Colorectal Cancer-Infiltrating Regulatory T Cells: Functional Heterogeneity, Metabolic Adaptation, and Therapeutic Targeting
出版年份 2022 全文链接
标题
Colorectal Cancer-Infiltrating Regulatory T Cells: Functional Heterogeneity, Metabolic Adaptation, and Therapeutic Targeting
作者
关键词
-
出版物
Frontiers in Immunology
Volume 13, Issue -, Pages -
出版商
Frontiers Media SA
发表日期
2022-07-08
DOI
10.3389/fimmu.2022.903564
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Immunosuppressive niche engineering at the onset of human colorectal cancer
- (2022) Chandler D. Gatenbee et al. Nature Communications
- CTLA-4 blockade drives loss of Treg stability in glycolysis-low tumours
- (2021) Roberta Zappasodi et al. NATURE
- Metabolic support of tumour-infiltrating regulatory T cells by lactic acid
- (2021) McLane J. Watson et al. NATURE
- Lipid signalling enforces functional specialization of Treg cells in tumours
- (2021) Seon Ah Lim et al. NATURE
- Wnt–β-catenin activation epigenetically reprograms Treg cells in inflammatory bowel disease and dysplastic progression
- (2021) Jasmin Quandt et al. NATURE IMMUNOLOGY
- Characterization of the fatty acid metabolism in colorectal cancer to guide clinical therapy
- (2021) Chengsheng Ding et al. Molecular Therapy-Oncolytics
- Wnt–β-catenin as an epigenetic switcher in colonic Treg cells
- (2021) Stefania Canè et al. NATURE IMMUNOLOGY
- Intratumoral regulatory T cells from colon cancer patients comprise several activated effector populations
- (2021) Louis Szeponik et al. BMC IMMUNOLOGY
- Expansion of tumor-associated Treg cells upon disruption of a CTLA-4-dependent feedback loop
- (2021) Francesco Marangoni et al. CELL
- RORγt Promotes Foxp3 Expression by Antagonizing the Effector Program in Colonic Regulatory T Cells
- (2021) Suniti Bhaumik et al. JOURNAL OF IMMUNOLOGY
- TCF-1 controls Treg cell functions that regulate inflammation, CD8+ T cell cytotoxicity and severity of colon cancer
- (2021) Abu Osman et al. NATURE IMMUNOLOGY
- Expression of Tim-3 drives phenotypic and functional changes in Treg cells in secondary lymphoid organs and the tumor microenvironment
- (2021) Hridesh Banerjee et al. Cell Reports
- Small-Molecule Inhibitors Overcome Epigenetic Reprogramming for Cancer Therapy
- (2021) Wenjing Xiao et al. Frontiers in Pharmacology
- IDO in Colorectal Tumorigenesis: Involvement of Immune Tolerance and Significance in Prevention and Therapy
- (2021) Shunan Tang et al. Cellular and Molecular Gastroenterology and Hepatology
- Mogamulizumab in Combination with Nivolumab in a Phase I/II Study of Patients with Locally Advanced or Metastatic Solid Tumors
- (2021) David S. Hong et al. CLINICAL CANCER RESEARCH
- CD36-mediated metabolic adaptation supports regulatory T cell survival and function in tumors
- (2020) Haiping Wang et al. NATURE IMMUNOLOGY
- Treg Heterogeneity, Function, and Homeostasis
- (2020) Daniil Shevyrev et al. Frontiers in Immunology
- Colorectal Cancer Immune Infiltrates: Significance in Patient Prognosis and Immunotherapeutic Efficacy
- (2020) Liang Guo et al. Frontiers in Immunology
- Effect of Combined Immune Checkpoint Inhibition vs Best Supportive Care Alone in Patients With Advanced Colorectal Cancer
- (2020) Eric X. Chen et al. JAMA Oncology
- Myeloid-Derived Suppressor Cells in Tumors: From Mechanisms to Antigen Specificity and Microenvironmental Regulation
- (2020) Yuhui Yang et al. Frontiers in Immunology
- The PD-1 expression balance between effector and regulatory T cells predicts the clinical efficacy of PD-1 blockade therapies
- (2020) Shogo Kumagai et al. NATURE IMMUNOLOGY
- Revisiting the PD-1 pathway
- (2020) Nikolaos Patsoukis et al. Science Advances
- High-Dimensional Mass Cytometric Analysis Reveals an Increase in Effector Regulatory T Cells as a Distinguishing Feature of Colorectal Tumors
