study from 2006 to 2016

(2019) Karine Marion-Sanchez et al.   BMC INFECTIOUS DISEASES

Pandonodin: A Proteobacterial Lasso Peptide with an Exceptionally Long C-Terminal Tail

(2019) Wai Ling Cheung-Lee et al.   ACS Chemical Biology

Discovery of ubonodin, an antimicrobial lasso peptide active against members of the Burkholderia cepacia complex

(2019) Wai Ling Cheung-Lee et al.   CHEMBIOCHEM

Lasso Peptide Benenodin-1 Is a Thermally Actuated [1]Rotaxane Switch

(2017) Chuhan Zong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Thermal Unthreading of the Lasso Peptides Astexin-2 and Astexin-3

(2016) Caitlin D. Allen et al.   ACS Chemical Biology

The native microbiome of the nematode Caenorhabditis elegans: gateway to a new host-microbiome model

(2016) Philipp Dirksen et al.   BMC BIOLOGY

Lasso Peptides: An Intriguing Class of Bacterial Natural Products

(2015) Julian D. Hegemann et al.   ACCOUNTS OF CHEMICAL RESEARCH

Lassomycin, a Ribosomally Synthesized Cyclic Peptide, Kills Mycobacterium tuberculosis by Targeting the ATP-Dependent Protease ClpC1P1P2

(2014) Ekaterina Gavrish et al.   CHEMISTRY & BIOLOGY

Structural basis for hijacking siderophore receptors by antimicrobial lasso peptides

(2014) Indran Mathavan et al.   Nature Chemical Biology

Discovery and Characterization of an Isopeptidase That Linearizes Lasso Peptides

(2013) Mikhail O. Maksimov et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Strategies to Minimize Antibiotic Resistance

(2013) Chang-Ro Lee et al.   International Journal of Environmental Research and Public Health

Innate Aminoglycoside Resistance of Achromobacter xylosoxidans Is Due to AxyXY-OprZ, an RND-Type Multidrug Efflux Pump

(2012) Julien Bador et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Lasso peptides: structure, function, biosynthesis, and engineering

(2012) Mikhail O. Maksimov et al.   NATURAL PRODUCT REPORTS

Precursor-centric genome-mining approach for lasso peptide discovery

(2012) M. O. Maksimov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Achromobacter animicus sp. nov., Achromobacter mucicolens sp. nov., Achromobacter pulmonis sp. nov. and Achromobacter spiritinus sp. nov., from human clinical samples

(2012) Peter Vandamme et al.   SYSTEMATIC AND APPLIED MICROBIOLOGY

Engineered gene clusters for the production of the antimicrobial peptide microcin J25

(2009) Si Jia Pan et al.   PROTEIN EXPRESSION AND PURIFICATION

Isolation and Structural Characterization of Capistruin, a Lasso Peptide Predicted from the Genome Sequence of Burkholderia thailandensis E264

(2008) Thomas A. Knappe et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY