Review
Oncology
Lars M. Schiffmann, Christiane J. Bruns, Thomas Schmidt
Summary: Anti-angiogenic therapies have not met expectations in clinical trials, as patients develop resistance. Understanding resistance mechanisms is crucial for improving treatment efficacy.
FRONTIERS IN ONCOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Bicai Tang, Wenjuan Ma, Yunfeng Lin
Summary: Studies have shown the potential of nanomaterials in inhibiting pathological angiogenesis, providing new options for cancer treatment. Compared to traditional anti-angiogenic agents, nanomaterials have better targeting capabilities and therapeutic outcomes, reducing side effects.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Chemistry, Multidisciplinary
Pingping Liang, Byron Ballou, Xinyi Lv, Weili Si, Marcel P. Bruchez, Wei Huang, Xiaochen Dong
Summary: Anti-angiogenic therapy targeting vascular endothelial cells to prevent tumor growth has shown modest clinical efficiency in solid tumors. Combining advanced drug delivery techniques or other therapeutic strategies with anti-angiogenic therapy can result in significantly synergistic effects in fighting cancer. Clinical difficulties of traditional anti-angiogenic therapy are discussed, while promising applications of anti-angiogenic nanoagents in monotherapies and combination therapies are highlighted.
ADVANCED MATERIALS
(2021)
Review
Oncology
Zi-Wu Ye, Zi-Li Yu, Gang Chen, Jun Jia
Summary: Tumor angiogenesis is crucial for cancer development, but its inhibition through anti-angiogenic therapy (AAT) is often limited due to resistance. Recent studies suggest that tumor cell-derived extracellular vesicles (T-EVs) play a major role in the development of resistance to AAT by promoting tumor angiogenesis. Furthermore, the role of EVs from non-tumor cells in angiogenesis and their involvement in resistance mechanisms are still not fully understood. This review provides a comprehensive overview of the role of EVs in tumor angiogenesis, resistance to AAT, and proposed strategies for improving AAT efficacy by inhibiting T-EVs.
Review
Biochemistry & Molecular Biology
Filipa Lopes-Coelho, Filipa Martins, Sofia A. Pereira, Jacinta Serpa
Summary: Anti-angiogenic therapy aims to fight cancer by disrupting the nutrient and oxygen supply to tumor cells, mainly by targeting vascular endothelial growth factor (VEGF). While some drugs in this category can enhance immune therapy, they often fall short in terms of efficacy. Researchers believe that targeting alternative angiogenic pathways in combination could be a promising solution.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Nehad M. Ayoub, Sara K. Jaradat, Kamal M. Al-Shami, Amer E. Alkhalifa
Summary: Angiogenesis plays a vital role in the growth and spread of solid cancers, but breast cancer has shown poor response to anti-angiogenic drugs. Assessing the angiogenic signaling mechanisms in breast cancer, exploring new drug targets, and improving treatment outcomes through vascular normalization and nanotechnology are important areas of research.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Wei Yu, Jianwen Huang, Qichao Dong, Wenting Li, Lei Jiang, Qian Zhang, Li Sun, Shengtao Yuan, Xu He
Summary: Ag120, a mutant isocitrate dehydrogenase 1 (IDH1) inhibitor, acts as an ASCT2 inhibitor in colorectal cancer cells. It blocks glutamine uptake and metabolism, leading to reduced cell proliferation, elevated autophagy, and increased oxidative stress, potentially through the ERK and mTOR signaling pathways.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Medicine, Research & Experimental
Xuan Yan, Zhangyan Zhao, Haicheng Tang
Summary: Lung cancer, a high incidence and mortality malignant tumor in China, is a major cause of death and a significant public health problem. Anti-angiogenesis has become a crucial approach to inhibit tumor development by rebalancing pro- and anti-angiogenic factors. This article reviews the mechanism of blood vessel formation in tumor tissues, the action mechanism of different anti-angiogenic drugs, the combination therapy of anti-angiogenic drugs with other anti-tumor drugs, and the mechanism of anti-angiogenic drug resistance.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Article
Engineering, Biomedical
Shimei Li, Zengzhen Chen, Longfei Tan, Qiong Wu, Xiangling Ren, Changhui Fu, Meng Niu, Hong Li, Xianwei Meng
Summary: This study proposes an integrated strategy derived from MOF@COF for remarkably augmenting single MWTT to reduce tumor recurrence.
