Article
Chemistry, Physical
Shringika Soni, Utkarsh Jain, Donald H. Burke, Nidhi Chauhan
Summary: Prescription stimulant drug (PSD) abuse is a global concern, and there is a need for the development of sensitive, rapid, and low-cost kits for on-spot PSD detection. In this study, a gold nanoflower modified, electrochemical aptasensor was successfully developed for Amphetamine (AMP) detection. The aptasensor showed high sensitivity, low limit of detection, and negligible interference from potentially interfering compounds. It was able to accurately detect AMP in spiked urine and water samples.
SURFACES AND INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Yawei Wang, Lei Chen, Tiantian Xuan, Jian Wang, Xiuwen Wang
Summary: An integrated electrode system consisting of a graphene working electrode, a carbon counter electrode, and an Ag/AgCl reference electrode was fabricated for label-free detection of carcinoembryonic antigen. The linear relationship between CEA concentration (0.2-15.0 ng/ml) and impedance change was demonstrated, with a calculated detection limit of 0.085 ng/ml.
FRONTIERS IN CHEMISTRY
(2021)
Article
Chemistry, Analytical
Jintao Liang, Fei Guo, Jiaying Huang, Xiaohong Tan, Lixian Sun, Zhide Zhou, Guiyin Li
Summary: An ultrasensitive label-free electrochemical aptasensing platform was constructed for the detection of GP73 protein in hepatocellular carcinoma.
MICROCHEMICAL JOURNAL
(2023)
Article
Chemistry, Analytical
Qingteng Lai, Yanke Zhang, Wei Chen, Zhengchun Liu
Summary: In this study, an ultrasensitive electrochemical-detection system was established for the detection of microRNA-141 (miRNA-141). A three-dimensional porous film was constructed on the electrode surface using chitosan, catechol, and nanomaterials. The system achieved a high sensitivity and stability of miRNA-141 detection by introducing ferrocene (Fc) into the electrode surface and forming a pseudocapacitor. The linear detection range was 0.5 fM to 800 pM, with a detection limit of 43.73 aM. This system overcame the limitations of traditional electroactive-ion labeling methods.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Biochemical Research Methods
Raluca-Ioana Stefan-van Staden, Andreea-Roxana Niculae, Jacobus Frederick van Staden, Ramona Georgescu State, Paula Sfirloaga
Summary: Two sensors based on nanographene decorated with gold nanoparticle paste modified with metal porphyrins were proposed for the ultrasensitive determination of sorbic acid in food. Square-wave voltammetry was used for the characterization and validation of the sensors. The sensors showed high sensitivity and reliability, making them suitable for the determination of sorbic acid in food.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Bongjin Jeong, Rashida Akter, Jeonghyun Oh, Dong-Gi Lee, Chang-Geun Ahn, Jong-Soon Choi, Md. Aminur Rahman
Summary: A novel and facile biosensor for post-mortem interval (PMI) detection was developed using a double-label strategy to detect the glyceraldehyde 3-phosphate dehydrogenase (GAPDH) biomarker. The sensor showed high sensitivity and selectivity for GAPDH, making it a promising tool for PMI determination in real samples.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Analytical
Joohyung Park, Minwoo Kim, Woochang Kim, Seongjae Jo, Woong Kim, Chihyun Kim, Hyunjun Park, Wonseok Lee, Jinsung Park
Summary: We developed a novel electrochemical aptasensor for the quantitative detection of 25-hydroxy vitamin D-3 in saliva, which is highly selective and ultra-sensitive.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Chemistry, Analytical
Lina Wang, Xiangbiao Zeng, Li Zhang, Ying Yu, Bixia Lin, Yumin Wang, Manli Guo, Yujuan Cao
Summary: In this study, a novel field-free electrochemical sensor based on inverted Y-type DNA conformation was developed for ultrasensitive determination of tetracycline. The sensor utilized the transformation of self-structure to generate signal response, avoiding steric hindrance effect, and reducing the influence of nonspecific signal on measurement accuracy through reference proportion.
