A dual-acting aldose reductase inhibitor impedes oxidative and carbonyl stress in tissues of fructose- and streptozotocin-induced rats: comparison with antioxidant stobadine

Cemtirestat, an aldose reductase inhibitor and antioxidant compound, induces ocular defense against oxidative and inflammatory stress in rat models for glycotoxicity

(2023) Tala Reihanifar et al.   CELL BIOCHEMISTRY AND FUNCTION

Caffeic acid regulates glucose homeostasis and inhibits purinergic and cholinergic activities while abating oxidative stress and dyslipidaemia in fructose-streptozotocin-induced diabetic rats

(2022) Veronica F Salau et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Nature-Inspired O-Benzyl Oxime-Based Derivatives as New Dual-Acting Agents Targeting Aldose Reductase and Oxidative Stress

(2022) Lidia Ciccone et al.   Biomolecules

Novel Hydroxychalcone-Based Dual Inhibitors of Aldose Reductase and α-Glucosidase as Potential Therapeutic Agents against Diabetes Mellitus and Its Complications

(2022) Xiaonan Zhang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Strategies in synthetic design and structure–activity relationship studies of novel heterocyclic scaffolds as aldose reductase‐2 inhibitors

(2022) Shaikh Yahya et al.   ARCHIV DER PHARMAZIE

Novel topical esmolol hydrochloride improves wound healing in diabetes by inhibiting aldose reductase, generation of advanced glycation end products, and facilitating the migration of fibroblasts

(2022) Sudhir A. Kulkarni et al.   Frontiers in Endocrinology

Protective Effects of Novel Substituted Triazinoindole Inhibitors of Aldose Reductase and Epalrestat in Neuron-like PC12 Cells and BV2 Rodent Microglial Cells Exposed to Toxic Models of Oxidative Stress: Comparison with the Pyridoindole Antioxidant Stobadine

(2021) Zubeyir Elmazoglu et al.   NEUROTOXICITY RESEARCH

Development of Novel Indole-Based Bifunctional Aldose Reductase Inhibitors/Antioxidants as Promising Drugs for the Treatment of Diabetic Complications

(2021) Lucia Kovacikova et al.   MOLECULES

Aldose Reductase: a cause and a potential target for the treatment of diabetic complications

(2021) Sapna Thakur et al.   ARCHIVES OF PHARMACAL RESEARCH

Lipid Peroxide-Derived Reactive Carbonyl Species as Mediators of Oxidative Stress and Signaling

(2021) Md. Sanaullah Biswas et al.   Frontiers in Plant Science

Antioxidant Mechanisms in the Neuroprotective Action of Cemtirestat: Studies in Chemical Models, Liposomes and Rat Brain Cortical Slices

(2020) Marta Soltesova Prnova et al.   NEUROSCIENCE

3-Mercapto-5H-1,2,4-Triazino[5,6-b]Indole-5-Acetic Acid (Cemtirestat) Alleviates Symptoms of Peripheral Diabetic Neuropathy in Zucker Diabetic Fatty (ZDF) Rats: A Role of Aldose Reductase

(2019) Marta Soltesova Prnova et al.   NEUROCHEMICAL RESEARCH

Dicarbonyls Generation, Toxicities, Detoxifications and Potential roles in Diabetes Complications

(2019) Sultan Alouffi et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

High dietary n6/n3 ratio decreases eicosapentaenoic to arachidonic acid ratios and upregulates NFκB/p50 expression in short-term low-dose streptozotocin and high-fructose rat model of diabetes

(2019) Kristina Starčević et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Dietary Fructose and the Metabolic Syndrome

(2019) Taskinen et al.   Nutrients

Triglyceride-lowering effect of the aldose reductase inhibitor cemtirestat—another factor that may contribute to attenuation of symptoms of peripheral neuropathy in STZ-diabetic rats

(2019) Marta Soltesova Prnova et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

The Antidiabetic Activity ofNigella sativaand Propolis on Streptozotocin-Induced Diabetes and Diabetic Nephropathy in Male Rats

(2017) Haddad A. El Rabey et al.   Evidence-based Complementary and Alternative Medicine

Epalrestat Stimulated Oxidative Stress, Inflammation, and Fibrogenesis in Mouse Liver

(2017) Yuan Le et al.   TOXICOLOGICAL SCIENCES

Dietary Sugars and Endogenous Formation of Advanced Glycation Endproducts: Emerging Mechanisms of Disease

(2017) Manuela Aragno et al.   Nutrients

Epalrestat Upregulates Heme Oxygenase-1, Superoxide Dismutase, and Catalase in Cells of the Nervous System

(2016) Kaori Yama et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Lutein attenuates oxidative stress markers and ameliorates glucose homeostasis through polyol pathway in heart and kidney of STZ-induced hyperglycemic rat model

(2016) Gurunathan Sharavana et al.   EUROPEAN JOURNAL OF NUTRITION

Identification of Novel Aldose Reductase Inhibitors Based on Carboxymethylated Mercaptotriazinoindole Scaffold

(2015) Milan Stefek et al.   JOURNAL OF MEDICINAL CHEMISTRY

Fructose-fed streptozotocin-injected rat: an alternative model for type 2 diabetes

(2014) Rachel D. Wilson et al.   Pharmacological Reports

Molecular strategies to prevent, inhibit, and degrade advanced glycoxidation and advanced lipoxidation end products

(2013) Giancarlo Aldini et al.   FREE RADICAL RESEARCH

Epalrestat increases intracellular glutathione levels in Schwann cells through transcription regulation

(2013) Keisuke Sato et al.   Redox Biology

Novel Hexahydropyridoindole Derivative as Prospective Agent Against Oxidative Damage in Pancreatic βCells

(2012) Lucia Rackova et al.   Medicinal Chemistry

Effect of long term, non cholesterol lowering dose of fluvastatin treatment on oxidative stress in brain and peripheral tissues of streptozotocin-diabetic rats

(2010) Ahmet Cumaoğlu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Epalrestat: An Aldose Reductase Inhibitor for the Treatment of Diabetic Neuropathy

(2008) Mary Ann Ramirez et al.   PHARMACOTHERAPY