Reversible Monoacylglycerol Lipase Inhibitors: Discovery of a New Class of Benzylpiperidine Derivatives
出版年份 2022 全文链接
标题
Reversible Monoacylglycerol Lipase Inhibitors: Discovery of a New Class of Benzylpiperidine Derivatives
作者
关键词
-
出版物
JOURNAL OF MEDICINAL CHEMISTRY
Volume 65, Issue 10, Pages 7118-7140
出版商
American Chemical Society (ACS)
发表日期
2022-05-07
DOI
10.1021/acs.jmedchem.1c01806
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Synthesis and evaluation of dual fatty acid amide hydrolase-monoacylglycerol lipase inhibition and antinociceptive activities of 4-methylsulfonylaniline-derived semicarbazones
- (2022) Shivani Jaiswal et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Monoacylglycerol lipase (MAGL) inhibitors based on a diphenylsulfide-benzoylpiperidine scaffold
- (2021) Giulia Bononi et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Application of MM-PBSA Methods in Virtual Screening
- (2020) Giulio Poli et al. MOLECULES
- ARS2/MAGL signaling in glioblastoma stem cells promotes self-renewal and M2-like polarization of tumor-associated macrophages
- (2020) Jinlong Yin et al. Nature Communications
- Design, synthesis and biological evaluation of second-generation benzoylpiperidine derivatives as reversible monoacylglycerol lipase (MAGL) inhibitors
- (2020) Carlotta Granchi et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Optimization of a Benzoylpiperidine Class Identifies a Highly Potent and Selective Reversible Monoacylglycerol Lipase (MAGL) Inhibitor
- (2019) Carlotta Granchi et al. JOURNAL OF MEDICINAL CHEMISTRY
- Computationally driven discovery of phenyl(piperazin-1-yl)methanone derivatives as reversible monoacylglycerol lipase (MAGL) inhibitors
- (2019) Giulio Poli et al. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
- Role of c-MET Inhibitors in Overcoming Drug Resistance in Spheroid Models of Primary Human Pancreatic Cancer and Stellate Cells
- (2019) Omidreza Firuzi et al. Cancers
- To Combine or Not Combine: Drug Interactions and Tools for Their Analysis. Reflections from the EORTC-PAMM Course on Preclinical and Early-phase Clinical Pharmacology
- (2019) BTISSAME EL HASSOUNI et al. ANTICANCER RESEARCH
- Monoacylglycerol lipase inhibitors: Modulators for lipid metabolism in cancer malignancy, neurological and metabolic disorders
- (2019) Hui Deng et al. Acta Pharmaceutica Sinica B
- Binding investigation and preliminary optimisation of the 3-amino-1,2,4-triazin-5(2H)-one core for the development of new Fyn inhibitors
- (2018) Giulio Poli et al. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
- Discovery of 1,5-Diphenylpyrazole-3-Carboxamide Derivatives as Potent, Reversible, and Selective Monoacylglycerol Lipase (MAGL) Inhibitors
- (2018) Mojgan Aghazadeh Tabrizi et al. JOURNAL OF MEDICINAL CHEMISTRY
- Discovery of long-chain salicylketoxime derivatives as monoacylglycerol lipase (MAGL) inhibitors
- (2018) Giulia Bononi et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Identification of ABX-1431, a Selective Inhibitor of Monoacylglycerol Lipase and Clinical Candidate for Treatment of Neurological Disorders
- (2018) Justin S. Cisar et al. JOURNAL OF MEDICINAL CHEMISTRY
- Design, synthesis, and evaluation of piperazinyl pyrrolidin-2-ones as a novel series of reversible monoacylglycerol lipase inhibitors
- (2018) Jumpei Aida et al. JOURNAL OF MEDICINAL CHEMISTRY
- Phospho-Akt overexpression is prognostic and can be used to tailor the synergistic interaction of Akt inhibitors with gemcitabine in pancreatic cancer
- (2017) Daniela Massihnia et al. Journal of Hematology & Oncology
- GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses
- (2017) Zefang Tang et al. NUCLEIC ACIDS RESEARCH
- Structural Optimization of 4-Chlorobenzoylpiperidine Derivatives for the Development of Potent, Reversible, and Selective Monoacylglycerol Lipase (MAGL) Inhibitors
- (2016) Carlotta Granchi et al. JOURNAL OF MEDICINAL CHEMISTRY
- Monoacylglycerol Lipase: A Novel Potential Therapeutic Target and Prognostic Indicator for Hepatocellular Carcinoma
- (2016) Junyong Zhang et al. Scientific Reports
- Identification of a new STAT3 dimerization inhibitor through a pharmacophore-based virtual screening approach