- (2019) Samuel E. Norton et al. JOURNAL OF IMMUNOLOGY
- Single-Cell Transcriptomics of Regulatory T Cells Reveals Trajectories of Tissue Adaptation
- (2019) Ricardo J. Miragaia et al. IMMUNITY
- FDA Approval Summary: Pembrolizumab for the treatment of microsatellite instability-high solid tumors
- (2019) Leigh Marcus et al. CLINICAL CANCER RESEARCH
- A review of bispecific antibodies and antibody constructs in oncology and clinical challenges
- (2019) Frans V. Suurs et al. PHARMACOLOGY & THERAPEUTICS
- Metabolic pathways regulating colorectal cancer initiation and progression
- (2019) Sofia La Vecchia et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- Characterization of a novel anti-human lymphocyte activation gene 3 (LAG-3) antibody for cancer immunotherapy
- (2019) Xiaojie Yu et al. mAbs
- Loss of TET2 and TET3 in regulatory T cells unleashes effector function
- (2019) Xiaojing Yue et al. Nature Communications
- The Pivotal Role of Regulatory T Cells in the Regulation of Innate Immune Cells
- (2019) Emeka B. Okeke et al. Frontiers in Immunology
- How does the immune system learn to distinguish between good and evil? The first definitive studies of T cell central tolerance and positive selection
- (2019) Paweł Kisielow IMMUNOGENETICS
- Regulatory T cells in skin are uniquely poised to suppress profibrotic immune responses
- (2019) Lokesh A. Kalekar et al. Science Immunology
- M2‐polarized tumor‐associated macrophages promote epithelial‐mesenchymal transition via activation of the AKT3/PRAS40 signaling pathway in intrahepatic cholangiocarcinoma
- (2019) Dalong Sun et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Advances of immune checkpoints in colorectal cancer treatment
- (2019) Qinlian Jiao et al. BIOMEDICINE & PHARMACOTHERAPY
- Regulation of Tumor Initiation by the Mitochondrial Pyruvate Carrier
- (2019) Claire L. Bensard et al. Cell Metabolism
- Mitochondrial Integrity Regulated by Lipid Metabolism Is a Cell-Intrinsic Checkpoint for Treg Suppressive Function
- (2019) Cameron S. Field et al. Cell Metabolism
- Amino Acids License Kinase mTORC1 Activity and Treg Cell Function via Small G Proteins Rag and Rheb
- (2019) Hao Shi et al. IMMUNITY
- Histone/protein deacetylase inhibitor therapy for enhancement of Foxp3+ T-regulatory cell function posttransplantation
- (2018) L. Wang et al. AMERICAN JOURNAL OF TRANSPLANTATION
- Fc Effector Function Contributes to the Activity of Human Anti-CTLA-4 Antibodies
- (2018) Frederick Arce Vargas et al. CANCER CELL
- Targeting CCR8 induces protective antitumor immunity and enhances vaccine-induced responses in colon cancer
- (2018) Daniel O Villarreal et al. CANCER RESEARCH
- Co-expression of LAG3 and TIM3 identifies a potent Treg population that suppresses macrophage functions in colorectal cancer patients
- (2018) Qiang Ma et al. CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
- Durable Clinical Benefit With Nivolumab Plus Ipilimumab in DNA Mismatch Repair–Deficient/Microsatellite Instability–High Metastatic Colorectal Cancer
- (2018) Michael J. Overman et al. JOURNAL OF CLINICAL ONCOLOGY
- Deregulated Mucosal Immune Surveillance through Gut-Associated Regulatory T Cells and PD-1+T Cells in Human Colorectal Cancer
- (2018) Hanae Fujimoto et al. JOURNAL OF IMMUNOLOGY
- Fatty acid metabolism complements glycolysis in the selective regulatory T cell expansion during tumor growth
- (2018) Ilenia Pacella et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Participation of CCL1 in Snail-Positive Fibroblasts in Colorectal Cancer Contribute to 5-Fluorouracil/Paclitaxel Chemoresistance
- (2018) Ziqian Li et al. Cancer Research and Treatment
- Anti-CTLA-4 antibodies in cancer immunotherapy: selective depletion of intratumoral regulatory T cells or checkpoint blockade?
