Intracellular polyamine depletion induces N-linked galactosylation of the monoclonal antibody produced by CHO DP-12 cells

Drifts in N-Linked Glycosylation Result in ADCC Potency Variation of Perjeta® from August 2020 to October 2021 in China

(2022) Bing Yao et al.   Biomed Research International

Spermidine activates mitochondrial trifunctional protein and improves antitumor immunity in mice

(2022) Muna Al-Habsi et al.   SCIENCE

Understanding the effect of increased cell specific productivity on galactosylation of monoclonal antibodies produced using Chinese hamster ovary cells

(2021) Sri R. Madabhushi et al.   JOURNAL OF BIOTECHNOLOGY

Functional roles of polyamines and their metabolite acrolein in eukaryotic cells

(2021) Kazuei Igarashi et al.   AMINO ACIDS

Strategic feeding of NS0 and CHO cell cultures to control glycan profiles and immunogenic epitopes of monoclonal antibodies

(2021) Carina Villacrés et al.   JOURNAL OF BIOTECHNOLOGY

The Cross-Links of Endoplasmic Reticulum Stress, Autophagy, and Neurodegeneration in Parkinson’s Disease

(2021) Haigang Ren et al.   Frontiers in Aging Neuroscience

Antibody glycosylation: impact on antibody drug characteristics and quality control

(2020) Ziyan Wang et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Vesicular polyamine transporter as a novel player in amine-mediated chemical transmission

(2020) Yoshinori Moriyama et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Demonstrating Analytical Similarity of Trastuzumab Biosimilar HLX02 to Herceptin® with a Panel of Sensitive and Orthogonal Methods Including a Novel FcγRIIIa Affinity Chromatography Technology

(2020) Liqi Xie et al.   BIODRUGS

Calnexin cycle – structural features of the ER chaperone system

(2020) Guennadi Kozlov et al.   FEBS Journal

Defects in Galactose Metabolism and Glycoconjugate Biosynthesis in a UDP-Glucose Pyrophosphorylase-Deficient Cell Line Are Reversed by Adding Galactose to the Growth Medium

(2020) Christelle Durrant et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Future perspectives of therapeutic monoclonal antibodies

(2019) Kanta Tsumoto et al.   Immunotherapy

In-depth site-specific O-Glycosylation analysis of therapeutic Fc-fusion protein by electron-transfer/higher-energy collisional dissociation mass spectrometry

(2019) Noritaka Hashii et al.   BIOLOGICALS

An arginase-based system for selection of transfected CHO cells without the use of toxic chemicals

(2019) Berta Capella Roca et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural basis for coupling protein transport and N-glycosylation at the mammalian endoplasmic reticulum

(2018) Katharina Braunger et al.   SCIENCE

Assessing the Heterogeneity of the Fc-Glycan of a Therapeutic Antibody Using an engineered FcγReceptor IIIa-Immobilized Column

(2018) Masato Kiyoshi et al.   Scientific Reports

Effects of polyamines on protein synthesis and growth ofEscherichia coli

(2018) Kazuei Igarashi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The atomic structure of a eukaryotic oligosaccharyltransferase complex

(2018) Lin Bai et al.   NATURE

Polyamines stimulate the CHSY1 synthesis through the unfolding of the RNA G-quadruplex at the 5′-untraslated region

(2018) Katsutoshi Yamaguchi et al.   BIOCHEMICAL JOURNAL

Fc-Galactosylation of Human Immunoglobulin Gamma Isotypes Improves C1q Binding and Enhances Complement-Dependent Cytotoxicity

(2017) Benjamin Peschke et al.   Frontiers in Immunology

Brefeldin A promotes the appearance of oligosaccharyl phosphates derived from Glc3Man9GlcNAc2-PP-dolichol within the endomembrane system of HepG2 cells

(2016) Ahmad Massarweh et al.   JOURNAL OF LIPID RESEARCH

Fc-galactosylation modulates antibody-dependent cellular cytotoxicity of therapeutic antibodies

(2016) Marco Thomann et al.   MOLECULAR IMMUNOLOGY

Polyamines release the let-7b-mediated suppression of initiation codon recognition during the protein synthesis of EXT2

(2016) Masataka Imamura et al.   Scientific Reports

A multi-pronged investigation into the effect of glucose starvation and culture duration on fed-batch CHO cell culture

(2015) Yuzhou Fan et al.   BIOTECHNOLOGY AND BIOENGINEERING

TFE3 Is a bHLH-ZIP-type Transcription Factor that Regulates the Mammalian Golgi Stress Response

(2015) Mai Taniguchi et al.   CELL STRUCTURE AND FUNCTION

Sialylation of IgG Fc domain impairs complement-dependent cytotoxicity

(2015) Isaak Quast et al.   JOURNAL OF CLINICAL INVESTIGATION

Engineered CHO cells for production of diverse, homogeneous glycoproteins

(2015) Zhang Yang et al.   NATURE BIOTECHNOLOGY

Glycosylation-directed quality control of protein folding

(2015) Chengchao Xu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Amino acid and glucose metabolism in fed-batch CHO cell culture affects antibody production and glycosylation

(2014) Yuzhou Fan et al.   BIOTECHNOLOGY AND BIOENGINEERING

Organizational Interplay of GolgiN-Glycosyltransferases Involves Organelle Microenvironment-Dependent Transitions between Enzyme Homo- and Heteromers

(2014) Antti Hassinen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pentamines as Substrate for Human Spermine Oxidase

(2013) Koichi Takao et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Metabolically programmed quality control system for dolichol-linked oligosaccharides

(2013) Y. Harada et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Production platforms for biotherapeutic glycoproteins. Occurrence, impact, and challenges of non-human sialylation

(2012) Darius Ghaderi et al.   Biotechnology & Genetic Engineering Reviews

Modulation of antibody galactosylation through feeding of uridine, manganese chloride, and galactose

(2011) Michael J. Gramer et al.   BIOTECHNOLOGY AND BIOENGINEERING

Analysis and metabolic engineering of lipid-linked oligosaccharides in glycosylation-deficient CHO cells

(2010) Meredith B. Jones et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Role of Polyamines in Supporting Growth of Mammalian Cells Is Mediated through Their Requirement for Translation Initiation and Elongation

(2010) Guy Landau et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chinese hamster ovary cells can produce galactose-α-1,3-galactose antigens on proteins

(2010) Carlos J Bosques et al.   NATURE BIOTECHNOLOGY

Characteristics of cellular polyamine transport in prokaryotes and eukaryotes

(2010) Kazuei Igarashi et al.   PLANT PHYSIOLOGY AND BIOCHEMISTRY

The Compartmentalisation of Phosphorylated Free Oligosaccharides in Cells from a CDG Ig Patient Reveals a Novel ER-to-Cytosol Translocation Process

(2010) Delphine Peric et al.   PLoS One

Structure of the Noncatalytic Domains and Global Fold of the Protein Disulfide Isomerase ERp72

(2009) Guennadi Kozlov et al.   STRUCTURE