Understanding the diversity and dynamics of in vivo efferocytosis: Insights from the fly embryo

A PI3K-calcium-Nox axis primes leukocyte Nrf2 to boost immune resilience and limit collateral damage

(2023) Giuliana D. Clemente et al.   JOURNAL OF CELL BIOLOGY

The Drosophila chemokine–like Orion bridges phosphatidylserine and Draper in phagocytosis of neurons

(2023) Hui Ji et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

LC3-associated phagocytosis promotes glial degradation of axon debris after injury in Drosophila models

(2023) Áron Szabó et al.   Nature Communications

Drosophila FGFR/Htl signaling shapes embryonic glia to phagocytose apoptotic neurons

(2023) Malak Ayoub et al.   Cell Death Discovery

Bacterial gasdermins reveal an ancient mechanism of cell death

(2022) Alex G. Johnson et al.   SCIENCE

Cell division in tissues enables macrophage infiltration

(2022) Maria Akhmanova et al.   SCIENCE

Live cell tracking of macrophage efferocytosis during Drosophila embryo development in vivo

(2022) Michael H. Raymond et al.   SCIENCE

Macrophage network dynamics depend on haptokinesis for optimal local surveillance

(2022) Neil Paterson et al.   eLife

A non-canonical vitamin K cycle is a potent ferroptosis suppressor

(2022) Eikan Mishima et al.   NATURE

A role for the centrosome in regulating the rate of neuronal efferocytosis by microglia in vivo

(2022) Katrin Möller et al.   eLife

Identification of functionally distinct macrophage subpopulations in Drosophila

(2021) Jonathon Alexis Coates et al.   eLife

Proteolytic activation of Growth-blocking peptides triggers calcium responses through the GPCR Mthl10 during epithelial wound detection

(2021) James T. O’Connor et al.   DEVELOPMENTAL CELL

A secreted factor NimrodB4 promotes the elimination of apoptotic corpses by phagocytes in Drosophila

(2021) Bianca Petrignani et al.   EMBO REPORTS

Murder on the Ovarian Express: A Tale of Non-Autonomous Cell Death in the Drosophila Ovary

(2021) Diane Patricia Vig Lebo et al.   Cells

Zones of cellular damage around pulsed-laser wounds

(2021) James O’Connor et al.   PLoS One

Temporal specificity and heterogeneity of Drosophila immune cells

(2020) Pierre B Cattenoz et al.   EMBO JOURNAL

Single-cell RNA sequencing identifies novel cell types in Drosophila blood

(2020) Yulong Fu et al.   Journal of Genetics and Genomics

Metabolites released from apoptotic cells act as tissue messengers

(2020) Christopher B. Medina et al.   NATURE

Macrophages Use Distinct Actin Regulators to Switch Engulfment Strategies and Ensure Phagocytic Plasticity In Vivo

(2020) Andrew J. Davidson et al.   Cell Reports

A single-cell survey of Drosophila blood

(2020) Sudhir Gopal Tattikota et al.   eLife

Lipid peroxidation regulates long-range wound detection through 5-lipoxygenase in zebrafish

(2020) Anushka Katikaneni et al.   NATURE CELL BIOLOGY

Overexposure to apoptosis via disrupted glial specification perturbs Drosophila macrophage function and reveals roles of the CNS during injury

(2020) Emma Louise Armitage et al.   Cell Death & Disease

Single-cell transcriptome maps of myeloid blood cell lineages in Drosophila

(2020) Bumsik Cho et al.   Nature Communications

PTPN21/Pez Is a Novel and Evolutionarily Conserved Key Regulator of Inflammation In Vivo

(2020) Jennie S. Campbell et al.   CURRENT BIOLOGY

Ena orchestrates remodelling within the actin cytoskeleton to drive robust Drosophila macrophage chemotaxis

(2019) Andrew J. Davidson et al.   JOURNAL OF CELL SCIENCE

Clearance by Microglia Depends on Packaging of Phagosomes into a Unique Cellular Compartment

(2019) Ambra Villani et al.   DEVELOPMENTAL CELL

Resident Macrophages Cloak Tissue Microlesions to Prevent Neutrophil-Driven Inflammatory Damage

