Targeting the hedgehog pathway in MET mutation cancers and its effects on cells associated with cancer development
出版年份 2023 全文链接
标题
Targeting the hedgehog pathway in MET mutation cancers and its effects on cells associated with cancer development
作者
关键词
-
出版物
Cell Communication and Signaling
Volume 21, Issue 1, Pages -
出版商
Springer Science and Business Media LLC
发表日期
2023-11-02
DOI
10.1186/s12964-023-01333-8
参考文献
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- Activated fibroblasts in cancer: Perspectives and challenges
- (2023) Giuseppina Caligiuri et al. CANCER CELL
- Cellular and molecular mechanisms of Hedgehog signalling
- (2023) Yunxiao Zhang et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Molecular mechanism(s) of regulation(s) of c-MET/HGF signaling in head and neck cancer
- (2022) Sibi Raj et al. Molecular Cancer
- Phase I Study of Glesatinib (MGCD265) in Combination with Erlotinib or Docetaxel in Patients with Advanced Solid Tumors
- (2022) Amita Patnaik et al. Targeted Oncology
- HGF/c-Met pathway facilitates the perineural invasion of pancreatic cancer by activating the mTOR/NGF axis
- (2022) Tao Qin et al. Cell Death & Disease
- HGF/c-Met: A Key Promoter in Liver Regeneration
- (2022) Yang Zhao et al. Frontiers in Pharmacology
- ERK2 MAP kinase regulates SUFU binding by multisite phosphorylation of GLI1
- (2022) A Jane Bardwell et al. Life Science Alliance
- The transcription factors Foxf1 and Foxf2 integrate the SHH, HGF and TGFβ signaling pathways to drive tongue organogenesis
- (2022) Jingyue Xu et al. DEVELOPMENT
- MET alterations in non-small cell lung cancer – current perspectives and future challenges
- (2022) Jordi Remon et al. Journal of Thoracic Oncology
- Cancer-Associated Fibroblasts Promote Radioresistance of Breast Cancer Cells via the HGF/c-Met Signaling Pathway
- (2022) Baiyao Wang et al. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
- Phase I Study Evaluating Glesatinib (MGCD265), An Inhibitor of MET and AXL, in Patients with Non-small Cell Lung Cancer and Other Advanced Solid Tumors
- (2022) Christian Kollmannsberger et al. Targeted Oncology
- Inhibition of Hedgehog signaling alters fibroblast composition in pancreatic cancer
- (2021) Nina G Steele et al. CLINICAL CANCER RESEARCH
- Constitutive GLI1 expression in chondrosarcoma is regulated by major vault protein via mTOR/S6K1 signaling cascade
- (2021) Wei Wang et al. CELL DEATH AND DIFFERENTIATION
- STAT3 induces the expression of GLI1 in chronic lymphocytic leukemia cells
- (2021) Uri Rozovski et al. Oncotarget
- Hedgehog signaling mechanism and role in cancer
- (2021) Jin Jiang SEMINARS IN CANCER BIOLOGY
- Defining super-enhancer landscape in triple-negative breast cancer by multiomic profiling
- (2021) Hao Huang et al. Nature Communications
- Promotion of cholangiocarcinoma growth by diverse cancer-associated fibroblast subpopulations
- (2021) Silvia Affo et al. CANCER CELL
- ZEB1 promotes cholangiocarcinoma progression through tumor dedifferentiation and tumor‐stroma paracrine signaling
- (2021) Cindy Lobe et al. HEPATOLOGY
- STAT3 is required for Smo‐dependent signaling and mediates Smo‐targeted treatment resistance and tumorigenesis in Shh medulloblastoma
- (2021) Liangping Yuan et al. Molecular Oncology
- Clinical and therapeutic relevance of cancer-associated fibroblasts
- (2021) Yang Chen et al. Nature Reviews Clinical Oncology
- HGF/c-MET pathway in cancer: from molecular characterization to clinical evidence
- (2021) Jianjiang Fu et al. ONCOGENE
- Structural basis of the activation of c-MET receptor
- (2021) Emiko Uchikawa et al. Nature Communications
- HGF and MET: From Brain Development to Neurological Disorders
- (2021) Claudia Desole et al. Frontiers in Cell and Developmental Biology
- Lactic acid in tumor invasion
- (2021) Dun Niu et al. CLINICA CHIMICA ACTA
- Anticancer drug resistance: An update and perspective
- (2021) Ruth Nussinov et al. DRUG RESISTANCE UPDATES
- Hedgehog-Interacting Protein is a multimodal antagonist of Hedgehog signalling
- (2021) Samuel C. Griffiths et al. Nature Communications
- ABHD5 inhibits YAP-induced c-Met overexpression and colon cancer cell stemness via suppressing YAP methylation
- (2021) Yan Gu et al. Nature Communications
- Hedgehog Pathway Inhibitors against Tumor Microenvironment