MICROCHEMICAL JOURNAL
(2022)
Article
Chemistry, Applied
Tao Zhan, Xiao-Zhen Feng, Yun-Yun Cheng, Guo-Cheng Han, Zhencheng Chen, Heinz-Bernhard Kraatz
Summary: We developed a facile sensor by conjugating heme with gold nanoparticles on a glass carbon electrode for the ultrasensitive detection of biotin. This sensor exhibits a broad detection range and a low detection limit. The mechanism of biotin electrooxidation was elucidated through electrochemical analyses and calculations. The sensor shows excellent selectivity, reproducibility, and stability, making it suitable for practical applications.
Article
Chemistry, Analytical
Jing Xu, Yinbing Liu, Ke-Jing Huang, Yang-Yang Hou, Xiaoxuan Sun, Jiaqiang Li
Summary: Realization of a highly sensitive analysis and sensing platform is crucial for early-stage tumor diagnosis. In this study, a self-powered biosensor with a novel sandwich graphdiyne (SGDY) structure combined with an aptamer-specific recognition function was developed to sensitively and accurately detect tumor markers.
ANALYTICAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Saloni Kakkar, Sakshi Chauhan, Manojkumar Rohit, Vijayender Bhalla
Summary: This study reports a label-free ultrasensitive electrochemical aptasensor (GO@GNP-A) for detecting cardiac biomarker Troponin I (TnI). The nanohybrid of graphene oxide (GO) and gold nanoparticles (GNP-A) is self-assembled to form the nanohybrid (GO@GNP-A), onto which the biomarker protein is analyzed. TnI interactions at the aptamer biointerfaced nanohybrid surface cause electrochemical signal enhancement. The sensitivity of this nanohybrid aptasensor platform is 0.001 pg/mL. The study has been further validated in clinical samples for early, sensitive, and efficient point-of-care detection of TnI in cases of Acute Myocardial Infarction (AMI).
BIOELECTROCHEMISTRY
(2023)
Article
Nanoscience & Nanotechnology
Derrick Butler, David Moore, Nicholas R. Glavin, Joshua A. Robinson, Aida Ebrahimi
Summary: The study demonstrates that by tuning the surface chemistry of graphene through a simple one-step annealing process, commercially available graphene ink can achieve selective and highly sensitive detection of dopamine. Optimal conditions lead to distinguishable and selective response to dopamine down to 5 pM, paving the way for developing sensitive and low-cost biosensors with potential applications in point-of-care diagnostics.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Nanoscience & Nanotechnology
Tingting Wang, Yifei He, Lei Shi, Jiangping Cao, Baizhao Zeng, Faqiong Zhao
Summary: In this study, a BiOBr0.8I0.2/CoSx nanocomposite with high photoelectrochemical and electrochemical activity was successfully prepared and used to construct a dual-mode sensing platform for the detection of HER2. The sensing platform showed low detection limits, large linear ranges, and excellent stability and applicability.
ACS APPLIED NANO MATERIALS
(2022)
Article
Biophysics
Ruiting Xu, Lidya Abune, Brandon Davis, Leixin Ouyang, Ge Zhang, Yong Wang, Jiang Zhe
Summary: This article introduces a method for detecting small biomolecules based on molecular recognition and nanoparticle counting. By releasing nanoparticles and counting them using a micropore sensor, the concentration of target biomolecules can be measured with high sensitivity and high throughput. The experiments demonstrate that this method has a low detection limit and high reproducibility, showing great potential for the ultrasensitive detection of low abundance small biomolecules.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Engineering, Electrical & Electronic
Nirgaman Bage, Pradip Kar
Summary: The study investigated the influence of silver nanoparticles labeled with biomolecules on electrochemical sensing, showing that AgNP labeled layers can serve as ultrasensitive detectors for detecting biotin-avidin couple and sensing concentration changes even at higher concentrations.
IEEE SENSORS JOURNAL
(2021)