(2019) Stefan Uderhardt et al.   CELL

Cortex glia clear dead young neurons via Drpr/dCed-6/Shark and Crk/Mbc/dCed-12 signaling pathways in the developing Drosophila optic lobe

(2019) Ryosuke Nakano et al.   DEVELOPMENTAL BIOLOGY

Two Nimrod receptors, NimC1 and Eater, synergistically contribute to bacterial phagocytosis in Drosophila melanogaster

(2019) Claudia Melcarne et al.   FEBS Journal

Lysosomal Machinery Drives Extracellular Acidification to Direct Non-apoptotic Cell Death

(2019) Albert A. Mondragon et al.   Cell Reports

Simu-dependent clearance of dying cells regulates macrophage function and inflammation resolution

(2019) Hannah Grace Roddie et al.   PLOS BIOLOGY

Phagocyte Responses to Cell Death in Flies

(2019) Andrew J. Davidson et al.   Cold Spring Harbor Perspectives in Biology

Characterization of TNF-induced cell death in Drosophila reveals caspase- and JNK-dependent necrosis and its role in tumor suppression

(2019) Mingli Li et al.   Cell Death & Disease

Ferritin heavy chain protects the developing wing from reactive oxygen species and ferroptosis

(2019) Simone Mumbauer et al.   PLoS Genetics

Persistent and polarized global actin flow is essential for directionality during cell migration

(2019) Lawrence Yolland et al.   NATURE CELL BIOLOGY

Systemic Lupus Erythematosus: Pathogenesis at the Functional Limit of Redox Homeostasis

(2019) Jay Pravda   Oxidative Medicine and Cellular Longevity

Glial phagocytosis in developing and mature Drosophila CNS: tight regulation for a healthy brain

(2019) Reut Hilu-Dadia et al.   CURRENT OPINION IN IMMUNOLOGY

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

(2018) Lorenzo Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Fat Body Cells Are Motile and Actively Migrate to Wounds to Drive Repair and Prevent Infection

(2018) Anna Franz et al.   DEVELOPMENTAL CELL

Drosophila TNF Modulates Tissue Tension in the Embryo to Facilitate Macrophage Invasive Migration

(2018) Aparna Ratheesh et al.   DEVELOPMENTAL CELL

The WD40 domain of ATG16L1 is required for its non‐canonical role in lipidation of LC3 at single membranes

(2018) Katherine Fletcher et al.   EMBO JOURNAL

The ABC Transporter Eato Promotes Cell Clearance in the Drosophila melanogaster Ovary

(2018) Clarissa S. Santoso et al.   G3-Genes Genomes Genetics

LC3-Associated Phagocytosis in Myeloid Cells Promotes Tumor Immune Tolerance

(2018) Larissa D. Cunha et al.   CELL

Spatial control of Draper receptor signaling initiates apoptotic cell engulfment

(2018) Adam P. Williamson et al.   JOURNAL OF CELL BIOLOGY

The Repo Homeodomain Transcription Factor Suppresses Hematopoiesis in Drosophila and Preserves the Glial Fate

(2018) Guillaume Trébuchet et al.   JOURNAL OF NEUROSCIENCE

WASP family proteins and formins compete in pseudopod- and bleb-based migration

(2017) Andrew J. Davidson et al.   JOURNAL OF CELL BIOLOGY

Hydrogen Peroxide Triggers a Dual Signaling Axis To Selectively Suppress Activated Human T Lymphocyte Migration

(2017) Jennifer A. Ball et al.   JOURNAL OF IMMUNOLOGY

A Near-Atomic Structure of the Dark Apoptosome Provides Insight into Assembly and Activation

(2017) Tat Cheung Cheng et al.   STRUCTURE

Regulation of Drosophila hematopoietic sites by Activin-β from active sensory neurons

(2017) Kalpana Makhijani et al.   Nature Communications

The “Phagocytic Synapse” and Clearance of Apoptotic Cells

(2017) Nicole D. Barth et al.   Frontiers in Immunology

Corpse Engulfment Generates a Molecular Memory that Primes the Macrophage Inflammatory Response

