Article
Immunology
Michelle Hoffner O'Connor, Ana Berglind, Meaghan M. Kennedy Ng, Benjamin P. Keith, Zachary J. Lynch, Matthew R. Schaner, Erin C. Steinbach, Jeremy Herzog, Omar K. Trad, William R. Jeck, Janelle C. Arthur, Jeremy M. Simon, R. Balfour Sartor, Terrence S. Furey, Shehzad Z. Sheikh
Summary: This study found that the BET inhibitor (+)-JQ1 can alter the functionality of macrophages and suppress inflammatory gene expression, thereby mitigating the inflammatory response in colitis. This finding provides new insights into potential therapeutic strategies.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Alex Cornwell, Hubert Ziolkowski, Alireza Badiei
Summary: This study investigates the role of Glut1-mediated glucose metabolism in the inflammatory response of macrophages. Glut1 is upregulated in response to inflammation to ensure sufficient glucose uptake for macrophage functions. Knocking down Glut1 reduces the expression of pro-inflammatory cytokines and markers. Glut1 activation promotes a pro-inflammatory profile through NF-kappa B, while silencing Glut1 blocks NF-kappa B activation.
Review
Immunology
Philippe Saas, Mathieu Vetter, Melissa Maraux, Francis Bonnefoy, Sylvain Perruche
Summary: Resolution therapy is a new therapeutic approach for chronic inflammatory diseases that aims to accelerate the resolution phase of inflammation. Macrophages play a critical role in this process by undergoing anti-inflammatory reprogramming and releasing pro-resolving factors. The secretome of efferocytic macrophages, known as SuperMApo, is a drug candidate in resolution therapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Naga Lakshmi Challa, Ankita Sarkar, Satyamoorthy Kapettu, Prakash Babu Phanithi, Partha Chakrabarti, Kishore V. L. Parsa, Parimal Misra
Summary: Macrophage-driven chronic low-grade inflammatory response is closely associated with insulin resistance and type 2 diabetes. The TGS1 gene plays a role in regulating macrophage activation and polarization, and affects the development of insulin resistance in skeletal muscle cells.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Immunology
Zhijia Li, Muzhou Teng, Yinbo Jiang, Litian Zhang, Xi Luo, Yuhui Liao, Bin Yang
Summary: This study provides the first demonstration of the role of m6A methylation in the pathological process of syphilis and offers new insight into the pathogenesis of TP infection.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Xiaorong Hu, Ruisong Ma, Jianlei Cao, Xianjin Du, Xinyong Cai, Yongzhen Fan
Summary: This study revealed the negative role of PTPN2 in atherosclerosis and provided a new potential target for its treatment.
Article
Immunology
Jiao Liu, Siqi Ming, Weifeng Song, Xiaojun Meng, Qiang Xiao, Minhao Wu, Yongjian Wu, Hanbin Xie, Jie Zhou, Haibo Zhong, Xi Huang
Summary: BTLA promotes host defense against mycobacteria by enhancing autophagy, which may provide potential therapeutic interventions against tuberculosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Arzu Ulu, Stefanie Sveiven, Amanpreet Bilg, Jalene V. Velazquez, Marissa Diaz, Maheswari Mukherjee, Ana G. Yuil-Valdes, Santosh Kota, Abigail Burr, Aileen Najera, Tara M. Nordgren
Summary: IL-22 plays a significant role in resolving inflammation induced by agricultural dust in the lungs, and it exerts its effects by acting on airway epithelium and macrophages.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Marcel S. Woo, Friederike Ufer, Jana K. Sonner, Anouar Belkacemi, Joseph Tintelnot, Pablo J. Saez, Paula F. Krieg, Christina Mayer, Lars Binkle-Ladisch, Jan Broder Engler, Simone Bauer, Nina Kursawe, Vanessa Vieira, Stefanie Mannebach, Marc Freichel, Veit Flockerzi, Pablo Vargas, Manuel A. Friese
Summary: The study identifies CACNB3 as a master regulator of ATP-dependent migDC migration, which plays a crucial role in regulating tissue-specific immune responses during injury and inflammation.
Article
Endocrinology & Metabolism
Thaise S. Martins, Bruno M. Fonseca, Irene Rebelo
Summary: This study found that M2 macrophages with anti-inflammatory characteristics can significantly increase the expression of COX-2 in hGCs, while M1 macrophages with pro-inflammatory characteristics can significantly increase the expression of 12-LOX in hGCs. In addition, CM from M2 macrophages can increase the expression of COX-2, 5-LOX and 15-LOX in COV434 cells.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2022)
Article
Immunology
Jan Nagenborg, Han Jin, Adele V. Ruder, Lieve Temmerman, Barend Mees, Casper Schalkwijk, Daniel Mueller-Klieser, Thorsten Berg, Pieter Goossens, Marjo M. P. C. Donners, Erik A. L. Biessen
Summary: In this study, the researchers identified STAT5A as an important determinant of macrophage functions and inflammation in the context of human atherosclerosis, highlighting its potential as a therapeutic target for plaque inflammation in human atherosclerosis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Arturo Gonzalez de la Aleja, Cristina Herrero, Monica Torres-Torresano, Juan Vladimir de la Rosa, Barbara Alonso, Enrique Capa-Sardon, Ittai B. Muller, Gerrit Jansen, Amaya Puig-Kroeger, Miguel A. Vega, Antonio Castrillo, Angel L. Corbi
Summary: LXR activation limits the anti-inflammatory polarization of human macrophages and promotes the acquisition of an inflammatory profile, which is associated with the expression of specific genes and the release of activin A.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Silvia Kuntschar, Giulia Cardamone, Kevin Klann, Rebekka Bauer, Sofie Patrizia Meyer, Rebecca Raue, Peter Rappl, Christian Munch, Bernhard Brune, Tobias Schmid
Summary: This study investigates the translational changes in inflammatory macrophages during the resolution phase, particularly focusing on the role of matrix metallopeptidase 12 (MMP12). The findings suggest that translational control of MMP12 plays an important role in altering the migratory properties of macrophages during the inflammatory response.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Genetics & Heredity
Xirui Ma, Huifang Liu, Jing Zhu, Caoxu Zhang, Yajie Peng, Ziming Mao, Yu Jing, Fengling Chen
Summary: MiR-185-5p has been identified as a negative regulator in pro-inflammatory activation of macrophages, exerting anti-inflammatory effects through the CDC42/JNK pathway.
