Review
Medicine, Research & Experimental
Xiaofan Yang, Yupeng Ma, Xin Chen, Jingjing Zhu, Wenlong Xue, Ke Ning
Summary: Cardiovascular diseases are a leading cause of illness and death globally, with atherosclerosis (AS)-caused cardiovascular disease being the main cause of death. Neutrophil extracellular traps (NETs) play a crucial role in promoting endothelial inflammation in AS. Understanding the mechanisms of NETs in AS is important as they could potentially serve as a new therapeutic target. This review summarizes the possible mechanisms of NETs in AS.
Review
Immunology
Andrea Herrero-Cervera, Oliver Soehnlein, Ellinor Kenne
Summary: Chronic inflammation is a common feature of many diseases and is especially prevalent in the aging population. The role of neutrophils in chronic inflammation is still not well understood, with conflicting evidence suggesting both beneficial and detrimental effects. However, emerging evidence indicates that neutrophils play a significant role in several chronic diseases.
CELLULAR & MOLECULAR IMMUNOLOGY
(2022)
Review
Medicine, General & Internal
Yuan Dong, Yuejie Zhang, Xuanyi Yang, Cen Yan, Yingmei Feng
Summary: This review introduces the roles of neutrophil extracellular traps (NETs) in immunity and non-infectious diseases, as well as their pathological involvement in cardiovascular disease. The focus is on how NETs contribute to cardiovascular disease progression and options for clinical intervention to inhibit NETs production and release.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Remo Poto, Leonardo Cristinziano, Luca Modestino, Amato de Paulis, Gianni Marone, Stefania Loffredo, Maria Rosaria Galdiero, Gilda Varricchi
Summary: Human neutrophils play a significant role in the host response against pathogens, and recent research has revealed their functional plasticity and involvement in cancer and angiogenesis. Neutrophils release angiogenic factors and form NETs, which promote tumor growth and metastasis through various mechanisms. Understanding the functions of NETs in cancer and angiogenesis could be important for early diagnosis, prevention, and treatment of tumors.
Review
Biochemistry & Molecular Biology
Maria Amparo Blanch-Ruiz, Raquel Ortega-Luna, Maria Angeles Martinez-Cuesta, Angeles Alvarez
Summary: Cardiovascular diseases are a leading cause of death, with blood-cell interactions and endothelial dysfunction playing a key role in thrombus formation. Neutrophil extracellular vesicles (EVs) and neutrophil extracellular traps (NETs) have been reported to contribute to thrombosis through various mechanisms, requiring exhaustive analysis of their structure and composition to clarify their role in pathological thrombus formation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Muhammad H. Shahzad, Lixuan Feng, Xin Su, Ariane Brassard, Iqraa Dhoparee-Doomah, Lorenzo E. Ferri, Jonathan D. Spicer, Jonathan J. Cools-Lartigue
Summary: Neutrophils play a role in cancer by releasing neutrophil extracellular traps (NETs) that interact with cancer cells, driving resistance to therapy. NETs are involved in various mechanisms of therapy resistance, including T-cell exhaustion, drug detoxification, angiogenesis, and extracellular matrix remodeling. Therefore, understanding and targeting NETs is crucial for effective cancer treatment.
Editorial Material
Oncology
Phei Er Saw, Jianing Chen, Erwei Song
Summary: Neutrophil extracellular traps (NETs) are involved in both infection control and tumor metastasis. The study by Mousset et al. published in Cancer Cell reveals that chemotherapy-induced inflammation promotes NETosis in malignant tumors, leading to chemoresistance. This finding highlights the potential of targeting inflammatory NETs for cancer treatment.
Review
Immunology
Puneetpal Singh, Nitin Kumar, Monica Singh, Manminder Kaur, Gurjinderpal Singh, Amit Narang, Abhinav Kanwal, Kirti Sharma, Baani Singh, Mario Di Napoli, Sarabjit Mastana
Summary: Atherosclerosis is the formation of plaque within arteries, caused by the accumulation of fats, cholesterol, and fibrous material, leading to blockage of blood flow and ischemia. It has a significant impact on global health statistics, being the main cause of morbidity and mortality for diseases such as rheumatological, heart, and brain disorders. Inflammation and coagulatory mediators contribute to the development and worsening of atherosclerotic plaque, with neutrophil extracellular traps and NLRP3 playing a significant role in this process. This review focuses on the contribution of these two processes in atherosclerosis, inflammation, and atherothrombosis.