Review
Biochemistry & Molecular Biology
Miljana Nenkov, Yunxia Ma, Nikolaus Gassler, Yuan Chen
Summary: Colorectal carcinoma is a common cancer characterized by metabolic reprogramming that provides tumor cells with energy and nutrients for malignant growth. The metabolic crosstalk between tumor cells, the tumor microenvironment, and gut microbiota facilitates the development and therapy resistance of colorectal carcinoma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Aranka Brockmueller, Saba Sameri, Alena Liskova, Kevin Zhai, Elizabeth Varghese, Samson Mathews Samuel, Dietrich Busselberg, Peter Kubatka, Mehdi Shakibaei
Summary: Resveratrol, a well-studied polyphenol, has the potential to complement traditional tumor therapy by targeting multiple signal transduction pathways involved in cancer processes like inflammation, angiogenesis, proliferation, metastasis, glucose metabolism, and apoptosis. Tumor cells display the Warburg effect, where they reprogram their metabolism to favor aerobic glycolysis, creating a low pH environment that promotes their survival and resistance to apoptosis. Resveratrol's ability to modulate tumor glucose metabolism and target multiple components in signaling pathways makes it a promising therapeutic agent in cancer treatment.
Review
Biochemistry & Molecular Biology
Mengyuan Cao, Yunmeng Wang, Guige Lu, Haoran Qi, Peiyu Li, Xiaoshuo Dai, Jing Lu
Summary: Although progress has been made in CRC research, CRC still remains the second most frequent type of malignancy and the major cause of cancer-related death among gastrointestinal cancers. Understanding the key signaling pathways that regulate CRC angiogenesis is critical in inhibiting CRC.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Bozhao Li, Tianjiao Chu, Jingyan Wei, Yinlong Zhang, Feilong Qi, Zefang Lu, Chao Gao, Tianjiao Zhang, Ershuai Jiang, Junchao Xu, Jiaqi Xu, Suping Li, Guangjun Nie
Summary: This study developed a customized strategy combining vascular disruption agents (VDAs) with an anti-angiogenic drug (AAD) using mesoporous silica nanoparticles coated with platelet membrane for efficient tumor targeting accumulation, showing promising potential for tumor eradication.
Article
Biotechnology & Applied Microbiology
Manman Pei, Kaiyuan Liu, Xiao Qu, Kairuo Wang, Qian Chen, Yuanyuan Zhang, Xinyue Wang, Zheng Wang, Xinyao Li, Feng Chen, Huanlong Qin, Yang Zhang
Summary: Selenium-doped manganese phosphate nanoparticles can reverse multidrug resistance in colorectal cancer cells through sustained release of selenium and down-regulation of MDR-related protein expression. These nanoparticles also serve as effective drug carriers of oxaliplatin and induce apoptosis in colorectal cancer cells. Based on in vivo studies, oxaliplatin-loaded Se-MnP NPs inhibit the proliferation of oxaliplatin-resistant tumor cells.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Bikash Chandra Jena, Mahitosh Mandal
Summary: The tumor microenvironment (TME) is a complex network of cellular organization supporting tumor growth through intercellular communication, with a pivotal role in the development of anti-cancer drug resistance. Exosomes have emerged as key players in mediating bidirectional interplay between tumor and TME, promoting drug resistance and challenging therapeutic strategies.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2021)
Article
Materials Science, Multidisciplinary
