Review
Biochemistry & Molecular Biology
Mohammad Amin Atazadegan, Mohammad Bagherniya, Gholamreza Askari, Aida Tasbandi, Amirhossein Sahebkar
Summary: This study reviewed the efficacy of bioactive natural compounds on homocysteine levels, with animal studies showing that black and green tea, cinnamon, resveratrol, curcumin, garlic extract, ginger, and soy significantly reduced homocysteine levels; clinical trials indicated that curcumin and resveratrol have favorable effects on serum homocysteine.
Review
Food Science & Technology
Teresa Pinto, Alfredo Aires, Fernanda Cosme, Eunice Bacelar, Maria Cristina Morais, Ivo Oliveira, Jorge Ferreira-Cardoso, Rosario Anjos, Alice Vilela, Berta Goncalves
Summary: Polyphenols and volatile compounds are crucial for the quality and characteristics of vegetables and medicinal and aromatic plants, possessing various bioactivities and disease prevention properties. Researchers are focusing on polyphenols, volatile compounds, and the new challenges in enhancing positive characteristics of plants.
Review
Biotechnology & Applied Microbiology
Mariana Zuleima Perez-Gonzalez, Maria Adelina Jimenez-Arellanes
Summary: The consumption of medicinal plants has increased in recent decades, leading to overexploitation and deforestation, endangering plant species. Plant biotechnology offers a solution by increasing compound yield, reducing costs, and aiding in the protection of endangered medicinal plants with important biological activity.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2021)
Review
Food Science & Technology
Raz Alfahel, Tomasz Sawicki, Monika Jablonska, Katarzyna E. Przybylowicz
Summary: This article explores the potential anti-hyperglycemic effects of bioactive compounds in functional foods, specifically flavonoids and phenolic acids, and their roles in mitigating chronic diseases and promoting human health. The study investigates how these compounds modulate glucose transporters, with the aim of identifying effective strategies for the prevention and treatment of diet-related diseases.
Review
Biochemistry & Molecular Biology
Radu Claudiu Fierascu, Irina Fierascu, Anda Maria Baroi, Alina Ortan
Summary: This paper discusses the alternative treatments and raw material uses of natural compounds from medicinal and aromatic plants, compares the advantages and disadvantages of traditional versus modern extraction techniques and the possibility for scale up, as well as the applications of these plants in medical, industrial, and nanotechnology fields.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Food Science & Technology
Meiby Fernandez-Rojas, Lyanne Rodriguez, Andres Trostchansky, Eduardo Fuentes
Summary: Cardiovascular diseases are the leading cause of death worldwide. Platelet hyperactivation can lead to thrombus formation and blood vessel obstruction, while a diet rich in bioactive compounds can help prevent cardiovascular diseases. This review collects the latest research on the cardioprotective and antiplatelet activities of different compounds extracted from natural products.
Review
Nutrition & Dietetics
Maryam Kazemi, Amir Hadi, Roger A. Pierson, Marla E. Lujan, Gordon A. Zello, Philip D. Chilibeck
Summary: The study found that a diet with low glycemic index (LGI) had significant effects on improving cardiometabolic and reproductive profiles in PCOS patients, including reducing insulin resistance, improving lipid metabolism, and decreasing abdominal fat.
ADVANCES IN NUTRITION
(2021)
Article
Cardiac & Cardiovascular Systems
Christoph Hochsmann, James L. Dorling, Corby K. Martin, Robert L. Newton, John W. Apolzan, Candice A. Myers, Kara D. Denstel, Emily F. Mire, William D. Johnson, Dachuan Zhang, Connie L. Arnold, Terry C. Davis, Vivian Fonseca, Carl J. Lavie, Eboni G. Price-Haywood, Peter T. Katzmarzyk
Summary: A pragmatic ILI delivered in primary care setting produced clinically relevant improvements in cardiometabolic health in underserved population over 24 months, including significant weight loss and improvements in blood glucose, cholesterol levels.