- (2018) Fei Tang et al. Cell and Bioscience
- RORγt-Expressing Tregs Drive the Growth of Colitis-Associated Colorectal Cancer by Controlling IL6 in Dendritic Cells
- (2018) Angelamaria Rizzo et al. Cancer Immunology Research
- STAT5 and TET2 Cooperate to Regulate FOXP3-TSDR Demethylation in CD4+ T Cells of Patients with Colorectal Cancer
- (2018) Hulin Ma et al. Journal of Immunology Research
- DNA methylation and repressive histones in the promoters of PD-1, CTLA-4, TIM-3, LAG-3, TIGIT, PD-L1, and galectin-9 genes in human colorectal cancer
- (2018) Varun Sasidharan Nair et al. Clinical Epigenetics
- T Helper Cell Cytokines Modulate Intestinal Stem Cell Renewal and Differentiation
- (2018) Moshe Biton et al. CELL
- LAG-3 inhibits the activation of CD4+ T cells that recognize stable pMHCII through its conformation-dependent recognition of pMHCII
- (2018) Takumi Maruhashi et al. NATURE IMMUNOLOGY
- DNA methylation of immune checkpoints in the peripheral blood of breast and colorectal cancer patients
- (2018) Asma A. Elashi et al. OncoImmunology
- Tim-3 and its role in regulating anti-tumor immunity
- (2017) Madhumita Das et al. IMMUNOLOGICAL REVIEWS
- Nivolumab in patients with advanced hepatocellular carcinoma (CheckMate 040): an open-label, non-comparative, phase 1/2 dose escalation and expansion trial
- (2017) Anthony B El-Khoueiry et al. LANCET
- Nivolumab in patients with metastatic DNA mismatch repair-deficient or microsatellite instability-high colorectal cancer (CheckMate 142): an open-label, multicentre, phase 2 study
- (2017) Michael J Overman et al. LANCET ONCOLOGY
- Phenotypic and Functional Properties of Tumor-Infiltrating Regulatory T Cells
- (2017) Gap Ryol Lee MEDIATORS OF INFLAMMATION
- Global metabolic reprogramming of colorectal cancer occurs at adenoma stage and is induced by MYC
- (2017) Kiyotoshi Satoh et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade
- (2017) Dung T. Le et al. SCIENCE
- Microbiome, inflammation and colorectal cancer
- (2017) Ju Chen et al. SEMINARS IN IMMUNOLOGY
- Role of LAP+CD4+ T cells in the tumor microenvironment of colorectal cancer
- (2017) Wu Zhong et al. WORLD JOURNAL OF GASTROENTEROLOGY
- Suppressive IL-17A+Foxp3+ and ex-Th17 IL-17AnegFoxp3+ Treg cells are a source of tumour-associated Treg cells
- (2017) Stephanie Downs-Canner et al. Nature Communications
- Synergistic Immunostimulatory Effects and Therapeutic Benefit of Combined Histone Deacetylase and Bromodomain Inhibition in Non–Small Cell Lung Cancer
- (2017) Dennis O. Adeegbe et al. Cancer Discovery
- An Atlas of Human Regulatory T Helper-like Cells Reveals Features of Th2-like Tregs that Support a Tumorigenic Environment
- (2017) Leena Halim et al. Cell Reports
- Glycolysis and glutaminolysis cooperatively control T cell function by limiting metabolite supply to N-glycosylation
- (2017) Lindsey Araujo et al. eLife
- Intratumoral FoxP3+Helios+ Regulatory T Cells Upregulating Immunosuppressive Molecules Are Expanded in Human Colorectal Cancer
- (2017) Azharuddin Sajid Syed Khaja et al. Frontiers in Immunology
- Tregs: Where We Are and What Comes Next?
