The Molecular Circadian Clock Is a Target of Anti-cancer Translation Inhibitors

Development and characterization of anti-fibrotic natural compound similars with improved effectivity

(2022) Fabian Philipp Kreutzer et al.   BASIC RESEARCH IN CARDIOLOGY

The circadian immune system

(2022) Chen Wang et al.   Science Immunology

A circadian clock translational control mechanism targets specific mRNAs to cytoplasmic messenger ribonucleoprotein granules

(2022) Kathrina D. Castillo et al.   Cell Reports

The rocaglate CR-31-B (−) inhibits SARS-CoV-2 replication at non-cytotoxic, low nanomolar concentrations in vitro and ex vivo

(2021) Christin Müller et al.   ANTIVIRAL RESEARCH

The circadian clock and metabolic homeostasis: entangled networks

(2021) Leonardo Vinícius Monteiro de Assis et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Inhibitors of Eukaryotic Translational Machinery as Therapeutic Agents

(2021) Angela Fan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Homoharringtonine Exerts Anti-tumor Effects in Hepatocellular Carcinoma Through Activation of the Hippo Pathway

(2021) Haina Wang et al.   Frontiers in Pharmacology

Narciclasine attenuates sepsis-induced myocardial injury by modulating autophagy

(2021) Rong Tang et al.   Aging-US

Paclitaxel chemotherapy disrupts behavioral and molecular circadian clocks in mice

(2021) Kyle A. Sullivan et al.   BRAIN BEHAVIOR AND IMMUNITY

Structural Insights into the Interactions of Digoxin and Na+/K+-ATPase and Other Targets for the Inhibition of Cancer Cell Proliferation

(2021) Yulin Ren et al.   MOLECULES

Nitecap: An Exploratory Circadian Analysis Web Application

(2021) Thomas G. Brooks et al.   JOURNAL OF BIOLOGICAL RHYTHMS

Methods for Detecting PER2:LUCIFERASE Bioluminescence Rhythms in Freely Moving Mice

(2021) Blanca Martin-Burgos et al.   JOURNAL OF BIOLOGICAL RHYTHMS

Proteomics reveal cap-dependent translation inhibitors remodel the translation machinery and translatome

(2021) J.J. David Ho et al.   Cell Reports

Adverse cardiac effects of cancer therapies: cardiotoxicity and arrhythmia

(2020) Joerg Herrmann   Nature Reviews Cardiology

Remdesivir, lopinavir, emetine, and homoharringtonine inhibit SARS-CoV-2 replication in vitro

(2020) Ka-Tim Choy et al.   ANTIVIRAL RESEARCH

Perturbation of the circadian clock and pathogenesis of NAFLD

(2020) Atish Mukherji et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Therapeutics on the clock: Circadian medicine in the treatment of chronic inflammatory diseases

(2020) Haritha Jacob et al.   BIOCHEMICAL PHARMACOLOGY

A steroid receptor coactivator stimulator (MCB-613) attenuates adverse remodeling after myocardial infarction

(2020) Lisa K. Mullany et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GIANT: galaxy-based tool for interactive analysis of transcriptomic data

(2020) Jimmy Vandel et al.   Scientific Reports

Structural insights of key enzymes into therapeutic intervention against SARS-CoV-2

(2020) Munazza Shahid et al.   JOURNAL OF STRUCTURAL BIOLOGY

Homoharringtonine exhibits potent anti-tumor effect and modulates DNA epigenome in acute myeloid leukemia by targeting SP1/TET1/5hmC

(2019) Chenying Li et al.   HAEMATOLOGICA

Digoxin sensitizes gemcitabine-resistant pancreatic cancer cells to gemcitabine via inhibiting Nrf2 signaling pathway

(2019) Yunjiang Zhou et al.   Redox Biology

L1000FWD: fireworks visualization of drug-induced transcriptomic signatures

(2018) Zichen Wang et al.   BIOINFORMATICS

Identification of circadian clock modulators from existing drugs

(2018) T Katherine Tamai et al.   EMBO Molecular Medicine

Daytime variation of perioperative myocardial injury in cardiac surgery and its prevention by Rev-Erbα antagonism: a single-centre propensity-matched cohort study and a randomised study

(2018) David Montaigne et al.   LANCET

Training the Circadian Clock, Clocking the Drugs, and Drugging the Clock to Prevent, Manage, and Treat Chronic Diseases

(2018) Gabriele Sulli et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

DRUG-seq for miniaturized high-throughput transcriptome profiling in drug discovery

(2018) Chaoyang Ye et al.   Nature Communications

Circadian Amplitude Regulation via FBXW7-Targeted REV-ERBα Degradation

(2016) Xuan Zhao et al.   CELL

Upstream Open Reading Frames Differentially Regulate Gene-specific Translation in the Integrated Stress Response

(2016) Sara K. Young et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of a Steroid Receptor Coactivator Small Molecule Stimulator that Overstimulates Cancer Cells and Leads to Cell Stress and Death

(2015) Lei Wang et al.   CANCER CELL

Ribosome profiling reveals the rhythmic liver translatome and circadian clock regulation by upstream open reading frames

(2015) Peggy Janich et al.   GENOME RESEARCH

Circadian and feeding rhythms differentially affect rhythmic mRNA transcription and translation in mouse liver

(2015) Florian Atger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rhythmic Degradation Explains and Unifies Circadian Transcriptome and Proteome Data

(2014) Sarah Lück et al.   Cell Reports

Homoharringtonine/Omacetaxine Mepesuccinate: The Long and Winding Road to Food and Drug Administration Approval

(2013) Hagop M. Kantarjian et al.   Clinical Lymphoma Myeloma & Leukemia

Mechanism for 12 Hr Rhythm Generation by the Circadian Clock

(2013) Pål O. Westermark et al.   Cell Reports

Cardiac Atrial Circadian Rhythms in PERIOD2::LUCIFERASE and per1:luc Mice: Amplitude and Phase Responses to Glucocorticoid Signaling and Medium Treatment

(2012) Daan R. van der Veen et al.   PLoS One

Digitoxin and a synthetic monosaccharide analog inhibit cell viability in lung cancer cells

(2011) Hosam A. Elbaz et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The mechanism of eukaryotic translation initiation and principles of its regulation

(2010) Richard J. Jackson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structure–activity relationship study of bone morphogenetic protein (BMP) signaling inhibitors

(2008) Gregory D. Cuny et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Circadian gene expression is resilient to large fluctuations in overall transcription rates

(2008) Charna Dibner et al.   EMBO JOURNAL

A High-Throughput Assay for siRNA-Based Circadian Screens in Human U2OS Cells

(2008) Christopher Vollmers et al.   PLoS One