Eric Volta-Duran, Olivia Cano-Garrido, Naroa Serna, Hector Lopez-Laguna, Laura Sanchez-Garcia, Mireia Pesarrodona, Alejandro Sanchez-Chardi, Ramon Mangues, Antonio Villaverde, Esther Vazquez, Ugutz Unzueta
SCIENCE CHINA-MATERIALS
(2020)
Article
Chemistry, Multidisciplinary
Julieta M. Sanchez, Hector Lopez-Laguna, Patricia Alamo, Naroa Serna, Alejandro Sanchez-Chardi, Veronica Nolan, Olivia Cano-Garrido, Isolda Casanova, Ugutz Unzueta, Esther Vazquez, Ramon Mangues, Antonio Villaverde
Article
Engineering, Biomedical
Ugutz Unzueta, Monica Roldan, Mireia Pesarrodona, Raul Benitez, Alejandro Sanchez-Chardi, Oscar Conchillo-Sole, Ramon Mangues, Antonio Villaverde, Esther Vazquez
ACTA BIOMATERIALIA
(2020)
Article
Chemistry, Multidisciplinary
Naroa Serna, Patricia Alamo, Prashanthi Ramesh, Daria Vinokurova, Laura Sanchez-Garcia, Ugutz Unzueta, Alberto Gallardo, Maria Virtudes Cespedes, Esther Vazquez, Antonio Villaverde, Ramon Mangues, Jan Paul Medema
JOURNAL OF CONTROLLED RELEASE
(2020)
Article
Oncology
Victor Pallares, Ugutz Unzueta, Aida Falgas, Laura Sanchez-Garcia, Naroa Serna, Alberto Gallardo, Gordon A. Morris, Lorena Alba-Castellon, Patricia Alamo, Jorge Sierra, Antonio Villaverde, Esther Vazquez, Isolda Casanova, Ramon Mangues
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2020)
Article
Chemistry, Physical
Naroa Serna, Olivia Cano-Garrido, Laura Sanchez-Garcia, Mireia Pesarrodona, Ugutz Unzueta, Alejandro Sanchez-Chardi, Ramon Mangues, Esther Vazquez, Antonio Villaverde
PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION
(2020)
Article
Pharmacology & Pharmacy
Patricia Alamo, Victor Pallares, Maria Virtudes Cespedes, Aida Falgas, Julieta M. Sanchez, Naroa Serna, Laura Sanchez-Garcia, Eric Volta-Duran, Gordon A. Morris, Alejandro Sanchez-Chardi, Isolda Casanova, Ramon Mangues, Esther Vazquez, Antonio Villaverde, Ugutz Unzueta
Article
Pathology
Yuval Ramot, Ameya Deshpande, Virginia Morello, Paolo Michieli, Tehila Shlomov, Abraham Nyska
Summary: The study compared the quantitative assessment of liver fibrosis using AI algorithms with semiquantitative assessment by a pathologist, showing excellent correlation at higher magnification levels.
TOXICOLOGIC PATHOLOGY
(2021)
Article
Gastroenterology & Hepatology
Kuai Ma, Weitao Que, Xin Hu, Wen-Zhi Guo, Er-li Gu, Liang Zhong, Virginia Morello, Manuela Cazzanti, Paolo Michieli, Terumi Takahara, Xiao-Kang Li
Summary: The study investigated the effect of the MET-agonistic antibody 71D6 on liver regeneration in a mouse model of SFSS. The results showed that 71D6 administration reduced mouse mortality, promoted liver regeneration, and accelerated the resolution of hepatic fibrosis. These findings suggest that activating the MET pathway via an hepatocyte growth factor-mimetic antibody may be beneficial in patients with SFSS and other liver disorders.
LIVER TRANSPLANTATION
(2022)
Article
Oncology
Olivia Cano-Garrido, Patricia Alamo, Laura Sanchez-Garcia, Aida Falgas, Alejandro Sanchez-Chardi, Naroa Serna, Eloi Parlade, Ugutz Unzueta, Monica Roldan, Eric Volta-Duran, Isolda Casanova, Antonio Villaverde, Ramon Mangues, Esther Vazquez
Summary: This study investigated the use of the human albumin-derived peptide, EPI-X4, as a suitable ligand for targeting colorectal cancer via the cell surface protein CXCR4. Biparatopic nanoparticles combining EPI-X4 with another ligand, T22, showed significantly improved biodistribution in mouse models of CXCR4(+) human cancer and enhanced target cell death. This approach offers a novel strategy for highly selective drug delivery in cancer therapy.