(2016) Helen Weavers et al.   CELL

Phagocytosis genes nonautonomously promote developmental cell death in theDrosophilaovary

(2016) Allison K. Timmons et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis

(2016) Wan Seok Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An evolutionary perspective on the necroptotic pathway

(2016) Yves Dondelinger et al.   TRENDS IN CELL BIOLOGY

Origins of glial cell populations in the insect nervous system

(2016) Jaison J Omoto et al.   Current Opinion in Insect Science

Microglia function during brain development: New insights from animal models

(2015) Parizad M. Bilimoria et al.   BRAIN RESEARCH

Draper/CED-1 Mediates an Ancient Damage Response to Control Inflammatory Blood Cell Migration In Vivo

(2015) Iwan Robert Evans et al.   CURRENT BIOLOGY

Drosophila immune cell migration and adhesion during embryonic development and larval immune responses

(2015) Aparna Ratheesh et al.   CURRENT OPINION IN CELL BIOLOGY

Origin and development of neuropil glia of the Drosophila larval and adult brain: Two distinct glial populations derived from separate progenitors

(2015) Jaison Jiro Omoto et al.   DEVELOPMENTAL BIOLOGY

Microglia: Multitasking Specialists of the Brain

(2015) Alessandra Maria Casano et al.   DEVELOPMENTAL CELL

Molecular characterization of LC3-associated phagocytosis reveals distinct roles for Rubicon, NOX2 and autophagy proteins

(2015) Jennifer Martinez et al.   NATURE CELL BIOLOGY

JNK pathway activation is able to synchronize neuronal death and glial phagocytosis in Drosophila

(2015) J Shklover et al.   Cell Death & Disease

Ecological developmental biology: environmental signals for normal animal development

(2015) Scott F. Gilbert   EVOLUTION & DEVELOPMENT

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

Developmental regulation of glial cell phagocytic function during Drosophila embryogenesis

(2014) Boris Shklyar et al.   DEVELOPMENTAL BIOLOGY

Enabled Negatively Regulates Diaphanous-Driven Actin Dynamics In Vitro and In Vivo

(2014) Colleen G. Bilancia et al.   DEVELOPMENTAL CELL

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

(2014) Jose Pedro Friedmann Angeli et al.   NATURE CELL BIOLOGY

Ena/VASP Enabled is a highly processive actin polymerase tailored to self-assemble parallel-bundled F-actin networks with Fascin

(2014) J. D. Winkelman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synchronized renal tubular cell death involves ferroptosis

(2014) Andreas Linkermann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SCAR/WAVE-mediated processing of engulfed apoptotic corpses is essential for effective macrophage migration in Drosophila

(2013) I R Evans et al.   CELL DEATH AND DIFFERENTIATION

WASH-driven actin polymerization is required for efficient mycobacterial phagosome maturation arrest

(2013) Margot Kolonko et al.   CELLULAR MICROBIOLOGY

Drosophila Rab14 mediates phagocytosis in the immune response toStaphylococcus aureus

(2013) Aprajita Garg et al.   CELLULAR MICROBIOLOGY

Calcium Flashes Orchestrate the Wound Inflammatory Response through DUOX Activation and Hydrogen Peroxide Release

(2013) William Razzell et al.   CURRENT BIOLOGY

Astrocytes engage unique molecular programs to engulf pruned neuronal debris from distinct subsets of neurons

(2013) O. E. Tasdemir-Yilmaz et al.   GENES & DEVELOPMENT

Phosphatidylserine recognition and induction of apoptotic cell clearance by Drosophila engulfment receptor Draper

(2013) Tran Thanh Tung et al.   JOURNAL OF BIOCHEMISTRY

Architects in neural circuit design: Glia control neuron numbers and connectivity

(2013) Megan M. Corty et al.   JOURNAL OF CELL BIOLOGY

Microglia Regulate the Number of Neural Precursor Cells in the Developing Cerebral Cortex

