Wherefore Art Tau? Functional importance of site-specific tau phosphorylation in diverse subcellular domains

Cerebrospinal fluid p-tau231 as an early indicator of emerging pathology in Alzheimer's disease

(2022) Nicholas J. Ashton et al.   EBioMedicine

Tau differentially regulates the transport of early endosomes and lysosomes

(2022) Linda Balabanian et al.   MOLECULAR BIOLOGY OF THE CELL

Maturation of neuronal AD-tau pathology involves site-specific phosphorylation of cytoplasmic and synaptic tau preceding conformational change and fibril formation

(2021) Luis Aragão Gomes et al.   ACTA NEUROPATHOLOGICA

Tau aggregates are RNA-protein assemblies that mislocalize multiple nuclear speckle components

(2021) Evan Lester et al.   NEURON

A current view on Tau protein phosphorylation in Alzheimer's disease

(2021) Susanne Wegmann et al.   CURRENT OPINION IN NEUROBIOLOGY

Synaptic tau: A pathological or physiological phenomenon?

(2021) Miranda Robbins et al.   Acta Neuropathologica Communications

Phosphorylation of the overlooked tyrosine 310 regulates the structure, aggregation, and microtubule- and lipid-binding properties of Tau

(2020) Nadine Ait-Bouziad et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tau PTM Profiles Identify Patient Heterogeneity and Stages of Alzheimer’s Disease

(2020) Hendrik Wesseling et al.   CELL

Tau Phosphorylation Rates Measured by Mass Spectrometry Differ in the Intracellular Brain vs. Extracellular Cerebrospinal Fluid Compartments and Are Differentially Affected by Alzheimer’s Disease

(2019) Nicolas R. Barthélemy et al.   Frontiers in Aging Neuroscience

Propagation of Tau via Extracellular Vesicles

(2019) Mar Pérez et al.   Frontiers in Neuroscience

Tau Propagation as a Diagnostic and Therapeutic Target for Dementia: Potentials and Unanswered Questions

(2019) Shuko Takeda   Frontiers in Neuroscience

The Binding Mode of a Tau Peptide with Tubulin

(2018) Harindranath Kadavath et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Detection of Aggregation-Competent Tau in Neuron-Derived Extracellular Vesicles

(2018) Francesc Guix et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Synaptogyrin-3 Mediates Presynaptic Dysfunction Induced by Tau

(2018) Joseph McInnes et al.   NEURON

A role for tau in learning, memory and synaptic plasticity

(2018) Fabrizio Biundo et al.   Scientific Reports

Unconventional Secretion Mediates the Trans-cellular Spreading of Tau

(2018) Taxiarchis Katsinelos et al.   Cell Reports

Tauopathies and Tau Oligomers

(2018) Akihiko Takashima   JOURNAL OF ALZHEIMERS DISEASE

Designing antibodies against LRRK2-targeted tau epitopes

(2018) Matthew Hamm et al.   PLoS One

The AMPA Receptor Code of Synaptic Plasticity

(2018) Graham H. Diering et al.   NEURON

Secretion of Tau via an Unconventional Non-vesicular Mechanism

(2018) Maria Merezhko et al.   Cell Reports

Extracellular Tau Oligomers Induce Invasion of Endogenous Tau into the Somatodendritic Compartment and Axonal Transport Dysfunction

(2017) Eric Swanson et al.   JOURNAL OF ALZHEIMERS DISEASE

The release and trans-synaptic transmission of Tau via exosomes

(2017) Yipeng Wang et al.   Molecular Neurodegeneration

Neurofibrillary Tangle Stage and the Rate of Progression of Alzheimer Symptoms

(2017) Jing Qian et al.   JAMA Neurology

Extracellular Tau and Its Potential Role in the Propagation of Tau Pathology

(2017) Kaoru Yamada   Frontiers in Neuroscience

High–Molecular-Weight Paired Helical Filaments from Alzheimer Brain Induces Seeding of Wild-Type Mouse Tau into an Argyrophilic 4R Tau Pathology in Vivo

(2016) Emilie Audouard et al.   AMERICAN JOURNAL OF PATHOLOGY

Seed-competent high-molecular-weight tau species accumulates in the cerebrospinal fluid of Alzheimer's disease mouse model and human patients

