期刊
ANALYTICAL CHEMISTRY
卷 94, 期 49, 页码 16980-16986出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.analchem.2c04278
关键词
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资金
- Talent Introduction Start-Up Foundation of Guangxi Minzu Uni-versity
- Natural Science Foundation of China
- [2021KJQD08]
- [22074130]
Realization of a highly sensitive analysis and sensing platform is crucial for early-stage tumor diagnosis. In this study, a self-powered biosensor with a novel sandwich graphdiyne (SGDY) structure combined with an aptamer-specific recognition function was developed to sensitively and accurately detect tumor markers.
Realization of a highly sensitive analysis and sensing platform is important for early-stage tumor diagnosis. In this work, a self-powered biosensor with a novel sandwich graphdiyne (SGDY) combined with an aptamer-specific recognition function was developed to sensitively and accurately detect tumor markers. Results indicated that the detection limits of microRNA (miRNA)-21 and miRNA-141 were 0.15 and 0.30 fM (S/N = 3) in the linear range of 0.05-10000 and 1-10000 fM, respectively. The newly designed platform has great promise for early-stage tumor diagnosis.
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