(2013) C. L. Cunningham et al.   JOURNAL OF NEUROSCIENCE

Caspase Activity Is Required for Engulfment of Apoptotic Cells

(2013) Boris Shklyar et al.   MOLECULAR AND CELLULAR BIOLOGY

Combined Inhibition of Autophagy and Caspases Fails to Prevent Developmental Nurse Cell Death in the Drosophila melanogaster Ovary

(2013) Jeanne S. Peterson et al.   PLoS One

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Arp2/3 Is Critical for Lamellipodia and Response to Extracellular Matrix Cues but Is Dispensable for Chemotaxis

(2012) Congying Wu et al.   CELL

Emergence of embryonic pattern through contact inhibition of locomotion

(2012) J. R. Davis et al.   DEVELOPMENT

Draper acts through the JNK pathway to control synchronous engulfment of dying germline cells by follicular epithelial cells

(2012) J. I. Etchegaray et al.   DEVELOPMENT

The Arp2/3 complex is required for lamellipodia extension and directional fibroblast cell migration

(2012) Praveen Suraneni et al.   JOURNAL OF CELL BIOLOGY

Trafficking defects in WASH-knockout fibroblasts originate from collapsed endosomal and lysosomal networks

(2012) Timothy S. Gomez et al.   MOLECULAR BIOLOGY OF THE CELL

Negative regulation of glial engulfment activity by Draper terminates glial responses to axon injury

(2012) Mary A Logan et al.   NATURE NEUROSCIENCE

The peripheral nervous system supports blood cell homing and survival in the Drosophila larva

(2011) K. Makhijani et al.   DEVELOPMENT

Actin polymerization driven by WASH causes V-ATPase retrieval and vesicle neutralization before exocytosis

(2011) Michael Carnell et al.   JOURNAL OF CELL BIOLOGY

Microtubule-associated protein 1 light chain 3 alpha (LC3)-associated phagocytosis is required for the efficient clearance of dead cells

(2011) J. Martinez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prioritization of Competing Damage and Developmental Signals by Migrating Macrophages in the Drosophila Embryo

(2010) Severina Moreira et al.   CURRENT BIOLOGY

Interdependence of macrophage migration and ventral nerve cord development in Drosophila embryos

(2010) I. R. Evans et al.   DEVELOPMENT

Ena drives invasive macrophage migration in Drosophila embryos

(2010) P. K. Tucker et al.   Disease Models & Mechanisms

Keeping the CNS clear: Glial phagocytic functions in Drosophila

(2010) Estee Kurant   GLIA

RhoL controls invasion and Rap1 localization during immune cell transmigration in Drosophila

(2010) Daria Siekhaus et al.   NATURE CELL BIOLOGY

Fascin is required for blood cell migration during Drosophila embryogenesis

(2009) J. Zanet et al.   DEVELOPMENT

Ensheathing Glia Function as Phagocytes in the Adult Drosophila Brain

(2009) J. Doherty et al.   JOURNAL OF NEUROSCIENCE

Exploring the Roles of Diaphanous and Enabled Activity in Shaping the Balance between Filopodia and Lamellipodia

(2009) Catarina C.F. Homem et al.   MOLECULAR BIOLOGY OF THE CELL

A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish

(2009) Philipp Niethammer et al.   NATURE

Sessile hemocytes as a hematopoietic compartment in Drosophila melanogaster

(2009) R. Markus et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Secondary necrosis in multicellular animals: an outcome of apoptosis with pathogenic implications

(2008) Manuel T. Silva et al.   APOPTOSIS

Six-Microns-Under Acts Upstream of Draper in the Glial Phagocytosis of Apoptotic Neurons

(2008) Estee Kurant et al.   CELL

Evolution of Genes and Repeats in the Nimrod Superfamily

(2008) K. Somogyi et al.   MOLECULAR BIOLOGY AND EVOLUTION

Draper-dependent glial phagocytic activity is mediated by Src and Syk family kinase signalling

(2008) Jennifer S. Ziegenfuss et al.   NATURE

A pathway for phagosome maturation during engulfment of apoptotic cells

(2008) Jason M. Kinchen et al.   NATURE CELL BIOLOGY