What is the most effective and safest Non-steroidal anti-inflammatory drug for treating osteoarthritis in patients with comorbidities?

Lessons from 20 years with COX‐2 inhibitors: importance of dose–response considerations and fair play in comparative trials

(2022) Carl‐Olav Stiller et al.   JOURNAL OF INTERNAL MEDICINE

Association between Non-Steroidal Anti-Inflammatory Drugs Use and the Risk of Type 2 Diabetes Mellitus: A Nationwide Retrospective Cohort Study

(2022) Ming-Hsun Lin et al.   Journal of Clinical Medicine

Reduced risk of NSAID‐Induced adverse events with concomitant use of misoprostol ( MICRO study)

(2022) Mark A. Munger et al.   PHARMACOTHERAPY

Management of Osteoarthritis: Expert Opinion on NSAIDs

(2021) Alberto Magni et al.   Pain and Therapy

Effectiveness and safety of non-steroidal anti-inflammatory drugs and opioid treatment for knee and hip osteoarthritis: network meta-analysis

(2021) Bruno R da Costa et al.   BMJ-British Medical Journal

ABCG2 rs2231142 variant in hyperuricemia is modified by SLC2A9 and SLC22A12 polymorphisms and cardiovascular risk factors in an elderly community-dwelling population

(2020) Jia Liu et al.   BMC Medical Genetics

Short-Course Systemic and Topical Non-Steroidal Anti-Inflammatory Drugs: Impact on Adverse Renal Events in Older Adults with Co-Morbid Disease

(2020) Cynthia Ciwei Lim et al.   DRUGS & AGING

Nonsteroidal anti-inflammatory drug use and risk of acute kidney injury and hyperkalemia in older adults: a population-based study

(2019) Danielle M Nash et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

OARSI guidelines for the non-surgical management of knee, hip, and polyarticular osteoarthritis

(2019) R.R. Bannuru et al.   OSTEOARTHRITIS AND CARTILAGE

Disease-modifying effects of COX-2 selective inhibitors and non-selective NSAIDs in osteoarthritis: a systematic review

(2018) K. Nakata et al.   OSTEOARTHRITIS AND CARTILAGE

Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

(2017) Theo Vos et al.   LANCET

Variability of the drug response to nonsteroidal anti-inflammatory drugs according to cyclooxygenase-2 genetic polymorphism

(2017) Sook Joung Lee et al.   Drug Design Development and Therapy

The IL-1B Genetic Polymorphism Is Associated with Aspirin-Induced PepticUlcers in a Korean Ethnic Group

(2016) Jae Hee Cho et al.   Gut and Liver

Cardiovascular Safety of Celecoxib, Naproxen, or Ibuprofen for Arthritis

(2016) Steven E. Nissen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Non-steroidal anti-inflammatory drugs and risk of heart failure in four European countries: nested case-control study

(2016) Andrea Arfè et al.   BMJ-British Medical Journal

Non-steroidal anti-inflammatory drugs and risk of heart failure in four European countries: nested case-control study

(2016) Andrea Arfè et al.   BMJ-British Medical Journal

Osteoarthritis

(2016) Johanne Martel-Pelletier et al.   Nature Reviews Disease Primers

Adverse Effects of Nonsteroidal Antiinflammatory Drugs: An Update of Gastrointestinal, Cardiovascular and Renal Complications

(2016) Sam Harirforoosh et al.   JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES

Topical Nonsteroidal Anti-Inflammatory Drugs

(2015) Robert L Barkin   AMERICAN JOURNAL OF THERAPEUTICS

Safe prescribing of non-steroidal anti-inflammatory drugs in patients with osteoarthritis – an expert consensus addressing benefits as well as gastrointestinal and cardiovascular risks

(2015) Carmelo Scarpignato et al.   BMC Medicine

Pain, Analgesics, and Safety in Patients with CKD

(2015) S. N. Davison   Clinical Journal of the American Society of Nephrology

State of the evidence

(2015) Kelli D. Allen et al.   CURRENT OPINION IN RHEUMATOLOGY

Lifetime Medical Costs of Knee Osteoarthritis Management in the United States: Impact of Extending Indications for Total Knee Arthroplasty