- (2015) Giulio Poli et al. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
- A Reversible and Selective Inhibitor of Monoacylglycerol Lipase Ameliorates Multiple Sclerosis
- (2014) Gloria Hernández-Torres et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Enzyme Inhibitor Discovery by Activity-Based Protein Profiling
- (2014) Micah J. Niphakis et al. Annual Review of Biochemistry
- Identification and characterization of a new reversible MAGL inhibitor
- (2014) Tiziano Tuccinardi et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Development of an Activity-Based Probe and In Silico Design Reveal Highly Selective Inhibitors for Diacylglycerol Lipase-α in Brain
- (2013) Marc P. Baggelaar et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- In vivocharacterization of the highly selective monoacylglycerol lipase inhibitor KML29: antinociceptive activity without cannabimimetic side effects
- (2013) B M Ignatowska-Jankowska et al. BRITISH JOURNAL OF PHARMACOLOGY
- Crizotinib Inhibits Metabolic Inactivation of Gemcitabine in c-Met-driven Pancreatic Carcinoma
- (2013) A. Avan et al. CANCER RESEARCH
- PTRAJ and CPPTRAJ: Software for Processing and Analysis of Molecular Dynamics Trajectory Data
- (2013) Daniel R. Roe et al. Journal of Chemical Theory and Computation
- The endocannabinoid signaling system in cancer
- (2013) Simona Pisanti et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Synthesis and Biological Characterization of Protease-Activated Prodrugs of Doxazolidine
- (2012) Benjamin L. Barthel et al. JOURNAL OF MEDICINAL CHEMISTRY
- The monoacylglycerol lipase inhibitor JZL184 suppresses inflammatory pain in the mouse carrageenan model
- (2012) Sudeshna Ghosh et al. LIFE SCIENCES
- Neuroprotective agents: Cannabinoids
- (2011) A.J. Sánchez et al. CLINICAL IMMUNOLOGY
- Monoglyceride Lipase Deficiency in Mice Impairs Lipolysis and Attenuates Diet-induced Insulin Resistance
- (2011) Ulrike Taschler et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Crystal structure of a soluble form of human monoglyceride lipase in complex with an inhibitor at 1.35 Å resolution
- (2011) Céline Schalk-Hihi et al. PROTEIN SCIENCE
- Endocannabinoid Hydrolysis Generates Brain Prostaglandins That Promote Neuroinflammation
- (2011) D. K. Nomura et al. SCIENCE
- Fatty Acid Amide Hydrolase and Monoacylglycerol Lipase Inhibitors Produce Anti-Allodynic Effects in Mice Through Distinct Cannabinoid Receptor Mechanisms
- (2010) Steven G. Kinsey et al. JOURNAL OF PAIN
- Monoacylglycerol Lipase Activity Is a Critical Modulator of the Tone and Integrity of the Endocannabinoid System
- (2010) P. K. Chanda et al. MOLECULAR PHARMACOLOGY
- Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system
- (2010) Joel E Schlosburg et al. NATURE NEUROSCIENCE
- Monoacylglycerol Lipase Regulates a Fatty Acid Network that Promotes Cancer Pathogenesis
- (2009) Daniel K. Nomura et al. CELL
- Discovery of Potent and Reversible Monoacylglycerol Lipase Inhibitors
- (2009) Alvin R. King et al. CHEMISTRY & BIOLOGY
- Discovery and Characterization of a Highly Selective FAAH Inhibitor that Reduces Inflammatory Pain
- (2009) Kay Ahn et al. CHEMISTRY & BIOLOGY
- AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility
- (2009) Garrett M. Morris et al. JOURNAL OF COMPUTATIONAL CHEMISTRY
- Selectivity of inhibitors of endocannabinoid biosynthesis evaluated by activity-based protein profiling
- (2008) Heather S. Hoover et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- CAY10499, a Novel Monoglyceride Lipase Inhibitor Evidenced by an Expeditious MGL Assay
- (2008) Giulio G. Muccioli et al. CHEMBIOCHEM
- Enzymatic Pathways That Regulate Endocannabinoid Signaling in the Nervous System
- (2008) Kay Ahn et al. CHEMICAL REVIEWS
- High throughput UV method for the estimation of thermodynamic solubility and the determination of the solubility in biorelevant media
- (2008) Bruno Bard et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
- Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects
- (2008) Jonathan Z Long et al. Nature Chemical Biology
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