Review
Nutrition & Dietetics
Elaine A. Yu, Rachael P. Jackman, Marshall J. Glesby, K. M. Venkat Narayan
Summary: Cardiometabolic diseases have been found to be associated with COVID-19 severity, but the specific mechanisms are unclear. Studies have shown that obesity is related to higher neutralizing antibody titers after SARS-CoV-2 infection, while diabetes, hypertension, and cardiovascular diseases are not associated with antibody levels.
ADVANCES IN NUTRITION
(2023)
Article
Agricultural Engineering
Alina Kalyniukova, Jaroslav Holusa, David Musiolek, Jana Sedlakova-Kadukova, Justyna Plotka-Wasylka, Vasil Andruch
Summary: The medicinal plants industry has grown rapidly in the past decade, with attention focused on the development of new separation procedures using deep eutectic solvents to improve yields and quality of bioactive compounds extracts. This review aims to collect details on the application of deep eutectic solvents in the separation of bioactive compounds in medicinal plants and provide a solid foundation for future research in this area.
INDUSTRIAL CROPS AND PRODUCTS
(2021)
Article
Infectious Diseases
Sundaram Muthukrishnan, Paranivasakam Prakathi, Thangavel Sivakumar, Muthu Thiruvengadam, Bindhu Jayaprakash, Venkidasamy Baskar, Maksim Rebezov, Marina Derkho, Gokhan Zengin, Mohammad Ali Shariati
Summary: Endophytic fungi residing in medicinal plants have the potential to produce various bioactive compounds. In this study, three endophytic fungi were isolated from different medicinal plants and their intra- and extracellular products were analyzed. The analysis revealed the presence of bioactive metabolites and phytochemicals, and the extracts exhibited strong antibacterial and antioxidant activity. Molecular docking analysis also suggested the potential anticancer activity of certain compounds. These findings highlight the importance of endophytic fungi in natural drug development and reducing the environmental burden of synthetic drugs.
Article
Biochemistry & Molecular Biology
Oluwafemi Adeleke Ojo, Adebola Busola Ojo, Charles Okolie, Mary-Ann Chinyere Nwakama, Matthew Iyobhebhe, Ikponmwosa Owen Evbuomwan, Charles Obiora Nwonuma, Rotdelmwa Filibus Maimako, Abayomi Emmanuel Adegboyega, Odunayo Anthonia Taiwo, Khalaf F. Alsharif, Gaber El-Saber Batiha
Summary: Flavonoid compounds from medicinal plants were evaluated for their inhibitory role on AChE, BChE, and MAO activity, with pharmacophore modeling, auto-QSAR prediction, and molecular studies used. The study produced pharmacophore models that identified active compounds with a high success rate, and machine learning-based models were used to predict bioactivities with promising results. Docking studies revealed potential lead compounds for drug improvement against neurodegenerative diseases.
Article
Food Science & Technology
Beatriz H. Paschoalinotto, Maria Ines Dias, Jose Pinela, Tania C. S. P. Pires, Maria Jose Alves, Andrei Mocan, Ricardo C. Calhelha, Lillian Barros, Rafael P. Ineu, Isabel C. F. R. Ferreira
Summary: This study explored the chemical composition and bioactive properties of several medicinal and aromatic plants in tisane form, with T5 showing the highest concentration of active compounds. T2 and T4 were highlighted for their antihemolytic, antimicrobial, and cytotoxic activities.