- (2017) Hai Zhao et al. Frontiers in Immunology
- Effect of Modified Vaccinia Ankara–5T4 and Low-Dose Cyclophosphamide on Antitumor Immunity in Metastatic Colorectal Cancer
- (2017) Martin Scurr et al. JAMA Oncology
- Prevalence and Spectrum of Germline Cancer Susceptibility Gene Mutations Among Patients With Early-Onset Colorectal Cancer
- (2017) Rachel Pearlman et al. JAMA Oncology
- Tissue Tregs
- (2016) Marisella Panduro et al. Annual Review of Immunology
- CCR2 Influences T Regulatory Cell Migration to Tumors and Serves as a Biomarker of Cyclophosphamide Sensitivity
- (2016) Pierre-Louis Loyher et al. CANCER RESEARCH
- The Emerging Hallmarks of Cancer Metabolism
- (2016) Natalya N. Pavlova et al. Cell Metabolism
- Structural basis for blocking PD-1-mediated immune suppression by therapeutic antibody pembrolizumab
- (2016) Zhenkun Na et al. CELL RESEARCH
- Lag-3, Tim-3, and TIGIT: Co-inhibitory Receptors with Specialized Functions in Immune Regulation
- (2016) Ana C. Anderson et al. IMMUNITY
- Transcriptional Landscape of Human Tissue Lymphocytes Unveils Uniqueness of Tumor-Infiltrating T Regulatory Cells
- (2016) Marco De Simone et al. IMMUNITY
- Regulatory T Cells Exhibit Distinct Features in Human Breast Cancer
- (2016) George Plitas et al. IMMUNITY
- Normalizing Microbiota-Induced Retinoic Acid Deficiency Stimulates Protective CD8 + T Cell-Mediated Immunity in Colorectal Cancer
- (2016) Nupur Bhattacharya et al. IMMUNITY
- Control of Foxp3 stability through modulation of TET activity
- (2016) Xiaojing Yue et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Guidance of regulatory T cell development by Satb1-dependent super-enhancer establishment
- (2016) Yohko Kitagawa et al. NATURE IMMUNOLOGY
- Two FOXP3+CD4+ T cell subpopulations distinctly control the prognosis of colorectal cancers
- (2016) Takuro Saito et al. NATURE MEDICINE
- Nivolumab for Recurrent Squamous-Cell Carcinoma of the Head and Neck
- (2016) Robert L. Ferris et al. NEW ENGLAND JOURNAL OF MEDICINE
- Elevated level of Interleukin-35 in colorectal cancer induces conversion of T cells into iTr35 by activating STAT1/STAT3
- (2016) Yanhui Ma et al. Oncotarget
- Helios Should Not Be Cited as a Marker of Human Thymus-Derived Tregs. Commentary: Helios+ and Helios− Cells Coexist within the Natural FOXP3+ T Regulatory Cell Subset in Humans
- (2016) Eyad Elkord Frontiers in Immunology
- IL-33 Receptor-Expressing Regulatory T Cells Are Highly Activated, Th2 Biased and Suppress CD4 T Cell Proliferation through IL-10 and TGFβ Release
- (2016) Julia Siede et al. PLoS One
- Inhibition of indoleamine 2,3-dioxygenase 1 expression alters immune response in colon tumor microenvironment in mice
- (2015) Manabu Takamatsu et al. CANCER SCIENCE
- Phase Ia Study of FoxP3+ CD4 Treg Depletion by Infusion of a Humanized Anti-CCR4 Antibody, KW-0761, in Cancer Patients
- (2015) K. Kurose et al. CLINICAL CANCER RESEARCH
- Hydrogen Sulfide Promotes Tet1- and Tet2-Mediated Foxp3 Demethylation to Drive Regulatory T Cell Differentiation and Maintain Immune Homeostasis
- (2015) Ruili Yang et al. IMMUNITY
- Ubiquitin-dependent regulation of Foxp3 and Treg function
- (2015) Joseph Barbi et al. IMMUNOLOGICAL REVIEWS
- Interleukin-35: Expanding Its Job Profile
- (2015) Deepali V. Sawant et al. JOURNAL OF INTERFERON AND CYTOKINE RESEARCH
- Foxp3+ T cells expressing RORγt represent a stable regulatory T-cell effector lineage with enhanced suppressive capacity during intestinal inflammation
- (2015) B-H Yang et al. Mucosal Immunology
