Monomeric α‐synuclein activates the plasma membrane calcium pump

Acute pyelonephritis: Increased plasma membrane targeting of renal aquaporin‐2

(2022) Christina V. Ernstsen et al.   Acta Physiologica

β-Synuclein: An Enigmatic Protein with Diverse Functionality

(2022) Junna Hayashi et al.   Biomolecules

Low dose DMSO treatment induces oligomerization and accelerates aggregation of α-synuclein

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Presynaptic endoplasmic reticulum regulates short-term plasticity in hippocampal synapses

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Separation of presynaptic Cav2 and Cav1 channel function in synaptic vesicle exo- and endocytosis by the membrane anchored Ca2+ pump PMCA

(2021) Niklas Krick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Insight into Calcium-Binding Motifs of Intrinsically Disordered Proteins

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Alpha-synuclein research: defining strategic moves in the battle against Parkinson’s disease

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Computational modeling predicts ephemeral acidic microdomains in the glutamatergic synaptic cleft

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SciPy 1.0: fundamental algorithms for scientific computing in Python

(2020) Pauli Virtanen et al.   NATURE METHODS

Avidity within the N-terminal anchor drives α-synuclein membrane interaction and insertion

(2020) Ersoy Cholak et al.   FASEB JOURNAL

Slow‐decaying presynaptic calcium dynamics gate long‐lasting asynchronous release at the hippocampal mossy fiber to CA3 pyramidal cell synapse

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The Non-Fibrillating N-Terminal of α-Synuclein Binds and Co-Fibrillates with Heparin

(2020) Line K. Skaanning et al.   Biomolecules

The physiological role of α‐synuclein and its relationship to Parkinson’s Disease

(2019) David Sulzer et al.   JOURNAL OF NEUROCHEMISTRY

Alpha‐synuclein aggregates activate calcium pump SERCA leading to calcium dysregulation

(2018) Cristine Betzer et al.   EMBO REPORTS

Evidence for a role of plasma membrane calcium pumps in neurodegenerative disease: Recent developments

(2018) Emanuel E. Strehler et al.   NEUROSCIENCE LETTERS

The PMCA pumps in genetically determined neuronal pathologies

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C-terminal calcium binding of α-synuclein modulates synaptic vesicle interaction

(2018) Janin Lautenschläger et al.   Nature Communications

Structure of the human plasma membrane Ca2+-ATPase 1 in complex with its obligatory subunit neuroplastin

(2018) Deshun Gong et al.   Nature Communications

An atlas of alternative splicing profiles and functional associations reveals new regulatory programs and genes that simultaneously express multiple major isoforms

(2017) Javier Tapial et al.   GENOME RESEARCH

Specific phospholipid binding to Na,K-ATPase at two distinct sites

(2017) Michael Habeck et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity

(2017) Michele Perni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synucleins Have Multiple Effects on Presynaptic Architecture

(2017) Karina J. Vargas et al.   Cell Reports

Cell Biology and Pathophysiology of α-Synuclein

(2017) Jacqueline Burré et al.   Cold Spring Harbor Perspectives in Medicine

Structural disorder of monomeric α-synuclein persists in mammalian cells

(2016) Francois-Xavier Theillet et al.   NATURE

Common molecular mechanism of amyloid pore formation by Alzheimer’s β-amyloid peptide and α-synuclein

(2016) Coralie Di Scala et al.   Scientific Reports

Plasma membrane calcium ATPases: From generic Ca2+ sump pumps to versatile systems for fine-tuning cellular Ca2+

(2015) Emanuel E. Strehler   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The plethora of PMCA isoforms: Alternative splicing and differential expression

(2015) Joachim Krebs   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Autocrine Boost of NMDAR Current in Hippocampal CA1 Pyramidal Neurons by a PMCA-Dependent, Perisynaptic, Extracellular pH Shift

(2015) H.-Y. Chen et al.   JOURNAL OF NEUROSCIENCE

KTKEGV repeat motifs are key mediators of normal α-synuclein tetramerization: Their mutation causes excess monomers and neurotoxicity