Article
Biochemistry & Molecular Biology
Philippe Aftimos, Christian Rolfo, Sylvie Rottey, Philippe Barthelemy, Christophe Borg, Keunchil Park, Do-Youn Oh, Sang-We Kim, Natalie De Jonge, Valerie Hanssens, Karen Zwanenpoel, Carla Molthoff, Danielle Vugts, Torsten Dreier, Peter Verheesen, Guus A. M. S. van Dongen, Julie Jacobs, Luc Van Rompaey, Anna Hultberg, Paolo Michieli, Patrick Pauwels, Samson Fung, Alain Thibault, Hans de Haard, Nicolas Leupin, Ahmad Awada
Summary: ARGX-111, targeting MET-positive advanced cancers, demonstrated anti-tumor activity in nearly half of patients. Mutations in the Fc of ARGX-111 increased affinity for FcRn, leading to enhanced transcytosis. PET/CT scans showed decreased metabolic activity in metastatic lesions after treatment, with a reduction in CTC numbers, supporting further clinical investigation of ARGX-111.
Article
Oncology
Biagio Ricciuti, Jieun Son, Jeffrey J. Okoro, Alessia Mira, Enrico Patrucco, Yoonji Eum, Xinan Wang, Raymond Paranal, Haiyun Wang, Mika Lin, Heidi M. Haikala, Jiaqi Li, Yue Xu, Joao Victor Alessi, Chhayheng Chhoeu, Amanda J. Redig, Jens Kohler, Kshiti H. Dholakia, Yunhan Chen, Elodie Richard, Marie-Julie Nokin, David Santamaria, Prafulla C. Gokhale, Mark M. Awad, Pasi A. Janne, Chiara Ambrogio
Summary: The study demonstrates the heterogeneity of KRAS isoforms in terms of concurrent genomic alterations and gene-expression profiles. Different mutant KRAS isoforms show isoform-specific properties and therapeutic responses. Stratification based on KRAS alleles should be considered in the design of future clinical trials.
CLINICAL CANCER RESEARCH
(2022)
Article
Multidisciplinary Sciences
Carlos Sebastian, Christina Ferrer, Maria Serra, Jee-Eun Choi, Nadia Ducano, Alessia Mira, Manasvi S. Shah, Sylwia A. Stopka, Andrew J. Perciaccante, Claudio Isella, Daniel Moya-Rull, Marianela Vara-Messler, Silvia Giordano, Elena Maldi, Niyati Desai, Diane E. Capen, Enzo Medico, Murat Cetinbas, Ruslan Sadreyev, Dennis Brown, Miguel N. Rivera, Anna Sapino, David T. Breault, Nathalie Y. R. Agar, Raul Mostoslavsky
Summary: This study reveals that the histone deacetylase SIRT6 controls tumor initiation in intestinal cancer through regulating glucose metabolism. The loss of SIRT6 leads to an increase in the number of intestinal stem cells (ISCs), resulting in enhanced tumor initiating potential. The researchers found a metabolic compartmentalization within the intestinal epithelium and adenomas, where a rare population of cells exhibit features of Warburg-like metabolism characterized by high pyruvate dehydrogenase kinase (PDK) activity. These cells are quiescent cells expressing +4 ISCs and enteroendocrine markers, and their active glycolysis suppresses ROS accumulation and enhances their stem cell and tumorigenic potential.
NATURE COMMUNICATIONS
(2022)
Review
Biochemistry & Molecular Biology
Hector Lopez-Laguna, Julieta Sanchez, Ugutz Unzueta, Ramon Mangues, Esther Vazquez, Antonio Villaverde
TRENDS IN BIOCHEMICAL SCIENCES
(2020)
Article
Medicine, Research & Experimental
Aida Falgas, Victor Pallares, Naroa Serna, Laura Sanchez-Garcia, Jorge Sierra, Alberto Gallardol, Lorena Alba-Castellon, Patricia Alamo, Ugutz Unzueta, Antonio Villaverde, Esther Vazquez, Ramon Mangues, Isolda Casanova