Article
Biochemistry & Molecular Biology
Haranatha R. Potteti, Lalith K. Venkareddy, Patrick M. Noone, Aparna Ankireddy, Chandramohan R. Tamatam, Dolly Mehta, Chinnaswamy Tiruppathi, Sekhar P. Reddy
Summary: This study demonstrates the crucial role of Nrf2 in optimal A20 transcriptional induction in macrophages in response to endotoxin, and shows that this regulation occurs in a contextual manner.
Article
Cell Biology
Kedeye Tuerxun, Kristine Midtbo, Eva Sarndahl, Egor Vorontsov, Roger Karlsson, Alexander Persson, Robert Kruse, Daniel Eklund
Summary: Myeloid-derived suppressor cells (MDSCs) are immunosuppressive cells that arise and expand during inflammation. This study aims to identify the mediators and transcriptional regulators associated with MDSC activity using endotoxin tolerance as a model. The study finds a unique pattern of immune mediators and identifies PU.1 as an important regulator of M-MDSC-like cells.
JOURNAL OF LEUKOCYTE BIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Joseph J. Bivona, Madeleine M. Mank, Renee D. Stapleton, D. Clark Files, Michael J. Toth, Matthew E. Poynter
Summary: Skeletal muscle is an important contributor to local and systemic cytokine abundance during inflammatory events. The study reveals the critical involvement of muscle fibers in the early systemic inflammatory cytokine response to endotoxin, showing the direct contribution of myofibers to systemic cytokine production.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Da Bin Kim, Banzragchgarav Unenkhuu, Grace Jisoo Kim, Seung-Woo Kim, Hong Seok Kim
Summary: Cynarin alleviates inflammation by upregulating the negative regulator MKP-3, which can suppress the LPS-induced inflammatory response in endothelial cells.
ANIMAL CELLS AND SYSTEMS
(2022)
Article
Engineering, Biomedical
Ana Carolina Fernandes Couto, Renan Villanova Homem de Carvalho, Guilherme Thomaz Pereira Brancini, Fernando Grine Martins, Carlos Arterio Sorgi, Raquel Assed Bezerra da Silva, Paulo Nelson-Filho, Francisco Wanderley Garcia Paula-Silva, Maria Cristina Borsatto, Gilberto Ubida Leite Braga, Arthur Belem Novaes Junior
Summary: This study evaluated the efficacy of different photosensitizers in antimicrobial photodynamic therapy for inhibiting lipopolysaccharide. The findings suggest that these photosensitizers can decrease LPS-induced inflammation.
LASERS IN MEDICAL SCIENCE
(2021)
Article
Immunology
Tobias Frauenlob, Theresa Neuper, Muamera Mehinagic, Hieu-Hoa Dang, Diana Boraschi, Jutta Horejs-Hoeck
Summary: Infection with H. pylori increases the sensitivity of human monocytes to bacterial stimuli, but this effect is only observed with viable H. pylori. This finding provides important insights into how H. pylori can induce chronic inflammation and contribute to the progression of gastric cancer.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Sangwoo Kim, Erina Yoneda, Kisaki Tomita, Mitsunori Kayano, Hiroyuki Watanabe, Motoki Sasaki, Takashi Shimizu, Yuki Muranishi
Summary: This study investigates the effects of lipopolysaccharide (LPS) endotoxin exposure on early embryonic development and fetal development in mice. It is found that LPS exposure leads to increased expression of Il-1 beta and Il-6, and significantly decreases the embryonic developmental rate. Different concentrations of LPS also have varying effects on placental weight, fetal weight, and crown-rump length (CRL). These findings suggest that LPS exposure during fertilization can result in abnormal embryonic phenotypes and fetal development, with potential long-term effects on epigenetic inheritance.
Review
Biochemistry & Molecular Biology
Alexandra C. Fux, Cristiane Casonato Melo, Sara Michelini, Benjamin J. Swartzwelter, Andreas Neusch, Paola Italiani, Martin Himly
Summary: Lipopolysaccharide (LPS), a major component of Gram-negative bacteria's outer cell wall, elicits severe immune reactions and requires accurate detection in medical devices and injectable pharmaceuticals.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Michael Resl, Matthias Wolfgang Heinzl, Carmen Klammer, Margot Egger, Roland Feldbauer, Johannes Pohlhammer, Benjamin Dieplinger, Martin Clodi
Summary: Acute inflammation has a significant impact on the cardiovascular system, leading to changes in a large number of cardiovascular biomarkers. Experimental low-dose inflammation treatment resulted in enormous pressure on the cardiovascular system in response, affecting the majority of the biomarkers tested.
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Anna Ciesielska, Marta Matyjek, Katarzyna Kwiatkowska
Summary: This article discusses the role of TLR4 in promoting inflammatory responses, including internalization and intracellular trafficking of exogenous endotoxin and bacteria. The authors emphasize the significant impact of internalization rate and endo-lysosomal compartment transport rate on inflammatory responses.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Cell Biology
Kokilavani Sivaraman, Sabine Wrenger, Bin Liu, Dirk Schaudien, Christina Hesse, Gema Gomez-Mariano, Sara Perez-Luz, Katherina Sewald, David DeLuca, Maria J. Wurm, Paco Pino, Tobias Welte, Beatriz Martinez-Delgado, Sabina Janciauskiene
Summary: Mouse models of aerosolized LPS-induced pulmonary inflammation were used to evaluate the effectiveness of systemically delivered anti-inflammatory drugs, such as different forms of alpha1-antitrypsin. The study found that aerosolized LPS induced lung inflammation in mice, and different forms of AAT did not significantly affect this response. This mouse model can be useful for systemic drug testing.
JOURNAL OF LEUKOCYTE BIOLOGY
(2023)
Review
Medicine, General & Internal
Grazia Maria Virzi, Maria Mattiotti, Massimo de Cal, Claudio Ronco, Monica Zanella, Silvia De Rosa
Summary: Lipopolysaccharide (LPS) is a major component of the cell wall of Gram-negative bacteria and plays a crucial role in the pathogenesis of sepsis. LPS activates the host defense system through Toll-like receptor 4, leading to pro-inflammatory mechanisms. Excessive activation of the immune system by LPS results in an exaggerated inflammatory response and extensive organ injury, contributing to sepsis damage.
Article
Cell Biology
Ruiqi Qiu, Mingzhu Yang, Weiping Wang, Jingyang Liu, Lin Yang, Bo Lei
Summary: VVN001 pretreatment effectively reduced inflammatory responses in human RPE cells and in a mouse model of EIU by inhibiting the overproduction of ICAM-1 and blocking the activation of the NLRP3 inflammasome and NF-kappa B signaling pathway.
Article
Immunology
Marco De Zuani, Chiara Dal Secco, Silvia Tonon, Alessandra Arzese, Carlo E. M. Pucillo, Barbara Frossi
Summary: Mast cells are important innate immune cells that can sense and respond to different stimuli. Studies have shown that mast cells can develop immunological memory, and their responses can be shaped by different stimulatory environments.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Massimiliano G. Bianchi, Martina Chiu, Giuseppe Taurino, Enrico Bergamaschi, Francesco Cubadda, Guido M. Macaluso, Ovidio Bussolati
Summary: Amorphous silica nanoparticles (ASNP) inhibit the response of human macrophages to natural activators, suppressing the production of pro-inflammatory and anti-inflammatory cytokines. This inhibition is achieved by suppressing NF kappa B activation and increasing the intracellular sequestration of the TLR4 receptor. Induction of glutamine synthetase (GS) may be secondary to cytokine stimulation. These findings suggest a dampening of the acute inflammatory response after exposure to ASNP.