Cascade catalysis – strategies and challenges en route to preparative synthetic biology

The coupling of ω-transaminase and Oppenauer oxidation reactions via intra-membrane multicomponent diffusion – A process model for the synthesis of chiral amines

(2015) T. Esparza-Isunza et al.   CHEMICAL ENGINEERING JOURNAL

Enzymatic cascade synthesis of (S)-2-hydroxycarboxylic amides and acids: Cascade reactions employing a hydroxynitrile lyase, nitrile-converting enzymes and an amidase

(2015) Fred van Rantwijk et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

Synthesis of 3-Arylated 3,4-Dihydrocoumarins: Combining Continuous Flow Hydrogenation with Laccase-Catalysed Oxidation

(2014) Sanel Suljić et al.   ADVANCED SYNTHESIS & CATALYSIS

Microbial Synthesis of Medium-Chain α,ω-Dicarboxylic Acids and ω-Aminocarboxylic Acids from Renewable Long-Chain Fatty Acids

(2014) Ji-Won Song et al.   ADVANCED SYNTHESIS & CATALYSIS

A Biocompatible Alkene Hydrogenation Merges Organic Synthesis with Microbial Metabolism

(2014) Gopal Sirasani et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Deracemization By Simultaneous Bio-oxidative Kinetic Resolution and Stereoinversion

(2014) Joerg H. Schrittwieser et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cover Picture: Excellent Stability of a Lithium-Ion-Conducting Solid Electrolyte upon Reversible Li+/H+Exchange in Aqueous Solutions (Angew. Chem. Int. Ed. 1/2015)

(2014) Cheng Ma et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Reaction and catalyst engineering to exploit kinetically controlled whole-cell multistep biocatalysis for terminal FAME oxyfunctionalization

(2014) Manfred Schrewe et al.   BIOTECHNOLOGY AND BIOENGINEERING

Validation of RetroPath, a computer-aided design tool for metabolic pathway engineering

(2014) Tamás Fehér et al.   Biotechnology Journal

A Coenzyme-Independent Decarboxylase/Oxygenase Cascade for the Efficient Synthesis of Vanillin

(2014) Toshiki Furuya et al.   CHEMBIOCHEM

Maximizing the Efficiency of Multienzyme Process by Stoichiometry Optimization

(2014) Pavel Dvorak et al.   CHEMBIOCHEM

Whole-Cell Teabag Catalysis for the Modularisation of Synthetic Enzyme Cascades in Micro-Aqueous Systems

(2014) Jochen Wachtmeister et al.   ChemCatChem

Monoamine Oxidase-ω-Transaminase Cascade for the Deracemisation and Dealkylation of Amines

(2014) Elaine O'Reilly et al.   ChemCatChem

How Green is Biocatalysis? To Calculate is To Know

(2014) Yan Ni et al.   ChemCatChem

Membrane-mediated cascade reactions by enzyme–polymer proteinosomes

(2014) Xin Huang et al.   CHEMICAL COMMUNICATIONS

Ink-jet printing an optimal multi-enzyme system

(2014) Yifei Zhang et al.   CHEMICAL COMMUNICATIONS

Biocontrolled Formal Inversion or Retention ofL-α-Amino Acids to Enantiopure (R)- or (S)-Hydroxyacids

(2014) Eduardo Busto et al.   CHEMISTRY-A EUROPEAN JOURNAL

Co-immobilization of multi-enzyme on control-reduced graphene oxide by non-covalent bonds: an artificial biocatalytic system for the one-pot production of gluconic acid from starch

(2014) Fuhua Zhao et al.   GREEN CHEMISTRY

Modular multi-enzyme cascade process using highly stabilized enzyme microbeads

(2014) Jinyang Chung et al.   GREEN CHEMISTRY

Efficient 2-step biocatalytic strategies for the synthesis of all nor(pseudo)ephedrine isomers

(2014) Torsten Sehl et al.   GREEN CHEMISTRY

A two-step biocatalytic cascade in micro-aqueous medium: using whole cells to obtain high concentrations of a vicinal diol

