Ligustrazine-Derived Chalcones-Modified Platinum(IV) Complexes Intervene in Cisplatin Resistance in Pancreatic Cancer through Ferroptosis and Apoptosis
出版年份 2023 全文链接
标题
Ligustrazine-Derived Chalcones-Modified Platinum(IV) Complexes Intervene in Cisplatin Resistance in Pancreatic Cancer through Ferroptosis and Apoptosis
作者
关键词
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出版物
JOURNAL OF MEDICINAL CHEMISTRY
Volume 66, Issue 19, Pages 13587-13606
出版商
American Chemical Society (ACS)
发表日期
2023-09-28
DOI
10.1021/acs.jmedchem.3c00922
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- (2023) Xiao-Meng Liu et al. Journal of Medicinal Chemistry
- Fighting cancer by triggering non-canonical mitochondrial permeability transition-driven necrosis through reactive oxygen species induction
- (2023) Qingwen Xiao et al. FREE RADICAL BIOLOGY AND MEDICINE
- Novel Indole–Chalcone Derivative-Ligated Platinum(IV) Prodrugs Attenuate Cisplatin Resistance in Lung Cancer through ROS/ER Stress and Mitochondrial Dysfunction
- (2023) Zhikun Liu et al. Journal of Medicinal Chemistry
- A Clinically Translatable Ternary Platinum(IV) Prodrug for Synergistically Reversing Drug Resistance
- (2023) Ying Liu et al. Journal of Medicinal Chemistry
- Neoadjuvant therapy for pancreatic cancer
- (2023) Christoph Springfeld et al. Nature Reviews Clinical Oncology
- Discovery of a Novel Stilbene Derivative as a Microtubule Targeting Agent Capable of Inducing Cell Ferroptosis
- (2022) Jingwei Zhou et al. JOURNAL OF MEDICINAL CHEMISTRY
- Platinum(IV) Prodrugs with Cancer Stem Cell Inhibitory Effects on Lung Cancer for Overcoming Drug Resistance
- (2022) Xinyi Wang et al. JOURNAL OF MEDICINAL CHEMISTRY
- A descriptive study on the treatment and outcomes of patients with platinum-sensitive, advanced, BRCA- or PALB2-related pancreatic cancer who have progressed on rucaparib.
- (2022) Timothy J Brown et al. JOURNAL OF CLINICAL ONCOLOGY
- Amlexanox-modified platinum(IV) complex triggers apoptotic and autophagic bimodal death of cancer cells
- (2022) Yan Guo et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Pt(IV)-Deferasirox Prodrug Combats DNA Damage Repair by Regulating RNA N6-Methyladenosine Methylation
- (2022) Zheng-Yin Pan et al. Journal of Medicinal Chemistry
- Broadening horizons: the role of ferroptosis in cancer
- (2021) Xin Chen et al. Nature Reviews Clinical Oncology
- In Situ Supramolecular Self‐Assembly of Pt(IV) Prodrug to Conquer Cisplatin Resistance
- (2021) Qian Wang et al. ADVANCED FUNCTIONAL MATERIALS
- Dual-target platinum(IV) complexes exhibit antiproliferative activity through DNA damage and induce ER-stress-mediated apoptosis in A549 cells
- (2021) Meng Wang et al. BIOORGANIC CHEMISTRY
- Structure–Activity Relationships of Triple-Action Platinum(IV) Prodrugs with Albumin-Binding Properties and Immunomodulating Ligands
- (2021) Philipp Fronik et al. JOURNAL OF MEDICINAL CHEMISTRY
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- (2021) Yuanjiang Wang et al. JOURNAL OF MEDICINAL CHEMISTRY
- ent-Kaurane diterpenoids induce apoptosis and ferroptosis through targeting redox resetting to overcome cisplatin resistance
- (2021) Yong Sun et al. Redox Biology
- Ketoprofen and Loxoprofen Platinum(IV) Complexes Displaying Antimetastatic Activities by Inducing DNA Damage, Inflammation Suppression, and Enhanced Immune Response
- (2021) Zuojie Li et al. JOURNAL OF MEDICINAL CHEMISTRY
- Identification of Frataxin as a regulator of ferroptosis
- (2020) Jing Du et al. Redox Biology
- Anticancer Melatplatin Prodrugs: High Effect and Low Toxicity, MT1-ER-Target and Immune Response In Vivo
- (2020) Xue-Qing Song et al. JOURNAL OF MEDICINAL CHEMISTRY
- xCT: A Critical Molecule That Links Cancer Metabolism to Redox Signaling
- (2020) Jinyun Liu et al. MOLECULAR THERAPY
- Ferroptosis: molecular mechanisms and health implications
- (2020) Daolin Tang et al. CELL RESEARCH
- Toward Multi-Targeted Platinum and Ruthenium Drugs—A New Paradigm in Cancer Drug Treatment Regimens?