- PD-1 Blockade in Tumors with Mismatch-Repair Deficiency
- (2015) Dung T. Le et al. NEW ENGLAND JOURNAL OF MEDICINE
- The microbiota regulates type 2 immunity through ROR t+ T cells
- (2015) C. Ohnmacht et al. SCIENCE
- Individual intestinal symbionts induce a distinct population of ROR + regulatory T cells
- (2015) E. Sefik et al. SCIENCE
- Glutamine-dependent α-ketoglutarate production regulates the balance between T helper 1 cell and regulatory T cell generation
- (2015) Dorota Klysz et al. Science Signaling
- PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation
- (2015) Nikolaos Patsoukis et al. Nature Communications
- Prognostic value of tumor-infiltrating FoxP3+ regulatory T cells in cancers: a systematic review and meta-analysis
- (2015) Bin Shang et al. Scientific Reports
- Glutamine-dependent α-ketoglutarate production regulates the balance between T helper 1 cell and regulatory T cell generation
- (2015) Dorota Klysz et al. Science Signaling
- The effects of CCR5 inhibition on regulatory T-cell recruitment to colorectal cancer
- (2014) S T Ward et al. BRITISH JOURNAL OF CANCER
- The Immunoreceptor TIGIT Regulates Antitumor and Antiviral CD8 + T Cell Effector Function
- (2014) Robert J. Johnston et al. CANCER CELL
- Control of the Inheritance of Regulatory T Cell Identity by a cis Element in the Foxp3 Locus
- (2014) Yongqiang Feng et al. CELL
- Regulatory T cells in cancer immunotherapy
- (2014) Hiroyoshi Nishikawa et al. CURRENT OPINION IN IMMUNOLOGY
- Enhanced suppressor function of TIM-3+FoxP3+regulatory T cells
- (2014) Anne-Sophie Gautron et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Regulatory T Cells Control Dendritic Cell/NK Cell Cross-Talk in Lymph Nodes at the Steady State by Inhibiting CD4+ Self-Reactive T Cells
- (2014) M. Terme et al. JOURNAL OF IMMUNOLOGY
- The Indoleamine 2,3-Dioxygenase Pathway Is Essential for Human Plasmacytoid Dendritic Cell-Induced Adaptive T Regulatory Cell Generation
- (2014) W. Chen et al. JOURNAL OF IMMUNOLOGY
- Higher FOXP3-TSDR demethylation rates in adjacent normal tissues in patients with colon cancer were associated with worse survival
- (2014) Changhua Zhuo et al. Molecular Cancer
- The alarmin IL-33 promotes regulatory T-cell function in the intestine
- (2014) Chris Schiering et al. NATURE
- An Increased Abundance of Tumor-Infiltrating Regulatory T Cells Is Correlated with the Progression and Prognosis of Pancreatic Ductal Adenocarcinoma
- (2014) Yichen Tang et al. PLoS One
- CD4+ T Cells Expressing Latency-Associated Peptide and Foxp3 Are an Activated Subgroup of Regulatory T Cells Enriched in Patients with Colorectal Cancer
- (2014) Jayashri Mahalingam et al. PLoS One
- -Catenin Promotes Colitis and Colon Cancer Through Imprinting of Proinflammatory Properties in T Cells
- (2014) S. Keerthivasan et al. Science Translational Medicine
- Early-onset colorectal cancer: A sporadic or inherited disease?
- (2014) Vittoria Stigliano WORLD JOURNAL OF GASTROENTEROLOGY
- A Special Population of Regulatory T Cells Potentiates Muscle Repair
- (2013) Dalia Burzyn et al. CELL
- Spatiotemporal Dynamics of Intratumoral Immune Cells Reveal the Immune Landscape in Human Cancer
- (2013) Gabriela Bindea et al. IMMUNITY
- Activating Fc γ receptors contribute to the antitumor activities of immunoregulatory receptor-targeting antibodies
- (2013) Yannick Bulliard et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti–CTLA-4 therapy against melanoma
- (2013) Tyler R. Simpson et al. JOURNAL OF EXPERIMENTAL MEDICINE