(2014) Andre Jakoblinnert et al.   GREEN CHEMISTRY

In vitro characterization of an enzymatic redox cascade composed of an alcohol dehydrogenase, an enoate reductases and a Baeyer–Villiger monooxygenase

(2014) Nikolin Oberleitner et al.   JOURNAL OF BIOTECHNOLOGY

Cross-linked polymersomes as nanoreactors for controlled and stabilized single and cascade enzymatic reactions

(2014) David Gräfe et al.   Nanoscale

XTMS: pathway design in an eXTended metabolic space

(2014) Pablo Carbonell et al.   NUCLEIC ACIDS RESEARCH

One-Pot Enzymatic Conversion of Sucrose to Synthetic Amylose by using Enzyme Cascades

(2014) Peng Qi et al.   ACS Catalysis

Cascade Reactions Catalyzed by Bionanostructures

(2014) Marco Filice et al.   ACS Catalysis

Combination of Asymmetric Organo- and Biocatalytic Reactions in Organic Media Using Immobilized Catalysts in Different Compartments

(2014) Marcel Heidlindemann et al.   ACS Catalysis

Bioinspired Approach to Multienzyme Cascade System Construction for Efficient Carbon Dioxide Reduction

(2014) Xiaoli Wang et al.   ACS Catalysis

Introduction to ACS Catalysis Virtual Special Issue on Cascade Catalysis

(2014) Wolfgang Kroutil et al.   ACS Catalysis

Heterogeneous Catalysis for Tandem Reactions

(2014) Maria J. Climent et al.   ACS Catalysis

Characterizing Efficiency of Multi-Enzyme Cascade-Based Biofuel Cells by Product Analysis

(2014) S. Xu et al.   ECS Electrochemistry Letters

An intercompartmental enzymatic cascade reaction in channel-equipped polymersome-in-polymersome architectures

(2014) Winna Siti et al.   Journal of Materials Chemistry B

Asymmetric Synthesis of 3-Substituted Cyclohexylamine Derivatives from Prochiral DiketonesviaThree Biocatalytic Steps

(2013) Elina Siirola et al.   ADVANCED SYNTHESIS & CATALYSIS

Direct Terminal Alkylamino-FunctionalizationviaMultistep Biocatalysis in One Recombinant Whole-Cell Catalyst

(2013) Manfred Schrewe et al.   ADVANCED SYNTHESIS & CATALYSIS

Direct Oxidation of Cycloalkanes to Cycloalkanones with Oxygen in Water

(2013) Svenja Staudt et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Multistep Enzymatic Synthesis of Long-Chain α,ω-Dicarboxylic and ω-Hydroxycarboxylic Acids from Renewable Fatty Acids and Plant Oils

(2013) Ji-Won Song et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Two Steps in One Pot: Enzyme Cascade for the Synthesis of Nor(pseudo)ephedrine from Inexpensive Starting Materials

(2013) Torsten Sehl et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Co-immobilization of an Enzyme and a Metal into the Compartments of Mesoporous Silica for Cooperative Tandem Catalysis: An Artificial Metalloenzyme

(2013) Karin Engström et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enzymatic Conversion of Flavonoids using Bacterial Chalcone Isomerase and Enoate Reductase

(2013) Mechthild Gall et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cascade Reactions in Multicompartmentalized Polymersomes

(2013) Ruud J. R. W. Peters et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cover Picture: Recoding the Genetic Code with Selenocysteine (Angew. Chem. Int. Ed. 1/2014)

(2013) Markus J. Bröcker et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Materials-based strategies for multi-enzyme immobilization and co-localization: A review

(2013) Feng Jia et al.   BIOTECHNOLOGY AND BIOENGINEERING

Efficient Biocatalysis with Immobilized Enzymes or Encapsulated Whole Cell Microorganism by Using the SpinChem Reactor System

(2013) Hendrik Mallin et al.   ChemCatChem

An Enzymatic Toolbox for Cascade Reactions: A Showcase for an In Vivo Redox Sequence in Asymmetric Synthesis

(2013) Nikolin Oberleitner et al.   ChemCatChem

Whole-Cell One-Pot Biosynthesis of Azelaic Acid

(2013) Konrad B. Otte et al.   ChemCatChem

Single Operation Stereoselective Synthesis ofAerangisLactones: Combining Continuous Flow Hydrogenation and Biocatalysts in a Chemoenzymatic Sequence