Review
Environmental Sciences
Muhammad Idrees Khan, Abdelhakim Bouyahya, Naoufal E. L. Hachlafi, Naoual El Menyiy, Muhammad Akram, Sabira Sultana, Gokhan Zengin, Lilya Ponomareva, Mohammad Ali Shariati, Oluwafemi Adeleke Ojo, Stefano Dall'Acqua, Tobiloba Christiana Elebiyo
Summary: This article introduces the role of medicinal plants and their bioactive compounds in the treatment of breast cancer. It is found that compounds in natural products have anti-cancer effects on breast cancer cells, and they work through various mechanisms, including inhibiting apoptotic pathways, blocking the cell cycle, and activating autophagy. In addition, they also exhibit anti-angiogenesis and anti-metastatic effects. However, the chemopreventive effects of different compounds on breast cancer vary.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Review
Plant Sciences
Sheikh Rashel Ahmed, Muhammad Fazle Rabbee, Anindita Roy, Rocky Chowdhury, Anik Banik, Khadizatul Kubra, Mohammed Mehadi Hassan Chowdhury, Kwang-Hyun Baek
Summary: When functioning properly, the stomach is the center of both physical and mental satisfaction. Gastrointestinal disorders, caused by infections and physiochemical abnormalities, are now widespread and are mostly inflammatory diseases. Treatment with medicinal plants and their active components is considered a safer and more effective option compared to synthetic drugs.
Article
Biochemistry & Molecular Biology
I. O. Omotuyi, M. O. Abiodun, K. Komolafe, O. C. Ejelonu, O. Olusanya
JOURNAL OF MOLECULAR MODELING
(2015)
Article
Biotechnology & Applied Microbiology
B. C. Ejelonu, A. A. Lasisi, A. G. Olaremu, O. C. Ejelonu
AFRICAN JOURNAL OF BIOTECHNOLOGY
(2011)
Article
Biochemistry & Molecular Biology
Olusola Olalekan Elekofehinti, Idowu Olaposi Omotuyi, Jean Paul Kamdem, Oluwamodupe Cecilia Ejelonu, Guimarae Vanessa Alves, Isaac Gbadura Adanlawo, Joao Batista Teixeira Rocha
JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
(2014)
Article
Environmental Sciences
Folasade M. Olajuyigbe, Oluwaseun A. Adeleye, Ayodele O. Kolawole, Tolulope O. Bolarinwa, Emmanuel A. Fasakin, Ebunoluwa R. Asenuga, Joshua O. Ajele
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2020)
Article
Endocrinology & Metabolism
Olusola Olalekan Elekofehinti, Victor Oluwatoyin Oyedokun, Opeyemi Iwaloye, Akeem Olalekan Lawal, Oluwamodupe Cecilia Ejelonu
Summary: This study suggests that bitter melon nanoparticles ameliorate diabetic nephropathy by regulating the SOCS/JAK/STAT and PI3K/Akt/PTEN signaling pathways, with potential anti-diabetic properties identified through molecular docking analysis.
JOURNAL OF DIABETES AND METABOLIC DISORDERS
(2021)
Article
Endocrinology & Metabolism
Olusola Olalekan Elekofehinti, Akeem Olalekan Lawal, Oluwamodupe Cecilia Ejelonu, Olorunfemi Raphael Molehin, Courage Dele Famusiwa
JOURNAL OF DIABETES AND METABOLIC DISORDERS
(2020)
Article
Mathematical & Computational Biology
Abiodun Julius Arannilewa, Oluwaseun Suleiman Alakanse, Adesola Oluwaseun Adeleye, Oluwaseyi Israel Malachi, Ifedayo Michael Obaidu, Oluwafemi Emmanuel Ekun, Emmanuel Damilola Afolayan, Patricia Folakemi Afere, Kayode Abdullateef Ayuba, Tolulope Oluwafemi Bolarinwa, George Oche Ambrose
Review
Endocrinology & Metabolism
Olusola Olalekan Elekofehinti, Oluwamodupe Cecilia Ejelonu, Jean Paul Kamdem, Oluwaseun Benedicta Akinlosotu, Isaac Gbadura Adanlawo
WORLD JOURNAL OF DIABETES
(2017)
Article
Medicine, Research & Experimental
Oluwamodupe Cecilia Ejelonu, Olusola Olalekan Elekofehinti, Isaac Gbadura Adanlawo
BIOMEDICINE & PHARMACOTHERAPY
(2017)