The lipid transfer proteins Nir2 and Nir3 sustain phosphoinositide signaling and actin dynamics during phagocytosis

PtdIns(3,4)P2, Lamellipodin, and VASP coordinate actin dynamics during phagocytosis in macrophages

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S-acylation by ZDHHC20 targets ORAI1 channels to lipid rafts for efficient Ca2+ signaling by Jurkat T cell receptors at the immune synapse

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Phagocytosis: Our Current Understanding of a Universal Biological Process

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Revisiting the role of calcium in phagosome formation and maturation

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Phagolysosome resolution requires contacts with the endoplasmic reticulum and phosphatidylinositol-4-phosphate signalling

(2019) Roni Levin-Konigsberg et al.   NATURE CELL BIOLOGY

Phagosome‐endoplasmic reticulum contacts: Kissing and not running

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Ca2+ and lipid signals hold hands at endoplasmic reticulum-plasma membrane contact sites

(2018) Tamas Balla   JOURNAL OF PHYSIOLOGY-LONDON

IP3 receptors and store-operated Ca2+ entry: a license to fill

(2018) Colin W Taylor et al.   CURRENT OPINION IN CELL BIOLOGY

STIM1 promotes migration, phagosomal maturation and antigen cross-presentation in dendritic cells

(2017) Paula Nunes-Hasler et al.   Nature Communications

Ca2+ signals initiate at immobile IP3 receptors adjacent to ER-plasma membrane junctions

(2017) Nagendra Babu Thillaiappan et al.   Nature Communications

The role of phosphatidylinositol-transfer proteins at membrane contact sites

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Homeostatic regulation of the PI(4,5)P 2 –Ca 2+ signaling system at ER–PM junctions

(2016) Chi-Lun Chang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Phosphatidylinositol-Phosphatidic Acid Exchange by Nir2 at ER-PM Contact Sites Maintains Phosphoinositide Signaling Competence

(2015) Yeun Ju Kim et al.   DEVELOPMENTAL CELL

Phosphatidylinositol 4,5-Bisphosphate Homeostasis Regulated by Nir2 and Nir3 Proteins at Endoplasmic Reticulum-Plasma Membrane Junctions

(2015) Chi-Lun Chang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Junctate boosts phagocytosis by recruiting endoplasmic reticulum Ca2+ stores near phagosomes

(2015) D. Guido et al.   JOURNAL OF CELL SCIENCE

The lipid-transfer protein Nir2 enhances epithelial-mesenchymal transition and facilitates breast cancer metastasis

(2014) O. Keinan et al.   JOURNAL OF CELL SCIENCE

The phosphatidylinositol-transfer protein Nir2 binds phosphatidic acid and positively regulates phosphoinositide signalling

(2013) SoHui Kim et al.   EMBO REPORTS

Phosphoinositides: Tiny Lipids With Giant Impact on Cell Regulation

(2013) Tamas Balla   PHYSIOLOGICAL REVIEWS

Role of Phospholipids in Endocytosis, Phagocytosis, and Macropinocytosis

(2013) Michal Bohdanowicz et al.   PHYSIOLOGICAL REVIEWS

Feedback Regulation of Receptor-Induced Ca2+ Signaling Mediated by E-Syt1 and Nir2 at Endoplasmic Reticulum-Plasma Membrane Junctions

(2013) Chi-Lun Chang et al.   Cell Reports

STIM1 Juxtaposes ER to Phagosomes, Generating Ca2+ Hotspots that Boost Phagocytosis

(2012) Paula Nunes et al.   CURRENT BIOLOGY

The Cell Biology of Phagocytosis

(2011) Ronald S. Flannagan et al.   Annual Review of Pathology-Mechanisms of Disease

Function of the phosphatidylinositol transfer protein gene family: is phosphatidylinositol transfer the mechanism of action?

(2011) Shamshad Cockcroft et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Phagocytosis

(2011) Roberto J. Botelho et al.   CURRENT BIOLOGY