Article
Immunology
Kajal H. Gupta, Christina Nowicki, Eileena F. Giurini, Amanda L. Marzo, Andrew Zloza
Summary: Cancer currently ranks as the sixth leading cause of death globally, with immunotherapy showing significant advancements in combating cancer. The use of bacteria and bacterial products as cancer therapy has promising potential to address ongoing challenges in cancer treatment.
Review
Pharmacology & Pharmacy
Jiawei Wang, Mohammed Maniruzzaman
Summary: This study conducted a global bibliometric analysis of the literature on bacteria-mediated cancer therapy from 2012 to 2021, using VOSviewer, CiteSpace, and Python. The analysis revealed that East Asia and North America contributed the most publications in this research area. The keyword analysis identified immunotherapy and nanoparticle-based drug delivery systems as popular topics, while the gut microbiota and probiotics emerged as research hotspots.
DRUG DISCOVERY TODAY
(2022)
Article
Pharmacology & Pharmacy
Ya-Jia Xie, Min Huang, Dan Li, Jin-Cai Hou, Hai-Hai Liang, Ali Adnan Nasim, Ju-Min Huang, Chun Xie, Elaine Lai-Han Leung, Xing-Xing Fan
Summary: Bacteria-based immunotherapy combined with nanotechnology shows promise in enhancing the efficacy of cancer treatment.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Ya-Jia Xie, Min Huang, Dan Li, Jin-Cai Hou, Hai-Hai Liang, Ali Adnan Nasim, Ju-Min Huang, Chun Xie, Elaine Lai-Han Leung, Xing-Xing Fan
Summary: Combining bacteria-based immunotherapy with nanotechnology for tumor treatment shows potential efficacy by stimulating immune responses, inhibiting tumor growth, and overcoming current treatment barriers.
PHARMACOLOGICAL RESEARCH
(2022)
Review
Immunology
Yan Zhao, Yuansong Bai, Meili Shen, Yapeng Li
Summary: Gastric cancer is a highly prevalent and lethal malignancy, and immunotherapy has shown survival benefits for GC patients. Targeted immune cells have emerged as a promising therapeutic strategy in the field of oncology. This review discusses the role and significance of immune cells in the tumor microenvironment of GC and summarizes the current landscape of immunotherapy, including immune checkpoint inhibitors and adoptive cell therapy. While more clinical data is needed, targeting immune cells provides a new direction for GC immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Sonia Aristin Revilla, Onno Kranenburg, Paul J. Coffer
Summary: Colorectal cancer is a heterogeneous disease with a high incidence and mortality rate worldwide. Tumor-infiltrating lymphocytes (TILs), particularly regulatory T (Treg) cells, play an important role in anti-tumor immunity. Increased numbers of Treg cells in colorectal tumors are associated with tumor development, immunotherapy failure, and a poorer prognosis. Targeting Treg cells is a potential strategy to improve cancer immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Engineering, Environmental
Yue Li, Qingqing Leng, Yan Zhang, Sheng Lin, Qinglian Wen, Yun Lu, Kang Xiong, Huan Shi, Yanlin Liu, Susu Xiao, Ling Zhao, Jingbo Wu, Zhiyong Qian, Shaozhi Fu
Summary: Tumor hypoxia negatively affects the clinical treatment of lung cancer. This study proposes a novel drug delivery strategy by implanting anaerobic Bifidobacterium infantis as a preimplanted target and using bacterial antibody decorated nano-drug missiles to enrich therapeutic drugs in the tumor hypoxic area. The study confirms the excellent anti-tumor effect of this strategy, with reduced systemic side effects. This work provides an elegant platform for in vivo delivery of chemotherapeutic drugs to the hypoxic area of solid tumors.
CHEMICAL ENGINEERING JOURNAL
(2022)
Review
Chemistry, Multidisciplinary
Caiyan Zhao, Xiaoyu Pang, Zuo Yang, Sheng Wang, Hongzhang Deng, Xiaoyuan Chen
Summary: TAMs are key players in tumor progression and can be modulated using nanotechnology-based strategies, such as inhibiting their recruitment, depleting M2-polarized macrophages, and reprogramming them into M1-polarized macrophages. Nanoparticles can also be used to image TAMs for novel treatment options and therapy monitoring.