(2013) Michael J. Fink et al.   ChemCatChem

Coupled Enzymatic Alcohol-to-Amine Conversion of Isosorbide using Engineered Transaminases and Dehydrogenases

(2013) Alexandra Lerchner et al.   ChemCatChem

Designer cells for stereocomplementary de novo enzymatic cascade reactions based on laboratory evolution

(2013) Rubén Agudo et al.   CHEMICAL COMMUNICATIONS

Chemoenzymatic Synthesis of All Four Diastereomers of 2,6-Disubstituted Piperidines through Stereoselective Monoamination of 1,5-Diketones

(2013) Robert C. Simon et al.   CHEMISTRY-A EUROPEAN JOURNAL

Cascade reactions in nanoreactors

(2013) MCM van Oers et al.   CURRENT OPINION IN BIOTECHNOLOGY

Direct biocatalytic one-pot-transformation of cyclohexanol with molecular oxygen into ɛ-caprolactone

(2013) Svenja Staudt et al.   ENZYME AND MICROBIAL TECHNOLOGY

Development of a whole-cell biocatalyst with NADPH regeneration system for biosulfoxidation

(2013) Xiao-Hong Zhai et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Metabolic engineering of Escherichia coli for production of salvianic acid A via an artificial biosynthetic pathway

(2013) Yuan-Feng Yao et al.   METABOLIC ENGINEERING

A synthetic system for expression of components of a bacterial microcompartment

(2013) F. Sargent et al.   MICROBIOLOGY-SGM

Multi-enzyme co-embedded organic–inorganic hybrid nanoflowers: synthesis and application as a colorimetric sensor

(2013) Jiayu Sun et al.   Nanoscale

Advances in the Process Development of Biocatalytic Processes

(2013) Pär Tufvesson et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Enzymatic transformation of nonfood biomass to starch

(2013) C. You et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The combi-CLEA approach: enzymatic cascade synthesis of enantiomerically pure (S)-mandelic acid

(2013) Andrzej Chmura et al.   TETRAHEDRON-ASYMMETRY

Cascade Biotransformations via Enantioselective Reduction, Oxidation, and Hydrolysis: Preparation of (R)-δ-Lactones from 2-Alkylidenecyclopentanones

(2013) Ji Liu et al.   ACS Catalysis

Multistep One-Pot Reactions Combining Biocatalysts and Chemical Catalysts for Asymmetric Synthesis

(2013) Carl A. Denard et al.   ACS Catalysis

Design and Analysis of Enhanced Catalysis in Scaffolded Multienzyme Cascade Reactions

(2013) Jyun-Liang Lin et al.   ACS Catalysis

Enantioselective trans-Dihydroxylation of Aryl Olefins by Cascade Biocatalysis with Recombinant Escherichia coli Coexpressing Monooxygenase and Epoxide Hydrolase

(2013) Shuke Wu et al.   ACS Catalysis

Retropath: Automated Pipeline for Embedded Metabolic Circuits

(2013) Pablo Carbonell et al.   ACS Synthetic Biology

Computer-Assisted Engineering of the Synthetic Pathway for Biodegradation of a Toxic Persistent Pollutant

(2013) Nagendra Prasad Kurumbang et al.   ACS Synthetic Biology

Application of a RecombinantEscherichia coliWhole-Cell Catalyst Expressing Hydroxynitrile Lyase and Nitrilase Activities in Ionic Liquids for the Production of (S)-Mandelic Acid and (S)-Mandeloamide

(2012) Stefanie Baum et al.   ADVANCED SYNTHESIS & CATALYSIS

Redox Self-Sufficient Biocatalyst Network for the Amination of Primary Alcohols

(2012) Johann H. Sattler et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Engineered catalytic biofilms for continuous large scale production ofn-octanol and (S)-styrene oxide

(2012) Rainer Gross et al.   BIOTECHNOLOGY AND BIOENGINEERING

Whole-cell-based CYP153A6-catalyzed (S)-limonene hydroxylation efficiency depends on host background and profits from monoterpene uptake via AlkL