Article
Cardiac & Cardiovascular Systems
Yutian Li, Shan Deng, Xiaohong Wang, Wei Huang, Jing Chen, Nathan Robbins, Xingjiang Mu, Kobina Essandoh, Tianqing Peng, Anil G. Jegga, Jack Rubinstein, David E. Adams, Yigang Wang, Jiangtong Peng, Guo-Chang Fan
Summary: This study utilizing a global Sectm1a-knockout mouse model revealed that Sectm1a deficiency leads to increased accumulation of inflammatory macrophages in the heart, worsening cardiac injury in response to inflammatory stimuli. By modulating LXR alpha signaling in macrophages, Sectm1a was identified as a novel regulator of inflammation-induced cardiac dysfunction, suggesting its potential as a therapeutic target for resolving inflammation and associated cardiac dysfunction.
CARDIOVASCULAR RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Helen Weavers, Iwan R. Evans, Paul Martin, Will Wood
Article
Cell Biology
Ioannis Xanthis, Celine Souilhol, Jovana Serbanovic-Canic, Hannah Roddie, Antreas C. Kalli, Maria Fragiadaki, Raymond Wong, Dhruv R. Shah, Janet A. Askari, Lindsay Canham, Nasreen Akhtar, Shuang Feng, Victoria Ridger, Jonathan Waltho, Emmanuel Pinteaux, Martin J. Humphries, Matthew T. Bryan, Paul C. Evans
JOURNAL OF CELL SCIENCE
(2019)
Review
Cardiac & Cardiovascular Systems
Celine Souilhol, Jovana Serbanovic-Canic, Maria Fragiadaki, Timothy J. Chico, Victoria Ridger, Hannah Roddie, Paul C. Evans
NATURE REVIEWS CARDIOLOGY
(2020)
Article
Cell Biology
Emma Louise Armitage, Hannah Grace Roddie, Iwan Robert Evans
CELL DEATH & DISEASE
(2020)
Article
Biochemistry & Molecular Biology
Nicholas Fraser, Liam Brierley, Gautam Dey, Jessica K. Polka, Mate Palfy, Federico Nanni, Jonathon Alexis Coates
Summary: Since the outbreak of COVID-19 in 2020, the scientific community has responded rapidly by releasing over 125,000 COVID-19-related scientific articles in less than 10 months, with over 30,000 hosted by preprint servers. Research has shown that COVID-19 preprints receive more attention, citations, and online sharing compared to non-COVID-19 preprints.
Article
Biology
Jonathon Alexis Coates, Elliot Brooks, Amy Louise Brittle, Emma Louise Armitage, Martin Peter Zeidler, Iwan Robert Evans
Summary: Vertebrate macrophages are highly heterogeneous, and recent studies have revealed the presence of subpopulations within Drosophila plasmatocytes, showing functional differences and varying in abundance across development. Enhancer analysis identified candidate genes regulating plasmatocyte behavior and exposure to increased apoptotic cell death levels modulated subpopulation cell numbers. These findings demonstrate macrophage heterogeneity in Drosophila and provide insights into subpopulation specification and function.
Article
Biochemistry & Molecular Biology
Liam Brierley, Federico Nanni, Jessica K. Polka, Gautam Dey, Mate Palfy, Nicholas Fraser, Jonathon Alexis Coates
Summary: During the COVID-19 pandemic, preprints in the biomedical sciences have gained significant attention. However, a study found that while some conclusions in preprints may change before publication, it does not significantly impact the overall findings.
Article
Multidisciplinary Sciences
Regis Joulia, Idaira Maria Guerrero-Fonseca, Tamara Girbl, Jonathon A. Coates, Monja Stein, Laura Vazquez-Martinez, Eleanor Lynam, James Whiteford, Michael Schnoor, David Voehringer, Axel Roers, Sussan Nourshargh, Mathieu-Benoit Voisin
Summary: This study reveals that perivascular mast cells regulate the final steps of neutrophil diapedesis through the outer pericyte layer via IL-17A production, potentially providing insights for inflammatory disorders driven by increased neutrophil diapedesis.
NATURE COMMUNICATIONS
(2022)