JOURNAL OF CONTROLLED RELEASE
(2022)
Review
Immunology
Larissa S. Carnevalli, Hormas Ghadially, Simon T. Barry
Summary: This article discusses how interactions between myeloid and NK cells shape anti-tumor responses by influencing an immunosuppressive TME, and how this may impact outcomes of treatment strategies involving drugs that target myeloid and NK cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Mubin Tarannum, Juan L. Vivero-Escoto
Summary: This article focuses on the pathological hallmarks of pancreatic ductal adenocarcinoma (PDAC) and the impact of nanotechnology in finding solutions for its treatment. It discusses the use of nanoparticle-based systems for delivering chemotherapeutic agents, overcoming chemoresistance, targeting molecular heterogeneity, improving immunotherapy, and remodeling the tumor microenvironment. A special section is dedicated to the design of non-traditional nanoparticle modalities that may hold promise for improving the dismal prognosis of PDAC.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Review
Immunology
Yongmin Li, Fei Liu
Summary: Extracellular vesicles (EVs) play a crucial role in cell-to-cell communication as small particles secreted by various cell types. They have become attractive candidates for treating tumors, including melanoma, due to their involvement in multiple physiological and pathological processes. Targeting the tumor microenvironment (TME) through EVs-based therapy has emerged as a cutting-edge strategy for inhibiting melanoma progression and enhancing anti-tumor immunity. This review aims to summarize and discuss the therapeutic role of EVs that target TME components in melanoma, providing insights into promising clinical strategies for melanoma treatment.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Pharmacology & Pharmacy
Mirela-Diana Ilie, Dario De Alcubierre, Anna Lucia Carretti, Emmanuel Jouanneau, Gerald Raverot
Summary: The complex tumor microenvironment (TME) has become an increasingly important target for cancer treatment. This study examined the use of immune-checkpoint inhibitors and anti-angiogenic drugs in treating aggressive pituitary tumors and pituitary carcinomas, reporting tumor response rates, potential predictors of response, and adverse events. The study found that the tumor type was the strongest predictor of response to immune-checkpoint inhibitors, while no predictors of response to anti-angiogenic drugs have been identified. The study also discussed the potential of TME-targeting strategies, including immunotherapy and targeting other TME components.
PHARMACOLOGY & THERAPEUTICS
(2023)
Review
Oncology
Jonathan Sholl, Gregory D. Sepich-Poore, Rob Knight, Thomas Pradeu
Summary: This article discusses the unexpected roles of the microbiota in cancer, as well as the microbiota's relevance to cancer development and therapeutic responsiveness. Studying the microbiota can greatly impact clinical oncology research and practice.
Review
Oncology
Chunxiao Li, Xiaofei Xu, Shuhua Wei, Ping Jiang, Lixiang Xue, Junjie Wang
Summary: Macrophages play a crucial role in the tumor microenvironment, where they can be polarized into tumor-associated macrophages (TAMs). The abundance of TAMs in tumors is closely linked with poor prognosis, leading to investigations into therapeutic strategies targeting TAMs. These strategies include inhibiting macrophage recruitment to tumors, repolarizing TAMs towards an anti-tumor phenotype, and inducing macrophage-mediated destruction of cancer cells. As tumor immunotherapy gains more importance, new anti-tumor strategies focusing on TAMs are being discussed.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Review
Biochemistry & Molecular Biology
Asmita Parab, Lokesh Kumar Bhatt, Abdelwahab Omri
Summary: Immunotherapy shows promise in cancer treatment, but challenges remain such as partial response, resistance, and toxicities. Combining immunotherapy with other therapeutic approaches is a potential solution. Aberrant epigenetic modifications play a role in carcinogenesis, immune cell functioning, and targeting these mechanisms could enhance the antitumor effect. Recent advancements in potent epigenetic drugs and immunomodulators offer hope for this combination therapy.
Review
Oncology
Rui Wang, Aashiq Hussain, Quanquan Guo, Meimei Ma
Summary: DNA is highly immunogenic and can activate the cGAS-STING pathway, which plays a crucial role in the pathogenesis and progression of neoplastic diseases. The modulation of cGAS-STING signaling holds great promise for cancer therapy, although there are disagreements on whether to activate or inhibit this pathway.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2024)
Review
Oncology
Ali Zarezadeh Mehrabadi, Faezeh Shahba, Hossein Khorramdelazad, Nazanin Aghamohammadi, Milad Karimi, Kowsar Bagherzadeh, Majid Khoshmirsafa, Ramin Massoumi, Reza Falak
Summary: IL-1 receptor accessory protein (IL-1RAP) plays a crucial role in inflammatory conditions and tumorigenesis in the tumor microenvironment. It is involved in the progression, metastasis, and angiogenesis of solid tumors and hematological malignancies.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2024)
Review
Oncology
Xiao Tang, Yujie Niu, Jinli Jian, Yuancheng Guo, Yin Wang, Yu Zhu, Bei Liu
Summary: Ferroptosis is an iron-dependent form of cell death that promotes tumor cell death by causing cell membrane rupture and accumulation of lipid peroxides. Extensive research has been conducted to explore the mechanism of ferroptosis inducers, but its role in hematological tumors is still limited.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2024)
Review
Oncology
Tanwei Yuan, Dominic Edelmann, Jakob N. Kather, Ziwen Fan, Katrin E. Tagscherer, Wilfried Roth, Melanie Bewerunge-Hudler, Alexander Brobeil, Matthias Kloor, Hendrik Blaeker, Barbara Burwinkel, Hermann Brenner, Michael Hoffmeister
Summary: The study aimed to analyze and validate previously published CpG-methylation-based prognostic biomarkers and prediction models for colorectal cancer (CRC) prognosis. The results showed that the discrimination ability of the models was insufficient and lacked clinical relevance.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2024)
Review
Oncology
Zhihui Duan, Dandan Yang, Ping Yuan, Xiaoming Dai, Guodong Chen, Daichao Wu
Summary: This article provides a comprehensive overview of therapeutic cancer vaccines, including their classification, clinical application, efficacy, and combination strategies with other therapies. It offers a valuable theoretical basis for the future clinical application and development of therapeutic cancer vaccines.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2024)