- (2021) Silpa Gampala et al. Cells
- The Influence of Met Receptor Level on HGF-Induced Glycolytic Reprogramming in Head and Neck Squamous Cell Carcinoma
- (2020) Verena Boschert et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Mechanistic Insights into the Generation and Transduction of Hedgehog Signaling
- (2020) Xiaofeng Qi et al. TRENDS IN BIOCHEMICAL SCIENCES
- DIVERSITY AND BIOLOGY OF CANCER-ASSOCIATED FIBROBLASTS
- (2020) Giulia Biffi et al. PHYSIOLOGICAL REVIEWS
- Discovery of [1,2,4]triazolo[4,3-a]pyridines as potent Smoothened inhibitors targeting the Hedgehog pathway with improved antitumor activity in vivo
- (2020) Nannan Tian et al. BIOORGANIC & MEDICINAL CHEMISTRY
- MET-dependent solid tumours — molecular diagnosis and targeted therapy
- (2020) Robin Guo et al. Nature Reviews Clinical Oncology
- Targeting MET Dysregulation in Cancer
- (2020) Gonzalo Recondo et al. Cancer Discovery
- YAP orchestrates heterotypic endothelial cell communication via HGF/c-MET signaling in liver tumorigenesis
- (2020) Stefan Thomann et al. CANCER RESEARCH
- Hedgehog pathway activation in oral squamous cell carcinoma: cancer-associated fibroblasts exhibit nuclear GLI-1 localization
- (2020) Vanessa Sousa Nazare Guimaraes et al. JOURNAL OF MOLECULAR HISTOLOGY
- Sterol and oxysterol synthases near the ciliary base activate the Hedgehog pathway
- (2020) Sarah Findakly et al. JOURNAL OF CELL BIOLOGY
- Genetic Heterogeneity of MET-aberrant Non-Small Cell Lung Cancer and its Impact on the Outcome of Immunotherapy
- (2020) A. Kron et al. Journal of Thoracic Oncology
- Distinct Localization of Mature HGF from its Precursor Form in Developing and Repairing the Stomach
- (2019) Nawaphat Jangphattananont et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Extracellular lipid loading augments hypoxic paracrine signaling and promotes glioma angiogenesis and macrophage infiltration
- (2019) Svenja Offer et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Sensitivity and Resistance of MET Exon 14 Mutations in Lung Cancer to Eight MET Tyrosine Kinase Inhibitors In Vitro
- (2019) Toshio Fujino et al. Journal of Thoracic Oncology
- The emergence of drug resistance to targeted therapies: Clinical evidence
- (2019) Ana Bela Sarmento-Ribeiro et al. DRUG RESISTANCE UPDATES
- Targeting signalling pathways and the immune microenvironment of cancer stem cells — a clinical update
- (2019) Joseph A. Clara et al. Nature Reviews Clinical Oncology
- Mechanisms of acquired resistance to first- and second-generation EGFR tyrosine kinase inhibitors
- (2018) D Westover et al. ANNALS OF ONCOLOGY
- Simultaneous inhibition of hedgehog signaling and tumor proliferation remodels stroma and enhances pancreatic cancer therapy
- (2018) Jun Zhao et al. BIOMATERIALS
- A highlight on Sonic hedgehog pathway
- (2018) Gabriela Basile Carballo et al. Cell Communication and Signaling
- ADAMTS-1 disrupts HGF/c-MET signaling and HGF-stimulated cellular processes in fibrosarcoma
- (2018) Heydi Noriega-Guerra et al. EXPERIMENTAL CELL RESEARCH
- Function of the c-Met receptor tyrosine kinase in carcinogenesis and associated therapeutic opportunities
- (2018) Yazhuo Zhang et al. Molecular Cancer
- Wnt and Hedgehog: Secretion of Lipid-Modified Morphogens
- (2018) Anup Parchure et al. TRENDS IN CELL BIOLOGY
- Paracrine HGF/c-MET enhances the stem cell-like potential and glycolysis of pancreatic cancer cells via activation of YAP/HIF-1α
- (2018) Bin Yan et al. EXPERIMENTAL CELL RESEARCH
- Papillary Renal Cell Carcinoma (PRCC)
- (2018) Mohammed Akhtar et al. ADVANCES IN ANATOMIC PATHOLOGY
- Extracellular Matrix Influencing HGF/c-MET Signaling Pathway: Impact on Cancer Progression
- (2018) Heydi Noriega-Guerra et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Dual MET and SMO Negative Modulators Overcome Resistance to EGFR Inhibitors in Human Nonsmall Cell Lung Cancer
- (2017) Floriana Morgillo et al. JOURNAL OF MEDICINAL CHEMISTRY
- Dual Inhibition of Hedgehog and c-Met Pathways for Pancreatic Cancer Treatment
- (2017) Agnieszka A. Rucki et al. MOLECULAR CANCER THERAPEUTICS
- Polymeric glabrescione B nanocapsules for passive targeting of Hedgehog-dependent tumor therapyin vitro
- (2017) Cinzia Ingallina et al. Nanomedicine
