STIM-mediated calcium influx regulates maintenance and selection of germinal center B cells

B cell receptor signaling in germinal centers prolongs survival and primes B cells for selection

(2023) Spencer T. Chen et al.   IMMUNITY

Germinal Centers

(2022) Gabriel D. Victora et al.   Annual Review of Immunology

Intravital quantification reveals dynamic calcium concentration changes across B cell differentiation stages

(2021) Carolin Ulbricht et al.   eLife

BCR-Induced Ca2+ Signals Dynamically Tune Survival, Metabolic Reprogramming, and Proliferation of Naive B Cells

(2020) Corbett T. Berry et al.   Cell Reports

Lack of NFATc1 SUMOylation prevents autoimmunity and alloreactivity

(2020) Yin Xiao et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Plasma cell differentiation during the germinal center reaction

(2019) Wataru Ise et al.   IMMUNOLOGICAL REVIEWS

STIM- and Orai-mediated Calcium Entry Controls NF-κB Activity and Function in Lymphocytes

(2018) Corbett T. Berry et al.   CELL CALCIUM

B Cell Receptor and CD40 Signaling Are Rewired for Synergistic Induction of the c-Myc Transcription Factor in Germinal Center B Cells

(2018) Wei Luo et al.   IMMUNITY

Germinal center entry not selection of B cells is controlled by peptide-MHCII complex density

(2018) Chen-Hao Yeh et al.   Nature Communications

B Cell Receptor Crosslinking Augments Germinal Center B Cell Selection when T Cell Help Is Limiting

(2018) Jackson Steed Turner et al.   Cell Reports

Germinal Center Selection and Affinity Maturation Require Dynamic Regulation of mTORC1 Kinase

(2017) Jonatan Ersching et al.   IMMUNITY

The transcription factor Foxo1 controls germinal center B cell proliferation in response to T cell help

(2017) Takeshi Inoue et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The microanatomic segregation of selection by apoptosis in the germinal center

(2017) Christian T. Mayer et al.   SCIENCE

A Population Dynamics Model for Clonal Diversity in a Germinal Center

(2017) Assaf Amitai et al.   Frontiers in Microbiology

Follicular Helper T Cells

(2016) Carola G. Vinuesa et al.   Annual Review of Immunology

Germinal center B cells recognize antigen through a specialized immune synapse architecture

(2016) Carla R Nowosad et al.   NATURE IMMUNOLOGY

Conditional knockdown of BCL2A1 reveals rate-limiting roles in BCR-dependent B-cell survival

(2015) M Sochalska et al.   CELL DEATH AND DIFFERENTIATION

The FOXO1 Transcription Factor Instructs the Germinal Center Dark Zone Program

(2015) David Dominguez-Sola et al.   IMMUNITY

PI3 Kinase and FOXO1 Transcription Factor Activity Differentially Control B Cells in the Germinal Center Light and Dark Zones

(2015) Sandrine Sander et al.   IMMUNITY

Cutting Edge: An In Vivo Reporter Reveals Active B Cell Receptor Signaling in the Germinal Center

(2015) James Mueller et al.   JOURNAL OF IMMUNOLOGY

T–B-cell entanglement and ICOSL-driven feed-forward regulation of germinal centre reaction

(2014) Dan Liu et al.   NATURE

Clonal selection in the germinal centre by regulated proliferation and hypermutation

(2014) Alexander D. Gitlin et al.   NATURE

Memory B cells contribute to rapid Bcl6 expression by memory follicular helper T cells

(2014) W. Ise et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Germinal Center Centroblasts Transition to a Centrocyte Phenotype According to a Timed Program and Depend on the Dark Zone for Effective Selection

(2013) Oliver Bannard et al.   IMMUNITY

Calcium signaling in B cells: Regulation of cytosolic Ca2+ increase and its sensor molecules, STIM1 and STIM2

(2013) Yoshihiro Baba et al.   MOLECULAR IMMUNOLOGY

Targeting antiapoptotic A1/Bfl-1 by in vivo RNAi reveals multiple roles in leukocyte development in mice

(2012) E. Ottina et al.   BLOOD

B Cell Receptor Signal Transduction in the GC Is Short-Circuited by High Phosphatase Activity

(2012) A. M. Khalil et al.   SCIENCE

BCL2A1: the underdog in the BCL2 family

(2011) M Vogler   CELL DEATH AND DIFFERENTIATION

The Calcium Sensors STIM1 and STIM2 Control B Cell Regulatory Function through Interleukin-10 Production

(2011) Masanori Matsumoto et al.   IMMUNITY

How T Cells Earn the Follicular Rite of Passage

(2011) Carola G. Vinuesa et al.   IMMUNITY

A dynamic T cell–limited checkpoint regulates affinity-dependent B cell entry into the germinal center

(2011) Tanja A. Schwickert et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The sphingosine 1-phosphate receptor S1P2 maintains the homeostasis of germinal center B cells and promotes niche confinement

(2011) Jesse A Green et al.   NATURE IMMUNOLOGY

Impact of Ca2+ signaling on B cell function

(2011) Yoshihiro Baba et al.   TRENDS IN IMMUNOLOGY

In-vitro derived germinal centre B cells differentially generate memory B or plasma cells in vivo

(2011) Takuya Nojima et al.   Nature Communications

Germinal Center Dynamics Revealed by Multiphoton Microscopy with a Photoactivatable Fluorescent Reporter

(2010) Gabriel D. Victora et al.   CELL

Mcl-1 Is Essential for Germinal Center Formation and B Cell Memory

(2010) I. Vikstrom et al.   SCIENCE

B Cell Signaling and Fate Decision

(2009) Tomohiro Kurosaki et al.   Annual Review of Immunology

The Many Roles of FAS Receptor Signaling in the Immune System

(2009) Andreas Strasser et al.   IMMUNITY

Instructive Role of the Transcription Factor E2A in Early B Lymphopoiesis and Germinal Center B Cell Development

(2008) Kyongrim Kwon et al.   IMMUNITY