- CCR7 provides localized access to IL-2 and defines homeostatically distinct regulatory T cell subsets
- (2013) Kate S. Smigiel et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Highly prevalent colorectal cancer-infiltrating LAP+ Foxp3− T cells exhibit more potent immunosuppressive activity than Foxp3+ regulatory T cells
- (2013) M Scurr et al. Mucosal Immunology
- Thymus-derived regulatory T cells contribute to tolerance to commensal microbiota
- (2013) Anna Cebula et al. NATURE
- mTORC1 couples immune signals and metabolic programming to establish Treg-cell function
- (2013) Hu Zeng et al. NATURE
- Microenvironmental regulation of tumor progression and metastasis
- (2013) Daniela F Quail et al. NATURE MEDICINE
- Tim-3 Expression Defines Regulatory T Cells in Human Tumors
- (2013) Jing Yan et al. PLoS One
- Aire-Dependent Thymic Development of Tumor-Associated Regulatory T Cells
- (2013) S. Malchow et al. SCIENCE
- Controlling the frontier: Regulatory T-cells and intestinal homeostasis
- (2013) Julia Bollrath et al. SEMINARS IN IMMUNOLOGY
- Anti-CTLA-4 Antibodies of IgG2a Isotype Enhance Antitumor Activity through Reduction of Intratumoral Regulatory T Cells
- (2013) M. J. Selby et al. Cancer Immunology Research
- Peripherally Induced Tregs – Role in Immune Homeostasis and Autoimmunity
- (2013) Mahesh Yadav et al. Frontiers in Immunology
- TIM3+FOXP3+regulatory T cells are tissue-specific promoters of T-cell dysfunction in cancer
- (2013) Kaori Sakuishi et al. OncoImmunology
- Regulatory T Cell Infiltration Predicts Outcome Following Resection of Colorectal Cancer Liver Metastases
- (2012) Steven C. Katz et al. ANNALS OF SURGICAL ONCOLOGY
- Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment
- (2012) Douglas Hanahan et al. CANCER CELL
- Tumor-Derived Chemokine CCL5 Enhances TGF- -Mediated Killing of CD8+ T Cells in Colon Cancer by T-Regulatory Cells
- (2012) L.-Y. Chang et al. CANCER RESEARCH
- The T-cell Receptor Repertoire of Tumor-Infiltrating Regulatory T Lymphocytes Is Skewed Toward Public Sequences
- (2012) A. Sainz-Perez et al. CANCER RESEARCH
- The Prognostic Value of FoxP3+ Tumor-Infiltrating Lymphocytes in Cancer: A Critical Review of the Literature
- (2012) R. J. deLeeuw et al. CLINICAL CANCER RESEARCH
- Colorectal cancer: a tale of two sides or a continuum?: Figure 1
- (2012) Mai Yamauchi et al. GUT
- T Cell Receptor Stimulation-Induced Epigenetic Changes and Foxp3 Expression Are Independent and Complementary Events Required for Treg Cell Development
- (2012) Naganari Ohkura et al. IMMUNITY
- Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+T reg cells
- (2012) Jonathan M. Weiss et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Neuropilin-1 distinguishes natural and inducible regulatory T cells among regulatory T cell subsets in vivo
- (2012) Mahesh Yadav et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Extrathymically generated regulatory T cells control mucosal TH2 inflammation
- (2012) Steven Z. Josefowicz et al. NATURE
- The composition and signaling of the IL-35 receptor are unconventional
- (2012) Lauren W Collison et al. NATURE IMMUNOLOGY
- TIM-3 Expression Characterizes Regulatory T Cells in Tumor Tissues and Is Associated with Lung Cancer Progression
- (2012) Xin Gao et al. PLoS One
- Prognostic Impact of FoxP3+ Regulatory T Cells in Relation to CD8+ T Lymphocyte Density in Human Colon Carcinomas
- (2012) Harry H. Yoon et al. PLoS One
- Immune microenvironmental shift along human colorectal adenoma–carcinoma sequence: is it relevant to tumor development, biomarkers and biotherapeutic targets?