(2012) Sjef Cornelissen et al.   BIOTECHNOLOGY AND BIOENGINEERING

A robust methodology for kinetic model parameter estimation for biocatalytic reactions

(2012) Naweed Al-Haque et al.   BIOTECHNOLOGY PROGRESS

In silico evaluation of a complex multi-enzymatic system using one-pot and modular approaches: Application to the high-yield production of hydrogen from a synthetic metabolic pathway

(2012) Inés Ardao et al.   CHEMICAL ENGINEERING SCIENCE

Synthetic cascades are enabled by combining biocatalysts with artificial metalloenzymes

(2012) V. Köhler et al.   Nature Chemistry

Interactions between the termini of lumen enzymes and shell proteins mediate enzyme encapsulation into bacterial microcompartments

(2012) C. Fan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Carboxylic acid reductase is a versatile enzyme for the conversion of fatty acids into fuels and chemical commodities

(2012) M. K. Akhtar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biotinylated Rh(III) Complexes in Engineered Streptavidin for Accelerated Asymmetric C-H Activation

(2012) T. K. Hyster et al.   SCIENCE

Biofilms as living catalysts in continuous chemical syntheses

(2012) Babu Halan et al.   TRENDS IN BIOTECHNOLOGY

Amination of benzylic and cinnamic alcohols via a biocatalytic, aerobic, oxidation–transamination cascade

(2012) Michael Fuchs et al.   RSC Advances

ePathBrick: A Synthetic Biology Platform for Engineering Metabolic Pathways in E. coli

(2012) Peng Xu et al.   ACS Synthetic Biology

Magical Power of Transition Metals: Past, Present, and Future (Nobel Lecture)

(2011) Ei-ichi Negishi   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cross-Coupling Reactions Of Organoboranes: An Easy Way To Construct CC Bonds (Nobel Lecture)

(2011) Akira Suzuki   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A retrosynthetic biology approach to metabolic pathway design for therapeutic production

(2011) Pablo Carbonell et al.   BMC Systems Biology

Evaluating the “Greenness” of chemical processes and products in the pharmaceutical industry—a green metrics primer

(2011) Concepción Jiménez-González et al.   CHEMICAL SOCIETY REVIEWS

Industrial biotechnology—the future of green chemistry?

(2011) Stefanie Wenda et al.   GREEN CHEMISTRY

Efficient in Vitro Encapsulation of Protein Cargo by an Engineered Protein Container

(2011) Bigna Wörsdörfer et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Construction and Application of Variants of the Pseudomonas fluorescens EBC191 Arylacetonitrilase for Increased Production of Acids or Amides

(2010) O. Sosedov et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Metabolic engineering of Escherichia coli for the production of 1,2-propanediol from glycerol

(2010) James M. Clomburg et al.   BIOTECHNOLOGY AND BIOENGINEERING

What is flux balance analysis?

(2010) Jeffrey D Orth et al.   NATURE BIOTECHNOLOGY

Construction of RecombinantEscherichia coliCatalysts which Simultaneously Express an (S)-Oxynitrilase and Different Nitrilase Variants for the Synthesis of (S)-Mandelic Acid and (S)-Mandelic Amide from Benzaldehyde and Cyanide

(2009) Olga Sosedov et al.   ADVANCED SYNTHESIS & CATALYSIS

Asymmetric dihydroxylation of aryl olefins by sequential enantioselective epoxidation and regioselective hydrolysis with tandem biocatalysts

(2009) Yi Xu et al.   CHEMICAL COMMUNICATIONS

Green Chemistry: Principles and Practice

(2009) Paul Anastas et al.   CHEMICAL SOCIETY REVIEWS

Multi-enzymatic synthesis

(2009) Fernando Lopez-Gallego et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Identification of Bacterial Carotenoid Cleavage Dioxygenase Homologues That Cleave the Interphenyl α,β Double Bond of Stilbene Derivatives via a Monooxygenase Reaction

(2008) Erinn K. Marasco et al.   CHEMBIOCHEM

Engineering BioBrick vectors from BioBrick parts

(2008) Reshma P Shetty et al.   Journal of Biological Engineering