Targeting MyD88: Therapeutic mechanisms and potential applications of the specific inhibitor ST2825

The TLR/MyD88 signalling cascade in inflammation and gastric cancer: the immune regulatory network of Helicobacter pylori

(2023) Meiqi Liu et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Acute iron oxide nanoparticles exposure induced murine eosinophilic airway inflammation via TLR2 and TLR4 signaling

(2022) Liang Yue et al.   ENVIRONMENTAL TOXICOLOGY

Preneoplastic somatic mutations including MYD88 L265P in lymphoplasmacytic lymphoma

(2022) Sara Rodriguez et al.   Science Advances

ST2825, a Small Molecule Inhibitor of MyD88, Suppresses NF-κB Activation and the ROS/NLRP3/Cleaved Caspase-1 Signaling Pathway to Attenuate Lipopolysaccharide-Stimulated Neuroinflammation

(2022) Shan-Shan Zhang et al.   MOLECULES

TLR7 gain-of-function genetic variation causes human lupus

(2022) Grant J. Brown et al.   NATURE

MyD88 in hepatic stellate cells enhances liver fibrosis via promoting macrophage M1 polarization

(2022) Jie Zhang et al.   Cell Death & Disease

Inhalation of Salvianolic Acid B Prevents Fine Particulate Matter-Induced Acute Airway Inflammation and Oxidative Stress by Downregulating the LTR4/MyD88/NLRP3 Pathway

(2022) Yan Guan et al.   Oxidative Medicine and Cellular Longevity

Inflammation Induced by Lipopolysaccharide and Palmitic Acid Increases Cholesterol Accumulation via Enhancing Myeloid Differentiation Factor 88 Expression in HepG2 Cells

(2022) Junbin Chen et al.   Pharmaceuticals

Targeting IL-6 to prevent cardiac allograft rejection

(2022) Cynthia L. Miller et al.   AMERICAN JOURNAL OF TRANSPLANTATION

MyD88-dependent signaling drives toll-like receptor-induced trained immunity in macrophages

(2022) Allison M. Owen et al.   Frontiers in Immunology

Sleep deprivation aggravates brain injury after experimental subarachnoid hemorrhage via TLR4-MyD88 pathway

(2021) Ye-Ping Xu et al.   Aging-US

MyD88 in myofibroblasts enhances colitis-associated tumorigenesis via promoting macrophage M2 polarization

(2021) Qi Yuan et al.   Cell Reports

MyD88 and beyond: a perspective on MyD88-targeted therapeutic approach for modulation of host immunity

(2021) Kamal U. Saikh   IMMUNOLOGIC RESEARCH

Neuroinflammation in Cerebral Ischemia and Ischemia/Reperfusion Injuries: From Pathophysiology to Therapeutic Strategies

(2021) Anamaria Jurcau et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

MyD88: At the heart of inflammatory signaling and cardiovascular disease

(2021) Abraham L. Bayer et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

MyD88 in myofibroblasts regulates aerobic glycolysis‐driven hepatocarcinogenesis via ERK ‐dependent PKM2 nuclear relocalization and activation

(2021) Qi Yuan et al.   JOURNAL OF PATHOLOGY

MyD88 deficiency ameliorates weight loss caused by intestinal oxidative injury in an autophagy‐dependent mechanism

(2021) Ming Qi et al.   Journal of Cachexia Sarcopenia and Muscle

Discovery of a Novel MyD88 Inhibitor M20 and Its Protection Against Sepsis-Mediated Acute Lung Injury

(2021) Jiali Song et al.   Frontiers in Pharmacology

Targeting MyD88 Downregulates Inflammatory Mediators and Pathogenic Processes in PBMC From DMARDs-Naïve Rheumatoid Arthritis Patients

(2021) Sergio Ramirez-Perez et al.   Frontiers in Pharmacology

Compound LM9, a novel MyD88 inhibitor, efficiently mitigates inflammatory responses and fibrosis in obesity-induced cardiomyopathy

(2020) Xu-yong Zheng et al.   ACTA PHARMACOLOGICA SINICA

TJ-M2010-5, a novel MyD88 inhibitor, corrects R848-induced lupus-like immune disorders of B cells in vitro

(2020) Zhimiao Zou et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

TLR2/4 promotes PGE2 production to increase tissue damage in Escherichia coli-infected bovine endometrial explants via MyD88/p38 MAPK pathway

(2020) Tingting Li et al.   THERIOGENOLOGY

Downregulation of Inflammatory Cytokine Release from IL-1β and LPS-Stimulated PBMC Orchestrated by ST2825, a MyD88 Dimerisation Inhibitor

(2020) Sergio Ramírez-Pérez et al.   MOLECULES

Author Correction: A guiding map for inflammation

(2020) Mihai G. Netea et al.   NATURE IMMUNOLOGY

In Systemic Sclerosis, a Unique Long Non Coding RNA Regulates Genes and Pathways Involved in the Three Main Features of the Disease (Vasculopathy, Fibrosis and Autoimmunity) and in Carcinogenesis

(2019) Marzia Dolcino et al.   Journal of Clinical Medicine

Toll-like receptor mediated inflammation requires FASN-dependent MYD88 palmitoylation