- (2012) Guanglin Cui et al. SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
- Expression of ROR t Marks a Pathogenic Regulatory T Cell Subset in Human Colon Cancer
- (2012) N. R. Blatner et al. Science Translational Medicine
- Inflammation and colorectal cancer: colitis-associated neoplasia
- (2012) Sergei I. Grivennikov Seminars in Immunopathology
- Single low-dose cyclophosphamide combined with interleukin-12 gene therapy is superior to a metronomic schedule in inducing immunity against colorectal carcinoma in mice
- (2012) Mariana Malvicini et al. OncoImmunology
- Regulatory T-cell-mediated inhibition of antitumor immune responses is associated with clinical outcome in patients with liver metastasis from colorectal cancer
- (2011) Kristoffer Watten Brudvik et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Prognostic role of FOXP3+ regulatory T cells infiltrating human carcinomas: the paradox of colorectal cancer
- (2011) Sylvain Ladoire et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- CD73-Deficient Mice Have Increased Antitumor Immunity and Are Resistant to Experimental Metastasis
- (2011) J. Stagg et al. CANCER RESEARCH
- Upregulated Expression of Indoleamine 2, 3-Dioxygenase in Primary Breast Cancer Correlates with Increase of Infiltrated Regulatory T CellsIn Situand Lymph Node Metastasis
- (2011) Jinpu Yu et al. Clinical & Developmental Immunology
- Vstm3 is a member of the CD28 family and an important modulator of T-cell function
- (2011) Steven D. Levin et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Intestinal Bacterial Colonization Induces Mutualistic Regulatory T Cell Responses
- (2011) Markus B. Geuking et al. IMMUNITY
- GATA3 controls Foxp3+ regulatory T cell fate during inflammation in mice
- (2011) Elizabeth A. Wohlfert et al. JOURNAL OF CLINICAL INVESTIGATION
- IL-17 + Regulatory T Cells in the Microenvironments of Chronic Inflammation and Cancer
- (2011) Ilona Kryczek et al. JOURNAL OF IMMUNOLOGY
- Cutting Edge: Distinct Glycolytic and Lipid Oxidative Metabolic Programs Are Essential for Effector and Regulatory CD4+ T Cell Subsets
- (2011) R. D. Michalek et al. JOURNAL OF IMMUNOLOGY
- Anti-CTLA4 monoclonal antibodies: the past and the future in clinical application
- (2011) Paolo A Ascierto et al. Journal of Translational Medicine
- Reversal of gastrointestinal carcinoma-induced immunosuppression and induction of antitumoural immunity by a combination of cyclophosphamide and gene transfer of IL-12
- (2011) Mariana Malvicini et al. Molecular Oncology
- Peripheral education of the immune system by colonic commensal microbiota
- (2011) Stephanie K. Lathrop et al. NATURE
- Tumor-Associated Macrophages Recruit CCR6+ Regulatory T Cells and Promote the Development of Colorectal Cancer via Enhancing CCL20 Production in Mice
- (2011) Jinlin Liu et al. PLoS One
- Colorectal Cancer-Derived Foxp3+IL-17+ T Cells Suppress Tumour-Specific CD8+ T Cells
- (2011) C. Ma et al. SCANDINAVIAN JOURNAL OF IMMUNOLOGY
- Trans-Endocytosis of CD80 and CD86: A Molecular Basis for the Cell-Extrinsic Function of CTLA-4
- (2011) O. S. Qureshi et al. SCIENCE
- Immunomodulatory effects of cyclophosphamide and implementations for vaccine design
- (2011) Antonella Sistigu et al. Seminars in Immunopathology
- Analysis of the T-Cell Receptor Repertoires of Tumor-Infiltrating Conventional and Regulatory T Cells Reveals No Evidence for Conversion in Carcinogen-Induced Tumors
- (2010) J. P. Hindley et al. CANCER RESEARCH
- Tremelimumab (anti-CTLA4) mediates immune responses mainly by direct activation of T effector cells rather than by affecting T regulatory cells
- (2010) Sameena Khan et al. CLINICAL IMMUNOLOGY
- Hereditary and Familial Colon Cancer
- (2010) Kory W. Jasperson et al. GASTROENTEROLOGY
- CD39/ENTPD1 Expression by CD4+Foxp3+ Regulatory T Cells Promotes Hepatic Metastatic Tumor Growth in Mice
- (2010) Xiaofeng Sun et al. GASTROENTEROLOGY
- Phase II Study of the Anti-Cytotoxic T-Lymphocyte–Associated Antigen 4 Monoclonal Antibody, Tremelimumab, in Patients With Refractory Metastatic Colorectal Cancer
- (2010) Ki Y. Chung et al. JOURNAL OF CLINICAL ONCOLOGY