(2015) Elena Losina et al.   ARTHRITIS CARE & RESEARCH

Hypersensitivity to non-steroidal anti-inflammatory drugs (NSAIDs): classification of a Danish patient cohort according to EAACI/ENDA guidelines

(2015) Christoffer V Nissen et al.   Clinical and Translational Allergy

OARSI guidelines for the non-surgical management of knee osteoarthritis

(2014) T.E. McAlindon et al.   OSTEOARTHRITIS AND CARTILAGE

An algorithm recommendation for the management of knee osteoarthritis in Europe and internationally: A report from a task force of the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO)

(2014) Olivier Bruyère et al.   SEMINARS IN ARTHRITIS AND RHEUMATISM

Epidemiology and burden of osteoarthritis

(2013) A. Litwic et al.   BRITISH MEDICAL BULLETIN

Individual NSAIDs and Upper Gastrointestinal Complications

(2013) Jordi Castellsague et al.   DRUG SAFETY

Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials

(2013)   LANCET

The use of proton pump inhibitors in treating and preventing NSAID-induced mucosal damage

(2013) James M Scheiman   ARTHRITIS RESEARCH & THERAPY

Role of inflammation in the pathogenesis of osteoarthritis: latest findings and interpretations

(2013) Jeremy Sokolove et al.   Therapeutic Advances in Musculoskeletal Disease

Osteoarthritis: A disease of the joint as an organ

(2012) Richard F. Loeser et al.   ARTHRITIS AND RHEUMATISM

Comparative effects of non-steroidal anti-inflammatory drugs (NSAIDs) on blood pressure in patients with hypertension

(2012) Hisham Aljadhey et al.   BMC Cardiovascular Disorders

The role of synovitis in osteoarthritis pathogenesis

(2012) Carla R. Scanzello et al.   BONE

Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010

(2012) Theo Vos et al.   LANCET

American College of Rheumatology 2012 recommendations for the use of nonpharmacologic and pharmacologic therapies in osteoarthritis of the hand, hip, and knee

(2012) Marc C. Hochberg et al.   ARTHRITIS CARE & RESEARCH

Hypersensitivity to nonsteroidal anti-inflammatory drugs (NSAIDs) - classification, diagnosis and management: review of the EAACI/ENDA# and GA2LEN/HANNA*

(2011) M. L. Kowalski et al.   ALLERGY

The Effects of Nonsteroidal Anti-Inflammatory Drugs on Blood Pressure in Hypertensive Patients

(2011) Stanley Snowden et al.   Cardiology in Review

Inflammation in osteoarthritis

(2011) Mary B. Goldring et al.   CURRENT OPINION IN RHEUMATOLOGY

Systematic review of design and effects of splints and exercise programs in hand osteoarthritis

(2011) Ingvild Kjeken et al.   ARTHRITIS CARE & RESEARCH

Variability among nonsteroidal antiinflammatory drugs in risk of upper gastrointestinal bleeding

(2010) Elvira L. Massó González et al.   ARTHRITIS AND RHEUMATISM

Epidemiology of Osteoarthritis

(2010) Yuqing Zhang et al.   CLINICS IN GERIATRIC MEDICINE

Coxibs interfere with the action of aspirin by binding tightly to one monomer of cyclooxygenase-1

(2009) G. Rimon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of Dose Potency in the Prediction of Risk of Myocardial Infarction Associated With Nonsteroidal Anti-Inflammatory Drugs in the General Population

(2008) Luis Alberto García Rodríguez et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

OARSI recommendations for the management of hip and knee osteoarthritis, Part II: OARSI evidence-based, expert consensus guidelines

(2008) W. Zhang et al.   OSTEOARTHRITIS AND CARTILAGE

Influence of CYP2C8 and CYP2C9 polymorphisms on pharmacokinetic and pharmacodynamic parameters of racemic and enantiomeric forms of ibuprofen in healthy volunteers

(2008) R LOPEZRODRIGUEZ et al.   PHARMACOLOGICAL RESEARCH