(2019) Young-Chan Kim et al.   Nature Chemical Biology

Inflammatory markers in systemic lupus erythematosus

(2019) Martin Aringer   JOURNAL OF AUTOIMMUNITY

MYD88L265P Mutation in Lymphoid Malignancies

(2018) Xinfang Yu et al.   CANCER RESEARCH

Hypoxia, oxidative stress and inflammation

(2018) Trudy McGarry et al.   FREE RADICAL BIOLOGY AND MEDICINE

Polygonatum sibiricum polysaccharides play anti-cancer effect through TLR4-MAPK/NF-κB signaling pathways

(2018) Tingting Long et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Peroxiredoxin 2 activates microglia by interacting with Toll-like receptor 4 after subarachnoid hemorrhage

(2018) Yue Lu et al.   Journal of Neuroinflammation

Genetics and Pathogenesis of Diffuse Large B-Cell Lymphoma

(2018) Roland Schmitz et al.   NEW ENGLAND JOURNAL OF MEDICINE

1,4-β-d-Glucomannan from Dendrobium officinale Activates NF-кB via TLR4 to Regulate the Immune Response

(2018) Yan-Ping Huang et al.   MOLECULES

Myeloid differentiation factor 88 is up-regulated in epileptic brain and contributes to experimental seizures in rats

(2017) Na Wang et al.   EXPERIMENTAL NEUROLOGY

Short-term Pharmacological Inhibition of MyD88 Homodimerization by a Novel Inhibitor Promotes Robust Allograft Tolerance in Mouse Cardiac and Skin Transplantation

(2017) Chao Li et al.   TRANSPLANTATION

Inhibition of myeloid differentiation primary response protein 88 provides neuroprotection in early brain injury following experimental subarachnoid hemorrhage

(2017) Huiying Yan et al.   Scientific Reports

Inhibition of myeloid differentiation factor 88(MyD88) by ST2825 provides neuroprotection after experimental traumatic brain injury in mice

(2016) Hua-Sheng Zhang et al.   BRAIN RESEARCH

Targeting Myddosome Assembly in Waldenstrom Macroglobulinaemia

(2016) Xia Liu et al.   BRITISH JOURNAL OF HAEMATOLOGY

Effect of ST2825 on the proliferation and apoptosis of human hepatocellular carcinoma cells

(2016) Y. Deng et al.   GENETICS AND MOLECULAR RESEARCH

Dioscin reduces lipopolysaccharide-induced inflammatory liver injury via regulating TLR4/MyD88 signal pathway

(2016) Hong Yao et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Polysaccharopeptide exerts immunoregulatory effects via MyD88-dependent signaling pathway

(2016) Zifang Feng et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Dioscin alleviates lipopolysaccharide-induced inflammatory kidney injury via the microRNA let-7i/TLR4/MyD88 signaling pathway

(2016) Meng Qi et al.   PHARMACOLOGICAL RESEARCH

Short-term MyD88 inhibition ameliorates cardiac graft rejection and promotes donor-specific hyporesponsiveness of skin grafts in mice

(2016) Wen-Tao He et al.   TRANSPLANT INTERNATIONAL

Toll-like receptor 4 contributes to vascular remodelling and endothelial dysfunction in angiotensin II-induced hypertension

(2015) R Hernanz et al.   BRITISH JOURNAL OF PHARMACOLOGY

Homeostasis, Inflammation, and Disease Susceptibility

(2015) Maya E. Kotas et al.   CELL

Dioscin attenuates renal ischemia/reperfusion injury by inhibiting the TLR4/MyD88 signaling pathway via up-regulation of HSP70

(2015) Meng Qi et al.   PHARMACOLOGICAL RESEARCH

Discovery of small molecule inhibitors of MyD88-dependent signaling pathways using a computational screen

(2015) Mark A. Olson et al.   Scientific Reports

Dioscin alleviates alcoholic liver fibrosis by attenuating hepatic stellate cell activation via the TLR4/MyD88/NF-κB signaling pathway

(2015) Min Liu et al.   Scientific Reports

Mutational Analysis Identifies Residues Crucial for Homodimerization of Myeloid Differentiation Factor 88 (MyD88) and for Its Function in Immune Cells

(2013) Maria Loiarro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MYD88 L265P Somatic Mutation in Waldenström's Macroglobulinemia

(2012) Steven P. Treon et al.   NEW ENGLAND JOURNAL OF MEDICINE

Oxidative stress, inflammation, and cancer: How are they linked?

(2010) Simone Reuter et al.   FREE RADICAL BIOLOGY AND MEDICINE

Pharmacologic Inhibition of Myeloid Differentiation Factor 88 (MyD88) Prevents Left Ventricular Dilation and Hypertrophy After Experimental Acute Myocardial Infarction in the Mouse

(2010) Benjamin W Van Tassell et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Oncogenically active MYD88 mutations in human lymphoma

(2010) Vu N. Ngo et al.   NATURE

Helical assembly in the MyD88–IRAK4–IRAK2 complex in TLR/IL-1R signalling

(2010) Su-Chang Lin et al.   NATURE

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Pharmacological inhibition of TLR9 activation blocks autoantibody production in human B cells from SLE patients

(2010) Federica Capolunghi et al.   RHEUMATOLOGY