- Deletion of ADAM-9 in HGF/CDK4 mice impairs melanoma development and metastasis
- (2017) N Giebeler et al. ONCOGENE
- Stroma-derived HGF drives metabolic adaptation of colorectal cancer to angiogenesis inhibitors
- (2017) Alessia Mira et al. Oncotarget
- Canadian Cancer Trials Group IND197: a phase II study of foretinib in patients with estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2-negative recurrent or metastatic breast cancer
- (2016) Daniel Rayson et al. BREAST CANCER RESEARCH AND TREATMENT
- A Phase I/II Multicenter Study of Single-Agent Foretinib as First-Line Therapy in Patients with Advanced Hepatocellular Carcinoma
- (2016) Thomas C.C. Yau et al. CLINICAL CANCER RESEARCH
- Paracrine sonic hedgehog signaling contributes significantly to acquired steroidogenesis in the prostate tumor microenvironment
- (2016) Amy A. Lubik et al. INTERNATIONAL JOURNAL OF CANCER
- Characterization of 298 Patients with Lung Cancer Harboring MET Exon 14 Skipping Alterations
- (2016) Alexa B. Schrock et al. Journal of Thoracic Oncology
- Comprehensive Molecular Characterization of Papillary Renal-Cell Carcinoma
- (2016) NEW ENGLAND JOURNAL OF MEDICINE
- Translating Hedgehog in Cancer: Controlling Protein Synthesis
- (2016) Davide D’Amico et al. TRENDS IN MOLECULAR MEDICINE
- Caveolin-1 promotes Ewing sarcoma metastasis regulating MMP-9 expression through MAPK/ERK pathway
- (2016) Laura Lagares-Tena et al. Oncotarget
- Targeting Notch, Hedgehog and Wnt pathways in cancer stem cells: clinical update
- (2015) Naoko Takebe et al. Nature Reviews Clinical Oncology
- Mitogen-activated protein kinases and Hedgehog-GLI signaling in cancer: A crosstalk providing therapeutic opportunities?
- (2015) Elisabetta Rovida et al. SEMINARS IN CANCER BIOLOGY
- MET Receptor Juxtamembrane Exon 14 Alternative Spliced Variant: Novel Cancer Genomic Predictive Biomarker
- (2015) P. C. Ma Cancer Discovery
- Activation of MET via Diverse Exon 14 Splicing Alterations Occurs in Multiple Tumor Types and Confers Clinical Sensitivity to MET Inhibitors
- (2015) G. M. Frampton et al. Cancer Discovery
- The impact of S6K1 kinase on neuroblastoma cell proliferation is independent of GLI1 signaling
- (2014) Yumei Diao et al. BMC CANCER
- Pilot Clinical Trial of Hedgehog Pathway Inhibitor GDC-0449 (Vismodegib) in Combination with Gemcitabine in Patients with Metastatic Pancreatic Adenocarcinoma
- (2014) E. J. Kim et al. CLINICAL CANCER RESEARCH
- Mechanisms of Hepatocyte Growth Factor Activation in Cancer Tissues
- (2014) Makiko Kawaguchi et al. Cancers
- Itraconazole and Arsenic Trioxide Inhibit Hedgehog Pathway Activation and Tumor Growth Associated with Acquired Resistance to Smoothened Antagonists
- (2013) James Kim et al. CANCER CELL
- The mechanisms of Hedgehog signalling and its roles in development and disease
- (2013) James Briscoe et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment
- (2012) Douglas Hanahan et al. CANCER CELL
- The Crosstalk of mTOR/S6K1 and Hedgehog Pathways
- (2012) Yan Wang et al. CANCER CELL
- Phase II and Biomarker Study of the Dual MET/VEGFR2 Inhibitor Foretinib in Patients With Papillary Renal Cell Carcinoma
- (2012) Toni K. Choueiri et al. JOURNAL OF CLINICAL ONCOLOGY
- Dispatched and Scube Mediate the Efficient Secretion of the Cholesterol-Modified Hedgehog Ligand
- (2012) Hanna Tukachinsky et al. Cell Reports
- MET signalling: principles and functions in development, organ regeneration and cancer
- (2010) Livio Trusolino et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Fibroblast-secreted hepatocyte growth factor plays a functional role in esophageal squamous cell carcinoma invasion
- (2010) K. D. Grugan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Paracrine Hedgehog Signaling in Cancer
- (2009) J.-W. Theunissen et al. CANCER RESEARCH
- GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation
- (2009) O. Nolan-Stevaux et al. GENES & DEVELOPMENT
- Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade
- (2009) J. M. Hyman et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis
- (2009) H. Tian et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A paracrine requirement for hedgehog signalling in cancer
- (2008) Robert L. Yauch et al. NATURE
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