- Phase I Study of Single-Agent Anti–Programmed Death-1 (MDX-1106) in Refractory Solid Tumors: Safety, Clinical Activity, Pharmacodynamics, and Immunologic Correlates
- (2010) Julie R. Brahmer et al. JOURNAL OF CLINICAL ONCOLOGY
- Blockade of CCL1 Inhibits T Regulatory Cell Suppressive Function Enhancing Tumor Immunity without Affecting T Effector Responses
- (2010) D. B. Hoelzinger et al. JOURNAL OF IMMUNOLOGY
- LAG-3 Expression Defines a Subset of CD4+CD25highFoxp3+ Regulatory T Cells That Are Expanded at Tumor Sites
- (2010) C. Camisaschi et al. JOURNAL OF IMMUNOLOGY
- Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate
- (2010) Ye Zheng et al. NATURE
- IL-35-mediated induction of a potent regulatory T cell population
- (2010) Lauren W Collison et al. NATURE IMMUNOLOGY
- Extracellular adenosine triphosphate and adenosine in cancer
- (2010) J Stagg et al. ONCOGENE
- In colorectal cancer mast cells contribute to systemic regulatory T-cell dysfunction
- (2010) N. R. Blatner et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species
- (2010) K. Atarashi et al. SCIENCE
- Development of Ipilimumab: Contribution to a New Paradigm for Cancer Immunotherapy
- (2010) Axel Hoos et al. SEMINARS IN ONCOLOGY
- Quantitative DNA Methylation Analysis of FOXP3 as a New Method for Counting Regulatory T Cells in Peripheral Blood and Solid Tissue
- (2009) G. Wieczorek et al. CANCER RESEARCH
- T-Regulatory Cells Shift from a Protective Anti-Inflammatory to a Cancer-Promoting Proinflammatory Phenotype in Polyposis
- (2009) Elias Gounaris et al. CANCER RESEARCH
- Intraepithelial Effector (CD3+)/Regulatory (FoxP3+) T-Cell Ratio Predicts a Clinical Outcome of Human Colon Carcinoma
- (2009) Frank A. Sinicrope et al. GASTROENTEROLOGY
- Lineage-specific DNA methylation in T cells correlates with histone methylation and enhancer activity
- (2009) C. Schmidl et al. GENOME RESEARCH
- Functional Delineation and Differentiation Dynamics of Human CD4+ T Cells Expressing the FoxP3 Transcription Factor
- (2009) Makoto Miyara et al. IMMUNITY
- High frequency of tumor-infiltrating FOXP3+regulatory T cells predicts improved survival in mismatch repair-proficient colorectal cancer patients
- (2009) Daniel M. Frey et al. INTERNATIONAL JOURNAL OF CANCER
- Antigen-specific Tregs control T cell responses against a limited repertoire of tumor antigens in patients with colorectal carcinoma
- (2009) Andreas Bonertz et al. JOURNAL OF CLINICAL INVESTIGATION
- In Situ Cytotoxic and Memory T Cells Predict Outcome in Patients With Early-Stage Colorectal Cancer
- (2009) Franck Pagès et al. JOURNAL OF CLINICAL ONCOLOGY
- IDO Activates Regulatory T Cells and Blocks Their Conversion into Th17-Like T Cells
- (2009) B. Baban et al. JOURNAL OF IMMUNOLOGY
- Molecular Basis of Colorectal Cancer
- (2009) Sanford D. Markowitz et al. NEW ENGLAND JOURNAL OF MEDICINE
- CTLA4 blockade expands FoxP3+ regulatory and activated effector CD4+ T cells in a dose-dependent fashion
- (2008) B. Kavanagh et al. BLOOD
- Clinical significance of tumor markers and an emerging perspective on colorectal cancer
- (2008) Keishi Yamashita et al. CANCER SCIENCE
- Regulatory T Cells and Immune Tolerance
- (2008) Shimon Sakaguchi et al. CELL
- Identification of CD8+CD25+Foxp3+ suppressive T cells in colorectal cancer tissue
- (2008) N Chaput et al. GUT
- CD4+CD25+ Tregs control the TRAIL-dependent cytotoxicity of tumor-infiltrating DCs in rodent models of colon cancer
- (2008) Stephan Roux et al. JOURNAL OF CLINICAL INVESTIGATION
- Tumor-Infiltrating FOXP3+ T Regulatory Cells Show Strong Prognostic Significance in Colorectal Cancer
- (2008) Paul Salama et al. JOURNAL OF CLINICAL ONCOLOGY
- Immune-mediated dormancy: an equilibrium with cancer
- (2008) Michele W. L. Teng et al. JOURNAL OF LEUKOCYTE BIOLOGY
- The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells
- (2008) Xin Yu et al. NATURE IMMUNOLOGY
- CTLA-4 Control over Foxp3+ Regulatory T Cell Function
- (2008) K. Wing et al. SCIENCE
- Regulatory T Cells: Mechanisms of Differentiation and Function
- (2007) Steven Z. Josefowicz et al. Annual Review of Immunology
Become a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get StartedAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started