- (2019) Reece G. Kenny et al. CHEMICAL REVIEWS
- Identification and Characterization of AES-135, a Hydroxamic Acid-Based HDAC Inhibitor That Prolongs Survival in an Orthotopic Mouse Model of Pancreatic Cancer
- (2019) Andrew E. Shouksmith et al. JOURNAL OF MEDICINAL CHEMISTRY
- P-Glycoprotein Overexpression Is Associated With Cisplatin Resistance in Human Osteosarcoma
- (2019) CHAO HE et al. ANTICANCER RESEARCH
- New NSAID-Pt(IV) prodrugs to suppress metastasis and invasion of tumor cells and enhance anti-tumor effect in vitro and in vivo
- (2019) Xue-Qing Song et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Targeting HDAC/OAZ1 axis with a novel inhibitor effectively reverses cisplatin resistance in non-small cell lung cancer
- (2019) Yuhong Sun et al. Cell Death & Disease
- Chemoresistance in Pancreatic Cancer
- (2019) Zeng et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Recent Progress in Ferroptosis Inducers for Cancer Therapy
- (2019) Chen Liang et al. ADVANCED MATERIALS
- Platinum-Based Modification of Styrylbenzylsulfones as Multifunctional Antitumor Agents: Targeting the RAS/RAF Pathway, Enhancing Antitumor Activity, and Overcoming Multidrug Resistance
- (2019) Zhikun Liu et al. JOURNAL OF MEDICINAL CHEMISTRY
- Stimuli-Responsive Therapeutic Metallodrugs
- (2018) Xiaohui Wang et al. CHEMICAL REVIEWS
- A phase Ib/II pilot trial with nab-paclitaxel plus gemcitabine plus cisplatin in patients (pts) with stage IV pancreatic cancer.
- (2017) Gayle S. Jameson et al. JOURNAL OF CLINICAL ONCOLOGY
- Glycosylated Platinum(IV) Complexes as Substrates for Glucose Transporters (GLUTs) and Organic Cation Transporters (OCTs) Exhibited Cancer Targeting and Human Serum Albumin Binding Properties for Drug Delivery
- (2017) Jing Ma et al. JOURNAL OF MEDICINAL CHEMISTRY
- Pancreatic cancer: Tailored therapy for pancreatic tumour subtype
- (2017) Iain Dickson Nature Reviews Gastroenterology & Hepatology
- The Next Generation of Platinum Drugs: Targeted Pt(II) Agents, Nanoparticle Delivery, and Pt(IV) Prodrugs
- (2016) Timothy C. Johnstone et al. CHEMICAL REVIEWS
- Discovery of New Monocarbonyl Ligustrazine–Curcumin Hybrids for Intervention of Drug-Sensitive and Drug-Resistant Lung Cancer
- (2016) Yong Ai et al. JOURNAL OF MEDICINAL CHEMISTRY
- Cisplatin resistance and opportunities for precision medicine
- (2016) Lauren Amable PHARMACOLOGICAL RESEARCH
- The ligation of aspirin to cisplatin demonstrates significant synergistic effects on tumor cells
- (2014) Qinqin Cheng et al. CHEMICAL COMMUNICATIONS
- Role of the ROS/AMPK signaling pathway in tetramethylpyrazine-induced apoptosis in gastric cancer cells
- (2013) BO YI et al. Oncology Letters
- Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
- (2012) Scott J. Dixon et al. CELL
- The status of platinum anticancer drugs in the clinic and in clinical trials
- (2010) Nial J. Wheate et al. DALTON TRANSACTIONS
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