Article
Immunology
Carlos Blanco-Camarillo, Omar Rafael Aleman, Carlos Rosales
Summary: The article discusses the different phenotypes and functional states of neutrophils in healthy and pathological conditions, with a focus on the presence and cellular functions of low-density neutrophils (LDN) in the blood of healthy individuals.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Medicine, Research & Experimental
Chun Gu, Bo Pang, Shipeng Sun, Cheng An, Min Wu, Na Wang, Yuliang Yuan, Guijian Liu
Summary: Neutrophil extracellular traps (NETs) are network-like structures released by activated neutrophils, which play a role in capturing pathogens and responding to sterile inflammatory stimuli. They are also involved in the pathogenesis of atherosclerosis, contributing to cellular dysfunction and tissue damage. This review discusses the role of NETs in atherosclerosis, including their interaction with lipids and inflammasomes, crosstalk with smooth muscle cells and inflammatory cells, and their potential as biomarkers and therapeutic targets.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Giacomo Buso, Elisabetta Faggin, Nathalie Rosenblatt-Velin, Maxime Pellegrin, Silvia Galliazzo, Luca Calanca, Marcello Rattazzi, Lucia Mazzolai
Summary: In recent years, the role of neutrophils in cardiovascular disease (CVD) has received increasing attention. Neutrophils have been found to play a role in the initiation, progression, and rupture of atherosclerotic plaque. While there has been extensive research on the role of neutrophils in coronary artery and cerebrovascular diseases, there is limited information available on their role in peripheral artery disease (PAD). This review aims to summarize the current understanding of neutrophil biology, their role in atherosclerosis, and the available evidence on their role in PAD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Lanlan Li, Yongchang Ma, Yi Hu, Pengfei Wang, Songling Han, Xiangjun Zhang, Jianxiang Zhang
Summary: This article reports a targeted treatment method for asthma using a cyclic oligosaccharide-derived nanotherapy. The treatment effectively alleviates oxidative stress, suppresses inflammatory responses, reverses airway remodelling, and improves pulmonary function. The method shows promising results for the treatment of eosinophilic and neutrophilic asthma.
Article
Chemistry, Multidisciplinary
Lianghan Zhu, Zhaoting Li, Ning Liu, Honghao Sun, Yixin Wang, Minjie Sun
Summary: The study explores a protein delivery strategy using poly amino acid conjugated with polyethylene glycol (PAAP) to prevent liver metastasis by degrading chromatin and disassembling NET-DNA. This approach not only suppresses tumor growth by degrading intracellular chromatin, but also prevents liver metastasis by disassembling NET-NDA, providing potential new inspiration for patients with metastatic colon and breast cancer.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Review
Immunology
Stijn Van Bruggen, Kimberly Martinod
Summary: Thrombus formation is a complex process involving multiple cells and soluble factors. Neutrophils, as key members of the immune system, play a crucial role in this process by forming neutrophil extracellular traps (NETs). NETs act as a scaffold for thrombus formation and can be formed in response to various stimuli, leading to immune-mediated thrombus formation.
IMMUNOLOGICAL REVIEWS
(2023)
Review
Immunology
Jingyi Wang, Yucong Zhou, Biao Ren, Ling Zou, Bing He, Mingyun Li
Summary: Periodontitis is a chronic, destructive disease of periodontal tissues caused by multifaceted interactions between periodontal bacteria and host immunity. Neutrophil extracellular traps (NETs) play a crucial role in the initiation and progression of late-onset periodontitis by eliciting an excessive immune response.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Binbin Chang, Zhang Wang, Hui Cheng, Tingyuan Xu, Jieyu Chen, Wan Wu, Yizhi Li, Yong Zhang
Summary: Acacetin can attenuate sepsis-induced ALI by inhibiting the inflammatory response and promoting macrophage polarization. This study is of great significance for the development of new treatments for sepsis-induced ALI.
Review
Biochemistry & Molecular Biology
Nikoleta Bizymi, Andreas M. Matthaiou, Irene Mavroudi, Aristea Batsali, Helen A. Papadaki
Summary: Myeloid-derived suppressor cells (MDSCs) are innate immune cells that have immunomodulatory properties. They interact extensively with other innate or adaptive immune cells and can either enhance or attenuate immune responses depending on the triggering conditions. However, their positive role in host defense mechanisms is rarely discussed in the literature.