(2016) Shuko Takeda et al.   ANNALS OF NEUROLOGY

Tau phosphorylation at Alzheimer's disease-related Ser356 contributes to tau stabilization when PAR-1/MARK activity is elevated

(2016) Kanae Ando et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Extracellular Vesicles Containing P301L Mutant Tau Accelerate Pathological Tau Phosphorylation and Oligomer Formation but Do Not Seed Mature Neurofibrillary Tangles in ALZ17 Mice

(2016) Siân Baker et al.   JOURNAL OF ALZHEIMERS DISEASE

Comprehensive Quantitative Profiling of Tau and Phosphorylated Tau Peptides in Cerebrospinal Fluid by Mass Spectrometry Provides New Biomarker Candidates

(2016) Claire L. Russell et al.   JOURNAL OF ALZHEIMERS DISEASE

Extracellular Vesicles Isolated from the Brains of rTg4510 Mice Seed Tau Protein Aggregation in a Threshold-dependent Manner

(2016) Juan Carlos Polanco et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Co-immunoprecipitation with Tau Isoform-specific Antibodies Reveals Distinct Protein Interactions and Highlights a Putative Role for 2N Tau in Disease

(2016) Chang Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Unique pathological tau conformers from Alzheimer’s brains transmit tau pathology in nontransgenic mice

(2016) Jing L. Guo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Neuronal activity enhances tau propagation and tau pathology in vivo

(2016) Jessica W Wu et al.   NATURE NEUROSCIENCE

Tunneling nanotubes: A possible highway in the spreading of tau and other prion-like proteins in neurodegenerative diseases

(2016) Saida Abounit et al.   Prion

The Prion-Like Behavior of Assembled Tau in Transgenic Mice

(2016) Florence Clavaguera et al.   Cold Spring Harbor Perspectives in Medicine

Tunneling nanotube (TNT)-mediated neuron-to neuron transfer of pathological Tau protein assemblies

(2016) Meryem Tardivel et al.   Acta Neuropathologica Communications

RNA Binds to Tau Fibrils and Sustains Template-Assisted Growth

(2015) Paul D. Dinkel et al.   BIOCHEMISTRY

Pseudophosphorylation of Tau at distinct epitopes or the presence of the P301L mutation targets the microtubule-associated protein Tau to dendritic spines

(2015) Di Xia et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Cellular Models of Aggregation-dependent Template-directed Proteolysis to Characterize Tau Aggregation Inhibitors for Treatment of Alzheimer Disease

(2015) Charles R. Harrington et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tau regulates the localization and function of End-binding proteins 1 and 3 in developing neuronal cells

(2015) Carmen Laura Sayas et al.   JOURNAL OF NEUROCHEMISTRY

Pre-synaptic C-terminal truncated tau is released from cortical synapses in Alzheimer's disease

(2015) Sophie Sokolow et al.   JOURNAL OF NEUROCHEMISTRY

Tau Phosphorylation at Serine 396 Residue Is Required for Hippocampal LTD

(2015) P. Regan et al.   JOURNAL OF NEUROSCIENCE

Tau post-translational modifications in wild-type and human amyloid precursor protein transgenic mice

(2015) Meaghan Morris et al.   NATURE NEUROSCIENCE

Tau in physiology and pathology

(2015) Yipeng Wang et al.   NATURE REVIEWS NEUROSCIENCE

Human secreted tau increases amyloid-beta production

(2015) Jessica Bright et al.   NEUROBIOLOGY OF AGING

Tau phosphorylation regulates the interaction between BIN1’s SH3 domain and Tau’s proline-rich domain

(2015) Yoann Sottejeau et al.   Acta Neuropathologica Communications

Lysine methylation is an endogenous post-translational modification of tau protein in human brain and a modulator of aggregation propensity

(2014) Kristen E. Funk et al.   BIOCHEMICAL JOURNAL

Neuronal activity regulates extracellular tau in vivo

(2014) Kaoru Yamada et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Intersection of Amyloid Beta and Tau at Synapses in Alzheimer’s Disease

(2014) Tara L. Spires-Jones et al.   NEURON

Ectosomes: A New Mechanism for Non-Exosomal Secretion of Tau Protein

(2014) Simon Dujardin et al.   PLoS One

Physiological release of endogenous tau is stimulated by neuronal activity

(2013) Amy M Pooler et al.   EMBO REPORTS

Microtubule-based transport - basic mechanisms, traffic rules and role in neurological pathogenesis

