Design, synthesis, ADME and biological evaluation of benzylpiperidine and benzylpiperazine derivatives as novel reversible monoacylglycerol lipase (MAGL) inhibitors

Tenebrio molitor as a Simple and Cheap Preclinical Pharmacokinetic and Toxicity Model

(2023) Annalaura Brai et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Reversible Monoacylglycerol Lipase Inhibitors: Discovery of a New Class of Benzylpiperidine Derivatives

(2022) Giulia Bononi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Monoacylglycerol lipase (MAGL) inhibitors based on a diphenylsulfide-benzoylpiperidine scaffold

(2021) Giulia Bononi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and biological evaluation of second-generation benzoylpiperidine derivatives as reversible monoacylglycerol lipase (MAGL) inhibitors

(2020) Carlotta Granchi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Optimization of a Benzoylpiperidine Class Identifies a Highly Potent and Selective Reversible Monoacylglycerol Lipase (MAGL) Inhibitor

(2019) Carlotta Granchi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Monoacylglycerol lipase inhibitors: Modulators for lipid metabolism in cancer malignancy, neurological and metabolic disorders

(2019) Hui Deng et al.   Acta Pharmaceutica Sinica B

2-Arachidonoylglycerol: A signaling lipid with manifold actions in the brain

(2018) Marc P. Baggelaar et al.   PROGRESS IN LIPID RESEARCH

Discovery of long-chain salicylketoxime derivatives as monoacylglycerol lipase (MAGL) inhibitors

(2018) Giulia Bononi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Identification of ABX-1431, a Selective Inhibitor of Monoacylglycerol Lipase and Clinical Candidate for Treatment of Neurological Disorders

(2018) Justin S. Cisar et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis, and evaluation of piperazinyl pyrrolidin-2-ones as a novel series of reversible monoacylglycerol lipase inhibitors

(2018) Jumpei Aida et al.   JOURNAL OF MEDICINAL CHEMISTRY

Antibacterial and Hypoglycemic Diterpenoids from Salvia chamaedryoides

(2017) Angela Bisio et al.   JOURNAL OF NATURAL PRODUCTS

Identification of a new STAT3 dimerization inhibitor through a pharmacophore-based virtual screening approach

(2015) Giulio Poli et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

A Reversible and Selective Inhibitor of Monoacylglycerol Lipase Ameliorates Multiple Sclerosis

(2014) Gloria Hernández-Torres et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enzyme Inhibitor Discovery by Activity-Based Protein Profiling

(2014) Micah J. Niphakis et al.   Annual Review of Biochemistry

Identification and characterization of a new reversible MAGL inhibitor

(2014) Tiziano Tuccinardi et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Development of an Activity-Based Probe and In Silico Design Reveal Highly Selective Inhibitors for Diacylglycerol Lipase-α in Brain

(2013) Marc P. Baggelaar et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

PTRAJ and CPPTRAJ: Software for Processing and Analysis of Molecular Dynamics Trajectory Data

(2013) Daniel R. Roe et al.   Journal of Chemical Theory and Computation

The endocannabinoid signaling system in cancer

(2013) Simona Pisanti et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The antinociceptive triterpene β-amyrin inhibits 2-arachidonoylglycerol (2-AG) hydrolysis without directly targeting cannabinoid receptors

(2012) A Chicca et al.   BRITISH JOURNAL OF PHARMACOLOGY

The monoacylglycerol lipase inhibitor JZL184 suppresses inflammatory pain in the mouse carrageenan model

(2012) Sudeshna Ghosh et al.   LIFE SCIENCES

Monoglyceride Lipase Deficiency in Mice Impairs Lipolysis and Attenuates Diet-induced Insulin Resistance

(2011) Ulrike Taschler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal structure of a soluble form of human monoglyceride lipase in complex with an inhibitor at 1.35 Å resolution

(2011) Céline Schalk-Hihi et al.   PROTEIN SCIENCE

Endocannabinoid Hydrolysis Generates Brain Prostaglandins That Promote Neuroinflammation

(2011) D. K. Nomura et al.   SCIENCE

Monoacylglycerol Lipase Activity Is a Critical Modulator of the Tone and Integrity of the Endocannabinoid System

(2010) P. K. Chanda et al.   MOLECULAR PHARMACOLOGY

Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system

(2010) Joel E Schlosburg et al.   NATURE NEUROSCIENCE

Central side-effects of therapies based on CB1 cannabinoid receptor agonists and antagonists: focus on anxiety and depression

(2009) Fabrício A. Moreira et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Monoacylglycerol Lipase Regulates a Fatty Acid Network that Promotes Cancer Pathogenesis

(2009) Daniel K. Nomura et al.   CELL

Discovery of Potent and Reversible Monoacylglycerol Lipase Inhibitors

(2009) Alvin R. King et al.   CHEMISTRY & BIOLOGY

AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

(2009) Garrett M. Morris et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Selectivity of inhibitors of endocannabinoid biosynthesis evaluated by activity-based protein profiling

(2008) Heather S. Hoover et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Enzymatic Pathways That Regulate Endocannabinoid Signaling in the Nervous System

(2008) Kay Ahn et al.   CHEMICAL REVIEWS

Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects

(2008) Jonathan Z Long et al.   Nature Chemical Biology