(2015) Ulf Dettmer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Parkinson-causing α-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation

(2015) Ulf Dettmer et al.   Nature Communications

Identification of Synaptosomal Proteins Binding to Monomeric and Oligomeric α-Synuclein

(2015) Cristine Betzer et al.   PLoS One

α-synuclein in the inner retina in parkinson disease

(2014) Ivan Bodis-Wollner et al.   ANNALS OF NEUROLOGY

Calcium signaling in Parkinson’s disease

(2014) Tito Calì et al.   CELL AND TISSUE RESEARCH

The Plasma Membrane Calcium Pump: New Ways to Look at an Old Enzyme

(2014) Raffaele Lopreiato et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Calcium CaV1 Channel Subtype mRNA Expression in Parkinson’s Disease Examined by In Situ Hybridization

(2014) Michael J. Hurley et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Parkinson’s disease is associated with altered expression of CaV1 channels and calcium-binding proteins

(2013) Michael J. Hurley et al.   BRAIN

Calcium in Red Blood Cells—A Perilous Balance

(2013) Anna Bogdanova et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

In VivoCross-linking Reveals Principally Oligomeric Forms of α-Synuclein and β-Synuclein in Neurons and Non-neural Cells

(2013) Ulf Dettmer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

α-Synuclein in Central Nervous System and from Erythrocytes, Mammalian Cells, andEscherichia coliExists Predominantly as Disordered Monomer

(2012) Bruno Fauvet et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A bimodular mechanism of calcium control in eukaryotes

(2012) Henning Tidow et al.   NATURE

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Structural basis for membrane targeting by the MVB12-associated  -prism domain of the human ESCRT-I MVB12 subunit

(2012) E. Boura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Apical localization of PMCA2w/b is enhanced in terminally polarized MDCK cells

(2011) Géza Antalffy et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Folding and misfolding of alpha-synuclein on membranes

(2011) Igor Dikiy et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Deletions and Mutations in the Acidic Lipid-binding Region of the Plasma Membrane Ca2+Pump

(2010) Marisa Brini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The role of alpha-synuclein in neurotransmission and synaptic plasticity

(2010) Furong Cheng et al.   JOURNAL OF CHEMICAL NEUROANATOMY

 -Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro

(2010) J. Burre et al.   SCIENCE

An efficient one-step site-directed deletion, insertion, single and multiple-site plasmid mutagenesis protocol

(2009) Huanting Liu et al.   BMC BIOTECHNOLOGY

Biophysics of Parkinsons Disease: Structure and Aggregation of α- Synuclein

(2009) Vladimir Uversky et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

α-Synuclein Aggregation and Ser-129 Phosphorylation-dependent Cell Death in Oligodendroglial Cells

(2009) Christine L. Kragh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Multiple Tight Phospholipid-Binding Modes of α-Synuclein Revealed by Solution NMR Spectroscopy

(2009) Christina R. Bodner et al.   JOURNAL OF MOLECULAR BIOLOGY

Inducible over-expression of wild type α-synuclein in human neuronal cells leads to caspase-dependent non-apoptotic death

(2009) Kostas Vekrellis et al.   JOURNAL OF NEUROCHEMISTRY

The plasma membrane Ca2+ ATPase of animal cells: Structure, function and regulation

(2008) Francesca Di Leva et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Presynaptic Calcium Channel Localization and Calcium-Dependent Synaptic Vesicle Exocytosis Regulated by the Fuseless Protein

(2008) A. A. Long et al.   JOURNAL OF NEUROSCIENCE

GFP-based optimization scheme for the overexpression and purification of eukaryotic membrane proteins in Saccharomyces cerevisiae

(2008) David Drew et al.   Nature Protocols

Red Blood Cells Are the Major Source of Alpha-Synuclein in Blood

(2008) Robin Barbour et al.   Neurodegenerative Diseases