(2013) M. A. M. Franker et al.   JOURNAL OF CELL SCIENCE

Synthetic Tau Fibrils Mediate Transmission of Neurofibrillary Tangles in a Transgenic Mouse Model of Alzheimer's-Like Tauopathy

(2013) M. Iba et al.   JOURNAL OF NEUROSCIENCE

Tau pathology and neurodegeneration

(2013) Maria Grazia Spillantini et al.   LANCET NEUROLOGY

The CAMKK2-AMPK Kinase Pathway Mediates the Synaptotoxic Effects of Aβ Oligomers through Tau Phosphorylation

(2013) Georges Mairet-Coello et al.   NEURON

A role for tau at the synapse in Alzheimer's disease pathogenesis

(2013) Amy M. Pooler et al.   NEUROPHARMACOLOGY

Microtubule-associated protein tau is essential for long-term depression in the hippocampus

(2013) T. Kimura et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Interaction of Endogenous Tau Protein with Synaptic Proteins Is Regulated byN-Methyl-d-aspartate Receptor-dependent Tau Phosphorylation

(2012) Siddhartha Mondragón-Rodríguez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Constitutive secretion of tau protein by an unconventional mechanism

(2012) Xiyun Chai et al.   NEUROBIOLOGY OF DISEASE

Propagation of Tau Pathology in a Model of Early Alzheimer's Disease

(2012) Alix de Calignon et al.   NEURON

Hyperphosphorylation and Cleavage at D421 Enhance Tau Secretion

(2012) Vanessa Plouffe et al.   PLoS One

Human P301L-Mutant Tau Expression in Mouse Entorhinal-Hippocampal Network Causes Tau Aggregation and Presynaptic Pathology but No Cognitive Deficits

(2012) Julie A. Harris et al.   PLoS One

Exosome-associated Tau Is Secreted in Tauopathy Models and Is Selectively Phosphorylated in Cerebrospinal Fluid in Early Alzheimer Disease

(2011) Sudad Saman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dendritic Function of Tau Mediates Amyloid-β Toxicity in Alzheimer's Disease Mouse Models

(2010) Lars M. Ittner et al.   CELL

Genome-wide Analysis of Genetic Loci Associated With Alzheimer Disease

(2010) Sudha Seshadri   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Nuclear Tau, a Key Player in Neuronal DNA Protection

(2010) Audrey Sultan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A  Oligomers Cause Localized Ca2+ Elevation, Missorting of Endogenous Tau into Dendrites, Tau Phosphorylation, and Destruction of Microtubules and Spines

(2010) H. Zempel et al.   JOURNAL OF NEUROSCIENCE

Tau Mislocalization to Dendritic Spines Mediates Synaptic Dysfunction Independently of Neurodegeneration

(2010) Brian R. Hoover et al.   NEURON

Propagation of Tau Misfolding from the Outside to the Inside of a Cell

(2009) Bess Frost et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transmission and spreading of tauopathy in transgenic mouse brain

(2009) Florence Clavaguera et al.   NATURE CELL BIOLOGY

Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease

(2009) Jean-Charles Lambert et al.   NATURE GENETICS

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

(2009) Denise Harold et al.   NATURE GENETICS

A novel GSK-3β inhibitor reduces Alzheimer's pathology and rescues neuronal loss in vivo

(2009) L. Serenó et al.   NEUROBIOLOGY OF DISEASE

A systematic investigation of the protein kinases involved in NMDA receptor-dependent LTD: evidence for a role of GSK-3 but not other serine/threonine kinases

(2009) Stéphane Peineau et al.   Molecular Brain

Proline-directed Pseudo-phosphorylation at AT8 and PHF1 Epitopes Induces a Compaction of the Paperclip Folding of Tau and Generates a Pathological (MC-1) Conformation

(2008) Sadasivam Jeganathan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tyrosine phosphorylation of ionotropic glutamate receptors by Fyn or Src differentially modulates their susceptibility to calpain and enhances their binding to spectrin and PSD-95

(2003) Yongqi Rong et al.   JOURNAL OF NEUROCHEMISTRY