Mfsd2a-mediated lysolipid transport is important for renal recovery after acute kidney injury

Mfsd2a utilizes a flippase mechanism to mediate omega-3 fatty acid lysolipid transport

(2023) Geok-Lin Chua et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Substrate binding-induced conformational transitions in the omega-3 fatty acid transporter MFSD2A

(2023) Shana Bergman et al.   Nature Communications

The lipid transporter Mfsd2a maintains pulmonary surfactant homeostasis

(2022) Bernice H. Wong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ferrostatin‐1 modulates dysregulated kidney lipids in acute kidney injury

(2022) Lucía Martín‐Saiz et al.   JOURNAL OF PATHOLOGY

Structural insights into the lysophospholipid brain uptake mechanism and its inhibition by syncytin-2

(2022) Maria Martinez-Molledo et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Comprehensive single-cell transcriptional profiling defines shared and unique epithelial injury responses during kidney fibrosis

(2022) Haikuo Li et al.   Cell Metabolism

Multimodal single cell sequencing implicates chromatin accessibility and genetic background in diabetic kidney disease progression

(2022) Parker C. Wilson et al.   Nature Communications

Structural basis of omega-3 fatty acid transport across the blood–brain barrier

(2021) Rosemary J. Cater et al.   NATURE

Structure and mechanism of blood–brain-barrier lipid transporter MFSD2A

(2021) Chase A. P. Wood et al.   NATURE

Single-Cell Analysis of Blood-Brain Barrier Response to Pericyte Loss

(2020) Maarja Andaloussi Mäe et al.   CIRCULATION RESEARCH

Fluorescent Retinoic Acid Analogues as Probes for Biochemical and Intracellular Characterization of Retinoid Signaling Pathways

(2019) David R. Chisholm et al.   ACS Chemical Biology

Single-Cell Profiling Reveals Sex, Lineage, and Regional Diversity in the Mouse Kidney

(2019) Andrew Ransick et al.   DEVELOPMENTAL CELL

FOXM1 drives proximal tubule proliferation during repair from acute ischemic kidney injury

(2019) Monica Chang-Panesso et al.   JOURNAL OF CLINICAL INVESTIGATION

Understanding the diversity of membrane lipid composition

(2018) Takeshi Harayama et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Lipid imaging for visualizing cilastatin amelioration of cisplatin-induced nephrotoxicity

(2018) Estefanía Moreno-Gordaliza et al.   JOURNAL OF LIPID RESEARCH

Homozygous mutation in MFSD2A, encoding a lysolipid transporter for docosahexanoic acid, is associated with microcephaly and hypomyelination

(2018) Tamar Harel et al.   NEUROGENETICS

The lysolipid transporter Mfsd2a regulates lipogenesis in the developing brain

(2018) Jia Pei Chan et al.   PLOS BIOLOGY

Mfsd2a Is a Transporter for the Essential ω-3 Fatty Acid Docosahexaenoic Acid (DHA) in Eye and Is Important for Photoreceptor Cell Development

(2016) Bernice H. Wong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondria–Power Players in Kidney Function?

(2016) Josephine M. Forbes   TRENDS IN ENDOCRINOLOGY AND METABOLISM

A partially inactivating mutation in the sodium-dependent lysophosphatidylcholine transporter MFSD2A causes a non-lethal microcephaly syndrome

(2015) Vafa Alakbarzade et al.   NATURE GENETICS

Inactivating mutations in MFSD2A, required for omega-3 fatty acid transport in brain, cause a lethal microcephaly syndrome

(2015) Alicia Guemez-Gamboa et al.   NATURE GENETICS

Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid

(2014) Long N. Nguyen et al.   NATURE

Acute kidney injury—epidemiology, outcomes and economics

(2014) Oleksa Rewa et al.   Nature Reviews Nephrology

Raising awareness of acute kidney injury: a global perspective of a silent killer

(2013) Andrew J.P. Lewington et al.   KIDNEY INTERNATIONAL

Functions of plasmalogen lipids in health and disease

(2012) Nancy E. Braverman et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Major Facilitator Superfamily Domain-Containing Protein 2a (MFSD2A) Has Roles in Body Growth, Motor Function, and Lipid Metabolism

(2012) Justin H. Berger et al.   PLoS One

The proximal tubule in the pathophysiology of the diabetic kidney

(2011) Volker Vallon   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

A robust and high-throughput Cre reporting and characterization system for the whole mouse brain

(2009) Linda Madisen et al.   NATURE NEUROSCIENCE

Membrane lipids: where they are and how they behave

(2008) Gerrit van Meer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY